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Science China(Life Sciences) 2014年第10期57卷 989-997页

作者： XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi zou yunzeng SUN AiJun QIAN JuYing GE JunBo Department of Cardiology Zhongshan Hospital Fudan University Institutes of Biomedical Sciences Fudan University Department of Cardiology Central Hospital of Minhang District

microRNA-210(miR-210)has generally been reported to be associated with cell survival under ***,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidative stress ***,we sought to investigate whether miR-210 over-expression could protect MSCs against oxidative stress injury and what the primary mechanisms involved *** results showed that over-expression of miR-210 significantly reduced the apoptosis of MSCs under oxidative stress,accompanied by obvious increases in cell viability and superoxide dismutase activity and remarkable decreases in malonaldehyde content and reactive oxygen species production,resulting in a noticeable reduction of apoptotic indices when compared with the ***,the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway ***,these results showed that miR-210 over-expression improved MSC survival under oxidative stress through antioxidation and c-Met pathway activation,indicating the potential development of a novel approach to enhance the efficacy of MSC-based therapy for injured myocardium.

关键词： microRNAs stem cells oxidative stress signal transduction

Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury

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Bioactive Materials 2021年第7期6卷 2058-2069页

作者： Xiaolei Sun Rifeng Gao Wenjia Li Yongchao Zhao Heng Yang Hang Chen Hao Jiang Zhen Dong Jingjing Hu Jin Liu yunzeng zou Aijun Sun Junbo Ge Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai200032China Institute of Biomedical Science Fudan UniversityShanghai200032China Shanghai Fifth People’s Hospital Fudan UniversityShanghai200240China The Second Affiliated Hospital of Nanchang University Nanchang330000China Heart Center of Fujian Province Union HospitalFujian Medical University29 Xin-Quan RoadFuzhou350001China

Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion(I/R)injury and can be alleviated via the mitochondrial *** efficiency of mitochondrial transplantation is determined by mitochondrial *** aldehyde dehydrogenase 2(ALDH2)has a key role in regulating mitochondrial homeostasis,we aimed to investigate its potential therapeutic effects on mitochondrial transplantation via the use of ALDH2 activator,*** present study demonstrated that time-dependent internalization of exogenous mitochondria by cardiomyocytes along with ATP production were significantly increased in response to mitochondrial ***,Alda-1 treatment remarkably promoted the oxygen consumption rate and baseline mechanical function of cardiomyocytes caused by mitochondrial *** transplantation inhibited cardiomyocyte apoptosis induced by the hypoxia-reoxygenation exposure,independent of Alda-1 ***,promotion of the mechanical function of cardiomyocytes exposed to hypoxia-reoxygenation treatment was only observed after mitochondrial Alda-1 treatment and *** using a myocardial I/R mouse model,our results revealed that transplantation of Alda-1-treated mitochondria into mouse myocardial tissues limited the infarction size after I/R injury,which was at least in part due to increased mitochondrial potential-mediated *** conclusion,ALDH2 activation in mitochondrial transplantation shows great potential for the treatment of myocardial I/R injury.

关键词： Ischemia-reperfusion Mitochondrial transfer ALDH2 activation Myocardial injury

CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2593-2607页

作者： Liliang Li Pan Gao Xinru Tang Zheng Liu Mengying Cao Ruoyu Luo Xiaoqing Li Jing Wang Xinyi Lin Chao Peng Zhihong Li Jianhua Zhang Xian Zhang Zhonglian Cao yunzeng zou Li Jin Department of Forensic Medicine School of Basic Medical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences&Human Phenome InstituteFudan UniversityShanghai 200438China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghai 200032China National Facility for Protein Science in Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of ScienceShanghai 201210China Academy of Forensic Science Ministry of Justiceand Shanghai Key Laboratory of Forensic MedicineShanghai 200063China Department of Cardiology Kunshan Hospital of Integrated Traditional Chinese and Western MedicineKunshanJiangsu 215301China School of Pharmacy Fudan UniversityShanghai 201203China Shanghai Medical College Fudan UniversityShanghai 200032China

Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or *** underlying antipsychotics cardiotoxicity remain largely *** we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics ***-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 ***,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the *** of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and ***-organ-based investigation revealed no additional toxicity of newer CB1R *** authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced *** results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics.

关键词： NLRP3 inflam rendering

Neuregulin-1 therapy improved cardiac function and reduced ANPmRNA expression in post myocardial infarction rats with cardiac dysfunction

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Journal of Geriatric Cardiology 2005年第4期2卷 236-239页

作者： Yuanfang LI Naisheng CAI Xinghua GU Jingmin ZHOU Keqiang WANG yunzeng zou Junbo GE Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Cardiovascular Disease Research InstituteShanghai 200032China

