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Baicalin inhibits inflammation of lipopolysaccharide-induced acute lung injury via toll like receptor-4/myeloid differentiation primary response 88/nuclear factor-kappa B signaling pathway

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Journal of Traditional Chinese Medicine 2022年第2期42卷 200-212页

作者： zhu changle FENG Cuiling FENG Feng Yao Xiaoqin WANG Guishu SHI Liangtian ZHENG Jiakun Department of respiration Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100000China Department of traditional Chinese Medicine Peking University People's HospitalBeijing100000China Department of Traditional Chinese Medicine Peking University International HospitalBeijing 100000China

OBJECTIVE:To explore the effect and mechanism of baicalin in the treatment of acute lung injury(ALI)by in vivo and in vitro experiments.METHODS:ALI was induced by instilling 10 mg/m L lipopolysaccharide(LPS)into the airway of rats.Different doses of baicalin(50 and 100 mg·kg^(-1)·d^(-1 ))were administered by gavage one day before modeling.RESULTS:Baicalin significantly reduced the permeability of the alveolocapillary membrane,alleviated tissue injury and inflammatory infiltration,and inhibited the secretion of inflammatory factors and the infiltration of neutrophils.The decline in these inflammations was related to the inhibition of the toll like receptor-4(TLR4)/myeloid differentiation factor 88(My D88)/nuclear factor-kappa B(NF-κB)/nod-like receptor pyrin containing 3(NLRP3)signaling pathway and the mitogen-activated protein kinase(MAPK)signaling pathway.CONCLUSIONS:Baicalin inhibits the secretion of inflammatory factors by inhibiting the TLR4-My D88-NF-κB/NLRP3 pathway and the MAPK signaling pathway.Thus,it reduces lung bronchial epithelial layer,alveolar damage,and pulmonary edema as detected in the in vivo and in vitro experiments.Therefore,baicalin may be a potential preventive and therapeutic drug for ALI.

关键词： baicalin acute lung injury epithelial cells lipopolysaccharides inflammation

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Effect of spleen-invigorating, Qi-replenishing and blood-arresting formula on zebrafish models with simvastatin-induced hemorrhage caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2018年第3期38卷 399-405页

作者： Gao Chong Wang Jun Wang Jia zhu Xiaoyu zhu changle Guo Shengya Wang Chong Fan Qiuyue Zhang Jianuo Xia Bo Chen Xinyi Department of Oncology and Hematology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Department of Hematology the First Affiliated Hospital of Zhejiang Chinese Medicine University Technical service Department Hangzhou Huan Te Biotech Company Ltd.

OBJECTIVE: To investigate the hemostasis effect of spleen-invigorating, Qi-replenishing and blood-arresting formula, on a zebrafish models with simvastatin-induced hemorrhage, and with symptom pattern caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine(TCM).METHODS: In the first experiment, 60 AB strain wild type zebrafishes were randomly assigned into two groups: normal group and model group. The model group was treated with 50 μM simvastatinfor 24 h. The second experiment: The melanin allele mutated Albino strain zebrafishes were divided into normal, model, A group and B group. The observational parameters were as follows: blood flow, velocity of movement, hemorrhage ratio and improvement ratio of hemorrhage.RESULTS: Hemorrhage ratio: in the first experiment, brain hemorrhage ratio was 75%. In the second experiment, heart hemorrhage ratio was 65%.Blood flow: compared with the normal group,there was a significantly decrease in the model group(P < 0.001). Velocity of movement: in the first experimental, compared with the normal group,there was a significantly decrease in the model group(P < 0.001). Improvement ratio of hemorrhage: agents A had little effect in heart hemorrhage of the zebrafish; agents B could reduce heart hemorrhage ratio of the zebrafish, and increase the improvement ratio of hemorrhage.CONCLUSION: The manifestation of zebrafish model with simvastatin-induced hemorrhage is basically similar to that of the clinical symptom pattern caused by spleen's failure to control blood. The Spleen-invigorating, Qi-replenishing and Blood-arresting Formula can reduce the heart hemorrhage ratio of zebrafish induced by simvastatin, and increase the Improvement ratio of hemorrhage.

