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Chinese Journal of Chemistry 2024年第4期42卷 343-350页

作者： Na Yao juan zhu Hongnan Jia Hengjiang Cong Wei Luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Developing highly efficient and low-cost electrocatalysts towards oxygen evolution reaction(OER)is essential for practical application in water electrolyzers and rechargeable metal-air *** Fe-based oxyhydroxides are regarded as state-of-the-art non-noble OER electrocatalysts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerable ***,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catalyst through a pre-conversion process during alkaline OER result from dynamic Fe dissolution,identifying the origin of Fe-vacancy-induced enhanced OER *** functional theory(DFT)calculations and experimental results including X-ray absorption fine-structure spectroscopy,in situ UV-Vis spectroscopy,and in situ Raman spectroscopy reveal that the Fe vacancies could significantly promote the d-band center and valence states of adjacent Co sites,alter the active site from Fe atom to Co atom,accelerate the formation of high-valent active Co^(4+)species,and reduce the energy barrier of the potential-determining step,thereby contribute to the significantly enhanced OER performance.

关键词： CoFe oxyhydroxide Oxygen evolution reaction Fe vacancy Electrocatalysis Kinetics Reaction mechanisms

Effects of ulinastatin combined with dexmedetomidine on cognitive dysfunction and emergence agitation in elderly patients who underwent total hip arthroplasty

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World Journal of Psychiatry 2024年第1期14卷 26-35页

作者： Qi-Fan Huo Li-juan zhu Jian-Wei Guo Yan-An Jiang Jing Zhao Department of Anesthesiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

BACKGROUND With the continuous growth of the modern elderly population,the risk of fracture *** fracture is a common type of fracture in older *** hip arthroplasty(THA)has significant advantages in relieving chronic pain and promoting the recovery of hip joint *** To investigate the effect of ulinastatin combined with dexmedetomidine(Dex)on the incidences of postoperative cognitive dysfunction(POCD)and emergence agitation in elderly patients who underwent *** A total of 397 patients who underwent THA from February 2019 to August *** conducted a three-year retrospective cohort study in Shaanxi Provincial People’s *** demographic data were obtained from the electronic medical record *** collected preoperative,intraoperative,and postoperative *** hundred twenty-nine patients who were administered Dex during the operation were included in the Dex *** hundred fifty patients who were intravenously injected with ulinastatin 15 min before anesthesia induction were included in the ulinastatin *** hundred eighteen patients who were administered ulinastatin combined with Dex during the operation were included in the Dex+ulinastatin *** patients’perioperative conditions,hemodynamic indexes,postoperative Mini-Mental State Examination(MMSE)scores,Ramsay score,incidence of POCD,and serum inflammatory cytokines were *** There was a significant difference in the 24 h visual analogue scale score among the three groups,and the score in the Dex+ulinastatin group was the lowest(P<0.05).Compared with the Dex and ulinastatin group,the MMSE scores of the Dex+ulinastatin group were significantly increased at 1 and 7 d after the operation(all P<0.05).Compared with those in the Dex and ulinastatin groups,incidence of POCD,levels of serum inflammatory cytokines in the Dex+ulinastatin group were significantly decreased at 1 and 7 d after the operation(all P<0.05).The observer’s assessment of th

关键词： Ulinastatin Dexmedetomidine Postoperative cognitive dysfunction Inflammatory cytokines Total hip arthroplasty

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

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World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-Wen Xu Xiao-Bo Guan Xue-Ying Wang Yang Feng Qi Zhang Jun-juan zhu Jian-Hua Chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is *** To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS *** This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric *** plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid *** patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were *** Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female *** and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 *** male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total *** Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

Accelerating Deprotonation Kinetics of RuO_(2)for Efficient Acidic Water Oxidation

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Renewables 2024年第3期2卷 204-212页

作者： Hongnan Jia Zhichang Liao juan zhu Wei Luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072

The development of a highly efficient noniridium-based oxygen evolution reaction catalyst is the key to realizing large-scale commercial application of the proton-exchange membrane water ***_(2)is the most promising alternative to IrO_(2),but if usually suffers from lattice-oxygenmediated corrosion and sluggish proton transfer kinetics under acidic ***,we propose an effective strategy of embedding RuO_(2)nanoparticles into a N-doped carbon support,termed as RuO_(2)-NC,to simultaneously prevent Ru dissolution and accelerate the bridging-oxygen-assisted deprotonation *** obtained RuO_(2)-NC electrocatalyst presents high activity with an overpotential of 159 mV to reach 10 mA cm^(−2) and remarkable stability for over 240 *** investigation and theoretical calculations reveal that the electron-rich NC substrate,as an electron donor,provides a buffered charge compensation to protect RuO_(2)from excessive oxidation and lattice oxygen loss by switching into a conventional adsorbate evolution mechanism(AEM).More importantly,the activated bridging oxygen(Obri)sites can facilitate the deprotonation of*OOH intermediates,leading to an optimized bridging-oxygen-assisted deprotonation AEM pathway.

