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SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1953-1969页

作者： Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu zhang Lili Wu Qiong Shi tianwen Gao Weinan Guo Chunying Department of Dermatology Xijing HospitalFourth Military Medical UniversityNo 127 of West Changle RoadXi’anShaanxi 710032China

Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of *** the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still *** tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor ***7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell ***,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains ***,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein *** first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon ***,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in ***,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting ***7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 ***,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 ***,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also *** together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy.

关键词： melanoma SIRT7 immunity

A study of soil dispersivity in Qian'an, western Jilin Province of China

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Research in Cold and Arid Regions 2015年第5期7卷 579-586页

作者： XuDong zhang Qing Wang tianwen Yu ShuoChao Bao Gang Wang Xin Zhou CenCen Niu College of Construction Engineering Jilin University

Saline soil is vulnerable to water erosion because of its dispersivity. This characteristic has a great influence on dam and slope engineering. There is a large area of saline soil in western Jilin Province, the seasonal frost zone, and this soil is highly dispersive. We studied the properties of soil samples collected from vertical holes near Qian＇an Dabusu Lake, as- sessing the particle size distribution and the chemical components. We also comprehensively identified the level of soil dispersivity by three standard methods, the pinhole test, the crumb test, and the double-hydrometer test. The soil compo- sition and basic physicochemical properties are proved to be the most important factors which determine the dispersion degree of the saline soil. Our results showed that, within depth ranges from 0 to 1 m, silt particles highly influenced the soil dispersivity, and the total soluble salt accounted for ≥0.3%. At the first sampling point, in a tall soil column, the dispersion degree decreased with increasing depth, but this was not as obvious at the second sampling point, which was in a flat area. Nevertheless, the superficial soils of these two sampling sites were strongly dispersive, which must be taken into consid- eration for soil engineering in this region.

关键词： particle-size analysis chemical properties dispersivity dispersion

中性粒细胞/血小板压积比值、粪便钙卫蛋白及血清学指标对克罗恩病疾病活动程度的判断价值

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中国中西医结合消化杂志 2024年第2期32卷 156-161页

作者：陈立基马燕颜张海燕刘添文张北平何志仁钟彩玲赵喜颖广州中医药大学第二临床医学院广州510405 广州中医药大学第二附属医院脾胃病科广州中医药大学第二附属医院肾病科广东省新黄埔中医药联合创新研究院

目的:探讨中性粒细胞-血小板压积比值(NPR)、粪便钙卫蛋白(FC)、D-二聚体(D-D)、中性粒细胞-淋巴细胞比值(NLR)在判断CD患者疾病活动程度的效用。方法:回顾性分析2019年4月—2023年4月在广州中医药大学第二附属医院收治的63例CD患者。... 详细信息

目的:探讨中性粒细胞-血小板压积比值(NPR)、粪便钙卫蛋白(FC)、D-二聚体(D-D)、中性粒细胞-淋巴细胞比值(NLR)在判断CD患者疾病活动程度的效用。方法:回顾性分析2019年4月—2023年4月在广州中医药大学第二附属医院收治的63例CD患者。根据蒙特利尔分型、克罗恩病活动指数(CDAI)进行分组,比较各组间FC、D-D、NLR、NPR水平的差异,绘制试者操作特征(ROC)曲线,计算ROC曲线下面积(AUC),评价各指标判断CD活动期、中重度活动期的价值。结果:缓解期、轻度活动期、中重度活动期CD患者的FC、D-D、NLR、NPR水平比较差异有统计学意义(P0.05)。FC、D-D、NLR、NPR水平与CD疾病活动程度呈正相关(均P0.7(均P<0.05)。其中,NPR的效用最佳,AUC为0.795(95%CI:0.682~0.908),灵敏度为70.0%,特异度为84.8%。结论:FC能有效判断CD疾病活动程度。NPR在判断中重度活动期CD患者的效用优于FC,在CD的疾病评估与监测中具有一定潜力。

