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Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway

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Genes & Diseases 2023年第4期10卷 1626-1640页

作者： Fanchun Zeng chunrong Zhao Rujie Wang Lingyan Ren Hao Qiu Zhi zou Haibin Ding Zhongyi Sun Jianmei Li Shiwu Dong Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsCollege of BioengineeringChongqing UniversityChongqing 400030China Department of Biomedical Materials Science Army Medical UniversityChongqing 400038China Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqing 400038China Antenatal Diagnosis Centre Guizhou Provincial People’s HospitalGuiyangGuizhou 550003China Department of Urology Shenzhen University General HospitalShenzhen UniversityShenzhenGuangdong 518055China

More than 50%of prostate cancer(PCa)patients have bone metastasis with osteo-blastic lesions.MiR-18a-5p is associated with the development and metastasis of PCa,but it remains unclear whether it is involved in osteoblastic lesions.We first found that miR-18a-5p was highly expressed in the bone microenvironment of patients with PCa bone metastases.To address how miR-18a-5p affects PCa osteoblastic lesions,antagonizing miR-18a-5p in PCa cells or pre-osteoblasts inhibited osteoblast differentiation in vitro.Moreover,injection of PCa cells with miR-18a-5p inhibition improved bone biomechanical properties and bone mineral mass in vivo.Furthermore,miR-18a-5p was transferred to osteoblasts by exosomes derived from PCa cells and targeted the Hist1h2bc gene,resulting in Ctnnb1 up-regulation in the Wnt/β-catenin signaling pathway.Translationally,antagomir-18a-5p significantly improved bone biomechanical properties and alleviated sclerotic lesions from osteoblastic me-tastases in BALB/c nude mice.These data suggest that inhibition of exosome-delivered miR-18a-5p ameliorates PCa-induced osteoblastic lesions.

关键词： Bone metastasis MiR-18a-5p Osteoblastic lesions Prostate cancer Wnt/β-catenin pathway

HSPOG:An Optimized Target Recognition Method Based on Histogram of Spatial Pyramid Oriented Gradients

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Tsinghua Science and Technology 2021年第4期26卷 475-483页

作者： Shaojun Guo Feng Liu Xiaohu Yuan chunrong zou Li Chen Tongsheng Shen National Innovation of Defense Technology Academy of Military Sciences PLA ChinaBeijing 100071China Department of Automation Tsinghua UniversityBeijing 100084China

The Histograms of Oriented Gradients(HOG)can produce good results in an image target recognition mission,but it requires the same size of the target images for classification of inputs.In response to this shortcoming,this paper performs spatial pyramid segmentation on target images of any size,gets the pixel size of each image block dynamically,and further calculates and normalizes the gradient of the oriented feature of each block region in each image layer.The new feature is called the Histogram of Spatial Pyramid Oriented Gradients(HSPOG).This approach can obtain stable vectors for images of any size,and increase the target detection rate in the image recognition process significantly.Finally,the article verifies the algorithm using VOC2012 image data and compares the effect of HOG.

关键词： Histograms of Oriented Gradients(HOG) Histogram of Spatial Pyramid Oriented Gradients(HSPOG) object recognition spatial pyramid segmentation

Fabrication and oxidation resistance of silicon nitride fiber reinforced silica matrix wave-transparent composites

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Journal of Materials Science & Technology 2019年第12期35卷 2761-2766页

作者： Xuejin Yang Bin Li Duan Li Changwei Shao Changrui Zhang chunrong zou Kun Liu Science and Technology on Advanced Ceramic Fibers and Composites Laboratory National University of Defense TechnologyChangsha 410073China School of Materials Sun Yat-sen UniversityGuangzhou 510275China Advance Interdisciplinary Technology Research Center Academy of Military ScienceBeijing 100010China Beijing Institute of Special Electromechanical Technology Beijing 100012China

Wave-transparent ceramic matrix composites for the high temperature use should possess excellent oxidation resistance. In this work, Si3N4f/SiO2 composites with different fiber content were fabricated by filament winding and sol gel method. The oxidation resistance was investigated by tracking the response of flexural strength to the testing temperature. The results show that the flexural strength and toughness of the composites with fiber content of over 37% can reach high levels at around 175.0 MPa and 6.2 MPa m^1/2, respectively. After 1 h oxidation at 1100℃, the flexural strength drops a lot but can still reach 114.4 MPa, which is high enough to ensure the safety of structures. However, when the oxidation temperature rises to 1200–1400℃, the flexural strengths continue to fall to a relatively low level at 50.0–66.4 MPa. The degradation at high temperatures is caused by the combination of over strong interfacial bonding, the damage of fiber and the crystallization of silica matrix.

关键词： Si3N4f/SiO2 Fiber content Oxidation resistance Mechanical property

Physiological Processes Contributing to the Difference in Grain Amino Acid Content Between Two Hybrid Rice(Oryza sativa L.)Cultivars

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 101-107页

作者： Min Huang Hengdong Zhang chunrong Zhao Guanghui Chen Yingbin zou Crop and Environment Research Center for Human Health College of AgronomyHunan Agricultural UniversityChangsha410128China.

