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Correlation of S1P1 and ERp29 expression to progression, metastasis, and poor prognosis of gallbladder adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 189-195页

作者： lian-Wen Yuan Dong-cai Liu zhu-Lin Yang Department of Geriatric Surgery Second Xiangya Hospital Central South University Research Laboratory of Hepatobiliary Diseases Second Xiangya Hospital Central South University

BACKGROUND: Gallbladder cancer (GBC) is one of the most aggressive malignant neoplasms with an extremely poor prognosis. Early diagnosis significantly increases the survival rate. The present study was undertaken to evaluate the diagnostic and prognostic value of sphingosine-1-phosphate receptor 1 (S1P1) and endoplasmic reticulum protein 29 (ERp29) in benign and malignant gallbladder lesions and to develop a possible alternative treatment for GBC. METHODS: A total of 100 gallbladder adenocarcinoma, 46 peritumoral, 30 gallbladder adenomatous, 15 gallbladder polyp and 35 chronic cholecystitis tissues were included. S1P1 and ERp29 expressions were evaluated by immunohistochemistry The correlation between S1P1 and ERp29 expression and tumor pathological features and prognosis was analyzed. RESULTS: S1P1 positive rate was significantly higher in gallbladder adenocarcinomas than that in peritumoral adenomatous, polyp, and chronic cholecystitis tissues. On the contrary, ERp29 positive rate was significantly lower in adenocarcinomas than that in peritumoral, adenomatous polyp, and chronic cholecystitis tissues. Benign lesions with positive S1P1 or negative ERp29 expression showed moderate or severe atypical hyperplasia in the gallbladder epithelium The overexpression of S1P1 or non-expression of ERp29 was significantly associated with tumor differentiation, tumor mass, lymph node metastasis, and adenocarcinoma invasion Univariate Kaplan-Meier analysis showed that the elevated S1P1 (P=0.008) or absence of ERp29 (P=0.043) was closely associated with decreased survival rate. Multivariate Cox regression analysis showed that S1P1 positive (P=0.004) or ERp29 negative (P=0.029) was an independent predictor of poor prognosis in gallbladder ***: S1P1 overexpression or ERp29 absence is related to the carcinogenesis and progression, and may be potential biomarkers for early detection of gallbladder adenocarcinoma.

关键词： gallbladder cancer gallbladder polyp chronic cholecystitis S1P1 ERp29

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臭氧对4种真菌的灭活作用

同济大学学报（医学版） 2011年第2期32卷 54-57页

作者：胡林凤李辰王小平李鸣宇朱彩莲上海市普陀区人民医院口腔科上海200060 同济大学附属口腔医院牙周黏膜科上海200072 上海市口腔医学研究所上海200011

目的观察不同浓度、作用时间的臭氧对白色念珠菌、热带念珠菌、近平滑念珠菌和光滑念珠茵的灭活作用。方法用碘滴定法测定打开臭氧发生器的1档、2档、3档至15、30、45min时的臭氧浓度。按载体定量杀菌试验法,将分别经臭氧和未经任何作... 详细信息

目的观察不同浓度、作用时间的臭氧对白色念珠菌、热带念珠菌、近平滑念珠菌和光滑念珠茵的灭活作用。方法用碘滴定法测定打开臭氧发生器的1档、2档、3档至15、30、45min时的臭氧浓度。按载体定量杀菌试验法,将分别经臭氧和未经任何作用的载体上的真菌洗下,各取洗脱液50μl,接种于SDA平板并置于培养箱（37℃）孵育24h后,进行活茵茵落计数,所得数据使用SAS6.12软件包进行χ~2检验。结果载体定量杀菌实验显示,当打开3组臭氧发生器45min时,臭氧对4种真菌的杀灭率达到100%。结论臭氧对这4种真菌有良好的杀菌效果,且杀菌效果随浓度和作用时间的增加而相应增强的趋势。

关键词：臭氧真菌灭菌作用

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臭氧水对伴放线放线杆菌的灭活效果观察

中华口腔医学研究杂志（电子版） 2009年第2期3卷 5-8页

作者：余芳王小平易敏李辰李鸣宇朱彩莲同济大学口腔医学院上海200072 上海第十人民医院口腔科上海交通大学医学院附属第九人民医院口腔微生物实验室

目的探讨臭氧水对牙周可疑致病菌伴放线放线杆菌(Aa)的灭活效果。方法采用悬液定量杀菌方法和和化学方法在实验室进行观察。用4、8、15mg/L的臭氧水分别对悬液中Aa作用1、2、3min。结果当臭氧水浓度为4mg/L对悬液中Aa没有杀灭作用。当... 详细信息

