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Anti-inflammatory effect of extracts of Dendropanax dentige and Lycopodiastrum casuarinoides on rheumatoid arthritis and their underlying mechanism in rats

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中国药理学与毒理学杂志 2016年第10期30卷 1036-1037页

作者： CHEN Gang LIU Zhi-kai HAN Chen-yun LI Jia-shuang zou yi-ping Key Laboratory of Natural Active Pharmaceutical Constituents of Jiangxi Province Yichun University

OBJECTIVE To investigate the anit-inflammatory effect of extracts of Dendropanax dentiger(Harms)Merr and Lycopodiastrum casuarinoides(Spring)Holub on rheumatoid arthritis(RA)using adjuvant arthritis(AA)rat model and possible *** The AA rat model of RA was induced in adult SparagueDawley(SD)rats by injecting of the adjuvant at base ***-week-old male SD rats were randomly divided into the following groups:normal saline group(blank control),*** decoction group(80g·kg-1·d-1),*** decoction group(80 g·kg·d-1),the total of glucoside Tripterygium(GTT)group(positive control,2 mg·kg-1·d-1).They were administered orally for *** of tissues arthritis rats was observed by H.E *** volume of paw swelling was measured and the arthritis inflammation index was *** expressions of tumor necrosis factor-α(TNF-α)and interlukin-1β(IL-1β)were detected by the ELISA *** addition,previous study has reported that plant-derived mi RNAs play a role for cross kingdom regulatory ***,we also performed RNA-seq technique to identify bioactive mi RNAs via comparative transcriptome analysis between *** and *** Comparing with AA model group,the volume of paw swelling and the arthritis index were increased significantly in the AA rat model group(P<0.01),suggesting that the AA model rats were prepared *** with the AA model group,the volume of paw swelling of *** decoction group,*** decoction group was decreased by 25.2%and 10.3%,respectively,and the arthritis index was decreased by 27.2%and 18.3%,*** with AA model group,TNF-αprotein expression of *** decoction group and *** decoction groups were decreased by 16.3%and 14.7%,and IL-1βprotein expression was decreased by 23.6%,18.9%(P<0.05,P<0.01),***,we found that some plant-derived homologous mi RNAs(such as mi RNA192 and mi RNA30a)associated with cell

关键词： rheumatoid arthrits aqueous extracts of D.dentiger and L.Cauarinoides anti-inflammatory effect miRNA cross-kingdom regulation

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Black hairy tongue associated with allo peripheral blood hematopoietic stem cell transplantation

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Chinese Medical Journal 2010年第13期123卷 1807-1808页

作者： LUO yi zou ping LI Qiu-bai YOU Yong Institute of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Tongue lesions resulting from mucositis are a frequent complication of high-dose chemotherapy and irradiation. They are very common in patients with hematopoiefic stem cell transplantation, and tongue lesions due to other causes have also been reported. Black hairy tongue （BHT） is a special tongue lesion, not rare in the population with tobacco abuse, but so far it has not been reported after allo peripheral blood hematopoietic stern cell transplantation （allo-PBHST）. Here we presented a patient who developed BHT after allo-PBHST and discussed the factors that may cause this condition.

关键词： tongue, hairy oral hygiene graft vs host disease

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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： yi Yu Guo-ping Liu yi Huang Peng Shi IEEE Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

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Autonomy Evaluation of Unmanned Systems Based on Task Models

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Machine Intelligence Research 2024年第5期21卷 815-830页

作者： yi zou Zehao Ni Xun Lei Chi Zhang Key Laboratory of Complex Aviation Simulation System Beijing100076China State Key Laboratory of Multimodal Artificial Intelligence Systems(MAIS) Institute of AutomationChinese Academy of Sciences(CASIA)Beijing100190China Hong Kong Institute of Science&Innovation Chinese Academy of Sciences(HKISI CAS)Hong Kong999077China

