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Determination of ribose and phosphorus contents in Haemophilus influenzae type b capsular polysaccharide by a quantitative NMR method using a single internal standard

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Chinese Journal of Natural Medicines 2022年第8期20卷 633-640页

作者： QIN Chun-Jun HU Jing TONG Wei ZHANG Teng-Teng TIAN Guang-Zong zou xiao-peng LIU Jian-Kai YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China National&Local Joint Engineering Laboratory for Novel Vaccine Development Technology Beijing Minhai Biotechnology Co.Ltd.Beijing 102600China Jiangnan University-Beijing Minhai Biotechnology Joint Research Center of Carbohydrate-Based Vaccines Jiangnan UniversityWuxi 214122China

The ribose and phosphorus contents in Haemophilus influenzae type b(Hib)capsular polysaccharide(CPS)are two important chemical indexes for the development and quality control of Hib conjugate vaccine.A quantitative ^(1)H-and ^(31)P-NMR method using a single internal standard was developed for simultaneous determination of ribose and phosphorus contents in Hib ***(HMPA)was successfully utilized as an internal standard in quantitative ^(1)H-NMR method for ribose content *** ribose and phosphorus contents were found to be affected by the concentration of polysaccharide ***,15–20 mg·L^(−1) was the optimal concentration range of Hib CPS in D_(2)O solution for determination of ribose and phosphorus contents by this *** ribose and phosphorus contents obtained by the quantitative NMR were consistent with those obtained by traditional chemical *** conclusion,this quantitative ^(1)H-and ^(31)P-NMR method using a single internal standard shows good specificity,accuracy and precision,providing a valuable approach for the quality control of Hib glycoconjugate vaccines.

关键词： Haemophilus influenzae type b Capsular polysaccharide Quantitative^(1)H-NMR Quantitative^(31)P-NMR Ribose content Phosphorus content

Total synthesis of D-glycero-D-mannno-heptose 1β, 7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative

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Chinese Journal of Natural Medicines 2020年第8期18卷 628-632页

作者： zou xiao-peng QIN Chun-Jun HU Jing FU Jun-Jie TIAN Guang-Zong MOSCOVITZ Oren SEEBERGER Peter H. YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of Biomolecular Systems Max Planck Institute of Colloids and InterfacesPotsdam 14476Germany Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

D-Glycero-D-mannno-heptose 1β,7-bisphosphate(HBPβ)is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern(PAMP)that regulates immune ***βwith 3-O-amyl amine linker and its monophosphate derivative D-glycero-D-mannno-heptose 7-phosphate(HP)with 1α-amyl amine linker have been synthesized as candidates for immunity study of HBPβ.The O3-amyl amine linker of heptose was installed by dibutyltin oxide-mediated regioselective alkylation under fine-tuned protecting *** stereoselective installation of 1β-phosphate ester was achieved by NIS-mediated phosphorylation at low *** strategy for installation of 3-O-amyl amine linker onto HBP derivative can be expanded to the syntheses of other conjugation-ready carbohydrates bearing anomeric phosphoester.

关键词： HBPβ-3-O-amyl amine HP-1α-O-amyl amine 3-O-Alkylation NIS-mediated phosphorylation

Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block

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Chinese Journal of Natural Medicines 2022年第5期20卷 387-392页

作者： QIN Chun-Jun HOU Hong-Li DING Mei-Ru QI Yi-Kuan TIAN Guang-Zong zou xiao-peng FU Jun-Jie HU Jing YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.