目的探讨臭氧水对牙周可疑致病菌伴放线放线杆菌(Aa)的灭活效果。方法采用悬液定量杀菌方法和和化学方法在实验室进行观察。用4、8、15mg/L的臭氧水分别对悬液中Aa作用1、2、3min。结果当臭氧水浓度为4mg/L对悬液中Aa没有杀灭作用。当臭氧水浓度为8mg/L时,对悬液中Aa作用1min,杀灭率为57%,当浓度上升至15mg/L时,对悬液中Aa作用1min,杀灭率上升至98%,而延长杀菌时间至3min,杀菌率维持在97%～99%。结论在25℃的室温条件下,臭氧水浓度达到15mg/L,臭氧水温控制在15℃～18℃时对悬液中Aa有快速、有效的杀灭作用。

关键词：臭氧水伴放线放线杆菌杀菌作用

Multiple Symmetric Lipomas: A Case Report

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第4期2卷 257-262页

作者： Qiuyuan FENG Xueyao cai Yucheng cai Guoyou ZHANG Jie lian lian zhu Department of Plastic Surgery Yixing HospitalJiangsu UniversityWuxiJiangsu 214200China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200003China

Multiple symmetric lipomas are a rare disease characterized by multiple symmetrical deposits of adipose tissue associated with alcohol abuse.A 68-year-old man was admitted to our hospital for being operated on for a mass growth on the neck and *** on the patient’s medical history and preoperative magnetic resonance imaging findings,we performed surgical *** was no recurrence at one year postoperatively.

关键词： Multiple symmetric lipomas Symmetric adipose tissue Alcohol abuse Surgical resection

68株临床分离口腔念珠菌对4种抗真菌药的体外药敏实验结果分析

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临床口腔医学杂志 2006年第3期22卷 178-180页

作者：周曾同赵民朱彩莲张秀丽李明宇上海交通大学医学院附属第九人民医院口腔内科上海200011 上海市口腔医学研究所

目的:评价临床致病性口腔念珠菌感染的种类及对氟康唑、两性霉素B、5-氟胞嘧啶和伊曲康唑的药物敏感性,比较各种口腔黏膜病中的感染菌株的种类和耐药比例,为临床用药提供指导。方法:收集临床菌株,经YBC Test Kit鉴定其念珠菌种类;根据NC... 详细信息

目的:评价临床致病性口腔念珠菌感染的种类及对氟康唑、两性霉素B、5-氟胞嘧啶和伊曲康唑的药物敏感性,比较各种口腔黏膜病中的感染菌株的种类和耐药比例,为临床用药提供指导。方法:收集临床菌株,经YBC Test Kit鉴定其念珠菌种类;根据NCCLS的M27-A2标准方案测定3组(口腔念珠菌病、口腔扁平苔藓合并口腔念珠菌感染、头颈部放化疗患者合并口腔念珠菌感染)菌株对4种抗真菌药物的最低抑菌浓度,并比较不同口腔黏膜病合并念珠菌感染菌株的耐药状况。结果:68株临床分离株对5-氟胞嘧啶全部敏感,91.2%对两性霉素B敏感,氟康唑和伊曲康唑的耐药比例分别为13.2%和22.1%,放化疗组的非白色念株菌比例及耐药比例明显高于口腔念珠菌病组和扁平苔藓组。结论:口腔念珠菌感染菌株对氟康唑和伊曲康唑存在较高耐药比例和交叉耐药比例,头颈部肿瘤放疗或化疗患者口腔念珠菌感染菌株的非白色念株菌比例及耐药比例明显高于口腔念珠菌病和扁平苔藓合并口腔念珠菌感染菌株。

关键词：口腔念珠菌口腔黏膜病药物敏感性实验

原位菌斑生物膜的一种完整获得方法和结构研究

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牙体牙髓牙周病学杂志 2008年第10期18卷 545-547页

作者：马瑞刘正黄正蔚唐子圣朱彩莲叶冬霞上海交通大学附属第九人民医院牙体牙髓病科上海200011 上海交通大学附属第九人民医院口腔医学研究所上海200011

目的:通过对一种方法获得原位牙菌斑生物膜的结构分析,证明这种方法的可行性。方法:选择安装有局部可摘义齿的志愿者在基托表面粘贴塑料片的方法,在塑料片上可获得1、4、24h牙菌斑生物膜,并用激光共聚焦扫描显微镜进行结构的观察和分析... 详细信息