In this study,relevant work on autonomy evaluation(AE)in recent years was comprehensively reviewed and classified from the perspective of task models,and a closed-loop task models based theoretical framework for AE was *** main contributions of this study are as follows.1)A taxonomy for AE based on task models was introduced to classify current theories,methods and standards.2)The limitations of the current autonomous evaluation methods were addressed to provide a theoretical framework for quantitative evaluation based on task models,and evaluation metrics for each stage were proposed based on the AE theoretical framework.3)Qualitative analyses of the superiority of the proposed AE framework based on the closed-loop task models were *** study attempts to provide a reference for researchers and engineers in the autonomous unmanned systems field and inspire future development of AE.

关键词： Unmanned system(UMS) autonomy evaluation task models closed-loop task models kill chain

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Effect mechanism of seepage force on the hydraulic fracture propagation

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International Journal of Coal Science & Technology 2024年第3期11卷 223-240页

作者： Haiyang Wang Desheng Zhou yi zou Peng Zheng School of Petroleum Engineering Xi’an Shiyou UniversityXi’an710065China Engineering Research Center of Development and Management for Low to Extra-Low Permeability Oil and Gas Reservoirs in West China Ministry of EducationXi’an Shiyou UniversityXi’an710065ShaanxiChina Xi’an University of Science and Technology Xi’an710054ShaanxiChina

The flow of fluid through the porous matrix of a reservoir rock applies a seepage force to the solid rock *** the seepage force exerted by fluid flow through the porous matrix of a reservoir rock has a notable influence on rock deformation and failure,its effect on hydraulic fracture(HF)propagation remains ***,in this study,we improved a traditional fluid–solid coupling method by incorporating the role of seepage force during the fracturing fluid seepage,using the discrete element ***,we validated the simulation results of the improved method by comparing them with an analytical solution of the seepage force and published experimental ***,we conducted numerical simulations in both homogeneous and heterogeneous sandstone formations to investigate the influence of seepage force on HF *** results indicate that fluid viscosity has a greater impact on the magnitude and extent of seepage force compared to injection rate,and that lower viscosity and injection rate correspond to shorter hydraulic fracture ***,seepage force influences the direction of HF propagation,causing HFs to deflect towards the side of the reservoir with weaker cementation and higher permeability.

关键词： Hydraulic fracturing Seepage force Fracture propagation Discrete element method Reservoir heterogeneity

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Gallstone recurrence after successful percutaneous cholecystolithotomy:a 10-year follow-up of 439 cases

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 199-203页

作者： zou, yi-ping Du, Ji-Dong Li, Wei-Min Xiao, yin-Qi Xu, Hong-Bin Zheng, Fang Huang, Hui Liu, Hao-Run Li, Hu-Cheng Beijing PLA 309 Hosp Dept Hepatobiliary Surg Beijing 100091 Peoples R China

BACKGROUND: Stone recurrence is a major problem in the medication of gallstones with gallbladder preservation. The aim of this study was to determine the long-term recurrence rate of gallstones and the clinical outcome after successful percutaneous cholecystolithotomy (PCCL) treatment, and to investigate the possible risk factors for gallstone recurrence. METHODS: After successful PCCL for gallstones, 439 patients were followed up during a 10-year period. The long-term gallstone recurrence rate and clinical outcome were evaluated. Risk factors associated with stone recurrence were identified. RESULTS: Gallstone recurrence was detected in 182 of 439 PCCL patients, giving an overall recurrence rate of 41.46%. The cumulative gallstone recurrence rate for each of the 10 post-operative years was 9.57%, 18.91%, 27.33%, 34.14%, 37.59%, 39.86%, 41.90%, 42.73%, 42.85%, and 43.21%, respectively. Among these recurrent patients, 94 were asymptomatic, 80 suffered from nonspecific upper gastrointestinal symptoms and 8 suffered from abdominal pain or biliary colic. Thirty-eight of the 182 patients were retreated with cholecystectomy. The risk factors for stone recurrence included a family history of gallstones, preference for fatty food, accompanying liver disease, multiple stones and poor gallbladder function pre-PCCL. CONCLUSIONS: In this study, the overall recurrence rate of gallstone was 41.46% during a 10-year period. The highest frequency of gallstone recurrence was during the 5th to 6th postoperative years and then continued to slowly increase. Risk factors for stone recurrence varied. We suggest that the use of PCCL in patients with gallstones should be considered carefully because of stone recurrence.

关键词： gallstone percutaneous cholecystolithotomy recurrence risk factors

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Analog spatiotemporal feature extraction for cognitive radio-frequency sensing with integrated photonics

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Light(Science & Applications) 2024年第3期13卷 478-487页

作者： Shaofu Xu Binshuo Liu Sicheng yi Jing Wang Weiwen zou State Key Laboratory of Advanced Optical Communication Systems and Networks Intelligent Microwave Lightwave Integration Innovation Center(imLic)Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghaiChina

Analog feature extraction(AFE)is an appealing strategy for low-latency and efficient cognitive sensing systems since key features are much sparser than the Nyquist-sampled ***,applying AFE to broadband radio-frequency(RF)scenarios is challenging due to the bandwidth and programmability bottlenecks of analog electronic ***,we introduce a photonics-based scheme that extracts spatiotemporal features from broadband RF signals in the analog *** feature extractor structure inspired by convolutional neural networks is implemented on integrated photonic circuits to process RF signals from multiple antennas,extracting valid features from both temporal and spatial *** of the tunability of the photonic devices,the photonic spatiotemporal feature extractor is trainable,which enhances the validity of the extracted ***,a digital-analog-hybrid transfer learning method is proposed for the effective and low-cost training of the photonic feature *** validate our scheme,we demonstrate a radar target recognition task with a 4-GHz instantaneous *** results indicate that the photonic analog feature extractor tackles broadband RF signals and reduces the sampling rate of analog-to-digital converters to 1/4 of the Nyquist sampling while maintaining a high target recognition accuracy of 97.5%.Our scheme offers a promising path for exploiting the AFE strategy in the realm of cognitive RF sensing,with the potential to contribute to the efficient signal processing involved in applications such as autonomous driving,robotics,and smart factories.

关键词： scheme driving smart

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Trace Cobalt Doping and Defect Engineering of High Surface Area α-Ni(OH)_(2) for Electrocatalytic Urea Oxidation

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Energy & Environmental Materials 2024年第2期7卷 111-118页

作者： yi Liu Zhihui Yang Yuqin zou Shuangyin Wang Junying He School of Metallurgy and Environment Central South UniversityChangsha 410083China State Key Laboratory of Chem/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Owing to the intrinsically sluggish kinetics of urea oxidation reaction(UOR)involving a six-electron transfer process,developing efficient UOR electrocatalyst is a great challenge remained to be ***,by taking advantage of 2-Methylimidazole,of which is a kind of alkali in water and owns strong coordination ability to Co^(2+)in methanol,trace Co(1.0 mol%)addition was found to induce defect engineering onα-Ni(OH)_(2)in a dual-solvent system of water and *** characterization results revealed that the synthesized electrocatalyst(WM-Ni_(0.99)Co_(0.01)(OH)_(2))was a kind of defective nanosheet with thickness around 5-6 nm,attributing to the synergistic effect of Co doping and defect engineering,its electron structure was finely altered,and its specific surface a rea was tremendously enlarged from 68 to 172.3 m^(2)g^(-1).With all these merits,its overpotential to drive 10 mA cm^(-2)was reduced by 110 ***,the interfacial behavior of UOR was also well deciphered by operando electrochemical impedance spectroscopy.

关键词： defect engineering electrocatalysis small molecule oxidation

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

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World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： Huan Wang Yan-ping Ruan Sheng Ma Ya-Qi Wang Xiao-Yu Wan yi-Hua He Jing Li Zhi-Yong zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

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Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun Xu Kun He Zhong-ping zou Hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

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