关键词： L-galactosaminuronic acid Chemical synthesis Orthogonal protection Glycal addition C6 oxidation

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我国股票市场的流动性风险溢价研究

浙江大学学报（人文社会科学版） 2007年第4期37卷 191-200页

作者：黄峰邹小芃上海交通大学金融系上海200030 浙江大学金融学系浙江杭州310027

我国股票预期回报率中包含显著的非流动性补偿和流动性风险溢价,而且非流动性补偿和流动性风险溢价更为显著地出现在流动性较差或者说价格冲击弹性较高的股票上。由于流动性水平和流动性风险在股票横截面上存在强相关性,使得代理流动性... 详细信息

我国股票预期回报率中包含显著的非流动性补偿和流动性风险溢价,而且非流动性补偿和流动性风险溢价更为显著地出现在流动性较差或者说价格冲击弹性较高的股票上。由于流动性水平和流动性风险在股票横截面上存在强相关性,使得代理流动性水平的非流动性指标能够抓住流动性风险的溢价效应。经典资本资产定价模型的价格风险敏感度对股票回报率缺乏解释力,意味着股票的风险溢价更多地来自对流动性风险的补偿,而非来自对单纯的价格风险的补偿。

关键词：流动性风险股票定价非流动性指标

基于VaR的权变投资组合保险策略及实证分析

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数理统计与管理 2006年第2期25卷 195-204页

作者：邹小芃钱英余君浙江大学经济学院杭州310027 浙江大学数学系杭州310027

传统的投资组合保险策略在投资期内全程进行保险操作,在熊市期间确能起到保险作用,但在牛市期间又会夹失部分收益。应用综合了VaR技术和滤嘴法则的VaR套补的权变投资组合保险策略,则能弥补上述缺憾,为保险资金或保本型基金投资股市提供... 详细信息

传统的投资组合保险策略在投资期内全程进行保险操作,在熊市期间确能起到保险作用,但在牛市期间又会夹失部分收益。应用综合了VaR技术和滤嘴法则的VaR套补的权变投资组合保险策略,则能弥补上述缺憾,为保险资金或保本型基金投资股市提供了有效的投资手段。

关键词： VaR 滤嘴法则投资组合保险尾指数

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao Yu-Gui peng peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

商标权证券化浅析——以Guess? Inc为例

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华东经济管理 2009年第8期23卷 153-155页

作者：邹小芃周梦宇李鹏浙江大学经济学院浙江杭州310027

"鲍伊债券"于1997年开创了知识产权证券化的先河。近年来,知识产权证券化在国外的实践主要涉及版权、专利权和商标权等领域,频受关注。商标权证券化是产品经营模式与企业融资模式的双重创新,文章解析国外商标权证券化案例,意在抛砖引玉... 详细信息

"鲍伊债券"于1997年开创了知识产权证券化的先河。近年来,知识产权证券化在国外的实践主要涉及版权、专利权和商标权等领域,频受关注。商标权证券化是产品经营模式与企业融资模式的双重创新,文章解析国外商标权证券化案例,意在抛砖引玉,希望引发国内学者和业界对商标权融资更深的研究。

关键词：商标权证券化案例解析经验借鉴

主观预期寿命对家庭资产配置的影响——基于CHARLS数据的经验分析

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经济理论与经济管理 2019年第2期39卷 44-61页

作者：邹小秡杨芊芊浙江越秀外国语学院国际商学院浙江大学经济学院

本文在基于生命周期的资产配置模型中引入主观预期寿命,对主观预期寿命、遗赠动机对中国家庭资产配置的影响进行分析。运用中国健康与养老追踪调查数据,本文的实证研究结果表明:中老年居民的主观预期寿命是理性的,该指标在研究家庭金融... 详细信息

本文在基于生命周期的资产配置模型中引入主观预期寿命,对主观预期寿命、遗赠动机对中国家庭资产配置的影响进行分析。运用中国健康与养老追踪调查数据,本文的实证研究结果表明:中老年居民的主观预期寿命是理性的,该指标在研究家庭金融决策问题上具有重要的参考意义;主观预期寿命的增长显著提升了家庭持有政府债券和风险资产的可能性,并增加了家庭在相应资产上的配置。遗赠动机会弱化主观预期寿命增长对家庭持有相应资产的可能性和配置比例的正向影响。通过使用多种估计方法和代理变量,笔者发现上述结论是稳健的。

关键词：家庭资产配置主观预期寿命中老年居民遗赠动机