关键词： Simvastatin Hemorrhage Spleen fail-ure governing blood Reinforcing Qi strengthening spleen Reinforcing Qi arresting bleeding Zebrafish

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Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of Vehicles

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Engineering 2024年第2期33卷 178-189页

作者： Xiaoming Yuan Jiahui Chen Ning Zhang Qiang(John)Ye changle Li Chunsheng zhu Xuemin Sherman Shen Qinhuangdao Branch Campus Northeastern UniversityQinhuangdao 066004China State Key Laboratory of Integrated Services Networks&the Research Institute of Smart Transportation Xidian UniversityXi’an 710071China Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4Canada Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada SUSTech Institute of Future Networks Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada

High-efficiency and low-cost knowledge sharing can improve the decision-making ability of autonomous vehicles by mining knowledge from the Internet of Vehicles(IoVs).However,it is challenging to ensure high efficiency of local data learning models while preventing privacy leakage in a high mobility environment.In order to protect data privacy and improve data learning efficiency in knowledge sharing,we propose an asynchronous federated broad learning(FBL)framework that integrates broad learning(BL)into federated learning(FL).In FBL,we design a broad fully connected model(BFCM)as a local model for training client data.To enhance the wireless channel quality for knowledge sharing and reduce the communication and computation cost of participating clients,we construct a joint resource allocation and reconfigurable intelligent surface(RIS)configuration optimization framework for FBL.The problem is decoupled into two convex subproblems.Aiming to improve the resource scheduling efficiency in FBL,a double Davidon–Fletcher–Powell(DDFP)algorithm is presented to solve the time slot allocation and RIS configuration problem.Based on the results of resource scheduling,we design a reward-allocation algorithm based on federated incentive learning(FIL)in FBL to compensate clients for their costs.The simulation results show that the proposed FBL framework achieves better performance than the comparison models in terms of efficiency,accuracy,and cost for knowledge sharing in the IoV.

关键词： Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces Resource allocation

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Roles of three classic TCM formulae in inhibiting gastric cancer growth in mice

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Journal of Traditional Chinese Medical Sciences 2017年第1期4卷 65-70页

作者： Liyun Yue changle zhu Chong Gao Chong Wang Xinyi Chen Tongde Tian Department of Hematology and Oncology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Integrated TCM&Western Medicine Department Henan Cancer HospitalZhengzhou 450000China

Objective:To explore the effects of three classic traditional Chinese medicine (TCM) formulae,Dahuang Huanglian Xiexin Decoction (DHXD),Fuzi Lizhong pills (FLP) and Liushen pills (LSP),in suppressing gastric cancer growth in mice and provide evidence for their clinical applications.Methods:MGC-803 cells (5 × 106 per mouse) were injected into the subcutaneous tissues of the neck and back of nude mice.One week later,the mice were divided into three batches (9 total groups) based on tumor size and a random number table.Within each batch,the mice were subdivided into control,low-and high-dose groups for the three classic formulae.After 21-d treatment,the mice were observed for their general conditions,and then sacrificed.Tumor tissues were harvested and weighed,and the tumor inhibition rate was calculated.Results:Compared with the control group,body weight in the low-and high-dose DHXD and FLP groups showed no significant change (P >.05),while the high-dose LSP group had significantly lower body weight (P =.049).Compared with the control group,the low-and high-dose DHXD groups showed no significant inhibitory effect on xenograft tumor growth (P >.05);lowdose FLP showed an inhibitory effect on tumor growth (P =.039),while high-dose LSP had a more significant effect (P =.004).Conclusions:DHXD did not inhibit xenograft tumor growth in mice.In contrast,low-dose FLP had a measurable inhibitory effect,and high-dose LSP more significantly suppressed xenograft tumor growth in mice.

关键词： Dahuang Huanglian Xiexin Decoction Fuzi Lizhong pills Liushen pills Gastric cancer Tumor inhibition rate

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稀土元素铈钕共掺氧化锌对降解罗丹明B光催化性能的影响

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无机盐工业 2022年第10期54卷 155-162页

作者：管志远张晓伟王觅堂张栋梁朱昌乐上海理工大学材料与化学学院上海200093

采用水热合成法制备纳米级半导体光催化材料,镧系元素是理想的金属掺杂剂,因为其独特的光学性质和未被完全占据的4f轨道,所以掺杂镧系元素可以提高催化剂的活性。最近的研究表明,通过共掺杂两种稀土元素可以更有效地改良光催化剂,不仅... 详细信息

