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Early inoculation with caecal fermentation broth alters small intestine morphology,gene expression of tight junction proteins in the ileum,and the caecal metabolomic profiling of broilers

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Journal of Animal Science and Biotechnology 2020年第2期11卷 440-452页

作者： Yujie Gong wenrui Xia Xueting wen wentao Lyu Yingping Xiao hua Yang Xiaoting zou Key Laboratory for Molecular Animal Nutrition of Ministry of Education Feed Sciences InstituteCollege of Animal SciencesZhejiang University(Zijingang Campus)Hangzhou 310058China State Key Laboratory for Quality and Safety of Agro-products Institute of Quality and Standards for Agro-productsZhejiang Academy of Agricultural SciencesHangzhou 310021China

Background:The establishment of stable microbiota in early life is beneficial to the *** in the intestinal environment during early life play a crucial role in modulating the gut ***,early intervention to change the intestinal environment can be regarded as a new regulation strategy for the growth and health of ***,the effects of intestinal environmental changes on host physiology and metabolism are rarely *** study was conducted to investigate the effects of early inoculation with caecal fermentation broth on small intestine morphology,gene expression of tight junction proteins in the ileum,and cecum microbial metabolism of ***:Our data showed that early inoculation with caecal fermentation broth could improve intestine *** small intestine villus height was significantly increased(P<0.05)in the intervened broilers compared to the control group,especially on day 28.A similar result was observed in the ratio of villus height to crypt depth(P<0.05).Meanwhile,we found early inoculation significantly increased(P<0.05)the expression levels of zonula occludens-1(ZO1)on days 14 and 28,claudin-1(CLDN1)on day 28,whereas the gene expression of claudin-2(CLDN2)was significantly decreased(P<0.05)on days 14 and *** chromatography time-of-flight/mass spectrometry(GC-TOF/MS)technology was further implemented to systematically evaluate the microbial metabolite *** component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)displayed a distinct trend towards separation between the fermentation broth group(F group)and the control group(C group).The differentially expressed metabolites were identified,and they were mainly functionally enriched in beta-alanine metabolism and biosynthesis of unsaturated fatty *** addition,1,3-diaminopropane was selected as a key biomarker that responded to early inoculation with caecal fermentation ***:These re

关键词： Broilers Early inoculation Gene expression Intestine morphology Metabolomics profiling

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Goal-Oriented Control Systems(GOCS):From HOW to WHAT

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 816-819页

作者： wen-hua Chen the Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershireLE113TUU.K.

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced ***-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.

关键词： automated instru system

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Assessment of the Sensitivity and Specificity of the Established Real-time Quaking-induced Conversion(RT-QuIC)Technique in Chinese CJD Surveillance

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Biomedical and Environmental Sciences 2020年第8期33卷 620-622页

作者： XIAO Kang YANG Xue hua zou wen Quan DONG Xiao Ping SHI Qi State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing 102206China Wuhan Institute of Virology Chinese Academy of ScienceWuhan 430071Hubei China

Real-time quaking-induced conversion(RT-QuIC)assay is a newly established PrPSc-detecting *** development of RT-QuIC improves the diagnosis of sporadic Creutzfeldt–Jakob disease(sCJD),showing good sensitivity and specificity in many countries when the method was used in cerebrospinal fluid(CSF)***,in China,the sensitivity and specificity of RT-QuIC has yet to be determined due to the lack of definitive diagnosis samples.

关键词： diagnosis CJD cerebrospinal

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Extending the correlation of L_R-L_X to gamma-ray bursts

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Research in Astronomy and Astrophysics 2015年第5期15卷 617-622页

作者： Jing L Jing-wen Xing Yuan-Chuan zou Wei-hua Lei Qing-wen Wu Ding-Xiong Wang GXU-NAOC Center for Astrophysics and Space Sciences Department of PhysicsGuangxi University Guangxi Key Laboratory for Relativistic Astrophysics School of Physics Huazhong University of Science and Technology

The well-known correlation between radio luminosity （LR） and X-ray luminosity （Lx）, LR/LX 10^-5, holds for a variety of objects, such as active galactic nuclei, Galactic black holes, solar flares and cool stars. Here we extend the relation to gamma-ray bursts （GRBs） and find that the GRBs also obey a similar LR - LX relation, with a slightly different slope of LR ∝ LX^1.1. This relation implies that the explosions that occur on different scales may have a common underlying origin.

