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Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

BIOCELL 2024年第1期48卷 123-138页

作者： ZHENHUA LI HUILAI LV FAN ZHANG ZIMING ZHU QIANG GUO MINGBO WANG CHAO HUANG LIJUAN CHEN WENPAN ZHANG YUN LI ziqiang tian Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer Genome Atlas(TCGA) Ubiquitination network

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Comparisons of minimally invasive esophagectomy and open esophagectomy in lymph node metastasis/dissection for thoracic esophageal cancer

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Chinese Medical Journal 2022年第20期135卷 2446-2452页

作者： Zhenhua Li Chunyue Gai Yuefeng Zhang Shiwang Wen Huilai Lv Yanzhao Xu Chao Huang Bo Zhao ziqiang tian Department of Thoracic Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Medical Iconography the Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China

Background:The study aimed to clarify the characteristics of lymph node metastasis(LNM)and to compare the oncologic outcomes of minimally invasive esophagectomy(MIE)with open esophagectomy(OE)in terms of lymph node dissection(LND)in thoracic esophageal cancer ***:The data from esophageal cancer patients who underwent MIE or OE from January 2016 to January 2019 were retrospectively *** characteristics of LNM in thoracic esophageal cancer were discussed,and the differences in numbers of LND,LND rate,and LNM rate/degree of upper mediastinum between MIE and OE were ***:For overall characteristics of LNM in 249 included patients,the highest rate of LNM was found in upper mediastinum,while LNM rate in middle and lower mediastinum,and abdomen increased with the tumor site moving *** patients were divided into MIE(n=204)and OE groups(n=45).In terms of number of LND,there were significant differences in upper mediastinum between MIE and OE groups(8[5,11]vs.5[3,8],P<0.001).The comparative analysis of regional lymph node showed there was no significant difference except the subgroup of upper mediastinal 2L and 4L group(3[1,5]vs.0[0,2],P<0.001 and 0[0,2]vs.0,P=0.012,respectively).Meanwhile,there was no significant difference in terms of LND rate except 2L(89.7%[183/204]vs.71.1%[32/45],P=0.001)and 4L(41.2%[84/204]vs.22.2%[10/45],P=0.018)*** LNM rate of T3 stage,there was no significant difference between MIE and OE groups,and the comparative analysis of regional lymph node showed that there was no significant difference except 2L group(11.1%[5/45]vs.38.1%[8/21],P=0.025).The LNM degree of OE group was significantly higher than that of MIE group(27.2%[47/173]vs.7.6%[32/419],P<0.001),and the comparative analysis of regional LNM degree showed that there was no significant difference except 2L(34.7%[17/49]vs.7.7%[13/169],P<0.001)and 4L(23.8%[5/21]vs.3.9%[2/51],P=0.031)***:MIE may have an advantage in LND of upper mediast

关键词： Esophageal neoplasms Lymph node Minimally invasive esophagectomy Open esophagectomy

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非小细胞肺癌胸腔镜术后并发症及其对预后的影响

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现代肿瘤医学 2024年第5期32卷 857-862页

作者：苏鹏田子强徐延昭吕会来李振华温士旺河北医科大学第四医院胸五科河北石家庄050011

目的:探讨非小细胞肺癌患者接受胸腔镜手术后的并发症及其对预后的影响。方法:本研究随机选择2017年06月至2020年06月在我院进行胸腔镜肺癌切除术治疗的102例非小细胞肺癌患者作为研究对象,收集患者临床及随访资料并进行分析。Logistic... 详细信息