关键词：克罗恩病粪便钙卫蛋白中性粒细胞/血小板压积比值活动度严重度

A Four-color Matching Method Combining Neural Networks with Genetic Algorithm

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High Technology Letters 2003年第4期9卷 39-43页

作者：苏小红 Wang Yadong zhang tianwen School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 P.R.China

A brief review of color matching technology and its application of printing RGB images by CMY or CMYK ink jet printers is presented, followed by an explanation to the conventional approaches that are commonly used in color matching. Then, a four color matching method combining neural network with genetic algorithm is proposed. The initial weights and thresholds of the BP neural network for RGB to CMY color conversion are optimized by the new genetic algorithm based on evolutionarily stable strategy. The fourth component K is generated by using GCR (Gray Component Replacement) concept. Simulation experiments show that it is well behaved in both accuracy and generalization performance.

关键词： color matching color reproduction back propagation (BP) neural networks genetic algorithm

护理学专业本科生外科实习岗位胜任能力里程碑评价体系的构建与思考

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中华医学教育杂志 2024年第6期44卷 421-425页

作者：黄天雯邓丽君刘圆圆张伟玲黄晓敏李娜中山大学附属第一医院骨科-显微外科医学部广东省骨科学重点实验室广州510080

目的构建护理学专业本科生外科实习岗位胜任能力里程碑评价体系。方法2022年5至10月,通过文献回顾拟定评价体系初稿,再采用德尔菲法进行2轮函询,通过专家积极系数、专家权威系数、专家意见协调程度和集中程度进行评价,其中专家积极系数... 详细信息

目的构建护理学专业本科生外科实习岗位胜任能力里程碑评价体系。方法2022年5至10月,通过文献回顾拟定评价体系初稿,再采用德尔菲法进行2轮函询,通过专家积极系数、专家权威系数、专家意见协调程度和集中程度进行评价,其中专家积极系数用问卷回收率表示,专家权威系数(Cr)使用专家熟悉程度和判断依据的均值表示,专家意见协调程度和集中程度分别用肯德尔和谐系数(Kendall's W)和变异系数(CV)表示,最终确定评价体系。结果遴选来自北京、上海、四川、湖北、广东的三级甲等综合性教学医院的18名专家进行函询。2轮专家函询的专家权威系数均为0.90,专家积极系数均为1.0,肯德尔和谐系数分别为0.194和0.474。最终构建的护理学专业本科生外科实习岗位胜任能力里程碑评价体系包括6项一级指标、28项二级指标。结论本研究构建的护理学专业本科生外科实习岗位胜任能力里程碑评价体系具有权威性,评价体系具有良好的信度和效度,科学可靠,可操作性强,可以为全面客观评价护理学专业本科生外科实习的综合能力提供参考。

关键词：护理学德尔菲法外科护理本科生实习岗位胜任力评价体系

Latest Scientific Results of China's Lunar and Deep Space Exploration(2022–2024)

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空间科学学报 2024年第4期44卷 622-632页

作者： XU Lin LI Lei LIU Jianzhong LIN Honglei LI Yang LIU Yang XIE Lianghai zhang Jinhai QIAO Fuhao HAN Juanjuan ZOU Yongliao General Office of the Lunar and Deep Space Exploration Chinese Academy of SciencesBeijng 100190 State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029

China has successfully launched six lunar probes so *** Chang'E-1 to Chang'E-4,they completed the circling,landing and roving exploration,of which Chang'E-4 was the first landing on the far side of the Moon in human ***'E-5 was launched in December 2020,bringing back 1731 g of lunar soil *** the detailed analysis of the samples,the scientists understand the history of late lunar volcanism,specifically extending lunar volcanism by about 800 million to 1 billion years,and proposed possible *** addition,there are many new understandings of space weathering such as meteorite impacts and solar wind radiation on the ***'s first Mars exploration mission tianwen-1 was successfully launched in July *** the study of scientific data,a number of important scientific achievements have been made in the topography,water environment and shallow surface structure of *** paper introduces the main scientific achievements of Chang'E-4,Chang'E-5 and tianwen-1 in the past two years,excluding technical and engineering *** to the large number of articles involved,this paper only introduces part of the results.

