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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin ZHANG Zhao-xin LI Li-fei HE feng CHEN Ming-long LIU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO feng zhu Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

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Synthesis of highly stable Ni nanoparticles via electrostatic self-assembly for enhanced hydrogen storage of MgH_(2)

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Rare Metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan Liu Rui Shi Yun-feng zhu Ji-Guang Zhang Ya-Na Liu Jun Wang Yao Zhang Xiao-Hui Hu Zhi-Bin Liu Li-Quan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering Southeast UniversityNanjing 211189China

Magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed Ni-based catalyst(Ni/Al_(2)O_(3)/GN)was fabricated to promote the hydrogen storage performance of MgH_(2)via the electrostatic effect of NiAl-LDH/GN precursor with a co-calcination reduction ***_(2)-5wt%Ni/Al_(2)O_(3)/GN exhibits excellent hydrogen storage performance,releasing about 5.7 wt%hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt%in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·mol^(-1).Impressively,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in Ni/Al_(2)O_(3)/GN on the hydrogen storage performance of MgH_(2)was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of Ni/Al_(2)O_(3)/GN was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： Magnesium hydride Ni/Al_(2)O_(3)/GN Hydrogen storage performance Catalytic mechanism

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Endovascular treatment of ruptured lobulated anterior communicating artery aneurysms:A retrospective study of 24 patients

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World Journal of Clinical Cases 2024年第15期12卷 2529-2541页

作者： Sheng-Xuan Huang Xun-Ping Ai Ze-Hui Kang Zhi-Yong Chen Ren-Man Li Zu-Chao Wu feng zhu Department of Neurosurgery Sanming First Hospital Affiliated to Fujian Medical UniversitySanming 365000Fujian ProvinceChina

BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the *** intracranial aneurysm is a complex aneurysm with complex morphology and structure and weak tumor wall,which is an independent risk factor for rupture and *** aneurysms located in the anterior communicating artery complex account for 36.9%of all intracranial lobular *** to its special anatomical structure,both craniotomy and endovascular treatment are more *** with single-capsule aneurysms,craniotomy for lobular intracranial aneurysms has a higher risk and complication *** To investigate the efficacy and safety of endovascular treatment for ruptured lobulated anterior communicating artery aneurysm(ACoAA).METHODS Patients with ruptured lobulated ACoAA received endovascular treatment in Sanming First Hospital Affiliated to Fujian Medical University from June 2020 to June 2022 were retrospectively *** demographic,clinical and imaging characteristics,endovascular treatment methods and follow-up results were *** A total of 24 patients with ruptured lobulated ACoAA were included,including 9 males(37.5%)and 15 females(62.5%).Their age was 56.2±8.9 years old(range 39-74).The time from rupture to endovascular treatment was 10.9±12.5 *** maximum diameter of the aneurysms was 5.1±1.0 mm and neck width were 3.0±0.7 *** patients(79.2%)were double-lobed and 5(20.8%)were ***'s grade:Grade 2 in 16 cases(66.7%),grade 3 in 6 cases(25%),and grade 4 in 2 cases(8.3%).Hunt-Hess grade:Grade 0-2 in 5 cases(20.8%),grade 3-5 in 19 cases(79.2%).Glasgow Coma Scale score:9-12 in 14 cases(58.3%),13-15 in 10 cases(41.7%).Immediately postprocedural Raymond-Roy grade:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Raymond-Roy grade in imaging follow-up for 2 wk to 3 months:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Followup for 2 to 12 months sho

关键词： Intracranial aneurysm Anterior cerebral artery Endovascular surgery Embolism Treatment outcome

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Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： Xin-Lin Huang Ju Gao Yong-Ming Wang feng zhu Jing Qin Qian-Nan Yao Xiao-Bin Zhang Hong-Yan Sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

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Application of UiO-66 and its composites for remediation and resource recovery of typical environmental contaminants:a review

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Rare Metals 2024年第6期43卷 2498-2526页

作者： Hui-Min Zhang Yun-Long Wang Xin-feng zhu Zhen-Zhen Huang Dan-Dan Pang Kai Wang Chao-Hai Wang Zhong-Xian Song Shi-Qiang Yin Lin-Lin Chang Jin-Hui Zhang School Infirmary Henan University of Urban ConstructionPingdingshan 467036China Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyKey Laboratory of Carbon Emission Reduction and Combined Air Pollution Control TechnologyHenan University of Urban ConstructionPingdingshan 467036China School of Resources&Environment Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic RegionHenan Polytechnic UniversityJiaozuo 454003China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou Higher Education Mega CentreSouth China University of TechnologyGuangzhou 510006China

