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Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN Guo-yao zhang Qiang zhang qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Wheat FHB resistance assessment using hyperspectral feature band image fusion and deep learning

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 240-249页

作者： Kun Liang Zhizhou Ren Jinpeng Song Rui Yuan qun zhang College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China Jiangsu Province Engineering Lab for Modern Facility Agriculture Technology&Equipment Nanjing 210031China

The breeding and selection of resistant varieties is an effective way to minimize wheat Fusarium head blight(FHB)hazards,so it is important to identify and evaluate resistant *** traditional resistance phenotype identification is still largely dependent on time-consuming manual *** this paper,the method for evaluating FHB resistance in wheat ears was optimized based on the fusion feature wavelength images of the hyperspectral imaging system and the Faster R-CNN *** spectral data from 400-1000 nm were preprocessed by the multiple scattering correction(MSC)*** feature wavelengths(553 nm,682 nm and 714 nm)were selected by analyzing the X-loading weights(XLW)according to the absolute value of the peaks and troughs in different principal component(PC)load coefficient ***,the different fusion methods of the three feature wavelengths were explored with different weight *** R-CNN was trained on the fusion and RGB datasets with VGG16,AlexNet,ZFNet,and ResNet-50 networks ***,the other detection models SSD,YOLOv5,YOLOv7,CenterNet,and RetinaNet were used to compare with the Faster R-CNN *** a result,the Faster R-CNN with VGG16 was best with the mAP(mean Average Precision)ranged from 97.7%to 98.8%.The model showed the best performance for the Fusion Image-1 ***,the Faster R-CNN model with VGG16 achieved an average detection accuracy of 99.00%,which was 23.89%,1.21%,0.75%,0.62%,and 8.46%higher than SSD,YOLOv5,YOLOv7,CenterNet,and RetinaNet ***,it was demonstrated that the Faster R-CNN model based on the hyperspectral feature image fusion dataset proposed in this paper was feasible for rapid evaluation of wheat FHB *** study provided an important detection method for ensuring wheat food security.

关键词： Fusarium head blight resistance evaluation hyperspectral feature band image fusion deep learning Faster R-CNN

Recent Advances of Bioactive Marine Natural Products in Drug Discovery

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Journal of Ocean University of China 2024年第5期23卷 1297-1318页

作者： zhang qun LV Liuxia WANG Wenhui WEI Meiyan GU Yucheng SHAO Changlun Key Laboratory of Marine Drugs Ministry of Education of China School of Medicine and Pharmacy Ocean University of China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical Engineering Hainan Normal University Syngenta Jealott's Hill International Research Centre

Marine natural products(MNPs) are valuable resources for drug development. To date, 17 drugs from marine sources are in clinical use, and 33 pharmaceutical compounds are in clinical trials. Presently the success of drug development from the marine resources is higher than the industry average. It is a feasible strategy to conduct the discovery of drug-lead compounds based on marine chemical ecology by fully exploiting the pharmacological potential of marine chemical defense matters. In the search for bioactive MNPs, our group has constructed a biological resources library including more than 1500 strains of fungi. Focusing on the strategy of Blue Drug Library, we have discovered a series of novel MNPs with abundant biological functions. Highly efficient and scalable total synthesis of(+)-aniduquinolone A(44) and pesimquinolone I(48) have been completed, which will facilitate access to sufficient quantities of candidates for in vivo pharmacological and toxicological studies. As a nucleoprotein(NP) inhibitor, QLA(75) possesses significant anti-influenza A virus(IAV) activities both in vitro and in vivo. CHNQD-00803(76) is a potent and selective AMPactivated kinase(AMPK) activator that can effectively inhibit metabolic disorders and metabolic dysfunction-associated steatohepatitis(MASH) progression. Moreover, we identified two new candidate molecules with potent anti-hepatocellular carcinoma effects. Particularly, as a natural guanine-nucleotide exchange factors for ADP-ribosylation factor GTPases(Arf-GEFs) inhibitor prodrug, CHNQD-01255(78) is qualified to be developed as a targeted candidate anticancer drug, which may be promising to apply for cancer immunotherapy. Hence, it is evident that MNPs play an important role in drug development.