目的:探讨非小细胞肺癌患者接受胸腔镜手术后的并发症及其对预后的影响。方法:本研究随机选择2017年06月至2020年06月在我院进行胸腔镜肺癌切除术治疗的102例非小细胞肺癌患者作为研究对象,收集患者临床及随访资料并进行分析。Logistic回归探讨影响术后并发症或严重并发症的危险因素。以复发为终点进行生存分析,比较不同组别患者之间无复发生存率的差异。结果:在纳入的102例患者中,我们发现,患者年龄(OR=4.009,95%CI:1.209~13.299,P=0.023)、糖尿病(OR=3.515,95%CI:1.045~11.819,P=0.042)、手术时间(OR=1.014,95%CI:1.002~1.026,P=0.020)、术中出血量(OR=1.016,95%CI:1.008~1.025,P<0.001)均为术后并发症的影响因素。同时,手术时间(OR=1.123,95%CI:1.008~1.252,P=0.036)为术后严重并发症的影响因素。并发症组的术后住院时间较无并发症组明显延长(P<0.001)。无并发症患者的无复发生存率显著高于有并发症患者(HR=1.43,95%CI:1.03~1.99,P=0.033),无严重并发症患者的无复发生存率明显高于严重并发症患者(HR=1.61,95%CI:1.15~2.24,P=0.005)。结论:对于接受胸腔镜手术治疗的非小细胞肺癌患者,年龄、糖尿病、手术时间、术中出血量是术后并发症的独立影响因素,且术后并发症可显著降低患者的无复发生存期。

关键词：非小细胞肺癌胸腔镜并发症糖尿病预后

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Detrital zircon U-Pb dating in the southern Hefei Basin: Evidence for exhumation of HP-UHP rocks of the Dabie Orogen

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Science China Earth Sciences 2020年第7期63卷 954-968页

作者： Yongsheng WANG Qiao BAI ziqiang tian Hui DU School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

The Hefei Basin of eastern China developed in response to uplift of the Dabie Orogen,and zircon dating can be used to assess the exhumation history of the *** were collected from samples of the Lower Jurassic Fanghushan Formation and Middle Jurassic Sanjianpu Formation in the southern Hefei Basin,and mica-quartz schist and biotite granite gneiss from the Susong Complex of the Dabie *** zircon U-Pb dating was undertaken using laser ablation-inductively coupled plasma-mass *** detrital zircons from conglomerates of the Fanghushan Formation and from clasts within the conglomerates have age-frequency distributions with the main clusters between 2.0 and 1.8 Ga,similar to age data of the Susong *** the other hand,the zircons of the Fanghushan Formation do not show the age cluster at 1000–900 Ma that characterizes zircons in the underlying metasediments of the lower Paleozoic Foziling Group.A cluster of Triassic zircon ages also appears in the arkosic sandstones of the Fanghushan *** data indicate that the provenance of the Fanghushan Formation was a mixture of high-pressure(HP)and ultrahigh-pressure(UHP)Triassic metamorphic rocks,Paleozoic magmatic rocks,and the Susong Complex,but not the lower Paleozoic Foziling Group even though it directly underlies the sediments of the Hefei *** samples from the Sanjianpu Formation show zircon age clusters at 797 and 791 Ma(middle Neoproterozoic)and 226 Ma(Triassic),and again,these are markedly different from the age clusters that characterize the Foziling *** seems,therefore,that despite the Foziling Group being at the surface in the underwater depositional area of the Hefei Basin,it was not exposed in the source area of the Hefei basinal sediments during the Jurassic,and there are two possible reasons for ***,the exhumation of the Dabie Orogen was directed partly towards the north,in the process of which some of the Foziling Group was ***,the Susong Compl

关键词： Dabie Orogen Exhumation of HP-UHP rocks Hefei Basin Lower-Middle Jurassic Zircon dating

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高龄患者行非同侧肺二次胸腔镜下肺段切除术的麻醉与围术期管理

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中华麻醉学杂志 2024年第3期44卷 361-365页

作者：周超王天龙张利东郑晖杨旭东尹春琳曹罡田子强薛张纲王古岩贾慧群河北医科大学第四医院麻醉科石家庄050011 首都医科大学宣武医院麻醉手术科北京100053 解放军东部战区总医院麻醉科南京210018 中国医学科学院肿瘤医院麻醉科北京100021 北京大学口腔医院麻醉科北京100034 首都医科大学宣武医院心血管内科北京100053 解放军东部战区总医院口腔科南京210018 河北医科大学第四医院胸外科石家庄050011 复旦大学附属中山医院麻醉科上海200032 首都医科大学附属北京同仁医院麻醉科北京100730