UiO-66 series metal-organic framework materials(MOFs)are typical porous materials assembled by Zr^(4+) with a large mass-to-nucleus ratio and terephthalic acid ligands,which form tetrahedral and octahedral cages arranged in a periodic triangular window *** to the strong interaction between Zr and O,UiO-66 series MOFs exhibit high thermal stability,structural stability,and chemical *** article mainly reviews the applications of UiO-66 and its composites in adsorption,photocatalysis,and resource utilization,while exploring the harm of pollutants to human health and the *** the first part,the differences in adsorption and removal mechanisms of liquid organic pollutants,heavy metals,and volatile organic compounds(VOCs)are *** results show that organic pollutants are mainly removed by physical adsorption,electrostatic interactions,hydrogen bonding,andπ-πinteractions,while heavy metals are mainly removed by chemical adsorption,electrostatic interactions,reduction,and *** are mainly removed by the pore volume and pore size structure of the *** catalysis can achieve non-toxic treatment of pollutants,and this study mainly focuses on UiO-based composite materials constructed by strategies such as semiconductor composites,ion doping,and metal/dye *** the second part,the synergistic effect between the components of UiO-based composite materials promotes the oriented and rapid separation and transfer of earriers at the material interface,thereby promoting the generation of active species such as h^(+),·O_(2)^(-) and·OH,and achieving rapid degradation of pollutants and detoxification of heavy *** the third part,heterojunctions can realize the resource utilization of pollutants in water and air,producing energy-type substances such as hydrogen and methanol while solving environmental *** addition,this article also summarizes the harm of common typical pollutants to the environment

关键词： UiO Adsorption Photocatalysis Environmental pollution Resource recovery

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基于MSISE-90研究高海拔宇宙线观测站处的大气深度廓线模型

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物理学报 2024年第16期73卷 229-237页

作者：祝凤荣柳靖夏君集张丰刘虎西南交通大学物理科学与技术学院成都611756 西藏大学理学院拉萨850000 天府宇宙线研究中心成都610213

高海拔宇宙线观测站(LHAASO)位于四川省稻城县海子山,它的广角切伦科夫望远镜阵(WFCTA)主要是通过观测广延大气簇射过程中产生的切伦科夫光信号对宇宙线进行研究.WFCTA的标定、模拟和重建都和大气深度有关,目前使用的大气深度模型是美... 详细信息

高海拔宇宙线观测站(LHAASO)位于四川省稻城县海子山,它的广角切伦科夫望远镜阵(WFCTA)主要是通过观测广延大气簇射过程中产生的切伦科夫光信号对宇宙线进行研究.WFCTA的标定、模拟和重建都和大气深度有关,目前使用的大气深度模型是美国标准大气深度廓线模型.本研究中将美国标准大气深度廓线模型与卫星TIMED搭载的红外辐射计SABER记录到的LHAASO处14-50 km处的大气深度廓线进行比较,同时也与LHAASO处地面气象站记录的大气深度进行比较,美国标准大气模型的大气深度均偏小.MSISE-90大气模型描述了地球大气中从地面到热层的中性温度和密度,进一步研究发现MSISE-90大气模型与TIMED/SABER和LHAASO处地面标准气象站记录的大气深度的一致性较好.根据MSISE-90大气模型计算得到LHAASO处的大气深度均值廓线在1月最低,其次是2月、3月、4月、11月和12月,这也是WFCTA运行的最佳观测月份.4月份的大气边界层最高,其大气深度存在约2%的日变化.利用美国标准大气模型的函数形式,拟合每月的4.4-100 km处的大气深度廓线,得到了LHAASO处的每月的大气深度廓线模型,并比较了30°天顶角入射的100 TeV的宇宙线质子在MSISE-90大气模型和美国标准大气模型中产生的切伦科夫光的横分布的差异,二者最大差异约可以达到20%.

关键词： MSISE-90大气模型大气深度廓线高海拔宇宙线观测站切伦科夫光

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高效液相色谱-串联质谱法同时测定染整助剂中5种异噻唑啉酮

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印染 2024年第8期50卷 74-77页

作者：朱峰福建省纤维检验中心福建福州350026 福建省纺织产品检测技术重点实验室福建福州350026

建立了高效液相色谱-串联质谱法同时测定染整助剂中5种异噻唑啉酮的分析方法。样品经甲醇超声波提取,Eclipse C_(18)柱(2.1 mm×100 mm,3.5μm)分离后,进行高效液相色谱-串联四极杆质谱外标法测定,流动相为甲醇-水。结果表明:该方法对MI... 详细信息

建立了高效液相色谱-串联质谱法同时测定染整助剂中5种异噻唑啉酮的分析方法。样品经甲醇超声波提取,Eclipse C_(18)柱(2.1 mm×100 mm,3.5μm)分离后,进行高效液相色谱-串联四极杆质谱外标法测定,流动相为甲醇-水。结果表明:该方法对MI、CMI、BIT的检出限和定量限分别为0.75 mg/kg和2.5 mg/kg,OI、DCOI的检出限和定量限分别为0.15 mg/kg和0.50 mg/kg;加标平均回收率为79.63%~108.78%,相对标准偏差为1.46%~8.24%;MI、CMI、BIT在0.05~0.50 mg/L,OI、DCOI在0.01~0.20 mg/L范围内线性相关系数大于0.99。该方法灵敏度高、重现性好,可满足染整助剂中异噻唑啉酮的检测要求。

关键词：测试高效液相色谱-串联质谱染整助剂异噻唑啉酮

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论违约行为侵害人格权的精神损害赔偿请求权基础

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吉林大学社会科学学报 2024年第5期64卷 99-112,237页

