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基于混合方法的中药注射剂上市后临床安全性综合评价模型构建研究思路探讨

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中国循证医学杂志 2024年第4期24卷 484-489页

作者：李春晓杨玉晴凌霄程子豪宋学坤郭静李学林河南中医药大学第一附属医院郑州450000 河南省中药临床应用、评价与转化工程研究中心/河南省中药临床药学中医药重点实验室郑州450000 河南中医药大学/呼吸疾病中医药防治省部共建协同创新中心郑州450006 河南中医药大学郑州450046

中药注射剂上市后临床安全性再评价研究分别获取了主动监测、被动监测及文献研究等多种研究类型的安全性证据。但缺乏可有效整合上述研究类型数据的综合评价方法,至今无法进一步产出更全面、更客观的高级别循证医学研究证据,严重影响了... 详细信息

中药注射剂上市后临床安全性再评价研究分别获取了主动监测、被动监测及文献研究等多种研究类型的安全性证据。但缺乏可有效整合上述研究类型数据的综合评价方法,至今无法进一步产出更全面、更客观的高级别循证医学研究证据,严重影响了中药注射剂的监督管理和临床合理使用。而建立综合评价方法的关键是先建立综合评价核心指标的优选方法,形成可赋权量化评分的模型应用于综合评价方法中。混合方法研究通过对数据反复进行定量与定性研究,可实现有效、深入整合不同研究类型数据并科学、规范地完成评价模型中指标的筛选;其次,对于模型构建研究中最关键的指标赋权与权重调节,笔者创新性地将层次分析法与不变权重次约束法相结合,引入混合方法研究设计的定量研究部分,保证模型构建过程中指标的准确赋权。故本文在参考针对有效性试验核心结局指标提出的核心指标集的研究基础上,提出运用混合方法开展基于多源复杂数据的指标筛选与权重调节研究,构建融合不同研究类型数据的中药注射剂上市后临床安全性综合评价模型,为中药注射剂上市后临床安全性综合评价提供测量工具和新方法。

关键词：混合方法研究临床安全性评价指标综合评价中药注射剂核心指标集

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中国氢能产业链技术现状及发展趋势

油气与新能源 2024年第4期36卷 19-30页

作者：付强杨洸金辉程子豪湖北省电力规划设计研究院有限公司武汉430000 湖北鄂电建设监理有限责任公司武汉430000

“双碳”目标下,氢能作为一种可再生的二次能源,具有来源丰富、应用广泛、利用形式多样、燃烧热值高、清洁环保等优点,在国家能源转型中承担着重要角色。中国氢能产业尚处于发展初期,加强对氢能产业链的现状研究,把握发展趋势,将有助于... 详细信息

“双碳”目标下,氢能作为一种可再生的二次能源,具有来源丰富、应用广泛、利用形式多样、燃烧热值高、清洁环保等优点,在国家能源转型中承担着重要角色。中国氢能产业尚处于发展初期,加强对氢能产业链的现状研究,把握发展趋势,将有助于推动加快能源转型。通过梳理氢能产业链各环节的关键技术现状,对比和分析各类技术的优势、不足及发展趋势,研究发现:中国氢能制取模式,短期内以“煤制氢+CCUS”技术为主,长远以电解水制氢耦合可再生能源电力为主,微生物制氢有望成为辅助;氢能储运呈现多元化发展趋势,大规模、远距离、连续性输送会通过管道进行;氢能制取、储运成本会逐步降低;氢能利用会逐步拓宽至工业、交通、电力、建筑等领域。建议完善氢能产业总体规划布局,加强核心技术攻关,稳步推进基础设施建设,实现氢能的低成本制取、储运与利用。

关键词：氢能产业链氢能制取氢能储运氢能利用 CCUS 发展趋势

Frequency comb swept laser with a high-Q microring filter

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Photonics Research 2020年第6期8卷 904-911页

作者： DONGMEI HUANG FENG LI CHAO SHANG zihao cheng S.T.CHU P.K.A.WAI Photonics Research Centre Department of Electronic and Information EngineeingThe Hong Kong Polytechnic UniversityHong Kong SARChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China Photonics Research Centre Department of Electrical EngineeringThe Hong Kong Polytechnic UniversityHong Kong SARChina Department of Physics and Materials Science City University of Hong KongHong Kong SARChina