一、病例介绍1.病历摘要:(1)一般情况:患者女性,年龄73岁,身高152 cm,体质量58 kg。因右肺下叶切除术后4月余,为行进一步治疗入院。第一次入院情况:患者主因发现肺部占位3 d于2023年2月2日入院,CT示:右肺下叶可见类圆形高密度影,边缘欠... 详细信息

一、病例介绍1.病历摘要:(1)一般情况:患者女性,年龄73岁,身高152 cm,体质量58 kg。因右肺下叶切除术后4月余,为行进一步治疗入院。第一次入院情况:患者主因发现肺部占位3 d于2023年2月2日入院,CT示:右肺下叶可见类圆形高密度影,边缘欠清,大小约为3.3 cm×2.5 cm,不除外肿瘤性病变;左肺上叶前段部分实性结节,大小约为0.9 cm×0.7 cm,不除外肿瘤性病变。因同期手术创伤大、恢复时间长、并发症发生率高等原因,与家属商议后决定先行右肺病变切除术。充分术前准备后,患者于2023年2月7日行胸腔镜下右肺下叶切除术+系统淋巴结清扫,手术顺利,术后安返病房。术后恢复顺利,于2023年2月14日出院。术后病理示:肺浸润性腺癌(腺泡状约70%,乳头状约30%),未见明确脉管瘤栓,脏层胸膜未见明确受侵。支气管残端(-)。淋巴结:2组0/2,4组0/3,7组0/3,10组0/2,11组0/3,12组0/3,13组0/2转移。本次入院情况:自出院以后,积极对患者进行康复指导:包括锻炼呼吸功能、优化饮食结构、适量锻炼等。患者病情相对平稳,恢复良好。于2023年7月3日复查CT示:右肺术后改变;左肺上叶磨玻璃结节(大小约0.9 cm×0.7 cm,较前无明显变化);两肺少许条索影。自上次出院以来,患者自诉体力较出院时有所恢复,自觉状态良好,为求进一步诊治,门诊以"左肺结节"收入胸外科。拟在全身麻醉下行胸腔镜下左肺上叶前段切除术。

关键词：左肺上叶支气管残端入院情况脏层胸膜右肺下叶肿瘤性病变胸外科高龄患者

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Phragmites australis and Typha orientalis in removal of pollutant in Taihu Lake, China

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Journal of Environmental Sciences 2009年第4期21卷 440-446页

作者： tian ziqiang ZHENG Binghui LIU Meizhen ZHANG Zhenyu River and Coastal Environment Research Center Chinese Research Academy of Environmental Sciences Beijing 100012 China. State Key Laboratory of Vegetation Environmental Change Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Department of Water Environmental Planning Chinese Academy for Environmental Planning Beijing 100012 China

Two plant populations of Phragmites australis and Typha orientalis grown in gravel and sediment substrate were studied to assess their capabilities for purifying polluted water in Taihu Lake, China. The substrate displayed most significant effects on the suspended matter （P 〈 0.01）, with the reduction of 76%-87% and 52%--63% for P. australis, and 83%-86% and 45%-62% for T. orientalis in gravel substrate and sediment substrate, respectively. Both species and substrates significantly decreased the N and P concentrations of water body （P 〈 0.01）. P. australis showed higher total N and P concentrations in tissues than T. orientalis and had a greater potential to remove nutrients from the lake. Phosphate was easily to concentrate in the belowground tissues, while nitrate concentration was higher in leaf and stalk. Therefore, harvesting the aboveground tissues could take most of nitrate out of the sediment. The saturate photosynthetic rate （Asat） of P. australis was higher than that of T. orientalis when grown in sediment substrate. But instance water-use- efficiency （WUEi）（A/E） and intrinsic water use efficiency （A/gs） showed the maximum values of two species grown in river water. With significant difference in gs, however, intercellular CO2 concentration （Ci） had no obvious difference in two species which indicated that high Asat value of P. australis might result from the increased carboxylation capacity of the mesophyll, because of the central role of N in photosynthetic enzymes. Our findings suggest that the plants could absorb most of nitrogen in polluted water, while gravel displayed a high capacity for absorbing the suspended matters and phosphate salts. Therefore, biological and physiological pathways for pollutant removal should be integrated.

