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Taichi Softball as a Novel Chinese Health-Promoting Exercise for Physical Health: A Systematic Review and Meta-Analysis

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Open Journal of Preventive Medicine 2017年第2期7卷 15-31页

作者： Liye zou Huiru Wang Mark Zhang Zhongjun Xiao qun Fang Department of Exercise Science Physical Education and Wellness Tennessee Tech University Cookeville TN USA Department of Physical Education and Health Education Springfield College Springfield MA USA Department of Physical Education Shanghai Jiao Tong University Shanghai China Department of Sport Management Delaware State University Dover DE USA Department of Foreign Language Jishou University Jishou China

Background: Taichi softball was voted as one of the most popular health-promoting exercises in the category of ball games, which is attributed to that Taichi softball is not only beneficial for lower extremity-related physical health (e.g., balance, leg strength, and flexibility), but can also develop manipulative skill and hand-eye coordination (eating, bathing, dressing, bathing required manipulative skills, grips movement and strength). However, the positive effects of Taichi softball on physical health have rarely been investigated. Therefore, the purpose of this systematic review was to evaluate the effect of Taichi softball on physical health. Methods: Five electronic databases were used to conduct literature searches. Two review authors independently extracted data in a standardized manner. The methodological quality of studies included was independently evaluated according to the Cochrane Collaboration’s for Assessing Risk of Bias from the Cochrane Handbook for Systematic Review Interventions. The standard mean difference (SMD) and 95% confidence interval (CI) using more conservative random effects model were calculated. Results: The sample size of 411 participants ranged from 32 to 150 in the RCTs, along with a wide age range from 18 to 75. The length of Taichi softball intervention peri-ods in the eligible studies ranged from 12 weeks to 12 months. The participants in the studies consisted of healthy college students, patients with Type 2 diabe-tes, and older adults from community centers. Six randomized controlled trials were used for the meta-analysis. The aggregated results are in favor of Taichi softball on improving physical health in participants with healthy status and Type 2 Diabetes Mellitus. The improvement on the primary components of the physical health consisted of handgrip strength (SMD, -0.6, 95% CI -0.84 to 0.36, p < 0.00001), trunk flexibility (SMD, -0.4, 95% CI -0.74 to -0.05, p = 0.03), static (SMD, -0.73, 95% CI -0.94 to -0.51, p < 0.00

关键词： Taichi Softball Health Diabetes Mellitus

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Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway

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当代医学科学(英文) 2023年第3期43卷 469-477页

作者： Jun-yu WEI Miao-yue HU Xiu-qi CHEN Jin-shuang WEI Jie CHEN Xuan-kai QIN Feng-ying LEI Jia-sen zou Shi-qun ZHU Yuan-han QIN Department of Pediatrics the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Children's Hospital of Chongqing Medical University Chongqing 400015China Shenzhen Children's Hospital Shenzhen 518034China

Objective The hypersensitivity of the kidney makes it susceptible to hypoxia *** involvement of neutrophil extracellular traps(NETs)in renal injury resulting from hypobaric hypoxia(HH)has not been *** this study,we aimed to investigate the expression of NETs in renal injury induced by HH and the possible underlying *** A total of 24 SD male rats were divided into three groups(n=8 each):normal control group,hypoxia group and hypoxia+pyrrolidine dithiocarbamate(PDTC)*** in hypoxia group and hypoxia+PDTC group were placed in animal chambers with HH which was caused by simulating the altitude at 7000 meters(oxygen partial pressure about 6.9 kPa)for 7 *** was administered at a dose of 100 mg/kg intraperitoneally once daily for 7 *** changes of the rat renal tissues were observed under a light microscope;the levels of serum creatinine(SCr),blood urea nitrogen(BUN),cell-free DNA(cf-DNA)and reactive oxygen species(ROS)were measured;the expression levels of myeloperoxidase(MPO),citrullinated histone H3(cit-H3),B-cell lymphoma 2(Bcl-2),Bax,nuclear factor kappa B(NF-κB)p65 and phospho-NF-κB p65(p-NF-κB p65)in rat renal tissues were detected by qRT-qPCR and Western blotting;the localization of NF-κB p65 expression in rat renal tissues was observed by immunofluorescence staining and the expression changes of NETs in rat renal tissues were detected by multiplex fluorescence immunohistochemical *** After hypoxia,the expression of NF-κB protein in renal tissues was significantly increased,the levels of SCr,BUN,cf-DNA and ROS in serum were significantly increased,the formation of NETs in renal tissues was significantly increased,and a large number of tubular dilatation and lymphocyte infiltration were observed in renal *** PDTC was used to inhibit NF-κB activation,NETs formation in renal tissue was significantly decreased,the expression level of Bcl-2 in renal tissues was significantly increased,the expres