Improving grain amino acid content of rice(Oryza sativa L.)is essential for the health of consumers.This study was conducted to identify the physiological processes that contribute to the higher grain amino acid content in hybrid rice cultivar Lingliangyou 268 compared to Luliangyou 996.The results showed that total amino acid content in grains was 9%higher in Lingliangyou 268 than in Luliangyou 996.There was no significant difference in grain nitrogen(N)content between Lingliangyou 268 and Luliangyou 996,while ratio of amino acid to N was 6%higher in Lingliangyou 268 compared to Luliangyou 996.A total of 16 differentially expressed proteins related to amino acid metabolism(e.g.,erythronate-4-phosphate dehydrogenase domain containing protein)were identified in grains between Lingliangyou 268 and Luliangyou 996.The identified proteins were involved in 10 molecular functions.Six of the 10 defined functions were related to binding(heterocyclic compound binding,nucleoside phosphate binding,nucleotide binding,organic cyclic compound binding,protein binding,and small molecule binding)and the other 4 defined functions were catalytic activity,enzyme regulator activity,hydrolase activity,and transferase activity.These results indicate that the higher grain amino acid content in Lingliangyou 268 compared to Luliangyou 996 is attributed to increased efficiency of converting N to amino acid that results from altered expression of proteins related to amino acid metabolism.

关键词： Amino acid content grain quality protein expression protein function hybrid rice

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硅纳米粒子的功能化及生物分析应用

中山大学学报（自然科学版） 2021年第3期60卷 1-11页

作者：李春荣邹小勇戴宗中山大学化学学院广东广州510275 中山大学生物医学工程学院广东深圳518107 黔南民族医学高等专科学校贵州都匀558013

硅纳米粒子作为一类新兴的荧光纳米材料在生物传感研究方面有许多优势。近年来,开展功能化硅纳米粒子修饰在生物传感器、生化分析、荧光探针等方面受到科研工作者的广泛关注。本综述对硅纳米粒子的功能化修饰技术,及其在荧光检测、生物... 详细信息

硅纳米粒子作为一类新兴的荧光纳米材料在生物传感研究方面有许多优势。近年来,开展功能化硅纳米粒子修饰在生物传感器、生化分析、荧光探针等方面受到科研工作者的广泛关注。本综述对硅纳米粒子的功能化修饰技术,及其在荧光检测、生物传感、成像分析等领域的研究进展进行了总结和评述,并对硅纳米粒子的功能化发展前景及应用进行了展望。

关键词：硅纳米粒子细胞成像功能化修饰生物传感荧光检测

孕中期子宫动脉多普勒超声血流参数联合血清学指标预测不良妊娠结局的价值

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发育医学电子杂志 2022年第3期10卷 189-195页

作者：邹旷妮姜春蓉张素蓉广元市妇幼保健院超声科四川广元628000

目的探讨孕中期子宫动脉多普勒超声血流参数联合母体血清学指标产前筛查预测不良妊娠结局的价值。方法纳入2018年12月至2020年5月在广元市妇幼保健院产检并分娩的782例孕妇为研究对象。均于孕15~20+6周,采用多普勒超声测量子宫动脉血流... 详细信息

目的探讨孕中期子宫动脉多普勒超声血流参数联合母体血清学指标产前筛查预测不良妊娠结局的价值。方法纳入2018年12月至2020年5月在广元市妇幼保健院产检并分娩的782例孕妇为研究对象。均于孕15~20+6周,采用多普勒超声测量子宫动脉血流参数[搏动指数(pulsatility index,PI)、血流阻力指数(resistance index,RI)],检测母体血清β-人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)、游离雌三醇(unconjugated estriol,uE3)、甲胎蛋白(alpha-fetoprotein,AFP)水平,并计算中位数倍数(multiple of median,MoM)值。随访至产后42 d,根据妊娠结局分为不良组和正常组。统计学方法采用χ^(2)检验、t检验、非参数检验、多因素Logistic回归分析、受试者操作特性(receiver operating characteristic,ROC)曲线。结果782例孕妇中,718例(91.8%)孕妇正常妊娠(正常组),64例(8.2%)发生不良妊娠结局(不良组)。不良组与正常组孕妇的PI评分[2(1,4)与1(0,1)分]、RI值[0.64(0.48,0.83)与0.43(0.34,0.54)]、血清β-hCG MoM值[1.34(0.80,2.12)与0.69(0.26,1.23)IU/L]、血清AFP MoM值[0.98(0.56,2.27)与0.63(0.32,1.44)μg/L]比较,不良组均高于正常组;不良组的血清uE3 MoM值低于正常组[0.63(0.28,0.96)与0.80(0.31,1.55)nmol/L];差异均有统计学意义(P值均<0.05)。多因素Logistic回归分析显示,PI评分升高(OR=3.917,95%CI:2.675~5.736)、RI值升高(OR=143.247,95%CI:28.726~714.313)、β-hCG升高(OR=3.050,95%CI:2.002~4.647)、AFP升高(OR=1.844,95%CI:1.292~2.631)、uE3降低(OR=0.556,95%CI:0.316~0.977)可能是不良妊娠结局的危险因素(P值均<0.05)。ROC曲线分析显示,PI评分预测不良妊娠结局的曲线下面积(AUC)为0.796,截断值为1.50分;RI值的AUC为0.791,截断值为0.62;β-hCG的AUC为0.742,截断值为0.85 IU/L;uE3的AUC为0.575,截断值为0.96 nmol/L;AFP的AUC为0.675,截断值为1.97μg/L;5项联合检测的AUC为0.929,均高于单项检测指标。结论孕中期子宫动脉多普勒超声血流参数和血清学指标异常与不良妊娠结局有关,PI评分、RI值及血清β-hCG、AFP升高、uE3降低可能是不良妊娠结局的危险因素,联合检测有助于提高不良妊娠结局的预测效果。

