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Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li wei-Hong zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu zong-Lin Li Xue-Feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Parallel naive Bayes algorithm for large-scale Chinese text classification based on spark

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Journal of Central South University 2019年第1期26卷 1-12页

作者： LIU Peng ZHAO Hui-han TENG Jia-yu YANG Yan-yan LIU Ya-feng zhu zong-wei Internet of Things Perception Mine Research Centre China University of Mining and Technology National and Local Joint Engineering Laboratory of Internet Application Technology on Mine School of Information and Control Engineering China University of Mining and Technology Communication Division NARI Technology Co. Ltd. Suzhou Institute of University of Science and Technology of China

The sharp increase of the amount of Internet Chinese text data has significantly prolonged the processing time of classification on these *** order to solve this problem,this paper proposes and implements a parallel naive Bayes algorithm(PNBA)for Chinese text classification based on Spark,a parallel memory computing platform for big *** algorithm has implemented parallel operation throughout the entire training and prediction process of naive Bayes classifier mainly by adopting the programming model of resilient distributed datasets(RDD).For comparison,a PNBA based on Hadoop is also *** test results show that in the same computing environment and for the same text sets,the Spark PNBA is obviously superior to the Hadoop PNBA in terms of key indicators such as speedup ratio and ***,Spark-based parallel algorithms can better meet the requirement of large-scale Chinese text data mining.

关键词： Chinese text classification naive Bayes spark hadoop resilient distributed dataset parallelization

具有衰退记忆的非自治弱耗散抽象发展方程的一致吸引子

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西北师范大学学报（自然科学版） 2014年第6期50卷 5-10,76页

作者：汪璇朱宗伟西北师范大学数学与统计学院甘肃兰州730070

研究具有衰退记忆的非自治弱耗散抽象发展方程的长时间动力学行为,其中外力项f(x,t)仅满足条件(C*).当忽略粘性阻尼项时,证明了一致吸引子在空间Vθ×H×Lθμ(R+;Vθ)中的存在性.

关键词：非自治弱耗散抽象发展方程记忆核一致吸引子一致条件(C)

Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU wei zhu Di LI Xing HU Liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Refined Rhubarb Tablets in the Treatment of Acute Hemorrhaging of the Upper Digestive Tract

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Chinese Journal of Integrative Medicine 1995年第1期1卷 100-103页

作者： Jiao Dong-hai(焦东海) zhu zong-wei (朱宗巍) Gan Zi-cheng (甘自成) Ge Guo-zheng (葛国政) Hua Bao-fen Gao Ya-ping (高雅萍) and Shen Xue-min (沈学敏) (Xiangshan Hospital of Traditional Chinese Medicine, Shanghai )(200020) Xiangshan Hospital of Traditional Chinese Medicine Shanghai

Refined rhubarb tablets were used to treat 182 cases of acute hemorrhaging of the upperdigestive tract with a total effective rate of 96. 1 % and an average hemostatic time ot 2. 8 days. Prospec-tive and double blind comparative studies of the drug revealed that it had a rernarkably higher hemostaticeffect than compound western medicines (P<0. 01) and was superior to crude rhubarb, which usuallycaused nausea and vomiting and had unstable therapeutic effects- Acute and subacute toxicity determina-tions. genetic toxicologic tests, as well as determinations of various indexes ot blood vessels, *** rheology, platelets, bleeding and blood coagulation factors were done, suggesting that refinedrhubarb tablets were nontoxic. safe and effective in local hemostasis and general hemodilution-likehemostasis.

关键词： refined rhubarb tablets acute hemorrhaging of upper digestive tract hemostasis,hemostatic time

Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin XU Chenchen DENG Jianfeng zhu Yao WANG Shaojun wei Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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论昆曲的传承发展与人才培养

浙江艺术职业学院学报 2007年第2期5卷 25-31页

作者：朱为总浙江昆剧团

本文以当代中国昆曲传承发展的现状为背景,就昆曲传承创新与当代生存的意义,及昆曲人才培养的迫切性、重要性等进行了叙述和辨析。提出了对民族文化传统的珍惜和保护,是人类文明进步的标志,继承的本身就意味着是一种发展和鼎新。而优秀... 详细信息

本文以当代中国昆曲传承发展的现状为背景,就昆曲传承创新与当代生存的意义,及昆曲人才培养的迫切性、重要性等进行了叙述和辨析。提出了对民族文化传统的珍惜和保护,是人类文明进步的标志,继承的本身就意味着是一种发展和鼎新。而优秀人才的培养和涌现,才真正是这一民族艺术绵延不绝、生生不息的保证和关键。

关键词：昆曲口传心授世界文化遗产传承发展人才培养

数学化思想及其在数学问题解决教学中的应用分析

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数学教育学报 2010年第1期19卷 20-22,102页

作者：孙雪梅朱维宗曲靖师范学院数学与信息科学学院云南曲靖655011 云南师范大学数学学院云南昆明650092

＂数学化＂思想是数学教学的主要形式,它可分为4个不同层次：情境层次、指涉层次、普遍层次及形式层次.问题解决是数学化的目的和原动力,并且为数学化提供方向和目标.只有经过数学化,问题的解决才能成为可能,没有数学化,实际问题将处于... 详细信息

＂数学化＂思想是数学教学的主要形式,它可分为4个不同层次：情境层次、指涉层次、普遍层次及形式层次.问题解决是数学化的目的和原动力,并且为数学化提供方向和目标.只有经过数学化,问题的解决才能成为可能,没有数学化,实际问题将处于一种模糊状态,无法定量的表达它,更不可能去认识它、解决它.问题解决的过程就是数学化的过程,学习者以问题为基础,通过数学化来实现问题的解决.同时在问题解决的过程中,再创造＂自己的＂数学知识,从而实现数学化.

关键词：数学化数学化层次问题解决教学