关键词： acidic oxygen evolution reaction electronic donation NC support RuO_(2) adsorbate evolution mechanism bridging-oxygen-assisted deprotonation

Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

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Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin Xiao-Qi Kong Ya-juan zhu Zong-Xin Chen Xi-Ming Wang Cai-Hua Xu Jin-Xian Pu Jian-Quan Hou Yu-Hua Huang Fu-Hai Ji Chen Huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

Magnetic resonance imaging of knees:a novel approach to predict recombinant human growth hormone therapy response in short-stature children in late puberty

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World Journal of Pediatrics 2024年第7期20卷 723-734页

作者： Xi Bai Zhi‑Bo Zhou Xiao‑Yuan Guo Yi‑Ling He Yue‑Lun Zhang Feng‑Dan Wang Feng Feng Hong‑Bo Yang Shi Chen Feng‑Ying Gong Hui‑juan zhu Hui Pan Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Key Laboratory of Endocrinology of National Health Commission Department of EndocrinologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background There is no appropriate tool to predict recombinant human growth hormone(rhGH)response before therapy initiation in short-stature children in late *** current study aimed to explore the associations between magnetic resonance imaging(MRI)stages of the knee growth plates and rhGH response in short-stature children in late *** In this prospective cohort study,short-stature children in late puberty were treated with rhGH and followed up for 6 *** proposed a novel knee MRI staging system according to the growth plate states of distal femurs or proximal tibias and divided the participants into three groups:unclosed growth plate group,marginally closed growth plate group,and nearly closed growth plate *** primary outcomes were height gain and growth velocity(GV),which were assessed three months *** Fifty participants were enrolled,including 23 boys and 27 *** and height gain after 6 months of rhGH therapy decreased successively in the three groups with an increased degree of growth plate fusion,especially when grouped by proximal tibias(GV_(1-3 mon)from 9.38 to 6.08 to 4.56 cm/year,GV_(4-6 mon)from 6.75 to 4.92 to 3.25 cm/year,and height gain from 4.03 to 2.75 to 1.95 cm,all P<0.001).Moreover,the MRI stages of growth plates independently served as a significant variable for GV and height gain after therapy,especially when grouped by proximal tibias(all P<0.01).Conclusion The MRI staging method is expected to be an effective tool for predicting rhGH response before therapy initiation in short-stature children in late puberty.

关键词： Growth hormone Growth velocity Late puberty Magnetic resonance imaging Short stature

江苏省县域耕地利用生态效率时空动态性及驱动机制

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长江流域资源与环境 2024年第4期33卷 784-798页

作者：朱文娟孙华浙江水利水电学院经济与管理学院浙江杭州310018 南京农业大学公共管理学院江苏南京210095

探究耕地利用生态效率时空动态性及驱动机制,对于全面把握地区农业可持续发展进程、及时优化调整政策制度,推动经济、资源、环境协调发展具有重大意义。运用超效率SBM-Undesirable模型、重心转移、ESTDA模型、分位数模型及时空跃迁嵌套... 详细信息

探究耕地利用生态效率时空动态性及驱动机制,对于全面把握地区农业可持续发展进程、及时优化调整政策制度,推动经济、资源、环境协调发展具有重大意义。运用超效率SBM-Undesirable模型、重心转移、ESTDA模型、分位数模型及时空跃迁嵌套探究江苏省77个县域单元耕地利用生态效率时空动态演变及驱动机制。研究表明:(1)江苏省县域耕地利用生态效率重心呈微偏东南后转西北方向的演变态势,高值区大多分布于“西北-东南”方向。(2)空间上以正向趋同关系为主导,“高高-低低”空间集聚显著。(3)耕地利用生态效率呈现空间协同与竞争并存的格局特征,且空间协同主导局部空间格局演变。时空演变路径依赖特征较为明显,存在一定的转移惰性和路径锁定。(4)各因素对不同水平生态效率的影响程度存在差异。种植结构-经营规模-产业结构高分位驱动、种植结构-经营规模低分位驱动、城乡差距-农业基础设施高分位制约、农业基础设施低分位制约等4种时空跃迁驱动/制约模式背后各自蕴含不同驱动机理。未来亟需以县域为单位构建区域耕地利用协同机制,统筹考虑多因素的综合影响,制定多要素协同联动的优化策略。同时因地制宜制定差异化的效率优化方案,为不同水平生态效率的提升提供针对性的建议指导。

关键词：耕地生态效率时空跃迁驱动机制

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融合CAM和ASPP的车道线检测算法研究

重庆理工大学学报（自然科学） 2024年第5期38卷 86-94页

作者：朱娟朱国吕岳晓峰长春工业大学机电工程学院长春130012

UFLD(ultra fast structure aware deep lane detection)是一种轻量化车道线检测模型,为提升模型的检测精度,对模型进行改进。引入CAM(channel attention mechanism)使模型能更关注携带重要车道线信息的特征通道和像素;为了感知车道线... 详细信息