目的:通过对一种方法获得原位牙菌斑生物膜的结构分析,证明这种方法的可行性。方法:选择安装有局部可摘义齿的志愿者在基托表面粘贴塑料片的方法,在塑料片上可获得1、4、24h牙菌斑生物膜,并用激光共聚焦扫描显微镜进行结构的观察和分析。结果:牙菌斑生物膜的细菌、基质清楚可见,1、4、24h菌斑生物膜的平均厚度分别是(21.41±0.03)μm,(34.03±0.02)μm,(58.53±0.03)μm。结论:这种方法获取的菌斑生物膜结构完整、简便可行,是一种很好的获取原位牙菌斑生物膜的方法,可为进一步的实验提供平台。

关键词：菌斑生物膜原位

Effect of sintering temperature on the physical properties and electrical contact properties of doped AgSnO_2 contact materials

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International Journal of Minerals,Metallurgy and Materials 2018年第11期25卷 1275-1285页

作者： Hai-tao Wang Zi-xiang Wang lian-zheng Wang Jing-qin Wang Yan-cai zhu State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Electrical EngineeringHebei University of Technology Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province School of Electrical EngineeringHebei University of Technology

AgSnO_ 2 electrical contact materials doped with Bi_2O_3,La_2O_3,and TiO_2 were successfully fabricated by the powder metallurgy method under different initial sintering *** electrical conductivity,density,hardness,and contact resistance of the Ag Sn O_2/Bi_2O_3,AgSnO_2/La_2O_3,and AgSnO_2/Ti O_2 contact materials were measured and *** arc-eroded surface morphologies of the doped AgSnO_2 contact materials were investigated by scanning electron microscopy(SEM).The effects of the initial sintering temperature on the physical properties and electrical contact properties of the doped AgSnO_2 contact materials were *** results indicate that the physical properties can be improved and the contact resistance of the AgSnO_2 contact materials can be substantially reduced when the materials are sintered under their optimal initial sintering temperatures.

关键词： sintering temperature contact materials physical properties electrical contact properties

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五白汤组分体外抗白色念珠菌活性筛选

临床口腔医学杂志 2011年第10期27卷 614-616页

作者：施琳俊金芝贵顾芳吴岚朱彩莲周曾同上海交通大学医学院附属第九人民医院.口腔医学院口腔黏膜科上海200011 上海市口腔医学重点实验室上海200011 上海交通大学医学院附属第九人民医院制剂科上海200011

目的:筛选五白汤组分中具有抗白色念珠菌活性的药物。方法:采用白色念珠菌标准菌株(ATCC76615)为研究对象,应用煎煮法及水提醇沉淀法分别对五白汤各组成药物进行制备,参照NCCLS M27-A2推荐的方法测定五白汤各组成药物对白色念珠菌的最... 详细信息

目的:筛选五白汤组分中具有抗白色念珠菌活性的药物。方法:采用白色念珠菌标准菌株(ATCC76615)为研究对象,应用煎煮法及水提醇沉淀法分别对五白汤各组成药物进行制备,参照NCCLS M27-A2推荐的方法测定五白汤各组成药物对白色念珠菌的最小抑菌浓度(MIC)。结果:白鲜皮水煎剂、苦参水煎剂和苦参醇提液对白色念珠菌的MIC分别为62.5 mg/mL、15.625 mg/mL、62.5 mg/mL。结论:白鲜皮水煎剂、苦参水煎剂以及苦参醇提液具有抗白色念珠菌活性。

关键词：白色念珠菌白鲜皮苦参药物敏感性实验抗真菌中药

A LINE SEARCH FILTER INEXACT SQP METHOD FOR NONLINEAR EQUALITY CONSTRAINED OPTIMIZATION

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Journal of Systems Science & Complexity 2012年第5期25卷 950-963页

作者： Li cai Detong zhu Department of Mathematics Shanghai Normal University College of Business Shanghai Normal University

This paper proposes an inexact SQP method in association with line search filter technique for solving nonlinear equality constrained optimization. For large-scale applications, it is expensive to get an exact search direction, and hence the authors use an inexact method that finds an approximate solution satisfying some appropriate conditions. The global convergence of the proposed algorithm is established by using line search filter technique. The second-order correction step is used to overcome the Maratos effect, while the line search filter inexact SQP method has q-superlinear local convergence rate. Finally, the results of numerical experiments indicate that the proposed method is efficient for the given test problems.

关键词： Constrained optimization convergence filter method inexact method maratos effect.