关键词： Phragmites australis Typha orientalis nutrient removal gas exchange Taihu Lake

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合并心脏传导阻滞的超高龄患者腮腺恶性肿瘤切除术的麻醉与围术期管理

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中华麻醉学杂志 2024年第3期44卷 358-360页

作者：程雪梅张利东贾慧群郑晖杨旭东曹罡尹春琳田子强王古岩薛张纲王天龙解放军东部战区总医院麻醉科南京210002 河北医科大学第四医院麻醉科石家庄050000 中国医学科学院肿瘤医院麻醉科北京100021 北京大学口腔医院麻醉科北京100081 解放军东部战区总医院口腔科南京210002 首都医科大学宣武医院心血管内科北京100053 河北医科大学第四医院胸外科石家庄050000 首都医科大学附属北京同仁医院麻醉科北京100730 复旦大学附属中山医院麻醉科上海200032 首都医科大学宣武医院麻醉手术科北京100053

一、病例介绍1.病史摘要(1)一般情况:患者女性,年龄91岁,身高155 cm,体质量46 kg。因"右面部无痛性渐大肿物1年余,伴溃疡半年"入院。1年前偶然发现右侧颧面部及耳屏前部有一"鹌鹑蛋"大小包块,无明显疼痛不适,后包块逐渐增大并溃疡,期间... 详细信息

一、病例介绍1.病史摘要(1)一般情况:患者女性,年龄91岁,身高155 cm,体质量46 kg。因"右面部无痛性渐大肿物1年余,伴溃疡半年"入院。1年前偶然发现右侧颧面部及耳屏前部有一"鹌鹑蛋"大小包块,无明显疼痛不适,后包块逐渐增大并溃疡,期间未做任何处理,症状无明显好转,为进一步救治收入我院。

关键词：心脏传导阻滞病史摘要围术期管理超高龄患者鹌鹑蛋切除术无痛性腮腺恶性肿瘤

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A Blockchain-Based Access Control Scheme for Reputation Value Attributes of the Internet of Things

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Computers, Materials & Continua 2024年第1期78卷 1297-1310页

作者： Hongliang tian Junyuan tian College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

The Internet of Things(IoT)access controlmechanism may encounter security issues such as single point of failure and data *** address these issues,a blockchain-based IoT reputation value attribute access control scheme is ***,writing the reputation value as an attribute into the access control policy,and then deploying the access control policy in the smart contract of the blockchain system can enable the system to provide more fine-grained access control;Secondly,storing a large amount of resources fromthe Internet of Things in Inter Planetary File System(IPFS)to improve system throughput;Finally,map resource access operations to qualification tokens to improve the performance of the access control *** simulation experiments based on the Hyperledger Fabric *** simulation experimental results,it can be seen that the access control system can achieve more fine-grained and dynamic access control while maintaining high throughput and low time delay,providing sufficient reliability and security for access control of IoT devices.

关键词： Blockchain IoT access control Hyperledger Fabric

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Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images

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Tsinghua Science and Technology 2024年第1期29卷 197-206页

作者： Weizhi Du Shihao tian Arts&Sciences College Washington University in St.LouisSt.LouisMO 63130USA Department of Electric and Computing Engineering Cornell UniversityIthacaNY 14850USA

Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis *** this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture ***,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model *** comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

关键词： super-resolution image reconstruction Transformer generative adversarial network(GAN)

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Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing ZHANG Wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

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