关键词： gamma-ray bursts general -- quasars general -- stars black holes

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不同宿主来源产气荚膜梭菌生物被膜形成前后药物敏感性分析

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动物医学进展 2025年第1期46卷 38-42页

作者：吴莹邵长军刘文华青岛农业大学动物医学院山东青岛266109 烟台市农科院山东烟台264200

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测... 详细信息

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测不同来源产气荚膜梭菌生物被膜形成能力和高敏药物对生物被膜的抑制和清除能力。药敏结果显示,5株不同宿主来源产气荚膜梭菌均对氨苄西林高度敏感,对其余6种抗菌药物有不同程度耐药;氨苄西林对不同菌株的MIC值在0.031~2.000μg/mL之间;所有菌株均能生成生物被膜,但生物被膜生成能力有差异;不同菌株在各自4、2、1 MIC下生物被膜的生成受到不同程度抑制,而亚抑菌浓度的氨苄西林能刺激生物被膜的生成,氨苄西林对已经生成的生物被膜不能完全清除。结果表明,不同来源产气荚膜梭菌形成生物被膜前后对药物敏感性不同,可为产气荚膜梭菌的临床用药选择及使用剂量提供一定的参考依据。

关键词：产气荚膜梭菌生物被膜最小抑菌浓度耐药性

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Enhancing point defect scattering in copper antimony selenides via Sm and S Co-doping

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Rare Metals 2018年第4期37卷 290-299页

作者： Tian-hua zou wen-Jie Xie Marc Widenmeyer Xing-Xing Xiao Xiao-Yin Qin Anke Weidenkaff Institute for Materials Science University of Stuttgart 70569Stuttgart Germany Key Laboratory of Materials Physics Institute of Solid StatePhysics Chinese Academy of Sciences Hefei 230031 China

Doping- and alloying-induced point defects lead to mass and strain field fluctuations which can be used as effective strategies to decrease the lattice thermal conductivity and consequently boost the performance of thermoelectric materials. Herein, we report the effects of Sm and S co-doping on thermoelectric transport properties of copper antimony selenides in the temperature range of 300 K 〈 T〈 650 K. Through the Callaway model, it demonstrates that Sm and S co-doping induces strong mass differences and strain field fluctuations in Cu3SbSe4. The results prove that doping with suitable elements can increase point defect scattering of heat-carrying phonons, leading to a lower thermal conductivity and a better ther- moelectric performance. The highest figure of merit （ZT） of - 0.55 at 648 K is obtained for the Sm and S co-doped sample with nominal composition of Cu2.995Sm0.005Sb- Se3.95S0.05, which is about 55% increase compared to the ZT of pristine Cu3SbSe4.

关键词： Thermoelectric Point defect scatteringCu3SbSe4 Lattice thermal conductivity

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玉米锌指蛋白基因ZmLSD1的生物信息学及表达特性分析

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辽宁农业科学 2020年第2期 1-6页

作者：周开明赵白杨张丙林刘卫娟邹华文长江大学农学院湖北荆州434025

为探究锌指蛋白基因ZmLSD1的功能,采用实时荧光定量PCR技术分析在干旱、盐、低温、高温、脱落酸和水杨酸胁迫下根、胚芽鞘、叶部位中ZmLSD1基因的转录表达。结果表明,根中ZmLSD1基因在干旱、盐、高温、低温和脱落酸处理下表达量上升,水... 详细信息

为探究锌指蛋白基因ZmLSD1的功能,采用实时荧光定量PCR技术分析在干旱、盐、低温、高温、脱落酸和水杨酸胁迫下根、胚芽鞘、叶部位中ZmLSD1基因的转录表达。结果表明,根中ZmLSD1基因在干旱、盐、高温、低温和脱落酸处理下表达量上升,水杨酸处理导致该基因的表达量降低;在胚芽鞘中,该基因受干旱、盐、脱落酸和水杨酸诱导上调表达,而高温和低温胁迫下基因呈现下调表达;在叶中ZmLSD1基因正向响应干旱、盐和脱落酸处理,但低温、高温和水杨酸条件下基因的表达受抑制。锌指蛋白基因ZmLSD1在玉米的干旱、盐、高温和低温等非生物胁迫响应中发挥了重要作用。

关键词：玉米锌指蛋白转录因子非生物胁迫表达分析

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Comparison of time optimal control for two level quantum systems

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Journal of Systems Engineering and Electronics 2014年第1期25卷 95-103页

作者： Shuang Cong Jie wen Xubo zou Department of Automation University of Science and Technology of China Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of Sciences

The time optimal problem for a two level quantum sys-tem is studied. We compare two different control strategies of bang-bang control and the geometric control, respectively, es-pecial y in the case of minimizing the time of steering the state from North Pole to South Pole on the Bloch sphere with bounded control. The time performances are compared for different param-eters by the individual numerical simulation experiments, and the experimental results are analyzed. The results show that the ge-ometric control spends less time than the bang-bang control does.

关键词： geometric control bang-bang control time optimal,comparison,

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BLUP Estimation of Linear Mixed-effects Models with Measurement Errors and Its Applications to the Estimation of Small Areas

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Acta Mathematica Sinica,English Series 2014年第12期30卷 2027-2044页

作者： Rong ZHU Guo hua zou Academy of Mathematics and Systems Science Chinese Academy of Sciences

The linear mixed-effects model （LMM） is a very useful tool for analyzing cluster data. In practice, however, the exact values of the variables are often difficult to observe. In this paper, we consider the LMM with measurement errors in the covariates. The empirical BLUP estimator of the linear combination of the fixed and random effects and its approximate conditional MSE are derived. The application to the estimation of small area is provided. Simulation study shows good performance of the proposed estimators.

关键词： BLUP linear mixed-effects models measurement errors small area estimation

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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