关键词： discovery and optimization drug development marine drug marine medicinal organisms natural products

Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK

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International Journal of Oral Science 2024年第3期16卷 471-485页

作者： Dexuan Zhuang Shuangshuang Wang Huiting Deng Yuxin Shi Chang Liu Xue Leng qun zhang Fuxiang Bai Bin Zheng Jing Guo Xunwei Wu School and Hospital of Stomatology Cheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral DiseasesJinanChina Engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology HospitalSavaid Stomatology SchoolHangzhou Medical CollegeNingboChina Cedars-Sinai Cancer Institute Department of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCAUSA

The efficient clinical treatment of oral squamous cell carcinoma(OSCC)is still a challenge that demands the development of effective new *** has been shown to produce more potent anti-tumor activities than metformin on different tumors,however,not much is known about the influence of phenformin on OSCC *** found that phenformin suppresses OSCC cell proliferation,and promotes OSCC cell autophagy and apoptosis to significantly inhibit OSCC cell growth both in vivo and in ***-seq analysis revealed that autophagy pathways were the main targets of phenformin and identified two new targets DDIT4(DNA damage inducible transcript 4)and NIBAN1(niban apoptosis regulator 1).We found that phenformin significantly induces the expression of both DDIT4 and NIBAN1 to promote OSCC ***,the enhanced expression of DDIT4 and NIBAN1 elicited by phenformin was not blocked by the knockdown of AMPK but was suppressed by the knockdown of transcription factor ATF4(activation transcription factor 4),which was induced by phenformin treatment in OSCC ***,these results revealed that phenformin triggers endoplasmic reticulum(ER)stress to activate PERK(protein kinase R-like ER kinase),which phosphorylates the transitional initial factor eIF2,and the increased phosphorylation of eIF2 leads to the increased translation of *** summary,we discovered that phenformin induces its new targets DDIT4 and especially NIBAN1 to promote autophagic and apoptotic cell death to suppress OSCC cell *** study supports the potential clinical utility of phenformin for OSCC treatment in the future.

关键词： drugs treatment AMPK DDI

Simultaneously Improved Curing,Mechanical,Antioxidative Properties and Reduced ZnO Loading of Silica Filled NR Composites by Incorporation of Low-cost Crude Carbon Dots via Conventional Melt-milling Method

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Chinese Journal of Polymer Science 2024年第6期42卷 815-825页

作者： Chao-Ying Sun Hai-Jun Ji Li-Wei Li Hui Yang Xiao-Peng An Yi-Ping Chen Ming-Jian Han Can Jiang Li-qun zhang Peng Yu Run-Guo Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan430205China

Rubbers or elastomers play an important role in hi-tech technology and civilian daily life because of their unique and strategical ***,the rubber additives are essential components for rubbers’practical ***,developing novel multifunctional additives has attracted increasing research *** this work,low-cost crude carbon dots(CCDs)were used as multifunctional additives for natural rubber/silica system(without any additional modification)through industrial compatible melt-mixing *** results revealed that the CCDs could disperse well in the NR/silica system,and they could not only endow the rubber compound with excellent anti-aging capability due to CCDs’radical scavenging activity because of their plenty of nitrogen-containing species,but also improve the curing rate and mechanical performance of the rubber ***,the CCDs could reduce the rolling resistance of the rubber composites(tanδvalue at 7%strain of the rubber composite could be decreased by 34%),which is promising for the application of energy-saving tire ***,the addition of CCDs could effectively reduce the ZnO dosage by at least 40%in the rubber composite without deteriorating its ***,this work provides valuable guidance to develop novel cheap yet effective additives for the elastomer.

关键词： Natural rubber Crude carbon dots Antioxidant ZnO reduction Vulcanization

马克思“劳动生产了美”的感性逻辑及其审美叙事--基于《1844年经济学哲学手稿》的哲学考察

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东北师大学报（哲学社会科学版） 2024年第4期 91-97页

作者：张群东北师范大学美术学院吉林长春130117

劳动生产了美,是马克思《1844年经济学哲学手稿》对美与自然、美与社会、美与人的类本质等思想的阐释。“劳动生产了美”的感性逻辑以对自然之美的生物学意义上的感性体验、对对象化现实生存生活的折射反馈、对资本异化劳动的审美的观... 详细信息

劳动生产了美,是马克思《1844年经济学哲学手稿》对美与自然、美与社会、美与人的类本质等思想的阐释。“劳动生产了美”的感性逻辑以对自然之美的生物学意义上的感性体验、对对象化现实生存生活的折射反馈、对资本异化劳动的审美的观念超越、对个体自由解放的外化确认呈现了“美”的本质。劳动生产了美,本质上是对人的“本质力量对象化”的表达,其在将个体审美感性转变为社会的普遍化审美感性过程中,实现了从谋生、求利到审美的飞跃。今天,在美日益抽象化、商品化的时代,回复到马克思的劳动语境之中,考察“劳动生产了美”的感性逻辑所呈现的审美叙事,就是真正以人的存在来面对美、在美之中来直面美的方式,唯有如此,才能在资本审美异化的扩大中,真正“按照美的规律构造”,使审美复归于人的感性丰盈、审美能力朝向人的自由之美。