采用水热合成法制备纳米级半导体光催化材料,镧系元素是理想的金属掺杂剂,因为其独特的光学性质和未被完全占据的4f轨道,所以掺杂镧系元素可以提高催化剂的活性。最近的研究表明,通过共掺杂两种稀土元素可以更有效地改良光催化剂,不仅可以通过协同效应有效提高催化剂的光吸收能力,同时也对光生载流子的复合产生了抑制。实验采用铈、钕两种镧系元素共掺杂制备改性半导体氧化锌光催化材料。通过XRD、SEM、XPS、EDS、BET、UV-vis和PL对制备的光催化材料进行分析与表征,得到了带隙更窄、比表面积更大、晶粒尺寸更小的高性能改性光催化材料。将其应用在降解废水中罗丹明B实验中,结果表明,2%Ce5.5%Nd掺杂配比的氧化锌在40 min时降解率达到92.2%,60 min时降解率达到98.3%,整体催化性能较单掺杂铈与单掺杂钕相比有了很大的提高。总结分析稀土金属铈、钕共掺杂提高氧化锌光催化性能的原因包括:氧化锌晶格的畸变、杂质能级的产生及稀土离子价态的影响、形貌及比表面积的影响、禁带宽度及稀土离子氧化还原对的产生等。

关键词：氧化锌光催化共掺杂稀土金属铈与钕罗丹明B

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新型竖缝互锁灌孔复合砌块墙体抗压及抗震性能试验研究

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震灾防御技术 2024年第1期19卷 24-36页

作者：徐笠畅李铮翔夏多田朱楚翔周长乐石河子大学水利建筑工程学院新疆石河子832003

新型竖缝互锁灌孔复合砌块墙体是一种绿色、环保且低碳的新型砌体结构,为研究其抗压性能与抗震性能,分别对墙体进行轴压试验与拟静力试验,分析灌孔方式与构造柱类型对该墙体抗压承载力、荷载分配与变形协调等方面的影响,以及不同构造柱... 详细信息

新型竖缝互锁灌孔复合砌块墙体是一种绿色、环保且低碳的新型砌体结构,为研究其抗压性能与抗震性能,分别对墙体进行轴压试验与拟静力试验,分析灌孔方式与构造柱类型对该墙体抗压承载力、荷载分配与变形协调等方面的影响,以及不同构造柱类型对墙体抗震性能的影响。结果表明,随着现浇构造柱与复合砌体部分强度差的减小,墙体整体变形协调能力有所提升;提出了适用于设置构造柱的新型墙体的抗压承载力计算公式,计算值与试验值吻合度较好;芯柱构造柱对墙体延性的提升效率高于现浇构造柱墙体,而现浇构造柱墙体的抗震承载力、极限位移等指标优于芯柱构造柱墙体。研发绿色、环保、低碳的新型砌体结构是助力国家乡村振兴战略和改善村镇建筑抗灾能力的有效途径,该新型墙体结构为新疆地区村镇建筑提供了一种新的选择。

关键词：灌孔复合砌块墙体竖缝互锁构造柱变形协调抗震性能

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浅析高校帮困助学工作与贫困学生心理干预

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科教导刊 2013年第19期 229-230,238页

作者：朱长乐四川省幼儿师范高等专科学校四川江油621709

帮困助学一直以来都是高校学生工作中的重要组成部分。随着近年来高校招生规模的扩大,贫困学生群体在高校中越来越突出,给帮困助学工作带来新的挑战。一部分贫困学生表现相当出色,但也有一部分学生由于家庭贫困造成了心理失衡,使他们成... 详细信息

帮困助学一直以来都是高校学生工作中的重要组成部分。随着近年来高校招生规模的扩大,贫困学生群体在高校中越来越突出,给帮困助学工作带来新的挑战。一部分贫困学生表现相当出色,但也有一部分学生由于家庭贫困造成了心理失衡,使他们成为心理上的弱势群体。因此高校帮困助学工作不应止步于从经济上予以资助,还应在心理上多给予关心和援助,并建立有效的心理危机应对机制。本文将结合高校帮困助学工作实践,对贫困学生的心理干预进行分析和研究。

