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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujia. Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Optimizing scheme for probabilistic remote preparation of a two-qubit state

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The Journal of China Universities of Posts and Telecommunications 2013年第6期20卷 109-116页

作者： XIA jia.fan zha Xin-wei School of Science Xi'an University of Posts and Telecommunications

Remote state preparation is increasingly becoming attractive in recent years, people have already started theoretical and experimental research, and have made valuable research results. Recently, a scheme for probabilistic remote preparation of a general two-qubit state was proposed （Wang Z Y in Quantum Inf Process. 11：1585, 2012））. In this paper, we present a modified scheme for probabilistic remote preparation of a general two-qubit state. To complete the scheme, the new and feasible complete orthogonal basis vectors have been introduced. Compared with the previous schemes, the advantage of our schemes is that the total success probability of remote state preparation will be greatly improved. The probability of success regarding this scheme is calculated in both general and particular cases. The results show that the success probability of remote state preparation can be improved a little. However, in certain special cases, the success probability of preparation can be greatly improved. In special cases, the success probability of preparation can be improved to 1. The security analysis of the scheme is provided in details.

关键词： remote state preparation w-type state orthogonal basis vector success probability of preparation

Study on the epoxidation of olefins with H_(2)O_(2)catalyzed by biquaternary ammonium phosphotungstic acid

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Chinese Journal of Chemical Engineering 2023年第6期58卷 146-154页

作者： Zijie zha.g Qianyu zha Ying Liu Zhibing zha.g jia.Liu Zheng Zhou School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China

Selective epoxidation of olefins is an important field in chemical *** this work,we developed a new phosphotungstic acid catalyst{[(C_8H_(17))(CH_(3))_(2)N]_(2)(CH_(2))_(3)}_(1.5){PO_(4)[WO(O_(2))_(2)]_(4)}with long carbon chain and biquaternary ammonium *** could be epoxidized to cyclohexene oxide in 96.3%conversion and 98.2%*** catalyst type,solvent type,catalyst loading,initial molar ratio,temperature,cycle performance and substrate extensibility were studied and optimized,the kinetic parameters about overall reaction and unit reaction were also *** light scattering analysis was carried out to explain the different catalytic performance between catalysts with different carbon chain *** novel catalyst and the corresponding dynamics and mechanism study could probably help the industrial application on the epoxidation of cyclohexene with H_(2)O_(2).

关键词： Epoxidation of olefins Phosphotungstic acid Cyclohexene Kinetic study

Advances in biotechnological production of santalenes and santalols

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Chinese Herbal Medicines 2021年第1期13卷 90-97页

作者： Wen-long zha jia.chen Zi Biotechnological Institute of Chinese Materia Medica Jinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

Sandalwood essential oil has been widely used not only as natural medicines but also in perfumery and food industries, with sesquiterpenoids as its major components including(Z)-a-santalol and(Z)-bsantalol and so on. The mature heartwoods of Santalum album, Santalum austrocaledonicum and Santalum spicatum are the major plant resources for extracting sandalwood essential oil, which have been overexploited. Synthetic biology approaches have been successfully applied to produce natural products on large scale. In this review, we summarize biosynthetic enzymes of santalenes and santalols, including various santalene synthases(STSs) and cytochrome P450 monooxygenases(CYPs), and then highlight the advances of biotechnological production of santalenes and santalols in heterologous hosts, especially metabolic engineering strategies for constructing santalene-and santalol-producing Saccharomyces cerevisiae.

关键词： biosynthesis biotechnological production sandalwood oil santalenes santalols

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Analysis of temporal and spatial distribution characteristics of ammonium chloride smoke particles in confined spaces

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Defence Technology（防务技术） 2022年第7期18卷 1269-1280页

作者： Chen-youshi Xu Bing-ting zha jia.qian Bao He zha.g Hong-xia Li ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyJiangsuNanjing210094China

In response to the demand for short-range detection of anti-smoke environment interference by laser fuzes,this study proposes a smoke environment simulation of non-uniform continuous point source diffusion and investigates an experimental laboratory smoke environment using an ammonium chloride smoke *** particle size distribution,composition,and mass flow distribution of the smoke were *** on a discrete phase model and a kεturbulence model,a numerical simulation was developed to model the smoke generation and diffusion processes of the smoke agent in a confined *** temporal and spatial distribution characteristics of the smoke mass concentration,velocity,and temperature in the space after smoke generation were analyzed,and the motion law governing the smoke diffusion throughout the entire space was *** with the experimental verification of the smoke environment laboratory,the results showed that the smoke plume changed from fan-shaped to umbrella-shaped during smoke generation,and then continued to spread ***,the mass concentration of smoke in the space decreased from the middle outward;the changes in temperature and velocity were small and *** the diffusion stage(after 900 s),the mass concentration of smoke above 0.8 m was relatively uniform across an area of smoke that was 12 m *** concentration decreased over time,following a consistent decreasing trend,and the attenuation was negligible in a very short ***,this system was suitable for conducting experimental research on laser fuzes in a smoke *** to the stability of the equipment and facilities,the setup could reproduce the same experimental smoke environment by artificially controlling the smoke emission of the smoke ***,this work provides a theoretical reference for subsequent research efforts regarding the construction of uniform smoke environments and evaluating laser transmission characteristics in smoky envir