UFLD(ultra fast structure aware deep lane detection)是一种轻量化车道线检测模型,为提升模型的检测精度,对模型进行改进。引入CAM(channel attention mechanism)使模型能更关注携带重要车道线信息的特征通道和像素;为了感知车道线的细节信息,引入ASPP(atrous spatial pyramid pooling)扩大卷积过程的感受野,提高模型分割精度;搭建引入CAM和ASPP后的改进模型,并在改进的模型上进行实验。实验结果表明:在TuSimple数据集上以ResNet18为主干网络的模型检测精度由95.81%提升至95.98%,以ResNet34为主干网络的模型检测精度由95.84%提升至96.12%;在CULane数据集上,无论是以ResNet18还是以ResNet34为主干网络模型,其平均精度均有不同程度的提高。

关键词：车道线检测 CAM ASPP 融合算法

老年人髋关节或膝关节置换术后延续护理对关节功能恢复的有效性及安全性:系统评价

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International Journal of Nursing Sciences 2024年第2期11卷 286-294,I0004页

作者：孙静徐益荣朱娟朱蓓高薇 School of Nursing Jiangsu Vocational College of MedicineYanchengChina Department of Nursing Faculty of NursingLincoln University CollegeKuala LumpurMalaysia

目的系统评价延续护理促进老年人关节功能恢复的有效性及安全性。方法检索Cochrane Library、Web of Science、PubMed、Embase数据库中有关延续护理应用于老年关节置换患者的随机对照试验和队列研究,检索时间从建库到2023年10月25日。2... 详细信息

目的系统评价延续护理促进老年人关节功能恢复的有效性及安全性。方法检索Cochrane Library、Web of Science、PubMed、Embase数据库中有关延续护理应用于老年关节置换患者的随机对照试验和队列研究,检索时间从建库到2023年10月25日。2名研究员独立完成文献筛选、数据提取,随机对照试验通过Cochrane偏倚风险工具进行文献偏倚分析,队列研究通过纽卡斯尔-渥太华标准进行文献质量评价。结果共纳入15篇文献,包括34186例膝关节和髋关节置换患者。促进老年髋关节置换患者功能改善的主要指标包括髋关节评分、出院后日常生活指数评分(Barthel Index)及生活质量;对老年膝关节置换患者进行延续护理明显改善的指标包括膝关节运动范围、骨关节炎指数、关节损伤和骨关节炎结果评分;延续护理对术后并发症并没有明显作用。文献质量评价显示纳入文献总体质量较高,但仅1项针对髋关节置换术后患者的研究运用了理论框架。结论延续护理在缓解膝关节疼痛、改善关节活动度及髋关节功能方面发挥了重要作用,但是对生活质量、患者满意度、经济、减少关节置换术后并发症和再次入院率方面的有效性尚需进一步明确。

关键词：老年人关节置换延续护理系统综述康复

小檗碱体内代谢产物对前脂肪细胞分化和脂代谢的影响

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中国临床药理学杂志 2024年第17期40卷 2503-2507页

作者：张晨阳朱娟娟卢晶首都医科大学附属北京同仁医院内分泌科北京100730 北京市糖尿病研究所北京100730

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(DHB)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL... 详细信息

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(DHB)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL)、药根碱(JAT)和去亚甲基小檗碱(DEM)组分别给予5μmol·L^(-1)BBR、2.5μmol·L^(-1)DHB、10μmol·L^(-1)BRB、20μmol·L^(-1)COL、25μmol·L^(-1)PAL、50μmol·L^(-1)JAT和50μmol·L^(-1)DEM处理;对照组给予正常培养。用实时荧光定量聚合酶链反应法检测脂蛋白脂肪酶(LPL)、乙酰辅酶A羧化酶A(ACACA)等mRNA的表达水平。结果DHB、COL、PAL、JAT、DEM孵育48 h与对照组相比,均不影响细胞存活率,20μmol·L^(-1)BRB可将细胞活性降至(86.55±1.99)%。培养12 d后,对照组和BBR、DHB、BRB、COL、PAL、JAT、DEM组的LPL mRNA相对表达水平分别为1.00±0.02、0.41±0.04、0.44±0.04、1.40±0.08、1.27±0.10、1.15±0.07、3.06±0.30和1.45±0.07,ACACA mRNA相对表达水平分别为1.01±0.01、0.62±0.04、0.69±0.06、1.78±0.17、4.77±0.19、4.20±0.14、6.38±0.30和1.18±0.08。BBR、DHB、JAT组的LPL mRNA相对表达水平与对照组比较,BRB、COL、PAL、JAT组的ACACA mRNA相对表达水平与对照组比较,在统计学上差异均有统计学意义(均P<0.05)。结论小檗碱体内代谢产物可以抑制脂肪细胞分化和促进脂代谢,从而减少细胞中脂质蓄积。

关键词：小檗碱体内代谢产物 3T3-L1前脂肪细胞细胞分化脂质代谢