关键词：帮困助学高校贫困学生心理干预

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黄芪注射液载入修饰胶原促进血管再生的研究

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中国中药杂志 2009年第4期34卷 464-467页

作者：严士海朱萱萱陈晓虎李七一龚韧姚昶朱长乐江苏省中医院江苏南京210029

目的:将黄芪载入胶原支架内,通过对胶原支架进行修饰,观察黄芪是否具有促血管生成活性及探讨可能的生物学机制。方法:将5,10μL黄芪注射液载入修饰后的胶原内,通过鸡胚绒毛尿囊膜(CAM,Chicken Chorioallantoic Membrane)实验模型,从胶... 详细信息

目的:将黄芪载入胶原支架内,通过对胶原支架进行修饰,观察黄芪是否具有促血管生成活性及探讨可能的生物学机制。方法:将5,10μL黄芪注射液载入修饰后的胶原内,通过鸡胚绒毛尿囊膜(CAM,Chicken Chorioallantoic Membrane)实验模型,从胶原周围微血管再生数量、胶原内血红蛋白含量、胶原干重、CD34抗原免疫组化标记等指标来考察黄芪注射液对肝素修饰后胶原促血管再生的作用。结果:黄芪联合肝素修饰后的胶原能够产生与血管内皮生长因子相当的疗效,血管计数、胶原血红蛋白含量、CD34的表达均显著性增加(P<0.01,与单纯胶原组比较);与单纯胶原组相比,胶原+黄芪10ul组胶原干重显著增加(P<0.05)。结论:黄芪注射液载入修饰后的胶原具有良好的促血管再生作用。

关键词：黄芪胶原血管生成

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Heterogeneousα-Diimine Nickel Catalysts with Improved Catalytic Performance in Ethylene Polymerization

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Chinese Journal of Chemistry 2023年第10期41卷 1155-1162页

作者： Zhanshan Ma Mengli Xu Ningning zhu Chen Tan changle Chen CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationKey Laboratory of Environment-Friendly Polymeric Materials of Anhui ProvinceAnhui UniversityHefeiAnhui 230601China

Heterogenization can improve the thermal tolerance of olefin polymerization catalysts and result in good product morphology con-trol,which are two important parameters for industrial polyethylene production.In this work,α-diimine nickel catalysts bearing-OH or-ONa anchoring groups were designed and prepared.The anchoring groups can enable facile heterogenization of the cata-lysts on silica.The heterogeneous catalysts demonstrated enhanced thermal stabilities,along with high catalytic activity at 120℃(up to 5.5×10^(6)g·PE·mol·Ni^(-1)·h^(-1)).Furthermore,the heterogenization process results in the improvements of many other parame-ters,including polymer morphology control,catalytic activity(up to 1.9×10^(7)g·PE·mol·Ni^(-1)·h^(-1))and polyethylene molecular weight(Mn up to 2.3×10^(6)g·mol^(-1)).More importantly,the structure and properties of the polymer products can be controlled by catalyst structures,polymerization conditions and heterogenization to achieve good mechanical properties and elasticity.

关键词： Ethylene polymerization Mechanical properties Nickel Supported catalysts Heterogeneous catalysis Polymerization Morphology

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旋转磁场对Sn-Bi合金凝固组织的影响

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特种铸造及有色合金 2008年第6期28卷 453-456页

作者：朱建华陈长乐陈钊西北工业大学理学院应用物理系

研究了Sn-Bi合金在不同凝固阶段施加旋转磁场对凝固组织的影响,分析了旋转磁场对各凝固组织的影响规律及细化作用。试验结果表明,对于Sn-55Bi亚共晶合金,旋转磁场对组织的影响主要是在初生相生成时产生的,所以β相处理效果接近于全程处... 详细信息

研究了Sn-Bi合金在不同凝固阶段施加旋转磁场对凝固组织的影响,分析了旋转磁场对各凝固组织的影响规律及细化作用。试验结果表明,对于Sn-55Bi亚共晶合金,旋转磁场对组织的影响主要是在初生相生成时产生的,所以β相处理效果接近于全程处理,初生Sn相被球化,呈颗粒状均匀分布在基体上;对于常规条件下重力偏析严重的Sn-65Bi过共晶合金,某个阶段的处理不能消除重力偏析,只有全程处理才能完全消除偏析,得到分布均匀的组织。

关键词：旋转磁场Sn-Bi合金凝固阶段枝晶碎断重力偏析

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