关键词： hypobaric hypoxia neutrophil extracellular traps hypoxia kidney injury NF-κB apoptosis

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Low-dose chloroquine treatment extends the lifespan of aged rats

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Protein & Cell 2022年第6期13卷 454-461页

作者： Wei Li Zhiran zou Yusheng Cai Kuan Yang Si Wang Zunpeng Liu Lingling Geng qun Chu Zhejun Ji Piu Chan Guang-Hui Liu Moshi Song Jing Qu Weiqi Zhang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Chongqing Renji Hospital University of Chinese Academy of SciencesChongqing 400062China

Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we discovered that low-dose CQ has a geroprotective effect on physiologically aged ***-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged ***,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic *** treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory ***,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly.

关键词： protective inhibited intestine

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碳中和背景下世界能源转型与中国式现代化能源革命

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石油科技论坛 2024年第1期43卷 1-17页

作者：邹才能熊波李士祥马锋潘松圻刘翰林张国生赵群关春晓中石油深圳新能源研究院有限公司中国石油勘探开发研究院

全球碳中和共识与地区冲突加剧的背景下,新能源已成为各个国家实现能源安全和绿色发展的主要方向。以风能、光能、地热能、氢能、储能、可控核聚变等为代表的新能源技术和规模优势正在不断增强,低成本风能、太阳能、储能将支撑全球能源... 详细信息

全球碳中和共识与地区冲突加剧的背景下,新能源已成为各个国家实现能源安全和绿色发展的主要方向。以风能、光能、地热能、氢能、储能、可控核聚变等为代表的新能源技术和规模优势正在不断增强,低成本风能、太阳能、储能将支撑全球能源转型,新能源生产与利用进入快速发展时期,2022年世界新能源消费平均占比达18.2%,预计2050年占比达到55%左右。世界能源在资源、消费地域、技术发展、人均消费量、节能领域、碳排放等存在分布不均的情况,化石能源低碳化提速、新能源规模化提速、能源管理智慧化提速的“三化提速”推动世界能源加快转型。中国式现代化强调人与自然和谐共生,积极稳妥推进碳达峰碳中和,深入推进能源革命,坚持“六性原则”,即能源生产的“独立性”、能源供给的“绿色性”、能源储备的“安全性”、能源消费的“高效性”、能源管理的“智慧性”、能源成本的“经济性”,加快规划建设新能源为主、新电力为主、新储能为主、新智慧能源为主“四个为主”绿色智慧的新型能源体系,确保能源安全。目前中国是能源大国但不是能源强国,能源消费结构有待进一步优化。中国能源安全发展新战略是能源消费革命、能源供给革命、能源技术革命、能源体制革命、全方面加强国际合作的“四个革命、一个合作”,推动中国能源革命和能源供应格局转变,由2022年含碳化石能源消费占比80%以上、碳基能源CO_(2)排放80%以上,转变到2060年非碳新能源消费占比80%以上、CO_(2)排放减少80%以上。加快新能源革命是建设能源强国、实现中国能源独立与民族复兴的战略选择,对实现“双碳”目标、构建新型绿色能源体系与建立绿色生态地球意义重大。

关键词：碳中和新能源能源转型新型能源体系能源革命能源消费能源安全能源独立

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Effect of Sodium Ferulate on Myocardial Ischemia Fibrosis Induced by Isoproterenol

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Chemical Research in Chinese Universities 2009年第5期25卷 699-704页

作者： GAO Hai-cheng SUN Bo YU Xiao-yan GAO Hai-mei SHI Yan MIAO Chun-sheng LI Xiang-jun LUO Ping zou Ying-gang WEI Hai-feng ZHAO Juan REN Li-qun School of Pharmacy Jilin University Changchun 130021 P. R. China The Second Clinical Hospital of Jilin University Changchun 130041 P. R. China