Objective To observe the influence of neuregulin-1 on the cardiac function of post-myocardial infarction *** Left ventricular MI was created in Sprague-Dawley rats by ligation of the left anterior descending *** months after the operation,rats were evaluated with echocardiology methods.36 rats that had an infarct area and a EF around 60%were randomized into 3 groups:MI group(n=12)were injected a blank vehicle fluid intravenously for 5 days,after which they continued to be raised on standard food and water for 30 ***+NRG group(n=12),received NRG-110μg·kg-^(1) intravenously for 5 days,after which they continued to be raised on standard food and water for 30 ***+Capt group(n=12)received captopril orally(dissolved in their drinking water 2g/L)for 30days,after which tap water substituted the solution for 5 *** echocardiographic and hemodynamic measurements were made at the end of 1 month of *** RNA was extracted from frozen left ventricular tissues,and was reverse transcribed into firststrand PCR was performed with primers for BNP、*** Rats treated with neuregulin had a smaller LVDs(P=0.014),a betterLVEF(P=0.004),and a tendency towards less lung perfusion than untreated *** decreased the expression of ANP mRNA in the ventricle(P=0.025).Conclusion Neuregulin markedly improved the cardiac function of rats that survived myocardial infarction,and decreased the expression of ANP mRNA in the ventricle.

关键词： neuregulin-1 myocardial infarction heart failure atrial natriuetic peptide

Aldehyde Dehydrogenase-2 Deficiency Attenuates Bone Marrow Mesenchymal Stem Cell Therapy for ischemia

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Aldehyde Dehydrogenase-2 Deficiency Attenuates Bone Marrow M...

中华医学会第十五次全国心血管病学大会

作者： Hongming Zhu Aijun Sun yunzeng zou Junbo Ge Institute of Biomedical Science Fudan University Department of Cardiology and Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University

Aim Cell therapy with mesenchymal stem cells (MSCs) represents a promising approach for alleviating ischemic injury and promoting tissue regeneration. Despite significant strides over the last decade, the hostile micr...

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Activation of histamine/H R signaling pathway promotes cardiac differentiation and maturation of human induced pluripotent stem cells

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解剖学杂志 2021年第S1期44卷 224-225页

作者： Zhu Xiaowei Ding Suling Zhu Baoling Wang Xiangfei zou yunzeng Yang Xiangdong Ge Junbo Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai 200032 Department of Cardiology Zhongshan HospitalFudan University

The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC CMs)is crucial for regenerative medicine,disease modeling,drug screening and the study of the development events during cardiac ***,their applications have been hampered by the differentiation efficiency,poor maturation and high interline *** studies have reported that histamine plays important roles in hema topoietic stem cell proliferation and neutrophil ***,its roles in cardiovascular tissue regeneration have not been thoroughly *** the current study,we identified a novel physiological function of the histamine/histamine 1 receptor(H,R)signal in regulating the differentiation of hiPSC-CMs and heart development.

关键词： cardiac cardiovascular thoroughly

AngiotensinⅡtype 1 receptor mediates cardiomyocyte autophagy induced by angiotensinⅡthrough p38 MAPK signal pathway

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AngiotensinⅡtype 1 receptor mediates cardiomyocyte autophag...

中华医学会第十五次全国心血管病学大会

作者： Li Lin Jianfeng Xu Yong Ye Junbo Ge yunzeng zou Xuebo Liu Shanghai East Hospital Tongji University Zhongshan Hospital Fudan University

Background Autophagy plays an important role in the development of angiotensinⅡ(AngⅡ)-induced cardiac remodeling. However, the mechanism has not been completely understood. This study is designated to investigate th...

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Angiotensin-(1-7) downregulates angiotensin Ⅱ type 1 receptor and inhibites mechanical stress-induced cardiomyocyte autophagy

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Angiotensin-(1-7) downregulates angiotensin Ⅱ type 1 recept...

中华医学会第十五次全国心血管病学大会

作者： Li Lin Xuebo Liu Jianfeng Xu Liqing Weng Junbo Ge yunzeng zou Department of Cardiovascular Medicine East Hospital Tongji University School of Medicine Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institute of Biomedical Science Fudan University

Objective To investigate that Ang-(1-7) has a protective role against the autophagy. Methods Mechanical stress was imposed to cultured cardiomyocytes or heart of mice by in vitro mechanical stretch (MS) or in vivo transverse aorta constriction (TAC) procedures, respectively. Cardiac hypertrophy was evaluated by echocardiography, morphology, immunohistochemistry or animo acid-incorporation

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High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells

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High glucose induces upregulation of scavenger receptors and...

中华医学会第十五次全国心血管病学大会

作者： Hao Lu Juying Qian Kang Yao Dong Huang Aijun Sun yunzeng zou Junbo Ge Department of Cardiology Zhongshan Hospital Shanghai Institute of Cardiovascular Diseases

Background Both hyperglycaemia and dendritic cells (DCs) play causative roles in atherosclerosis. However, whether they interact in atherosclerosis remains uncertain. Therefore, we examined whether high glucose could ...

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Activation of histamine/H1R signaling pathway promotes cardiac differentiation and maturation of human induced pluripotent stem cells

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Activation of histamine/H1R signaling pathway promotes cardi...

中国解剖学会2021年年会

作者： Zhu Xiaowei Ding Suling Zhu Baoling Wang Xiangfei zou yunzeng Yang Xiangdong Ge Junbo Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan University Department of Cardiology Zhongshan HospitalFudan University

The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is crucial for regenerative medicine, disease modeling,drug screening and the study of the development events during cardiac ***,their applications have been hampered by the differentiation efficiency,poor maturation and high interline variability.

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