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Acta Pharmaceutica Sinica B 2024年第6期14卷 2657-2668页

作者： Chenxu Zhao Jingrong Li Yue Hu Lingyu Li Meng Yu Yunfeng Huang Tao Zhang Hai Shang zhongmei zou State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Institute of Chinese Medicine Resources Guangxi Institute of Chinese Medicine&Pharmaceutical ScienceNanning 530000China

A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.***.2.0^(3,8)]decene *** planar and three-dimensional structures were exhaustively characterized by comprehensive spectroscopic data and X-ray diffraction *** by the hypothetical biosynthetic pathway,the biomimetic synthesis of racemic 1 was achieved using 4-hydroxy-5-methylcoumarin and citral as the starting material via oxa-6πelectrocyclization and intramolecular[2+2]***,the results of the biological activity assay demonstrated that both(+)-1a and(-)-1b exhibited potent lipid-lowering effects in 3T3-L1 adipocytes and the high-fat diet zebrafish ***,the lipid-lowering activity of(+)-1a is better than that of(-)-1b at the same concentration,and molecular mechanism study has shown that(+)-1a and(-)-1b impairs adipocyte differentiation and stimulate lipolysis by regulating C/EBPα/PPARγsignaling and Perilipin signaling in vitro and in *** findings provide a promising drug model molecule for the treatment of obesity.

关键词： Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis Lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model

Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala

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Chinese Chemical Letters 2023年第1期34卷 284-288页

作者： Haixin Zhang Jingrong Li Jinguang Si Chengya Dong Qi Li Meng Yu Lingling Qin Lingyu Li Chenxu Zhao Tao Zhang zhongmei zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Medical Sciences Guizhou Medical UniversityGuiyang 550000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100193China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450000China

Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes *** structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray *** plausible biosynthetic pathways for compounds 1-3 are ***,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase.

关键词： Atractylodes macrocephala Compositae Sesquiterpene-phenol hybrids Anti-cancer Neutrophil elastase

Screening the effective components in treating dampness stagnancy due to spleen deficiency syndrome and elucidating the potential mechanism of Poria water extract

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Chinese Journal of Natural Medicines 2023年第2期21卷 83-98页

作者： LI Huijun ZHANG Dandan WANG Tianhe LUO Xinyao XIA Heyuan PAN Xiang HAN Sijie YOU Pengtao WEI Qiong LIU Dan zou zhongmei YE Xiaochuan Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine School of PharmacyHubei University of Chinese MedicineWuhan 430065China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Poria is an important medicine for inducing diuresis to drain dampness from the middle ***,the specific effective components and the potential mechanism of Poria remain largely *** identify the effective components and the mechanism of Poria water extract(PWE)to treat dampness stagnancy due to spleen deficiency syndrome(DSSD),a rat model of DSSD was established through weight-loaded forced swimming,intragastric ice-water stimulation,humid living environment,and alternate-day fasting for 21 *** 14 days of treatment with PWE,the results indicated that PWE increased fecal moisture percentage,urine output,D-xylose level and weight;amylase,albumin,and total protein levels;and the swimming time of rats with DSSD to different *** highly related components were screened out using the spectrum-effect relationship and *** studies revealed that PWE significantly increased the expression of serum motilin(MTL),gastrin(GAS),ADCY5/6,p-PKAα/β/γcat,and phosphorylated cAMP-response element binding protein in the stomach,and AQP3 expression in the ***,it decreased the levels of serum ADH,the expression of AQP3 and AQP4 in the stomach,AQP1 and AQP3 in the duodenum,and AQP4 in the *** induced diuresis to drain dampness in rats with *** main effective components were identified in *** exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach,MTL and GAS levels in the serum,AQP1 and AQP3 expression in the duodenum,and AQP3 and AQP4 expression in the colon.

关键词： Poria water extract Dampness stagnancy due to spleen deficiency syndrome Spectrum-effect relationship Effective components Mechanisms

Equisetin is an anti-obesity candidate through targeting 11β-HSD1

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2358-2373页

作者： Zhenlu Xu Dongyun Liu Dong Liu Xue Ren Haibo Liu Guihong Qi Yue Zhou Chongming Wu Kui Zhu zhongmei zou Jing Yuan Wenhan Lin Peng Guo Pharmacology and Toxicology Research Center Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China Capital Institute of Pediatrics Beijing 100020China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China National Center for Veterinary Drug Safety Evaluation College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China

Obesity is increasingly prevalent globally, searching for therapeutic agents acting on adipose tissue is of great importance. Equisetin(EQST), a meroterpenoid isolated from a marine sponge-derived fungus, has been reported to display antibacterial and antiviral activities. Here, we revealed that EQST displayed anti-obesity effects acting on adipose tissue through inhibiting adipogenesis in vitro and attenuating HFD-induced obesity in mice, doing so without affecting food intake, blood pressure or heart *** demonstrated that EQST inhibited the enzyme activity of 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), a therapeutic target of obesity in adipose tissue. Anti-obesity properties of EQST were all offset by applying excessive 11β-HSD1’s substrates and 11β-HSD1 inhibition through knockdown in vitro or 11β-HSD1 knockout in vivo. In the 11β-HSD1 bypass model constructed by adding excess11β-HSD1 products, EQST’s anti-obesity effects disappeared. Furthermore, EQST directly bond to11β-HSD1 protein and presented remarkable better intensity on 11β-HSD1 inhibition and better efficacy on anti-obesity than known 11β-HSD1 inhibitor. Therefore, EQST can be developed into anti-obesity candidate compound, and this study may provide more clues for developing higher effective 11β-HSD1 inhibitors.