We examined whether the powerful sodium ferulate（SF） could improve myocardial ischemia fibrosis degree and gain the information of myocardial energy metabolism via experimental model of myocardial ischemia fibrosis. The model of myocardial ischemia fibrosis was made for the wistar rats induced with 15 mg/kg isoproterenol（Iso） subcutaneous injection. In experiment l, Iso effective model drug of myocardial ischemia fibrosis at present was administrated to the rats with myocardial ischemia fibrosis and 2, 4, 6, 12, 24, 48 and 72 h, 7 and 21 d later, the changes of adenosine content in rat myocardial tissue and hydroxyproline in blood serum were compared. In experiment 2, SF was administrated to the rats with myocardial ischemia fibrosis and 21 d later, the effect of SF on benazepril as reference drug curing myocardial ischemia fibrosis was evaluated by measuring the changes of adenosine in rat myocardial tissue and hydroxyproline content in blood serum. In the model group, there was a remarkable increase in hydroxyproline content and a decrease in adenosine content of myocardial tissue in experiment 1; there was a remarkable decrease in hydroxyproline in blood serum and a increase in adenosine content in myocardial tissue, which were recovered gradually to control in experiment 2（P〈0.05）. The results of experiment 1 show that with the increasing of pathological change degree, the rat adenosine content reduced gradually and arrived at the lowest value three weeks later（P〈0.05）; the hydroxyproline content was obviously higher compared with that of control group（P〈0.05）. The results of experiment 2 show that rat adenosine content in myocardial tissue and hydroxyproline content in blood serum were recovered gradually to normal level after injection SF. The effect of SF against myocardial ischemia fibrosis in preventive group is better than that of improving the myocardial ischemia fibrosis drug. Meanwhile, hinting HPLC is a good method to measure the adenosine content.

关键词： Energy metabolism Hydroxyproline Myocardial fibrosis HPLC

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DMD基因突变的孤独症谱系障碍儿童1例报告并文献复习

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实用临床医学（江西） 2024年第3期25卷 47-54,59页

作者：詹国栋李建英游聪周丽容刘映平刘宇翀邹小兵岑超群中山大学附属第三医院儿童发育行为中心广州510630

目的对DMD基因突变的1例6岁孤独症谱系障碍(autism spectrum disorder,ASD)男性患儿进行报告,并通过文献回顾探讨DMD基因缺陷患者的ASD共患率,分析该类患者的遗传学特点,以提高对该亚型ASD的认识。方法利用染色体微阵列分析技术对ASD先... 详细信息

目的对DMD基因突变的1例6岁孤独症谱系障碍(autism spectrum disorder,ASD)男性患儿进行报告,并通过文献回顾探讨DMD基因缺陷患者的ASD共患率,分析该类患者的遗传学特点,以提高对该亚型ASD的认识。方法利用染色体微阵列分析技术对ASD先证者进行检测,多重连接探针扩增技术(multiplex ligation-dependent probe amplification,MLPA)对候选突变进行家系验证。对患儿临床表型与基因型进行分析,并系统复习DMD基因突变与ASD的相关文献。结果患儿存在DMD基因arr[hg19]Xp21.1(31,518,750-31,878,971)×0微缺失,涉及DMD基因48—55号外显子,MLPA验证提示该缺失遗传自无疾病表型的母亲。文献回顾表明:贝克尔肌营养不良症(Becker muscular dystrophy,BMD)患者ASD的共患率在0.00%(0/17)~11.43%(8/70),而杜氏肌营养不良症(Duchenne muscular dystrophy,DMD)在0.0%(0/50)~54.5%(30/55)。BMD与DMD相比,前者所有队列ASD共患率的中位数(3.6%)低于后者的中位数(6.4%),但差异无统计学意义。DMD基因突变的位置与ASD发病是否相关存在争议。结论DMD基因48—55号外显子缺失可能是患儿存在BMD和ASD的共同病因。DMD基因的基因型与ASD临床表型的关系需要进一步的研究。

关键词： DMD基因孤独症谱系障碍杜氏肌营养不良症贝克尔肌营养不良症基因变异

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浙江道地延胡索优质品种性状及其生物碱含量研究

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四川师范大学学报（自然科学版） 2024年第6期47卷 779-785页

作者：董枥爻李群李嘉诚赵欣芸邹鸿伶马焕艳陈琳李明乾祝永强汪淑芳四川师范大学生命科学学院四川成都610101 浙江省农业技术推广中心浙江杭州310020 浙江省农业科学院蚕桑与茶叶研究所浙江杭州310021 浙江省中医药研究院(浙江省立同德医院)肿瘤研究所浙江杭州310012

延胡索是我国传统中药材中的常用大宗药材之一,产地多且适应性强,其中浙江省为其主要的道地产区之一.延胡索生产中多采用自繁自种的无性繁殖,易产生种质退化等问题,导致其产量和品质良莠不齐.采用基因条形码ITS2序列检测技术、田间延胡... 详细信息

