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QCD Approach to B→Dπ Decays and CP Violation

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Communications in Theoretical Physics 2008年第3期49卷 707-716页

作者： su fang WU Yue-Liang YANG Ya-Dong zhuang Ci Kavli Institute for Theoretical Physics China. Institute of Theoretical Physics the Chinese Academy of Sciences （KITPC/ITP-CAS） Beijing 100080 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Institute of Particle Physics Huazhong Normal University Wuhan 430079 China

分叉的比率和 B → 的 CP 违背Dπ 腐烂，包括两个允许颜色并且压制颜色的模式，被考虑导致二夸克的三有效水流的所有图在 QCD 框架以内详细调查。一个动态 gluon 团被介绍对待软在同一直线上的近似在端点区域引起的红外线的分叉的内在... 详细信息

分叉的比率和 B → 的 CP 违背Dπ 腐烂，包括两个允许颜色并且压制颜色的模式，被考虑导致二夸克的三有效水流的所有图在 QCD 框架以内详细调查。一个动态 gluon 团被介绍对待软在同一直线上的近似在端点区域引起的红外线的分叉的内在的集体规模，和 Cutkosky 规则被采用处理物理区域的奇特上集体壳的夸克增殖者。什么时候动态 gluon 团 μsuB > g suB> 被认为是通用规模，在 μsuB 附近被提取 > g suB>= 从测量得好的 B → 之一的 440 兆电子伏Dπ 腐烂模式。为所有分叉的比率的产生预言与当前的试验性的大小一致。当这些腐烂没有企鹅贡献，没有直接 CP 不对称现象。由于干扰在之间压制 Cabibbo 并且 favourCabibbo 的振幅，导致混合的 CP 违背在 B → 被预言D suP> ± suP>πsuP>suP> 腐烂与在 1-σ 水平的试验性的数据一致。更精确的大小将对提取弱角度有用 2 β+γ 。

关键词：量子动力学衰变核物理胶子

FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3639-3649页

作者： Shaoxing Guan Xi Chen Youhao Chen Guohui Wan Qibiao su Heng Liang Yunpeng Yang Wenfeng fang Yan Huang Hongyun Zhao Wei zhuang Shu Liu Fei Wang Wei Feng Xiaoxu Zhang Min Huang Xueding Wang Li Zhang Laboratory of Drug Metabolism and Pharmacokinetics School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China College of Health Science Guangdong Pharmaceutical UniversityGuangzhou 510006China sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510080China Ersha Department of Pharmacy the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510105China

Hepatotoxicity is a common side effect for patients treated with gefitinib,but the related pathogenesis is unclear and lacks effective predictor and management strategies.A multi-omics approach integrating pharmacometabolomics,pharmacokinetics and pharmacogenomics was employed in non-small cell lung cancer patients to identify the effective predictor for gefitinib-induced hepatotoxicity and explore optional therapy substitution.Here,we found that patients with rs4946935 AA,located in Forkhead Box O3(FOXO3)which is a well-known autophagic regulator,had a higher risk of hepatotoxicity than those with the GA or GG variant(OR=18.020,95%CI=2.473 to 459.1784,P=0.018)in a gefitinib-concentration dependent pattern.Furthermore,functional experiments identified that rs4946935_A impaired the expression of FOXO3 by inhibiting the promotor activity,increasing the threshold of autophagy initiation and inhibiting the autophagic activity which contributed to gefitinib-induced liver injury.In contrast,erlotinib-induced liver injury was independent on the variant and expression levels of FOXO3.This study reveals that FOXO3 mutation,leading to autophagic imbalance,plays important role in gefitinib-induced hepatotoxicity,especially for patients with high concentration of gefitinib.In conclusion,FOXO3 mutation is an effective predictor and erlotinib might be an appropriately and well-tolerated treatment option for patients carrying rs4946935 AA.

关键词： Gefitinib Hepatotoxicity Pharmacometabolomic Pharmacokinetics Pharmacogenomics FOXO3 Autophagy

Layered oxide cathodes for sodium-ion batteries:microstructure design,local chemistry and structural unit

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Science China Chemistry 2024年第1期67卷 191-213页

作者： Ling-Yi Kong Han-Xiao Liu Yan-fang Zhu Jia-Yang Li Yu su Hong-Wei Li Hai-Yan Hu Yi-Feng Liu Ming-Jing Yang zhuang-Chun Jian Xin-Bei Jia Shu-Lei Chou Yao Xiao Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Because of the low price and abundant reserves of sodium compared with lithium,the research of sodium-ion batteries(SIBs)in the field of large-scale energy storage has returned to the research spotlight.Layered oxides distinguish themselves from the mains cathode materials of SIBs owing to their advantages such as high specific capacity,simple synthesis route,and environmental benignity.However,the commercial development of the layered oxides is limited by sluggish kinetics,complex phase transition and poor air stability.Based on the research ideas from macro-to micro-scale,this review systematically summarizes the current optimization strategies of sodium-ion layered oxide cathodes(SLOC)from different dimensions:microstructure design,local chemistry regulation and structural unit construction.In the dimension of microstructure design,the various structures such as the microspheres,nanoplates,nanowires and exposed active facets are prepared to improve the slow kinetics and electrochemical performance.Besides,from the view of local chemistry regulation by chemical element substitution,the intrinsic electron/ion properties of SLOC have been enhanced to strengthen the structural stability.Furthermore,the optimization idea of endeavors to regulate the physical and chemical properties of cathode materials essentially is put forward from the dimension of structural unit construction.The opinions and strategies proposed in this review will provide some inspirations for the design of new SLOC in the future.

关键词： sodium-ion batteries layered oxide cathodes microstructure design local chemistry structural unit

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中老年人社会参与情况及对死亡风险的影响

现代预防医学 2022年第13期49卷 2403-2408页

作者：谢开红徐哲庄素芳浙江中医药大学

目的旨在研究社会参与及分类对中老年人全因死亡事件的关系。方法本文利用CHARLS动态队列数据，构建Cox比例风险模型，评估11种特定社会活动对死亡事件的影响。结果社会参与数目、二分类变量和四项社会参与和死亡风险独立相关。“与... 详细信息

目的旨在研究社会参与及分类对中老年人全因死亡事件的关系。方法本文利用CHARLS动态队列数据，构建Cox比例风险模型，评估11种特定社会活动对死亡事件的影响。结果社会参与数目、二分类变量和四项社会参与和死亡风险独立相关。“与朋友互动”(HR=0.83,95%CI:0.72～0.95),“打麻将、下棋、打牌，或去社区俱乐部玩桌游”(HR=0.87,95%CI:0.78～0.96)、“向家人、朋友或邻居提供帮助”(HR=0.67,95%CI:0.53～0.87)、“参加体育运动、社交或其他类型的俱乐部”(HR=0.62,95%CI:0.48～0.80)与死亡存在负相关。社会参与对患有记忆疾病的中老年人的寿命影响显著(HR=0.58,95%CI:0.34～0.99;HR=0.86,95%CI:0.81～0.91);社会参与对慢病组死亡的保护性高于非慢病组(HR=0.92,95%CI:0.92～1.07;HR=0.92,95%CI:0.85～0.99)。结论社会参与有选择地对中老年人产生积极影响，尤其是慢病群体，且与社会参与类型密切相关。

关键词：社会参与死亡队列

Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： Min Wang Yang Ou Xiang-Lian Yuan Xiu-fang Zhu Ben Niu zhuang Kang Bing Zhang Anwar Ahmed Guo-Qiang Xing Heng su School of Chemical Science and Technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGROUND The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early intervention/prevention efforts.Elevated branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:Tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical studies.However,improvement is needed to support its clinical utility.AIM To evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body weight.METHODS Ninety-seven new-onset T2DM patients(suLTS Fasting serum AAAs,BCAAs,glutamate,and alanine were greater and high-density lipoprotein(HDL)was lower(Psupport T2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW individuals.This potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to be used as the T2DM predictor.

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

Toughness for Fractional (2, b, k)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2023年第1期11卷 197-205页

作者： su-fang Wang Wei Zhang School of Public Management Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina Oujiang College Wenzhou UniversityWenzhou325035ZhejiangChina

Let h:E(G)→[0,1]be a function.If a≤∑e∋xh(e)≤b holds for each x∈V(G),then we call G[Fh]a fractional[a,b]-factor of G with indicator function h,where Fh={e:e∈E(G),h(e)>0}.A graph G is called a fractional[a,b]-covered graph if for every edge e of G,there is a fractional[a,b]-factor G[Fh]with h(e)=1.Zhou,Xu and sun[S.Zhou,Y.Xu,Z.sun,Degree conditions for fractional(a,b,k)-critical covered graphs,Information Processing Letters 152(2019)105838]defined the concept of a fractional(a,b,k)-critical covered graph,i.e.,for every vertex subset Q with|Q|=k of G,G−Q is a fractional[a,b]-covered graph.In this article,we study the problem of a fractional(2,b,k)-critical covered graph,and verify that a graph G withδ(G)≥3+k is a fractional(2,b,k)-critical covered graph if its toughness t(G)≥1+1b+k2b,where b and k are two nonnegative integers with b≥2+k2.

关键词： Graph Toughness Fractional[a,b]-factor Fractional[a,b]-covered graph Fractional(a,b,k)-critical

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中国氟塑料制品业基础能力提升研究

化工新型材料 2014年第7期42卷 1-2,5页

作者：庄甦吕方刘秋晨北京市塑料研究所北京100009

介绍了中国氟塑料制品业的基础,分析了氟塑料市场需求变化,总结了中国氟塑料加工行业与国际先进水平的差距,提出了提升基础能力的建议。

关键词：氟塑料制品基础能力

Discussion on Fractional(a,b,k)-critical Covered Graphs

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 304-311页

作者： Wei ZHANG su-fang WANG School of Economics and Management China University of Mining and TechnologyXuzhou 221116China School of Economics and Management Wenzhou University of TechnlogogyWenzhou 325000China School of Public Management Jiangsu University of Science and TechnologyZhenjiang 212100China

A graph G is called a fractional[a,b]-covered graph if for each e∈E(G),G contains a fractional[a,b]-factor covering e.A graph G is called a fractional(a,b,k)-critical covered graph if for any W■V(G)with|W|=k,G-W is fractional[a,b]-covered,which was first defined and investigated by Zhou,Xu and sun[S.Zhou,Y.Xu,Z.sun,Degree conditions for fractional(a,b,k)-critical covered graphs,Information Processing Letters 152(2019)105838].In this work,we proceed to study fractional(a,b,k)-critical covered graphs and derive a result on fractional(a,b,k)-critical covered graphs depending on minimum degree and neighborhoods of independent sets.

关键词： network fractional(a,b,k)-critical covered graph minimum degree neighborhood of independent set

基于GSM/GPRS和3S技术的环境应急应用

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环境科学与技术 2006年第1期29卷 40-42页

作者：李素庄大方中国科学院地理科学与资源研究所中国科学院研究生院北京100101

介绍了应用GSM\GPRS和3S等高新技术建立的环境应急远程指挥系统。该系统能够实现对环境突发事件的远程监控和管理,提高了我国对环境突发事件的应急反应能力,在我国环保行业是一个新的尝试。文中对系统的设计、工作原理、数据组织、功能... 详细信息

介绍了应用GSM\GPRS和3S等高新技术建立的环境应急远程指挥系统。该系统能够实现对环境突发事件的远程监控和管理,提高了我国对环境突发事件的应急反应能力,在我国环保行业是一个新的尝试。文中对系统的设计、工作原理、数据组织、功能、实现和应用情况等进行了详细的阐述。

关键词： GSM\GPRS 3S 远程指挥监控中心