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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie Jin-Gang He zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen Tao Tao Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China Department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China Department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability *** PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely *** potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced *** this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term *** indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury *** kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of ***,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying ***,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for *** studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum

A N-CoSe/CoSe_(2)-C@Cu hierarchical architecture as a current collector-integrated anode for potassium-ion batteries

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Rare Metals 2024年第8期43卷 3702-3712页

作者： Zi-Jie Mu Yan-Jun Gao Wen-Shuai Dong zong-You Li Qing-Yi Song Han-Jiao Huang Li-Dong Xing Jian-Guo Zhang Wei Wang Qi-Yao Yu State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China school of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The highly reversible insertion/extraction of large-radius K^+into electrode materials remains a tough goal,especially for con version-type ***,we design a current collector-integrated electrode(N-CoSe/CoSe_(2)-C@Cu) as an advanced anode for potassium-ion battery(PIBs).The conductive CoSe/CoSe_(2) heterojunction with rich Se vacancy defects,conductive sp^2 N-doped carbon layer,and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural ***,the well-designed N-CoSe/CoSe_(2)-C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity(325.1 mAh·g^(-1) at 0.1 A·g^(-1) after 200cycles),an exceptional rate capability(223.5 mAh·g^(-1) at2000 mA·g^(-1)),and an extraordinary long-term cycle stability(a capacity fading of only 0.019% per cycle over1200 cycles at 2000 mA·g^(-1)).Impressively,ex situ scanning electron microscopy(SEM) characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N-CoSe/CoSe_(2)-C@Cu heterostructure,which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process.

关键词： Potassium-ion battery Integrated collector electrode CoSe CoSe_2 Heterojunction Copper foil matrix N-doped carbon

The 4^(th)CCL Organic Chemistry Forum held in Zhangye

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Chinese Chemical Letters 2024年第8期35卷 3-6页

作者： Yingxiao zong Yangfei Wei Xiaoqing Liu Junke Wang Huanfang Guo Junli Wang Zhuangzhi Shi Tao Tu Cheng Yang Chongyang Wang Leyong Wang Key Laboratory of Hexi Corridor Resources Utilization of Gansu School of Chemistry and Chemical EngineeringHexi UniversityZhangye 734000China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China school of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry Sichuan UniversityChengdu 610064China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

The first Chinese Chemical Letters(CCL)Organic Chemistry Forum was held in Xiamen of Fujian in Jan.2018,followed by the successful events in Zhengzhou of Henan in Dec.2019 and Linzhi of Tibet in July *** series of forums aim to build a high-level organic chemistry academic exchange platform for(Chinese)youthful organic chemists,fully showcase their latest fron-tier achievements,and enhance the international level of organic chemistry in *** the same time,the convening of the series of forums has also played a positive role in promoting the devel-opment of china’s scientific journal publishing,accelerating the re-alization of the strategic goal of building a world-class journal.

关键词： journal Forum Xiamen

Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA Koen ZHANG Jing Xian XIE Wei zong Wen Qi ZUO Hui ZHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands school of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

数字经济的节能减排效应及作用机制——基于空间关联网络溢出模式

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工业技术经济 2024年第1期43卷 13-20页

作者：周梦雯刘传明对外经济贸易大学国际经济研究院北京100029 山东财经大学经济学院济南250014

本文将数字经济、能源强度和碳排放强度三者置于统一框架,构建数字经济空间关联网络权重矩阵,利用空间杜宾模型检验发现:数字经济对能源强度和碳排放强度的影响均呈现倒“N”型特征,具有显著的空间溢出效应,数字经济发展到一定阶段可以... 详细信息

本文将数字经济、能源强度和碳排放强度三者置于统一框架,构建数字经济空间关联网络权重矩阵,利用空间杜宾模型检验发现:数字经济对能源强度和碳排放强度的影响均呈现倒“N”型特征,具有显著的空间溢出效应,数字经济发展到一定阶段可以实现“节能”与“减排”双赢。数字产业化和产业数字化双重维度的检验发现,数字产业化通过数字产业在地区间的布局和对要素吸引力改变产业集聚程度影响碳排放强度;产业数字化通过数字技术嵌入各个行业,改善资源配置效率和能源利用效率,通过能源强度影响碳排放强度。本文为数字经济政策制定和实现“双碳”目标提供了启示。