关键词： Lunar and deep space exploration of China Chang’E-4 mission Chang’E-5 mission tianwen-1 mission

A high-energy-density and long-cycling-lifespan Mars battery

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Science Bulletin 2024年第16期69卷 2491-2495页

作者： Xu Xiao Zhuojun zhang Aijing Yan Peng Tan Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei 230026China

In 2004,Mars Science Laboratory(MSL)of National Aeronautics and Space Administration(NASA)landed two rovers,Courage and Opportunity,to unveil the mysteries of *** 2021,China became the second country to successfully land Zhurong rover on the surface of Mars by tianwen 1 probe,achieving the goal of 90 Martian *** Mars-2022 was planned by the European Space Agency and the Russian Federal Space *** exploration has become a battleground for economic and technological competition among major powers.

关键词： battery cycling Russian

中药单体调控线粒体功能改善非酒精性脂肪性肝病研究进展

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中医学报 2024年第10期39卷 2052-2059页

作者：关海梅莫世聪张日云廖莹莹曾阳玲王恬雯毛德文广西中医药大学研究生院广西南宁530001 广西中医药大学第一附属医院广西南宁530023

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种以肝脂肪变性为主要特征的慢性肝病,其发病机制与线粒体功能障碍密切相关。线粒体功能障碍可引起许多病理变化,如脂质代谢紊乱、氧化应激、自噬异常等,可加重脂肪肝... 详细信息

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种以肝脂肪变性为主要特征的慢性肝病,其发病机制与线粒体功能障碍密切相关。线粒体功能障碍可引起许多病理变化,如脂质代谢紊乱、氧化应激、自噬异常等,可加重脂肪肝进展,引起肝细胞炎症和死亡,甚至导致肝细胞癌的发生。中药单体(白藜芦醇、丁香酚、天麻素、姜黄素、葛根素、黄芩苷、槲皮素、川芎嗪、丹酚酸B、枸杞多糖、人参皂苷等)可通过调控线粒体脂质代谢紊乱、氧化应激及自噬异常等起到防治NAFLD、延缓NAFLD进展的作用。

关键词：中药单体非酒精性脂肪性肝病线粒体脂质代谢紊乱氧化应激自噬异常

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祝融号火星车次表层探测雷达有效探测深度

科学通报 2024年第18期69卷 2674-2681页

作者：张领方向恺韩硕中山大学地球科学与工程学院珠海519080

2021年5月,中国首次火星探测任务“天问一号”携带祝融号火星车,成功着陆在乌托邦平原南部.祝融号火星车上搭载的次表层探测雷达(RoPeR)对于研究火星近表层精细结构和物理性质,以及了解是否赋存水冰提供了重要依据.深入研究祝融号火星... 详细信息

2021年5月,中国首次火星探测任务“天问一号”携带祝融号火星车,成功着陆在乌托邦平原南部.祝融号火星车上搭载的次表层探测雷达(RoPeR)对于研究火星近表层精细结构和物理性质,以及了解是否赋存水冰提供了重要依据.深入研究祝融号火星车次表层探测雷达的有效探测深度,将不仅帮助分析次表层探测雷达数据的有效性,而且还能表征近表层物质对电磁波的散射和吸收特征.本文首先基于祝融号火星车次表层探测雷达的探测参数,建立了有效探测深度与介电常数和损耗率的关系模型;其次,根据实测次表层探测雷达数据的相似性,确定有效信号深度;最后,通过祝融号火星车雷达的两个通道实际数据的能量衰减特性,计算出不同深度的损耗角正切值,与探测深度模型和有效信号深度进行匹配.祝融号火星车次表层探测雷达的有效探测深度研究,将帮助分析火星近表层物质成分,为我国深空探测助力.

关键词：祝融号火星车次表层探测雷达有效探测深度损耗角正切值