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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Infliximab treatment of glycogenosis Ib with Crohn's-like enterocolitis: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5280-5286页

作者： You-Zhe Gong Xue-mei zhong Ji-Zhen zou Gastroenterology Department Capital Institute of PediatricsBeijing 100020China Pathology Department Capital Institute of PediatricsBeijing 100020China

BACKGROUND Glycogen storage disease type Ib(GSD-Ib)is a glycogen metabolism disorder that leads to the manifestations of inflammatory bowel disease(IBD),especially Crohn’s disease(CD)-like *** biological agents are effective for treating CD,their application in the treatment of GSD-Ib with CD-like colitis has been rarely *** SUMMARY A 13-year-old Han male was diagnosed with GSD-Ib with *** patient was treated with granulocyte colony-stimulating *** he had symptoms of CD-like colitis,he was continuously pumped with enteral nutrition and administered oral mesalazine for 2 wk;however,the symptoms did not improve ***,infliximab(IFX)was ***,the patient has been followed up for 1 year,and no clinical manifestations have been *** 6 mo of treatment(fifth IFX treatment),the disease activity index and all inflammatory indexes decreased,and a review of the colonoscopy data showed that the ulcers appeared *** In this study,the patient was successfully treated with *** cases of GSD-Ib,IBD should be highly considered.

关键词： Crohn’s disease Glycogen storage disease type I Treatment Infliximab Case report

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地胆草抗肿瘤活性成分研究

国际药学研究杂志 2018年第3期45卷 219-225页

作者：沙合尼西.赛力克江张涛李凌宇哈斯特尔.木他西波拉提.马卡比力邹忠梅新疆师范大学生命科学学院乌鲁木齐830054 中国医学科学院北京协和医学院药用植物研究所北京100193 新疆维吾尔自治区药物研究所(自治区哈萨克医药研究所) 乌鲁木齐830004

目的为寻找地胆草(Elephantopus scaber)中的活性化合物,对其全草95%乙醇提取物的化学成分进行研究。方法采用硅胶柱色谱、凝胶柱色谱、开放ODS柱色谱和半制备高效液相色谱等技术进行分离纯化,通过磁共振、质谱等方法鉴定化合物的结构,... 详细信息

目的为寻找地胆草(Elephantopus scaber)中的活性化合物,对其全草95%乙醇提取物的化学成分进行研究。方法采用硅胶柱色谱、凝胶柱色谱、开放ODS柱色谱和半制备高效液相色谱等技术进行分离纯化,通过磁共振、质谱等方法鉴定化合物的结构,并对从地胆草中分离得到的部分化合物进行体外抗肿瘤活性评价。结果从大孔树脂90%乙醇洗脱部位中分离并鉴定13个化合物,分别鉴定为:异去氧地胆草内酯(1)、地胆草种内酯(2)、去氧地胆草内酯(3)、异地胆草种内酯(4)、香叶木素(5)、木犀草素(6)、表木栓醇(7)、羽扇豆醇(8)、羽扇豆醇乙酸酯(9)、木栓酮(10)、(Z)-8,11,12-三羟基-9-十八碳烯酸(11)、(-)-丁香脂素(12)、羽扇豆醇-20(29)-烯-3β-二十烷酸酯(13),其中化合物1~4对人肝癌Hep G2细胞显示有抑制活性,IC50在(1.17±0.14)^(38.24±4.17)mmol/L之内。结论化合物11、12和13为首次从地胆草属中分离得到;化合物1的绝对构型首次通过圆二色(CD)谱和X线单晶衍射法进行了确定,化合物2~4的绝对构型首次通过CD谱进行了确定;倍半萜类化合物1、2、3和4具有潜在的抗肿瘤活性。

关键词：地胆草化学成分结构鉴定抗肿瘤活性

Baculovirus-expressed FAdV-4 penton base protein protects chicken against hepatitis-hydropericardium syndrome

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Journal of Integrative Agriculture 2019年第11期18卷 2598-2604页

作者： ZHANG Jun-qin WEI Yan-ming HUANG Kun SUN Xiao-mei zou zhong JIN mei-lin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070P.R.China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070P.R.China Key Laboratory of Development of Veterinary Diagnostic Products Ministry of AgricultureWuhan 430070P.R.China

Hepatitis-hydropericardium syndrome(HHS)is an infectious disease caused by fowl adenovirus serotype 4(FAdV-4).Several structural and non-structural proteins of FAdV-4 have been expressed in Escherichia coli and baculovirus expression system to develop candidate subunit ***,the protective efficiency of baculovirus-expressed penton base protein has not been *** this study,two recombinant capsid proteins,penton base and fiber-2,were *** then,penton base and fiber-2 were administrated alone or together to specific pathogen-free(SPF)chickens at 14 days of life and boosted at 28 days of *** 42 days of life,the immunized groups and the control group were challenged with FAdV-4 virulent *** show that inoculating penton base or penton base+fiber-2 provided 100%protection to the *** groups vaccinated with the recombinant protein produced detectable antibodies and showed no apparent ***,baculovirus-expressed penton base protein is a promising candidate subunit vaccine.

关键词： fowl adenovirus serotype 4 hepatitis-hydropericardium syndrome penton base subunit vaccine baculovirus expression system

Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng Yi Haihan zou Gao Deng Ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

Two New Saponins from Lysimachia capillipes Hemsl.