关键词：数字经济节能减排产业集聚倒“N”型曲线空间关联网络空间杜宾模型

Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2106-2118页

作者： Xiao Wang Zhao-Yi Lin You Zhou Qin Zhong zong-Ren Li Xi-Xiang Lin Ming-Gen Hu Kun-Lun He Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Medical school of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Hepatobiliary Surgery Chinese PLA 970th HospitalYantai 264001Shandong ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China school of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Post-hepatectomy liver failure(PHLF)is a common consequence of radical partial hepatectomy in hepatocellular carcinoma(HCC).AIMS To investigate the relationship between preoperative antiviral therapy and PHLF,as well as assess the potential efficacy of hepatitis B virus(HBV)DNA level in predicting *** A retrospective study was performed involving 1301 HCC patients with HBV who underwent radical *** operating characteristic(ROC)analysis was used to assess the capacity of HBV DNA to predict PHLF and establish the optimal cutoff value for subsequent *** regression analyses were performed to assess the independent risk factors of *** increase in the area under the ROC curve,categorical net reclassification improvement(NRI),and integrated discrimination improvement(IDI)were used to quantify the efficacy of HBV DNA level for predicting *** P<0.05 was considered statistically *** Logistic regression analyses showed that preoperative antiviral therapy was independently associated with a reduced risk of PHLF(P<0.05).HBV DNA level with an optimal cutoff value of 269 IU/mL(P<0.001)was an independent risk factor of *** the reference models by adding the variable of HBV DNA level had an improvement in area under the curve,categorical NRI,and IDI,particularly for the fibrosis-4 model,with values of 0.729(95%CI:0.705-0.754),1.382(95%CI:1.341-1.423),and 0.112(95%CI:0.110-0.114),*** the above findings were statistically *** In summary,preoperative antiviral treatment can reduce the incidence of PHLF,whereas an increased preoperative HBV DNA level has a correlative relationship with an increased susceptibility to PHLF.

关键词： Hepatocellular carcinoma Hepatitis B virus Preoperative antiviral treatment Liver resection Post-hepatectomy liver failure

Trichoderma viride F7 improves peanut performances while remediating cadmium-contaminated soil with microplastics

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Pedosphere 2024年第5期34卷 971-980页

作者： Xin SONG Jianpeng JIN Hongliang YIN Tingjuan WANG Haiying zong Fangli WANG Jun LIU Xiaoli HUANG Bin WANG Chao CHAI Zhi LI Dongsheng LIU Xuexia WANG Ningning SONG school of Resources and Environment Qingdao Agricultural University Central Laboratory Qingdao Agricultural University Institute of Soil Fertilizer and Agricultural Water Saving Xinjiang Academy of Agricultural Sciences Institute of Plant Nutrition and Resources Beijing Agricultural Forestry Academy Sciences

Microplastics(MPs) and cadmium(Cd) in soil have serious negative impacts on plant growth. As a bioremediator, Trichoderma viride may modulate the impacts of MPs and/or Cd on plant growth and heavy metal uptake. In this study, T. viride F7 was used to treat Cd-contaminated soil with and without the presence of polylactic acid MPs to investigate its effects on peanut growth, Cd uptake efficiency, and soil properties. Results showed that F7 increased soil pH,dissolved organic carbon, cation exchange capacity, microbial biomass nitrogen, and microbial biomass carbon, which resulted in increases of 2.10%–19.83% in peanut biomass and mitigated the negative effects of MPs and Cd on peanut growth. Trichoderma viride F7 reduced the soil bioavailable Cd and plant Cd concentrations by 16.68%–34.20% and 5.37%–25.84%, respectively. Regression path analysis showed that F7 could improve peanut performances by altering soil properties and reducing peanut Cd concentrations in MP-Cd-contaminated soil. Soil fungal community analysis indicated that the microbial community was altered via F7 inoculation, which antagonized Fusarium and promoted peanut growth. This study reveals the mechanisms of F7 in mitigating Cd contamination in the soil with the presence of MPs, which provides new ideas for managing MP-heavy metal-contaminated soil and improving soil health.