作者：朱晓峰中央财经大学法学院北京100081

《民法典》第996条是独立的请求权基础,可以作为合同相对人主张精神损害赔偿请求权的主要规范发挥作用。该条规定的精神损害赔偿在体系定位上构成违约损害赔偿的例外,本质上仍属侵权损害赔偿范畴,与《民法典》合同编第583条、侵权责任编... 详细信息

《民法典》第996条是独立的请求权基础,可以作为合同相对人主张精神损害赔偿请求权的主要规范发挥作用。该条规定的精神损害赔偿在体系定位上构成违约损害赔偿的例外,本质上仍属侵权损害赔偿范畴,与《民法典》合同编第583条、侵权责任编第1183条等规定的损害赔偿,共同构成现行民法上的精神损害赔偿体系。该条在规范作用的发挥上以具体侵害行为同时符合违约责任与侵权责任的构成要件为前提,与第1183条及第583条等在规范适用上构成竞合关系。若受害人选择依据第996条在违约之诉中主张精神损害赔偿请求权,那么在解释上应当将相应的精神损害赔偿责任判断置于侵权损害赔偿规范体系内展开,原则上不受违约损害赔偿中的可预见规则限制,以贯彻立法者通过该条强调充分保护人格权并适当兼顾行为自由的平衡保护立场。

关键词：人格权编精神损害赔偿侵权责任违约责任责任竞合

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Non-Hermitian CHSH^(*)Game with a Single Trapped-Ion Qubit

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Chinese Physics Letters 2024年第6期41卷 1-10页

作者：宋潇刘腾边纪陆鹏飞刘泱朱峰罗乐 School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shenzhen Research Institute of Sun Yat-Sen University Shenzhen 518057China Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area Shenzhen 518048China Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing Zhuhai 519082China

The Clauser-Horne-Shimony-Holt(CHSH)game provides a captivating illustration of the advantages of quantum strategies over classical *** a recent study,a variant of the CHSH game leveraging a single qubit system,referred to as the CHSH^(*)game,has been *** demonstrate that this mapping relationship between these two games remains effective even for a non-unitary *** we delve into the breach of Tsirelson’s bound in a non-Hermitian system,predicting changes in the upper and lower bounds of the player’s winning probability when employing quantum strategies in a single dissipative qubit *** experimentally explore the impact of the CHSH^(*)game on the player’s winning probability in a single trapped-ion dissipative system,demonstrating a violation of Tsirelson’s bound under the influence of parity-time(PT)*** results contribute to a deeper understanding of the influence of non-Hermitian systems on quantum games and the behavior of quantum systems under PT symmetry,which is crucial for designing more robust and efficient quantum protocols.

关键词： quantum system dissipative

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Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

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World Journal of Hepatology 2024年第2期16卷 264-278页

作者： Hao Ouyang Hui Miao Zhen Li Duan Wu Si-Cheng Gao Yao-Yao Dai Xiao-Di Gao Hai-Sheng Chai Wei-Ye Hu Jun-feng zhu Department of Liver Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 201203China

BACKGROUND Liver fibrosis is a formidable global medical challenge,with no effective clinical treatment currently *** granule(YHG)is a proprietary Chinese medicine comprising Scutellariae Radix and Lonicerae Japonicae *** is frequently used for upper respiratory tract infections,pharyngitis,as well as acute and chronic *** To investigate the potential of YHG in alleviating carbon tetrachloride(CCl4)-induced liver fibrosis in *** To induce a hepatic fibrosis model in mice,this study involved intraperitoneal injections of 2 mL/kg of CCl4 twice a week for 4 ***,liver fibrosis mice in the low dose of YHG(0.4 g/kg)and high dose of YHG(0.8 g/kg)groups were orally administered YHG once a day for 4 *** alanine/aspartate aminotransferase(ALT/AST)activity and liver hydroxyproline content were *** red and Masson's trichrome staining assay were *** polymerase chain reaction,western-blot and enzyme-linked immunosorbent assay were *** glutathione content,superoxide dismutase activity level,reactive oxygen species and protein carbonylation amount were *** The administration of YHG ameliorated hepatocellular injury in CCl4-treated mice,as reflected by decreased serum ALT/AST activity and improved liver histological *** also attenuated liver fibrosis,evident through reduced liver hydroxyproline content,improvements in Sirius red and Masson's trichrome staining,and lowered serum hyaluronic acid ***,YHG hindered the activation of hepatic stellate cells(HSCs)and ameliorated oxidative stress injury and inflammation in liver from CCl4-treated *** prompted the nuclear accumulation of nuclear factor erythroid 2-related factor 2(Nrf2)and upregulated the expression of Nrf2-dependent downstream antioxidant *** addition,YHG promoted mitochondrial biogenesis in liver from CCl4-treated mice,as demonstrated by increased liver adenosine triphosphate content,

关键词： Yinhuang granule Liver fibrosis Hepatic stellate cells Oxidative injury Nuclear factor erythroid 2-related factor 2 Inflammation

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