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Percutaneous valve stent insertion to correct the pulmonary regurgitation： an animal feasibility study

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Chinese Medical Journal 2010年第21期123卷 3127-3131页

作者： BAI Yuan zong gang-jun JIANG Hai-bing LI Wei-ping WU Hong ZHAO Xian-xian QIN Yong-wen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Ultrasonography Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Cardiology 101 Hospital of People's Liberation Army Wuxi Jiangsu 214044 China

Background Pulmonary regurgitation leads to progressive right ventricular dysfunction, susceptibility to arrhythmias,and sudden cardiac death. Percutaneous valve replacement has been developed in recent years, providing patients with an alternative option. Percutaneous pulmonary valve replacement has been recently introduced into clinical practice. The goal of this study was to evaluate the feasibility of percutaneous valve stent insertion to correct the pulmonary regurgitation in sheep using a cup-shaped valve *** Pulmonary regurgitation was created by percutaneous cylindrical stent insertion in native pulmonary annulus of 8 sheep. One month after the initial procedure, the sheep with previous cylindrical stent implanted underwent the same implantation procedure of pulmonary valve stent. The valve stent consisted of a cup-shaped stent and pericardial *** assessments of the bioprosthetic pulmonary valve were obtained by echocardiography at immediately post-implant and at 2 months follow *** Successful transcatheter cylindrical stent insertion was performed in 7 sheep but failed in 1 sheep because the cylindrical stent was released to right ventricle outflow tract. After one month the 7 sheep with pulmonary regurgitation underwent valve stent implantation successfully. Echocardiography confirmed the stents were in desired position during the follow-up. No evidence of pulmonary valve insufficiency occurred in any animals. Echocardiography showed all heart function markers were *** Percutaneous cylindrical stent insertion to induce significant pulmonary regurgitation in sheep was feasible, simple and reproducible. Percutaneous pulmonary valve stent implantation can reduce pulmonary regurgitation in a sheep model. Further development of animal model and clinical trials are warranted.

关键词： percutaneous pulmonary regurgitation valve stent animal model

Percutaneous aortic valve replacement using a W-model valved stent： a preliminary feasibility study in sheep

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Chinese Medical Journal 2009年第6期122卷 655-658页

作者： BAI Yuan zong gang-jun WANG Yan-yan JIANG Hai-bin LI Wei-ping WU Hong ZHAO Xian-xian QIN Yong-wen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Ultrasonography Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Cardiology 101 Hospital of PLA Wuxi Jiangsu 210044 China Department of' Internal' Medicine Zhongshan Hospital Fudan University Shanghai 200032 China

Background Percutaneous aortic valve replacement is a promising strategy in the treatment of patients with aortic valve stenosis. And many kinds of valved stents have been implanted in selected patients worldwide. However, the clinical experience is still limited. We developed a W-model valved stent and evaluated the feasibility and safety of percutaneous implantation of the device in the native aortic valve position.Methods A self expanding nitinol stent with W-model, containing porcine pericardium valves in its proximal part, was implanted in six sheep by means of a 14 French catheter through the right common iliac artery under guidance of fluoroscopy. During stent deployment the original aortic valve was pushed against the aortic wall by the self expanding force of the stent while the new valve was expanded. These sheep were followed up shortly after procedure with supra-aortic angiogram and left ventriculography. Additionally, one sheep was sacrificed after the procedure for anatomic evaluation.Results It was possible to replace the aortic valve in the beating heart in four sheep. The procedure failed in two sheep due to coronary orifice occlusion in one case and severe aortic valve regurgitation in the other case. One sheep was killed one hour after percutaneous aortic valve replacement for anatomic evaluation. There were no signs of damage of the aortic JntJma, or of obstruction of the coronary orifice,Conclusions Percutaneous aortic valve replacement with a W-model valved stent in the beating heart is possible. Further studies are mandatory to assess safety and efficacy of this kind of valved stent in larger sample size and by longer follow-up period.

关键词： percutaneous aortic valve valved stent bioprosthesis

Percutaneous establishment of tricuspid regurgitation： an experimental model for transcatheter tricuspid valve replacement

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Chinese Medical Journal 2010年第7期123卷 806-809页

作者： BAI Yuan CHEN Hai-yan zong gang-jun JIANG Hai-bing LI Wei-ping WU Hong ZHAO Xian-xian QIN Yong-wen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433China Department of Cardiology Changzheng Hospital Second Military Medical University Shanghai 200003 China Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433China Department of Ultrasonography Changhai Hospital Second Military Medical University Shanghai 200433China