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Journal of Integrative Plant Biology 2005年第10期47卷 1271-1275页

作者： Jing-Kui TIAN zhong-mei zou Li-Zhen XU Shi-Lin YANG Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310027 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia capilUpes Hemsl., two new saponins, named capilliposide E （1） and capilliposide F （2）, were isolated. The structures of the new saponins were elucidated as 3β, 22α-dihydroxy-16α-acetat-28→ 13-lactone-oleanane-3-O- [β-D-glucopyranosyl- （1 →2）-α-L-arabinpyranoyl]-22-O-β-D-glucopyranoside （1） and 3β, 22α-dihydroxy- 16α-acetat-28→ 13-lactone-oleanane-3-O-{ [β-D-glucopyranosyl-（1→2）-β-D-glucopyranosyl-（1→4）]-α-L-arabinpyranoyl}-22-O-β- D-glucopyranoside （2）. The structures of these compounds were determined by 1D- and 2D-NMR, MS techniques, and chemical methods.

关键词： capilliposide E and F, Lysimachia capillipes triterpene saponin.

New Cytotoxic Saponins from Lysimachia davurica Ledeb.

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Journal of Integrative Plant Biology 2006年第2期48卷 232-235页

作者： Jing-Kui Tian zhong-mei zou Li-Zhen Xu Shi-Lin Yang Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310028 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I （compound 1） and E （compound 2） were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 1） and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 2） on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.

关键词： davuricoside I and E Lysimachia davurica triterpene saponin.

Two New Polyoxygenated Cyclohexenes from Uvaria kweichowensis

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Chinese Chemical Letters 2005年第10期16卷 1343-1346页

作者： Qiong Ming XU zhong mei zou Li Zhen XU Shi Lin YANG Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medicinal Sciences Beijing 100094

Two new polyoxygenated cyclohexenes, kweichowenol A and B were isolated from the leaves of Uvaria kweichowensis and their structures were established on the basis of their spectral data.

关键词： Annonaceae Uvaria kweichowensis leaves cyclohexenes kweichowenol A kweichowenol B.

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穿心草全草中两个新的二苯醚类化合物

药学学报 2024年第12期59卷 3335-3341页

作者：张梦雨刘娇刘畅张涛邹忠梅河南中医药大学药学院河南郑州450046 中国医学科学院北京协和医学院药用植物研究所北京100193 沈阳药科大学中药学院辽宁沈阳110016

采用硅胶柱色谱、MCI柱色谱、聚酰胺柱色谱、Sephadex LH-20柱色谱及ODS柱色谱,结合半制备高效液相色谱等技术手段,从穿心草(Canscora lucidissima)全草95%乙醇提取物中分离纯化得到12个化合物。依据其理化性质和波谱数据(UV、IR、MS、N... 详细信息

采用硅胶柱色谱、MCI柱色谱、聚酰胺柱色谱、Sephadex LH-20柱色谱及ODS柱色谱,结合半制备高效液相色谱等技术手段,从穿心草(Canscora lucidissima)全草95%乙醇提取物中分离纯化得到12个化合物。依据其理化性质和波谱数据(UV、IR、MS、NMR)等对所分离得到的化合物进行结构鉴定,分别为穿心草二苯醚A (1)、穿心草二苯醚B (2)、穿心草二苯甲酮A (3)、(-)-松脂素(4)、间羟基苯甲酸(5)、ω-羟基大黄素(6)、二氢山柰酚(7)、6,7-二羟基香豆素(8)、4-羟基-3,5-二甲氧基苯甲酸(9)、4-羟基-3,5-二甲氧基肉桂酸(10)、2-羟基-3-甲氧基苯甲酸(11)、(-)-丁香树脂酚(12)。其中,化合物1和2为新化合物,化合物3为新天然产物。化合物8通过抑制脂多糖诱导的RAW264.7细胞NO的生成,表现出一定的抗炎活性。

关键词：龙胆科穿心草化学成分二苯醚抗炎作用

RP-HPLC同时测定全缘叶蓝刺头地上部分两种黄酮醇

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中国药学杂志 2018年第2期53卷 136-139页

作者：波拉提.马卡比力孟繁桐孔亮朱沈彤李伟裴迪木尼热.艾兰汗顾政一谭成玉邹忠梅中国医学科学院北京协和医学院药用植物研究所北京100193 新疆维吾尔自治区药物研究所(新疆哈萨克医药研究所) 乌鲁木齐830002 大连海洋大学海洋科技与环境学院辽宁大连116023

目的建立反相高效液相色谱法同时测定全缘叶蓝刺头中两种黄酮醇化合物——柯伊利素和矢车菊黄素的含量。方法采用Kromasil C18色谱柱(4.6 mm×250 mm,5μm),流动相为乙腈-水-冰乙酸(35∶65∶2),流速1.0 m L·min^(-1),检测波长为350 nm... 详细信息

目的建立反相高效液相色谱法同时测定全缘叶蓝刺头中两种黄酮醇化合物——柯伊利素和矢车菊黄素的含量。方法采用Kromasil C18色谱柱(4.6 mm×250 mm,5μm),流动相为乙腈-水-冰乙酸(35∶65∶2),流速1.0 m L·min^(-1),检测波长为350 nm,柱温为30℃。结果柯伊利素和矢车菊黄素在进样质量浓度分别为0.4~2.4、0.6~2.6mg·L^(-1)内呈良好线性关系,相关系数分别为0.999 8和0.999 9,加样回收率(n=6)分别为91.6%和92.7%,RSD分别为1.37%和1.08%。结论该方法经方法学验证可用于全缘叶蓝刺头样品中柯伊利素和矢车菊黄素的含量测定。

关键词：全缘叶蓝刺头柯伊利素矢车菊黄素高效液相色谱法含量测定