关键词：劳动生产了美本质力量感性逻辑审美叙事

Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2074-2078页

作者： Wan-Ling Xu Wen-Jing Tang Wei-Ying Yang Li-Chao Sun Ze-qun zhang Wei Li Xiu-Xian Zang Department of Emergency Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Chinese Traditional Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying *** SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed *** patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital *** poisoning can cause lifethreatening MODS and is rare *** case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt *** This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

关键词： Cantharidin Poisoning Multiorgan dysfunction syndrome Clinical treatment and management Case report

企业破产程序中“促就业”目标实现的共治路径

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河北学刊 2024年第4期44卷 205-214页

作者：章群柳翠西南财经大学公共管理学院西南财经大学法学院

企业破产程序是影响“高质量充分就业”的重要因素,故有必要推进企业破产程序功能向治理维度和促进可持续发展转型,在企业破产程序中树立“促就业”目标。该目标在内涵上具有“量”与“质”的双重性要求,其正当性在于对“高质量充分就... 详细信息

企业破产程序是影响“高质量充分就业”的重要因素,故有必要推进企业破产程序功能向治理维度和促进可持续发展转型,在企业破产程序中树立“促就业”目标。该目标在内涵上具有“量”与“质”的双重性要求,其正当性在于对“高质量充分就业”公共政策的积极落实,对企业破产情境下职工就业权的充分保护,且具有坚实的法律支撑,其实现过程具有共治性。中国已基本形成以宪法为根基、以非破产法为一般遵循、以企业破产法为特别规定的企业破产程序中“促就业”目标法律体系,但企业破产程序中“促就业”实践仍存在认识性、协同性、制度性关键缺失。适逢企业破产法修订,应在“促就业”目标建设中坚持中国共产党的领导、人民当家作主、依法治国有机统一,在破产法中明确“促就业”目标以凝聚主体间目标共识,细化职工就业权内容以强化职工就业自主决策地位,明确“促就业”目标执行事务分工,以法院监督为主导形成协同监督机制,数字赋能主体间“促就业”目标信息沟通,实现“促就业”目标共建共治共享共赢。

关键词：高质量充分就业企业破产程序职工共治

惯性增强动力吸振器-浮置板轨道低频减振性能研究

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铁道学报 2024年第8期46卷 102-111页

作者：张群程志宝石志飞北京交通大学土木建筑工程学院智能材料与结构研究所北京100044 北京交通大学结构风工程与城市风环境北京市重点实验室北京100044 中国建筑科学研究院有限公司北京构力科技有限公司北京100013

浮置板轨道(floating slab track, FST)对低频车轨耦合振动具有放大作用,由此引起的低频环境振动难以解决。引入惯性增强动力吸振系统(inerter enhanced dynamic vibration absorber, IDVA),提出带有IDVA的FST,即FST-IDVA,以减小列车移... 详细信息

浮置板轨道(floating slab track, FST)对低频车轨耦合振动具有放大作用,由此引起的低频环境振动难以解决。引入惯性增强动力吸振系统(inerter enhanced dynamic vibration absorber, IDVA),提出带有IDVA的FST,即FST-IDVA,以减小列车移动荷载下的低频振动影响。理论分析给出浮置板轨道结构等效单自由度系统;考虑轮轨激励随机性,应用H_(2)优化理论给出IDVA的设计参数理论解;开发一种Matlab-Ansys联合仿真技术,应用该技术计算8编组列车运行过程中的车轨耦合动力响应。对比无动力吸振器和普通动力吸振器,验证惯性增强动力吸振器对浮置板轨道低频振动的抑制性能。研究结果表明,移动车辆荷载作用下,应用惯性增强动力吸振器后,FST板在其基频处加速度响应、钢弹簧支反力、单块板传往基础的合力均得到有效减小。惯容器的动态质量效果使吸振器与FST之间的相对位移减小大于50%。该技术可在浮置板轨道有限空间内实现更好的低频减振性能。

关键词：浮置板轨道动力吸振器惯容器车轨耦合低频减振