关键词： EQST Obesity Adipocyte Lipid accumulation Preadipocyte differentiation Adipose tissue 11β-HSD1 11β-HSD1 inhibitor

Studies on Diterpenoid Constituents from Dichrocephala benthamii ***

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Studies on Diterpenoid Constituents from Dichrocephala benth...

第十四届全国中药和天然药物学术研讨会

作者： Bo Song Gang Ding Xinhui Tian Qiubo Zhang Haoli Sun zhongmei zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College

Objective To study the diterpenoid constituents of the whole herb of Dichrocephala benthamii *** The compounds were isolated by column chromatography on silica gel,Sephadex LH-20 and semi-preparative *** structures were identified on the basis of spectral analysis,physicochemical characters and comparison of their spectral data with those in the *** Ten diterpenoids were isolated and identified as dichrocephnoid C（1）,dichrocephnoid D（2）,16-oxo-15,16H-strictic acid（3）,floridiolide A（4）,15-methoxyl-16-oxo-15,16H-strictic acid（5）,16-oxo-15,16H-hardwickiic acid（6）,15-methoxyl-16-oxo-15,16H-hardwickiic acid（7）,15-ethyoxyl-16-oxo-15,16H-hardwickiic acid（8）,15- hydroxy-16-oxo-15,16H-hardwickiic acid（9）,15-hydroxy-16-oxo-15,16H-strictic acid（10）,*** Compounds 1-10 were isolated for the first time form this genus,whereas dichrocephnoid C（1） and dichrocephnoid D（2）were new compounds.

关键词： Dichrocephala benthamii C.B.Clarke Compositae Diterpenoid Constituents

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葱属植物化学及药理研究进展

药学学报 1999年第5期34卷 395-400页

作者：邹忠梅于德泉丛浦珠中国医学科学院中国协和医科大学药物研究所中国医学科学院中国协和医科大学药用植物研究所

百合科（Ｌｉｌｉａｃｅａｅ）葱属（Ａｌｉｕｍ）植物约有５００种，我国有１１０种（包括变种和引进的外来种），主要分布于东北、华北、西北及西南地区［１］。本属的不少品种既可食用也可药用，如小根蒜、蒜、韭、葱等［２］。对葱... 详细信息

百合科（Ｌｉｌｉａｃｅａｅ）葱属（Ａｌｉｕｍ）植物约有５００种，我国有１１０种（包括变种和引进的外来种），主要分布于东北、华北、西北及西南地区［１］。本属的不少品种既可食用也可药用，如小根蒜、蒜、韭、葱等［２］。对葱属植物的研究始于上世纪，国内外学者...

关键词：葱属植物化学成分药理作用

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紫玉盘属植物乌藤化学成分研究

中国中药杂志 2009年第5期34卷 567-570页

作者：刘安徐丽珍邹忠梅中国中医科学院中药研究所北京100700 中国医学科学院药用植物研究所北京100094

目的:分离鉴定乌藤中化学成分。方法:采用各种色谱法进行分离,运用多种波谱方法鉴定化合物结构。结果:分离并鉴定了7个化合物,分别是乌藤素C(1),-βsenepoxide(2),2,4-二羰基六氢-1,3-二氮杂卓(3),山柰酚-3,7-O-α-L-二鼠李糖苷(4),安... 详细信息

目的:分离鉴定乌藤中化学成分。方法:采用各种色谱法进行分离,运用多种波谱方法鉴定化合物结构。结果:分离并鉴定了7个化合物,分别是乌藤素C(1),-βsenepoxide(2),2,4-二羰基六氢-1,3-二氮杂卓(3),山柰酚-3,7-O-α-L-二鼠李糖苷(4),安诺洛宾(anolob ine,5),(-)-lyon iresinol(6)和sch izandriside(7)。结论:化合物1是新化合物,化合物2~7为首次从该植物中分离得到。

关键词：乌藤乌藤素C 化学成分

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对叶豆黄酮类化学成分研究

中国中药杂志 2009年第7期34卷 861-863页

作者：刘安徐丽珍邹忠梅杨世林中国中医科学院中药研究所北京100700 中国医学科学院药用植物研究所北京100193

目的:分离鉴定对叶豆Cassia alata中的化学成分,为其药效物质研究奠定基础。方法:采用溶剂萃取、正相硅胶色谱、凝胶色谱等方法进行分离;应用1DNMR,IR,UV,MS等谱学方法进行结构鉴定。结果:分离得到12个化合物,分别鉴定为金圣草素(1),山... 详细信息

目的:分离鉴定对叶豆Cassia alata中的化学成分,为其药效物质研究奠定基础。方法:采用溶剂萃取、正相硅胶色谱、凝胶色谱等方法进行分离;应用1DNMR,IR,UV,MS等谱学方法进行结构鉴定。结果:分离得到12个化合物,分别鉴定为金圣草素(1),山柰酚(2),槲皮素(3),5,7,4′-三羟基二氢黄酮(4),山柰酚-3-O-β-D-葡萄糖苷(5),山柰酚-3-O-葡萄糖-(6→1)-O-葡萄糖苷(6),17-羟基三十四烷(7),正三十二烷醇(8),正三十醇(9),棕榈酸二十六酯(10),硬脂酸(11),棕榈酸(12)。结论:除化合物1,2外,其余10个化合物均是首次从对叶豆中分离得到。

关键词：对叶豆化学成分黄酮

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地胆草全草化学成分研究

中国药学杂志 2023年第17期58卷 1547-1553页

作者：裴迪付露于猛张涛邹忠梅中国医学科学院北京协和医学院药用植物研究所北京100193

目的研究地胆草(Elephantopus scaber Linn.)全草体积分数95%乙醇提取物的化学成分。方法利用HP-20大孔树脂柱色谱,硅胶柱色谱,Sephadex LH-20凝胶柱色谱,ODS柱色谱和半制备高效液相色谱及重结晶等方法对地胆草全草体积分数95%乙醇提取... 详细信息

目的研究地胆草(Elephantopus scaber Linn.)全草体积分数95%乙醇提取物的化学成分。方法利用HP-20大孔树脂柱色谱,硅胶柱色谱,Sephadex LH-20凝胶柱色谱,ODS柱色谱和半制备高效液相色谱及重结晶等方法对地胆草全草体积分数95%乙醇提取物进行分离纯化,根据化合物理化性质及多种波谱数据鉴定化合物结构。结果共分离得到21个化合物,分别鉴定为:(2E)-2-甲基-丁-2-烯-1,4-二醇-6'-O-咖啡酰-1-O-β-吡喃葡萄糖苷(1)、鹅掌楸树脂酚A(2)、去氢催吐萝芙叶醇(3)、3β-羟基-β-紫罗酮(4)、异夏佛塔苷(5)、东莨菪素(6)、4-羟基蜂蜜曲菌素(7)、3,5,3',5'-四甲氧基-4-羟基(8-O-肉桂醇)-7-O-葡糖苷(8)、3β-羟基-β-紫罗兰酮3-O-β-D-吡喃葡萄糖苷(9)、myrsinionoside A(10)、正己烷基O-β-D-吡喃葡萄糖苷(11)、(Z)-4-[3'-(β-D-吡喃葡萄糖基氧基)丁烯基]-3,5,5-三甲基-2-环己烯-1-酮(12)、对香豆酸(13)、阿魏酸(14)、对羟基苯甲醛(15)、香草酸(16)、香草醛(17)、丁香酸(18)、丁香醛(19)、木犀草素-7-O-β-D-葡萄糖苷(20)和地芰普内酯(21)。结论化合物1~12为首次从地胆草属植物中分离得到。

关键词：地胆草鹅掌楸树脂酚A 异夏佛塔苷结构鉴定

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血三七化学成分的研究

中国中药杂志 2009年第2期34卷 183-185页

作者：任恒春万定荣邹忠梅中国医学科学院北京协和医学院药用植物研究所北京100193 中南民族大学生命科学学院湖北武汉430073

目的:对民间药材血三七的化学成分进行研究。方法:用硅胶、葡聚糖凝胶Sephadex LH-20等手段进行分离纯化,通过IR,~1H-NMR,^(13)C-NMR,MS等波谱鉴定结构。结果:分离鉴定了8个化合物,分别为木栓酮(friedelin,1),β-谷甾醇(β-sitosterol,... 详细信息

目的:对民间药材血三七的化学成分进行研究。方法:用硅胶、葡聚糖凝胶Sephadex LH-20等手段进行分离纯化,通过IR,~1H-NMR,^(13)C-NMR,MS等波谱鉴定结构。结果:分离鉴定了8个化合物,分别为木栓酮(friedelin,1),β-谷甾醇(β-sitosterol,2),西米杜鹃酮(simiarenone,3),白芷内酯(angelicin,4),补骨脂内酯(psoralen,5).棕榈酸(palmitic acid,6),表儿茶素[(-)-epicatechin,7]和槲皮素(quercetin,8)。结论:所有化合物均为首次从该植物中分离得到,除化合物2,7,8外,其他5个化合物均为首次从该属植物中分离得到。

关键词：血三七蓼属表儿茶素香豆素三萜