延胡索是我国传统中药材中的常用大宗药材之一,产地多且适应性强,其中浙江省为其主要的道地产区之一.延胡索生产中多采用自繁自种的无性繁殖,易产生种质退化等问题,导致其产量和品质良莠不齐.采用基因条形码ITS2序列检测技术、田间延胡索性状记录及高效液相色谱分析等技术,对浙江省3个主要品种来源的延胡索浙胡1号(YHS-1)、浙胡2号(YHS-2)和延胡索3号(农户自保种,YHS-3)进行延胡索的基源鉴定、田间性状分析和主要苄基异喹啉型生物碱的含量分析,以筛选浙江地区延胡索的优良品种.基源鉴定数据结果显示,YHS-2与延胡索Corydalis Yanhusuo W. T. Wang(NCBI编号MH260617.1和MH260618.1)的亲缘关系较近,YHS-3次之,而YHS-1亲缘关系较远.田间数据结果显示,与另外2个品种相比,YHS-2具有花多且密,花期短以及块茎产量高的优良生产性状.建立6种苄基异喹啉型生物碱的快速检测方法分析3个品种中生物碱的含量.结果显示,YHS-2中各生物碱的含量显著优于YHS-1和YHS-3(p<0.05).表明3个品种中YHS-2更为适合浙江地区的生存环境,可作为目前延胡索浙江栽培的优质品种推广种植和使用.

关键词：延胡索基因条形码田间性状生物碱含量

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Settlement characteristics of bridge approach embankment based on scale model test

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Journal of Central South University 2020年第7期27卷 1956-1964页

作者： ZHANG jiu-peng LIU Tao PEI Jian-zhong LI Rui zou Dao-guang ZHANG Yu-qing School of Highway Chang’an UniversityXi’an 710064China China Railway Second Academy Engineering Group Co.Ltd. Chengdu 610036China National Engineering Laboratory of Highway Maintenance Technology Changsha University of Science&TechnologyChangsha 410114China Aston Institute of Materials Research Engineering Systems&Management GroupAston UniversityBirmingham B47ETUK

In order to analyze the effects of backfill materials, geometries and slab setting on the settlement of bridge approach embankment, scale model was built based on the structural characteristics of bridge approach embankment, and scale model tests were carried out under different conditions. The results show that when graded gravels were selected as the backfill materials, the effect of setting approach slab to reduce the differential settlement is more prominent. When lime soils were selected as the backfill material, approach slab can moderate the longitudinal settlement slope. When using different backfill materials, the ultimate settlement of the positive trapezoidal backfill geometries is less than that of the inverted trapezoid, and the backfill geometries have little effect on the settlement slope.

关键词： bridge approach embankment scale model settlement backfill

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高速公路建设项目综合管控系统的研究与实现

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筑路机械与施工机械化 2015年第9期32卷 62-65,71页

作者：邹群邹国平南昌工程学院土木与建筑工程学院江西南昌330029 江西赣粤高速公路股份有限公司江西南昌330025

针对高速公路建设项目管理的特点及现有工程建设管理信息系统的局限性,研究了高速公路建设项目综合管控系统,介绍了系统总体框架、功能和组成;基于SOA架构,采用B/S结构模式,开发了系统的统一管控平台。该系统在江西奉铜高速公路建设管... 详细信息

针对高速公路建设项目管理的特点及现有工程建设管理信息系统的局限性,研究了高速公路建设项目综合管控系统,介绍了系统总体框架、功能和组成;基于SOA架构,采用B/S结构模式,开发了系统的统一管控平台。该系统在江西奉铜高速公路建设管理中得以实施并应用,结果表明:该系统能够对项目全方位进行实时管控,对提高管理效率、确保工程质量、加快应急反应速度、保障施工安全等方面起到十分重要的作用。

关键词：高速公路建设项目管理综合管控系统面向服务的架构管理效率

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视图增量计算的延迟部分补偿算法

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计算机集成制造系统 2011年第5期17卷 1024-1031页

作者：邹先霞潘久辉贾维嘉中南大学信息科学与工程学院湖南长沙410083 暨南大学计算机系广东广州510632 香港城市大学计算机系

为解决异步传播算法中视图增量计算时间过长、占用系统资源过多及某些错误补偿问题,提出了在数据源上进行延迟部分补偿的算法。该算法要求获取数据源的基表增量时记下增量的事务时间,在实化视图层记录已用于视图增量计算的基表增量的最... 详细信息

为解决异步传播算法中视图增量计算时间过长、占用系统资源过多及某些错误补偿问题,提出了在数据源上进行延迟部分补偿的算法。该算法要求获取数据源的基表增量时记下增量的事务时间,在实化视图层记录已用于视图增量计算的基表增量的最大事务提交时间。当计算实化视图新的增量时,比较同一个数据源在实化视图层上的记录时间与增量子查询的执行时间,如果这段时间基表产生新的增量,则进行补偿查询。补偿过程采用单个数据源上的时间进行比较,避免了全局时间问题,也解决了现有部分补偿算法可能产生的错误。该算法利用基表之间的主外码约束来减少计算次数,提高计算效率。分析和实验表明,该算法在计算效率和正确性方面都有所提高。

关键词：实化视图异步传播增量计算部分补偿数据仓库算法

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