Frequency comb swept lasers are the enabling technology of circular interferometric *** was proposed to break the bottleneck of data acquisition and proessing in optical coherence tomography(OCT)at video *** this paper,we propose and demonstrate a highly coherent frequency comb swept laser by using a high-quality(high-Q)microring comb filter to discretize a Fourier domain mode-locked(FDML)*** microring filter has a Q factor of^2×10^6 and a linewidth of^90 *** demonstrate the improvement in performance,a Fabry-Perot comb filter with a Q factor of 6.2×10^4 and a linewidth of 3.1 GHz is also used in the experiment for *** comb filters have free spectral ranges(FSRs)of^50 GHz for *** and clearly discretized temporal waveforms and frequency comb spectra with 50 GHz FSR are *** of the high-Q microring filter narrows the instantaneous linewidth of the FDML laser down to 1.5 *** OCT system with the frequency comb swept laser source with a microring filter demonstrates an ultralong imaging range,which has a 6,10,and 15 dB sensitivity roll-off length of^53,~73,and over 100 mm,respectively.

关键词： microring filter laser

LNG船气密性检测中的氦气试验并联管路CFD仿真建模

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造船技术 2024年第4期52卷 37-42页

作者：程自豪黄凯华张逸飞张泽禹上海船舶工艺研究所上海200032

针对液化天然气(Liquefied Natural Gas,LNG)船气密性检测中的氦气试验,进行并联管路计算流体力学(Computational Fluid Dynamics,CFD)仿真建模。基于流体力学理论,建立并联管路模型,分析支管数量、支管长度、管壁厚和入口流体压强对主... 详细信息

针对液化天然气(Liquefied Natural Gas,LNG)船气密性检测中的氦气试验,进行并联管路计算流体力学(Computational Fluid Dynamics,CFD)仿真建模。基于流体力学理论,建立并联管路模型,分析支管数量、支管长度、管壁厚和入口流体压强对主管的流体速度与流体压强的影响,为多根支管并联管路工装开发提供参考。

关键词： LNG船氦气试验并联管路 CFD 流体速度流体压强

Modulating of MoSe_(2)functional plane via doping-defect engineering strategy for the development of conductive and electrocatalytic mediators in Li-S batteries

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Journal of Energy Chemistry 2022年第12期75卷 512-523,I0013页

作者： Mohammed A.Al-Tahan Yutao Dong Aml E.Shrshr Xiyang Kang Hui Guan Yumiao Han zihao cheng Weihua Chen Jianmin Zhang College of Chemistry Zhengzhou UniversityZhengzhou 450001HenanChina College of Science Henan Agricultural UniversityZhengzhou 450002HenanChina Chemistry Department Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt

The lithium polysulfide shuttle and sluggish sulfur reaction kinetics still pose significant challenges to lithium-sulfur(Li-S)*** functional plane of Fe-MoSe_(2)@r GO nanohybrid with abundant defects has been designed and applied in Li-S batteries to develop the functional separator and multi-layer sulfur *** cell with a functional separator exhibits a retention capacity of 462 m Ah g^(-1)after the 1000th at 0.5 C and 516 m Ah g^(-1)after the 600th at 0.3 *** at low electrolyte conditions(7.0μL_(mgsulfur)^(-1)and 15μL_(mgsulfur)^(-1))under high sulfur loadings(3.46 mg cm^(-2)and 3.73 mg cm^(-2)),the cell still presents high reversible discharge capacities 679 and 762 m Ah g^(-1)after 70 cycles,***,at sulfur loadings up to 8.26 and 5.2 mg cm^(-2),the cells assembled with the bi-layers sulfur cathode and the tri-layers sulfur cathode give reversible capacities of 3.3 m Ah cm^(-2)after the 100th cycle and 3.0 m Ah cm^(-2)after the 120th cycle,*** research not only demonstrates that the FeMoSe_(2)@r GO functional plane is successfully designed and applied in Li-S batteries with superior electrochemical performances but also paves the novel way for developing a unique multi-layer cathode technique to enhance and advance the electrochemical behavior of Li-S cells at a high-sulfur-loading cathode under lean electrolyte/sulfur(E/S)ratio.