关键词： bioremediation compound pollution emerging pollutant heavy metal polyethylene soil health

Self-Assembly of Bacteria in Alternating-Current Electric Fields

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Chinese Physics Letters 2024年第10期41卷 137-143页

作者： Yan-Ran Li Yi-Wu zong Hong Zhang Jing-Chao Zhang Chun-Ying Feng Jian-Jun Qiao Hao Song Kun Zhao Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Petrochemical Research Institute of Petrochina Co. Ltd.Beijing 102206China Center for Medical Genetics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Jiangsu Key Laboratory of Sericultural and Animal Biotechnology School of BiotechnologyJiangsu University of Science and TechnologyZhenjiang 212100China Key Laboratory of Silkworm and Mulberry Genetic Improvement Ministry of Agriculture and Rural AffairsSericultural Scientific Research CenterChinese Academy of Agricultural SciencesZhenjiang 212100China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China The Sichuan Provincial Key Laboratory for Human Disease Gene Study and The Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 610054China

Self-assembly of bacteria in electric fields is a promising route to fabricate biomaterials with reversible and specific ***,due to relatively less studies,our understanding of the self-assembly of bacteria in electric fields is still ***,how different bacterial species behave differently in their fieldmediated self-assembly behavior remains to be *** this study,we choose four bacterial species,including Shewanella oneidensis,Pseudomonas aeruginosa,Bacillus subtilis and Lactococcus lactis as model systems,and investigate their self-assembly behavior in alternating-current(AC)electric fields for both diluted and concentrated *** phase diagrams in the plane of applied field strength vs frequency are *** results show that in diluted suspensions,a transition sequence of isotropic–paranematic–string–columnar phases is observed in all strains as the field strength *** of the assembled structures are quantitatively differentiated among different *** concentrated suspensions,besides the isotropic and paranematic phases,a higher ordered phase with interdigitating rectangular crystal domains(OIR)and an ordered phase with smectic A liquid crystal domains are observed for *** and ***,*** findings shed new light on fabricating potential biomaterials by assembling cells of appropriately chosen bacterial species that have desired surface properties under AC electric fields.

关键词： suspensions diluted biomaterials

Numeration and type synthesis of 3-DOF orthogonal translational parallel manipulators

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Progress in Natural Science:Materials International 2008年第5期18卷 563-574页

作者： Jingjun Yua, Jian S. Dai b, Shusheng Bi a, Guanghua zong a a Robotics Institute, Beihang university, beijing 100083, china b Department of Mechanical Engineering, school of Physical Science and Engineering, King’s College, university of London, The Strand, London WC2R 2LS, UK Robotics Institute Beihang University Beijing 100083 China Department of Mechanical Engineering School of Physical Science and Engineering King’s College University of London The Strand London WC2R 2LS UK

Low-degree-of-freedom (Low-DOF) parallel manipulators (PMs) have drawn extensive interests, particularly in type synthesis in which two main formal approaches were established by using the reciprocal screw system theory and Lie group theory. This paper aims at numeration and type synthesis of orthogonal translational parallel manipulators (OTPMs) by resorting to an integration of the group- based method and graphical representation of the topology. For this purpose, the concept of Cartesian DOF-characteristic matrix, orig- inated from displacement subgroup and displacement submanifold, is proposed. A new approach based on the combination of the atlas of Cartesian DOF-characteristic matrix and the displacement group-theoretic method is addressed for both exhaustive classi cation and type synthesis of OTPMs. The proposed approach is prone to construct an orthogonal structure and is easy to realize the complete clas- si cation and exhaustive enumeration of this class of low-DOF PMs.

关键词： Type synthesis Displacement group Orthogonal translational parallel manipulator