关键词： Laser fuze Smoke environment Temporal distribution Spatial distribution Confined space Smoke agent

Preparation and Identification of HLA-A*1101 Tetramer Loading with Human Cytomegalovirus pp65 Antigen Peptide

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Cellular & Molecular Immunology 2007年第2期4卷 141-146页

作者： Fengyao Li Lihui Xu Qingbing zha Xiaoyun Chi Qiantao jia.Kianhui He Institute of Tissue Transplantation and Immunology College of Life Science and Technology Jinan University Guangzhou 510632 China Institute of Bioengineering College of Life Science and Technology Jinan University Guangzhou 510632 China Clinical Experimental Center of the First Affiliated Hospital Jinan University Guangzhou 510632 China

MHC/peptide tetramer technology has been widely used to study antigen-specific T cells, especially for identifying virus-specific CD8^＋ T cells in humans. The tetramer molecule is composed of HLA heavy chain, β2-microglobulin （β2m）, an antigenic peptide, and fluorescent-labeled streptavidin. To further investigate the HLA-A＊1101-restricted CD8^＋ T cell responses against human cytomegalovirus （HCMV）, we established an approach to prepare HLA-A＊1101 tetramer complexed with a peptide from HCMV. The cDNA encoding HLA-A＊1101 heavy chain was cloned and the prokaryotic expression vector for the ectodomain of HLA-A＊1101 fused with a BirA substrate peptide （HLA-A＊1101-BSP） at its carboxyl terminus was constructed. The fusion protein was highly expressed as inclusion bodies under optimized conditions in Escherichla coli. Moreover, HLA-A＊1101-BSP protein was refolded in the presence of β2m and an HCMV peptide pp6516.24 （gPISgHVLK, gPI）. Soluble HLA-A＊1101-gPI monomer was biotinylated and purified to a purity of 95%, which was subsequently combined with streptavidin to form tetramers at a yield of 〉 80%. The HLA-A＊1101-gPI tetramers could bind to virus-specific CD8^＋ T cells, suggesting soluble HLA-A＊1101-gPI tetramers were biologically functional. This study provides the basis for further evaluation of HLA-A＊1101-restricted CD8^＋ T cell responses against HCMV infection.

关键词： HLA-A* 1101 tetramer cytomegalovirus CD8^+T cell epitope

Modeling plants with sensor data

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Science in China(Series F) 2009年第3期52卷 500-511页

作者： MA Wei XIANg Bo zha HongBin LIU jia.zha.g XiaoPeng Key Laboratory of Machine Perception (Ministry of Education) Peking University Beijing 100871 China LIAMA-NLPR Institute of Automation Chinese Academy of Sciences Beijing 100080 China

Sensor data, typically images and laser data, are essential to modeling real plants. However, due to the complex geometry of the plants, the measurement data are generally limited, thereby bringing great difficulties in classifying and constructing plant organs, comprising leaves and branches. The paper presents an approach to modeling plants with the sensor data by detecting reliable sharp features, i.e. the leaf apexes of the plants with leaves and the branch tips of the plants without leaves, on volumes recovered from the raw data. The extracted features provide good estimations of correct positions of the organs. Thereafter, the leaves are reconstructed separately by simply fitting and optimizing a generic leaf model. One advantage of the method is that it involves limited manual intervention. For plants without leaves, we develop an efficient strategy for decomposition-based skeletonization by using the tip features to reconstruct the 3D models from noisy laser data. Experiments show that the sharp feature detection algorithm is effective, and the proposed plant modeling approach is competent in constructing realistic models with sensor data.

关键词： plant modeling image-based modeling laser-based modeling sharp feature detection decomposition skeletonization

A review:biosynthesis of plant-derived labdane-related diterpenoids

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Chinese Journal of Natural Medicines 2021年第9期19卷 666-674页

作者： gAO Ke zha Wen-Long ZHU jia.-Xun ZHENg Cheng ZI jia.Chen College of Pharmacy Jinan UniversityGuangzhou 510632China Zhejia.g Institute for Food and Drug Control NMPA Key Laboratory for Quality Evaluation of Traditional Chinese MedicineHangzhou 310052China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Plant-derived labdane-related diterpenoids(LRDs)represent a large group of *** possess either a labdane-type bicyclic core structure or more complex ring systems derived from labdane-type skeletons,such as abietane,pimarane,kaurane,*** to their various pharmaceutical activities and unique properties,many of LRDs have been widely used in pharmaceutical,food and perfume *** of various LRDs has been extensively studied,leading to characterization of a large number of new biosynthetic *** biosynthetic pathways of important LRDs and the relevant enzymes(especially diterpene synthases and cytochrome P450 enzymes)were summarized in this review.

关键词： Biosynthesis Cytochrome P450 enzyme Diterpene synthase Labdane-related diterpenoids