关键词： Lithium-sulfur batteries Modified separator Fe-MoSe_(2)@rGO Multi-layers cathode Defect engineering

Missing Value Imputation for Radar-Derived Time-Series Tracks of Aerial Targets Based on Improved Self-Attention-Based Network

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Computers, Materials & Continua 2024年第3期78卷 3349-3376页

作者： zihao Song Yan Zhou Wei cheng Futai Liang Chenhao Zhang Department of Early Warning Intelligence Early Warning AcademyWuhan430019China

The frequent missing values in radar-derived time-series tracks of aerial targets(RTT-AT)lead to significant challenges in subsequent data-driven ***,the majority of imputation research focuses on random missing(RM)that differs significantly from common missing patterns of *** method for solving the RM may experience performance degradation or failure when applied to RTT-AT *** autoregressive deep learning methods are prone to error accumulation and long-term dependency *** this paper,a non-autoregressive imputation model that addresses the issue of missing value imputation for two common missing patterns in RTT-AT is *** model consists of two probabilistic sparse diagonal masking self-attention(PSDMSA)units and a weight fusion *** learns missing values by combining the representations outputted by the two units,aiming to minimize the difference between the missing values and their actual *** PSDMSA units effectively capture temporal dependencies and attribute correlations between time steps,improving imputation *** weight fusion unit automatically updates the weights of the output representations from the two units to obtain a more accurate final *** experimental results indicate that,despite varying missing rates in the two missing patterns,our model consistently outperforms other methods in imputation performance and exhibits a low frequency of deviations in estimates for specific missing *** to the state-of-the-art autoregressive deep learning imputation model Bidirectional Recurrent Imputation for Time Series(BRITS),our proposed model reduces mean absolute error(MAE)by 31%~50%.Additionally,the model attains a training speed that is 4 to 8 times faster when compared to both BRITS and a standard Transformer model when trained on the same ***,the findings from the ablation experiments demonstrate that the PSDMSA,the weight fusion unit,cascade network design

关键词： Missing value imputation time-series tracks probabilistic sparsity diagonal masking self-attention weight fusion

Reconfigurable time-stretched swept laser source with up to 100 MHz sweep rate,100 nm bandwidth,and 100 mm OCT imaging range

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Photonics Research 2020年第8期8卷 1360-1367页

作者： DONGMEI HUANG FENG LI CHAO SHANG zihao cheng P.K.A.WAI Photonics Research Centre Department of Electronic and Information EngineeringThe Hong Kong Polytechnic UniversityHong Kong SARChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China Photonics Research Centre Department of Electrical EngineeringThe Hong Kong Polytechnic UniversityHong Kong SARChina Key Laboratory of Luminescence and Optical Information Ministry of EducationSchool of ScienceBeijing Jiaotong UniversityBeijing 100044China

The sweep rate,sweep range,and coherence length of swept sources,respectively,determine the acquisition rate,axial resolution,and imaging range of optical coherence tomography(OCT).In this paper,we demonstrate a reconfigurable high-speed and broadband swept laser by time stretching of a flat spectrum femtosecond pulse train with over 100 nm bandwidth and a repetition rate of 100 *** incorporating an optical modulator and utilizing appropriate dispersive modules,the reconfiguration of the swept source is demonstrated with sweep rates of 25 and 2.5 *** 2.5 MHz swept source enables an imaging range of>110 mm with 6 dB sensitivity rolloff in OCT,which is the longest imaging range ever reported for megahertz OCT.

关键词： laser modulator source

Optimizing 2D-metal contact in layered Tin-selenide via native oxide modulation

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Nano Research 2024年第4期17卷 3014-3020页

作者： Yue Zheng Qi You Zhentian Yin Jian Tang Ke Jiang zihao Xie Henan Li cheng Han Yumeng Shi International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China

The discovery of two-dimensional(2D)semiconductor has opened up new avenues for the development of short-channel field-effect transistors(FETs)with desired electrical *** them,orthorhombic tin-selenide(SnSe)has garnered increasing attention due to its potential applications in a variety of electronic,optoelectronic,and thermoelectric ***,the realization of high-performance SnSe FETs with low contact resistance(Rc)remains a ***,we systematically investigate the contact of few-layer SnSe FETs through the modulation of native oxide on SnSe by using different *** is found that chromium(Cr)-contacted devices possess the best FET performance,such as electron mobility up to 606 cm^(2)/(V·s)at 78 K,current on/off ratio exceeding 1010,and saturation current of~550μA/μm,where a negligible Schottky barrier(SB)of~30 meV and a low contact resistance of~425Ωμm are achieved.X-ray photoelectron spectroscopy(XPS)and cross-sectional electron dispersive X-ray spectroscopy(EDX)results further reveal that the improved contact arises from the Cr-induced reduction of native oxide(SnOx)to Sn,which thins the tunneling barrier for efficient electron *** findings provide a deep insight into the 2D-metal contact of SnSe and pave the way for its applications in future nanoelectronics.

关键词： few-layer SnSe field-effect transistors(FETs) Cr contact native oxide contact resistance(Rc) Schottky barrier(SB)

Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He Fei Wang Nan Wang Yi-cheng Fu zihao Xing Zhiyu Jia Guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction