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Strain energy evolution and damage characteristics of deep clay under different stress rates

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Journal of Central South University 2022年第6期29卷 2005-2018页

作者： SONG Fang-nian HUANG Xin LUO Ting-ting zou jiu-qun FU Ran State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining Science and TechnologyXuzhou 221116China School of Civil Engineering Anhui University of TechnologyHuainan 232000China

Deformation and failure of deep clay samples are closely related to energy *** the energy conversion and damage behavior of deep clay during loading and unloading tests has important significance for prevention-control of soil destabilization damage caused by mine shaft *** the present work,triaxial tests of consolidated clay under different stress paths and stress rates were *** results reveal that the mechanical properties of soils have strong stress rate effects and the samples mainly experience energy storage in the elastic stage,after that,the energy conversion mainly undergoes an increase of dissipative energy and release of elastic energy,which is also confirmed by the results of the analysis in the subsequent CT *** damage indicators were compared,finding that the indicator based on dissipative energy has more obvious differences in two stress paths and can be used as a better indicator to describe the damage evolution of ***,in the triaxial shear test,due to the unloading effect of confining pressure,the damage of soils increased more rapidly near breaking than in the triaxial compression test,which indicates that the damage caused by unloading on deep soil is more abrupt than that caused by loading.

关键词： deep clay damage evolution computer tomography(CT) triaxial testing

Torque Limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei Gu Zaiyu Chen qun Li Minghui Yin Qiang Li Yun zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TLIC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TLIC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TLIC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TLIC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TLIC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

Long-Term Survival Trend of Gynecological Cancer:A Systematic Review of Population-Based Cancer Registration Data

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Biomedical and Environmental Sciences 2024年第8期37卷 897-921页

作者： Xiaohui Zhou Danni Yang Yixin zou Dandan Tang Jun Chen Zhuoying Li Qiuming Shen qun Xu Yongbing Xiang Department of Epidemiology&State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China School of Public Health Fudan UniversityShanghai 200025China Health Management Center Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Gynecological cancer significantly affect the health of *** review aimed to describe the global patterns and trends in the survival of patients with gynecological *** searched PubMed,Embase,Web of Science,SinoMed,and SEER for survival analyses of cancer registration data of cervical,endometrial,and ovarian cancers published between 1980 and ***,the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan,Liaoning,China(2008-2017).The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland(1995-1999,82.5%)and Singapore(1988-1992,62.0%).The 5-year relative survival rate of cervical cancer patients was higher in Haining,Zhejiang,China(2011-2014,85.8%).Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers,*** rates have improved for cervical,endometrial,and ovarian *** aged≥75 years and those with advancedstage disease had the worst 5-year survival *** rates were better for squamous cell carcinoma in cervical cancer,for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer,and for germ cell and sex-cord stromal tumors in ovarian *** the past four decades,the survival rates of gynecological cancers have increased globally,with notable increases in cervical and endometrial *** rates are higher in developed countries,with a slow-growing *** studies should focus on improving survival,especially in ovarian cancer patients.

关键词： Survival Cancer globally

Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome:a real-world study

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World Journal of Pediatrics 2024年第8期20卷 834-847页

作者： Wen He Qiu-Hong Wang jiu-Wei Li Yang-Yang Wang Xiao-Mei Luo Lin Wan Jing Wang Xiu-Yu Shi Wei-Hua Zhang Fang Fang Li-Ping zou Senior Department of Pediatrics the Seventh Medical Center of Chinese PLA General HospitalDepartment of Pediatricsthe First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Infantile epileptic spasms syndrome(IESS)is a serious disease in infants,and it usually evolves to other epilepsy types or syndromes,especially refractory or super-refractory focal *** adrenocorticotropic hormone(ACTH)is one of the first-line and effective treatment plans for IESS,it has serious side effects and is not sufficiently *** A retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate(MgSO4)therapy for IESS in two hospital centers was *** major outcome of the single and combined treatment was evaluated by changes in seizure frequency and improvements in hypsarrhythmia electroencephalography(EEG).To reduce the confounding bias between the two groups,we used SPSS for the propensity score matching(PSM)*** We initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO4 and ACTH *** 1005 patients were enrolled in the treatment(ACTH combined with MgSO4:744,ACTH:261),and both treatment plans had a more than 55%response ***,compared to patients treated with ACTH alone,those patients treated with ACTH combined with MgSO4 had better performance in terms of the seizure frequency and hypsarrhythmia *** PSM,the two groups also showed significant differences in responder rate[70.8%(95%confidence interval,CI)=66.7%–74.8%)vs.53.8%(95%CI=47.4%–60.2%),P3 months(P<0.05).In addition,the overall incidence of adverse reactions in the ACTH combined with MgSO4 group was much lower than that in the ACTH group(31.4%vs.63.1%,P<0.001).During the treatment,only

关键词： Adrenocorticotropic hormone Clinical trial Infantile epileptic spasms syndrome Magnesium sulfate Real-world study

Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma

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World Journal of Gastroenterology 2024年第17期30卷 2321-2331页

作者： Zhi-Peng Lin Xiao-Long Hu Du Chen Da-Bei Huang Xu-Gong zou Hai Zhong Sheng-Xiang Xu Yuan Chen Xiao-qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than ***,the mechanisms underlying this innovative treatment modality have not been *** To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable *** We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment *** The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,*** surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy Immunotherapy Adverse events

分层施工法在深井大硐室围岩动态控制中的数值模拟研究——以淮南张集矿硐室施工为例

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新余学院学报 2016年第2期21卷 11-15页

作者：刘光程邹久群淮南职业技术学院安徽淮南232001 中国矿业大学江苏徐州221116

以淮南张集矿硐室施工为例,运用数值模拟计算了分层开挖法在深井大硐室围岩稳定性中的影响及控制方法,得到分层开挖的应力应变状态,开挖松动区的大小直接影响到支护参数。现场工业性试验监测表明了分层施工法在深井大硐室围岩稳定性中... 详细信息

以淮南张集矿硐室施工为例,运用数值模拟计算了分层开挖法在深井大硐室围岩稳定性中的影响及控制方法,得到分层开挖的应力应变状态,开挖松动区的大小直接影响到支护参数。现场工业性试验监测表明了分层施工法在深井大硐室围岩稳定性中的优越性。

关键词：深井大硐室分层开挖动态控制 Midas/GTS 工业试验

Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National Science Review 2024年第7期11卷 106-125页

作者： Yan-Nong Dou Yuan Liu Wen-qun Ding Qing Li Hua Zhou Ling Li Meng-Ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan zou Anan Li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

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全封闭U型棚架与锚网喷注联合支护应用研究

山西建筑 2013年第33期39卷 41-43页

作者：刘光程邹久群李红淮南职业技术学院安徽淮南232001 安徽理工大学土木建筑学院安徽淮南232001

基于淮南地区煤矿受软弱破碎围岩及回采动压等影响,巷道支护失稳变形的情况,根据现场勘测支护破坏特征分析了破坏机理,提出了此围岩条件下的U型全封闭钢架和注浆及锚网喷注的联合支护方案,经后期支护效果监测,揭示了65 d后支护变形趋于... 详细信息

基于淮南地区煤矿受软弱破碎围岩及回采动压等影响,巷道支护失稳变形的情况,根据现场勘测支护破坏特征分析了破坏机理,提出了此围岩条件下的U型全封闭钢架和注浆及锚网喷注的联合支护方案,经后期支护效果监测,揭示了65 d后支护变形趋于稳定,说明了该支护形式在复杂围岩条件下是可行的。

关键词：全封闭U型棚架复杂围岩动压巷道联合支护工业试验

World's Energy Transition and Chinese-style Modern Energy Revolution under Carbon Neutrality(Ⅰ)

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China Oil & Gas 2024年第2期31卷 3-13页

作者： zou Caineng Xiong Bo Li Shixiang Ma Feng Pan Songqi Liu Hanlin Zhang Guosheng Zhao qun Guan Chunxiao PetroChina Shenzhen New Energy Research Institute Research Institute of Petroleum Exploration&Development

Under global consensus on carbon neutrality and the intensification of regional conflicts,new energy has become the primary direction for various countries to achieve energy security and green *** by wind,solar,geothermal,hydrogen and stored energy,and controllable nuclear fusion,the technological and scale advantages of new energy are being continuously ***-cost wind,solar,and stored energy will support the global energy *** production and utilization of new energy enter a rapid development *** 2022,the average global consumption of new energy accounted for 18.2%,and it is expected to reach around 55%by *** distribution of the world's energy resources,consumption regions,technological development,per capita consumption,energy-saving fields,and carbon emissions is *** acceleration of low-carbon development in fossil fuels,the scale-up of renewable energy,and the intelligentization of energy management drives the rapid transition of global energy.

关键词： Transition strengthened acceleration