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Recent Advances of Metal-Organic Frameworks-based Nanozymes for Bio-applications

Chemical Research in Chinese Universities 2022年第6期38卷 1324-1343页

作者： WANG Yuda zulpya mahmut ZHANG Xinyao XU Shihan SUN Jiao DONG Biao Department of Cell Biology Norman Bethune College of Medicine Jilin UniversityChangchun 130021P.R.China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012P.R.China Department of Bioengineering University of WashingtonSeattleWAUnited States

Artificial nanoenzymes with enzyme-like catalytic activity have gradually become an alternative to natural enzymes due to their low production cost,high stability,and good *** recent years,various enzyme mimics have emerged with the rapid development of ***-organic frameworks(MOFs)are a novel class of porous inorganic-organic hybrid materials made from metal ions/clusters and organic ligands,and MOFs-based nanozymes show great prospect in biosensing,biocatalysis,biomedical imaging,and therapeutic applications,due to unique properties,such as high specific surface area,high porosity,tunable morphology,and excellent biocatalytic *** this paper,the recent progresses concerning MOFs-based nanozymes are systematically summarized,including the synthesis,design strategies and related applications,which are divided into two major categories,namely,MOFs structured nanoenzymes and MOFs composite structured ***,the applications of various classifications of MOFs research are *** the end,current challenges and future perspectives of MOFs-based nanozymes are also *** is highly expected that this review on this important area can provide a meaningful guidance for tumor therapy,biosensing and other aspects.

关键词： Metal-organic framework Biocatalytic Nanoenzyme Catalytic performance Biosensing

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