Background Valve replacement or repair Is recommended in patients with tricuspid regurgitation when deterioration of their clinical status occurs as a consequence of right ventricular dysfunction. Percutaneous valve replacement was developed in recent years. To investigate the feasibility, effectiveness and long-term results of percutaneous tricuspid valve replacement, an experimental model with tricuspid regurgitation is needed. We developed a simple and reproducible percutaneous approach for the creation of tricuspid regurgitation in *** A specially designed grasping forceps were used to grasp chordae tendineae or the tricuspid valve leaflets through a catheter. Transcatheter creation of tricuspid regurgitation was performed on 7 healthy sheep. These sheep were followed up shortly after the procedure and at 6th month post-procedure with echocardiography. Additionally, all the sheep were sacrificed for anatomic evaluation at 6th month after the *** Creation of tricuspid regurgitation was successfully accomplished in all sheep. Necropsy confirmed that damage was done to the tricuspid valve apparatus in all animals （tearing of the anterior leaflet of the tricuspid valve in five animals and posterior leaflet of the tricuspid valve in two animals）. At the six-month follow-up, there was no significant increase in the right ventricle dimension and ejection fraction measured by echocardiography. Autopsy examinations demonstrated the tearing of tricuspid valve *** The creation of an animal model of tricuspid regurgitation via a percutaneous approach using forceps to sever one or more tricuspid leaflets is feasible and will allow investigation of devices designed replace the tricuspid valve via a percutaneous approach. Despite significant tricuspid regurgitation, the hemodynamics did not change during the follow-up period in this model.

关键词： tricuspid regurgitation percutaneous, animal model

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工程测量中新旧坐标转换的一种实现方法

西安科技大学学报 2007年第3期27卷 401-404页

作者：宗刚军姚顽强陕西能源职业技术学院地质测量系陕西咸阳712000 西安科技大学测量工程系陕西西安710054

常规的测量坐标转换模型因采用确定的变换参数而导致坐标换算误差。将转换区域内各新旧坐标公共点视为精度均匀的离散点,通过计算区域重心坐标和坐标转换的初始参数,求取各公共点的坐标换算近似值及其改正数。在此基础上,根据公共点旧... 详细信息

常规的测量坐标转换模型因采用确定的变换参数而导致坐标换算误差。将转换区域内各新旧坐标公共点视为精度均匀的离散点,通过计算区域重心坐标和坐标转换的初始参数,求取各公共点的坐标换算近似值及其改正数。在此基础上,根据公共点旧坐标与其改正数的对应关系,利用常规数字成图软件的离散函数插值功能,获取任意点的坐标换算改正数,实现新、旧坐标转换。实例应用表明,该法简便可行,换算精度高,是新旧测量坐标转换的有效方法。

关键词：工程测量坐标转换初始换算参数坐标改正数

GPS RTK技术在数字化地形测量中的应用

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煤 2009年第9期18卷 40-41页

作者：宗刚军陕西能源职业技术学院地质测量系陕西咸阳712000

GPS新技术的出现,可以高精度并快速地测定各级控制点的坐标,在地形控制测量中已得到广泛应用。文章主要介绍GPS RTK技术在地形图图根测量、碎部测量中的操作方法和步骤及注意事项。

关键词： GPSRTK 基准站流动站测图地形图

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野外数字化测图与坐标法测图的比较

煤 2010年第6期19卷 59-59,63页

作者：宗刚军陕西能源职业技术学院地质测量系陕西咸阳712000

介绍野外数字化测图的方法和步骤,对两种测图方法的误差来源进行了分析,总结了数字化测图的优点,预测未来测图的发展趋势。

关键词：数字化测图坐标法测图优点

带瓣膜主动脉瓣支架的研制及体外经导管植入实验

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第二军医大学学报 2009年第2期30卷 117-119页

作者：顾明标白元宗刚军秦永文第二军医大学长海医院心内科上海200433

目的:评价一种新的带瓣膜主动脉瓣支架经导管植入的可行性及其对冠脉血流的影响。方法:用超弹性镍钛记忆合金丝编织成圆柱状网状支架,腰部凹陷,并将网孔扩大,下段内置瓣膜环,将新鲜的猪心包经脱细胞处理后给予0.6%戊二醛浸泡36h,缝合在... 详细信息

目的:评价一种新的带瓣膜主动脉瓣支架经导管植入的可行性及其对冠脉血流的影响。方法:用超弹性镍钛记忆合金丝编织成圆柱状网状支架,腰部凹陷,并将网孔扩大,下段内置瓣膜环,将新鲜的猪心包经脱细胞处理后给予0.6%戊二醛浸泡36h,缝合在瓣膜环上,制成带瓣膜主动脉瓣支架。支架近端连接丝线,收入鞘管,取离体猪心脏标本,经升主动脉将带瓣膜支架送至左室,直视下送至主动脉瓣位置,释放支架,注水观察瓣膜功能及冠脉水流量。结果:制备的带瓣膜主动脉瓣支架可牢固地置于原主动脉瓣位置,释放后可回收,人工瓣膜启闭功能好,冠脉流量及二尖瓣前叶活动未受影响。结论:带瓣膜主动脉瓣支架设计合理,可经导管释放并回收,瓣膜功能良好,不影响冠脉开口,可用于动物体内植入实验研究。

关键词：主动脉瓣心导管术心脏瓣膜假体植入支架

经导管植入钳夹装置治疗三尖瓣膜关闭不全的应用解剖

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中国临床解剖学杂志 2015年第5期33卷 514-516页

作者：宗刚军姜海滨吴刚勇王霄夏阳中国人民解放军第101医院心血管内科江苏无锡214044

目的为经导管植入钳夹装置治疗三尖瓣膜关闭不全提供三尖瓣区相关的应用解剖。方法解剖28例(男18,女10)外形大小正常的成年人心脏标本,观察三尖瓣膜的形态及与周围组织的解剖关系,测量与三尖瓣膜相关的数据。结果三尖瓣环周长为(109.4±... 详细信息

目的为经导管植入钳夹装置治疗三尖瓣膜关闭不全提供三尖瓣区相关的应用解剖。方法解剖28例(男18,女10)外形大小正常的成年人心脏标本,观察三尖瓣膜的形态及与周围组织的解剖关系,测量与三尖瓣膜相关的数据。结果三尖瓣环周长为(109.4±14.2)mm,长径为(43.5±6.5)mm,短径为(29.3±5.4)mm。前瓣游离缘到附着缘最大距离为(22.3±4.1)mm,后瓣游离缘到附着缘最大距离为(20.5±3.8)mm。结论钳夹装置的大小和形状的设计应根据三尖瓣区解剖特点及与周边结构的关系来决定,钳夹三尖瓣的前后瓣叶可行。

关键词：经导管心脏三尖瓣钳夹装置应用解剖

血清C反应蛋白/载脂蛋白A1比值与冠状动脉病变的相关性初步探讨

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第二军医大学学报 2021年第10期42卷 1148-1156页

作者：吴祖飞陈诗苏文韬周雨婷宗刚军吴刚勇安徽医科大学无锡临床学院心内科无锡214044 中国人民解放军联勤保障部队904医院心血管内科无锡214044

目的探讨血清CRP、载脂蛋白A1(ApoA1)及CRP与ApoA1比值(CRP/ApoA1)评估冠状动脉病变的价值。方法回顾性连续纳入2018年12月至2019年12月因胸痛在中国人民解放军联勤保障部队904医院住院治疗并行冠状动脉造影检查的533例患者。根据Gensin... 详细信息

目的探讨血清CRP、载脂蛋白A1(ApoA1)及CRP与ApoA1比值(CRP/ApoA1)评估冠状动脉病变的价值。方法回顾性连续纳入2018年12月至2019年12月因胸痛在中国人民解放军联勤保障部队904医院住院治疗并行冠状动脉造影检查的533例患者。根据Gensini积分和冠状动脉造影结果将患者分为冠状动脉正常组(Gensini积分为0分,n=118)、冠状动脉粥样硬化组(Gensini积分为1~18分但不满足冠心病诊断,n=109)和冠心病组(Gensini积分为1~180分且符合冠心病诊断标准,n=306)。依据Gensini积分将冠心病患者分为轻度病变组(Gensini评分为1~<30分,n=177)和重度病变组(Gensini评分为30~180分,n=129)。根据血管病变数目将冠心病患者分为冠状动脉单支血管病变组(n=147)、冠状动脉双支血管病变组(n=90)、冠状动脉3支及以上血管病变组(n=69)。记录各组患者的血清CRP、ApoA1、白蛋白等血液学指标,并计算CRP/ApoA1。采用多因素logistic二元回归分析确定冠心病及重度病变的独立危险因素,应用ROC曲线分析CRP/ApoA1对冠心病、冠心病重度病变、冠状动脉3支及以上血管病变的预测价值,并与CRP/白蛋白比值(CAR)、CRP和ApoA1的预测价值进行比较。结果冠心病组患者的CRP/ApoA1高于冠状动脉正常组(P<0.01),冠心病重度病变组患者的CRP/ApoA1高于冠心病轻度病变组(P<0.01)。多因素logistic二元回归分析提示CRP/ApoA1是冠心病和冠心病重度病变的独立危险因素(OR=2.171,95% CI 1.293~3.647,P<0.01;OR=6.306,95% CI 3.591~11.073,P<0.01)。Spearman相关性分析结果表明CRP/ApoA1与Gensini积分呈正相关(r=0.419,P<0.01),且CRP/ApoA1与冠状动脉病变血管支数呈正相关(r=0.431,P<0.05)。ROC曲线分析结果显示,CRP/ApoA1对冠心病、冠心病重度病变和冠状动脉3支及以上血管病变有较高的预测价值(AUC值分别为0.704、0.796、0.820),且均优于CAR(AUC值分别为0.684、0.783、0.806)、CRP(AUC值分别为0.682、0.778、0.800)和ApoA1(AUC值分别为0.641、0.669、0.687),差异均有统计学意义(P均<0.05)。结论 CRP/ApoA1与冠心病及其病变严重程度相关,其诊断价值优于CAR、CRP、ApoA1,可用于冠心病的诊断与病情评估。

关键词： C反应蛋白载脂蛋白A1 Gensini积分冠状动脉疾病