关键词：不良妊娠结局出生缺陷子宫动脉超声搏动指数血清学指标产前筛查

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太阳辐射对山区桥梁高墩温度作用的影响

铁道建筑 2021年第12期61卷 23-27页

作者：胡安庆邹春蓉中铁西南科学研究院有限公司成都611731

根据天文学理论光线追踪方法构建了高墩太阳辐射分析模型,在模型中考虑了太阳辐射、环境、上部结构遮阴等主要因素,并以宜万(宜昌—万州)铁路马水河桥为例进行高墩温度分布分析和现场测试。研究结果表明:山区桥梁高墩温度场受气象、桥... 详细信息

根据天文学理论光线追踪方法构建了高墩太阳辐射分析模型,在模型中考虑了太阳辐射、环境、上部结构遮阴等主要因素,并以宜万(宜昌—万州)铁路马水河桥为例进行高墩温度分布分析和现场测试。研究结果表明:山区桥梁高墩温度场受气象、桥梁走向、周围山体影响较大,在合理考虑这些因素的情况下所建模型能较好地模拟出高墩的日照温度场,而得到的最不利温差计算值略大于实际值,用于分析温度作用效应是安全保守的。

关键词：铁路桥梁温度作用高墩日照遮阴模型光线追踪方法太阳辐射

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新建高速公路桥梁对既有隧道安全影响分析

现代隧道技术 2019年第S1期56卷 132-137页

作者：邹春蓉康圣雨任东华中铁西南科学研究院有限公司成都611731

当新建高速公路连续梁桥跨越铁路隧道时,在施工中存在较多安全隐患;桩基施工引起既有隧道沉降,若不均匀沉降过大,将导致既有隧道衬砌的开裂,影响既有隧道衬砌结构的安全和交通安全运营。文章以某新建高速公路大桥与铁路隧道交叉工程为依... 详细信息

当新建高速公路连续梁桥跨越铁路隧道时,在施工中存在较多安全隐患;桩基施工引起既有隧道沉降,若不均匀沉降过大,将导致既有隧道衬砌的开裂,影响既有隧道衬砌结构的安全和交通安全运营。文章以某新建高速公路大桥与铁路隧道交叉工程为依托,建立三维空间有限元模型,分析了桥梁基础施工引起的既有隧道结构及围岩的变形,对桥梁基础施工时存在的交叉影响进行了安全风险分析,可为同类工程的安全评估及防护提供参考。

关键词：公路桥梁上跨铁路隧道风险分析数值计算安全评估围岩变形

稻田土壤反硝化厌氧甲烷氧化菌的时空分布与群落结构分析

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环境科学学报 2015年第3期35卷 729-737页

作者：周蓉祝贵兵周磊榴邹雨璇王春荣中国科学院饮用水科学与技术重点实验室北京100085 中国矿业大学(北京)化学与环境工程学院北京100083

由'Candidatus Methylomirabilis oxyfera'主导发生的以甲烷和亚硝酸盐为底物的反硝化厌氧甲烷氧化反应(nitrite-dependent anaerobic methane-oxidizing,n-damo)的发现,将生物地球化学碳循环和氮循环以新的方式结合起来.本研究以夏季和冬季江阴稻田土壤柱状样品为研究对象,对稻田土壤M.oxyfera-like菌的时空分布和群落结构进行了考察.M.oxyfera-like菌16S rRNA基因的定量PCR结果显示M.oxyfera-like菌的丰度随着土壤深度的增加而增加,且无明显季节性差异,60~200 cm深度的稻田土壤是M.oxyfera-like菌的高丰度区域.M.oxyfera-like菌pmo A基因的系统发育分析和生物多样性分析显示M.oxyfera-like菌的群落结构具有一定的时空异质性,且生物多样性随着土壤深度的增加而增加.这些结果都说明江阴稻田深层土壤(60~200 cm)是适宜M.oxyfera-like菌生存的生态环境.

关键词： M.oxyfera-like菌稻田土壤丰度生物多样性