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Identifying the Static and Dynamic Relationships Between Rural Population and Settlements in Jiangsu Province, China

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Chinese Geographical Science 2020年第5期30卷 810-823页

作者： ZHU ZhiQing KONG Xuesong LI Yajing School of Resource and Environmental Sciences Wuhan UniversityWuhan 430079China Key Laboratory of Geographic In-formation System Ministry of EducationWuhan UniversityWuhan 430079China

Rapid urbanization has triggered large rural population floating into cities, which in turn affects rural human-land relationships. The actual human-land relationship involves the coupling level of a time point and dynamic change of a time interval. However, few studies have identified the rural human-land relationship from these two perspectives. This study combined static coupling analysis with a dynamic decoupling model to analyze the relationships between rural population and settlements from 2009 to 2018 in Jiangsu Province, China. Although the static coupling degree in Jiangsu Province was relatively high, the decoupling analysis found that the rural human-land relationship in most counties was uncoordinated. There were 11 combination types based on the coupling and decoupling relationships. The most common two types(accounting for 76.74%) were recession decoupling with high-level coupling and strong decoupling with high-level coupling. Although the majority of counties had a high-level coupling degree, an uncoordinated change in rural population and rural settlements was observed in these counties. Counties with relatively reasonable human-land relationships accounted for only 12.79% of the total. The combination features for each type were identified and differential policies were proposed for optimizing human-land relationship in rural areas. This study would contribute to our understanding of the multiple relationships between rural population and settlements involved in different patterns and processes, and expect to provide theoretical and methodological support for promoting rural revitalization and sustainable development in practice.

关键词： rural settlements population human-land relationship coupling and decoupling rural revitalization

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Recent insights for the emerging COVID-19:Drug discovery,therapeutic options and vaccine development

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 4-23页

作者： Yuefei zhu Jia Li zhiqing Pang Department of Biomedical Engineering Columbia UniversityNew York 10027USA Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Biomedical Sciences Faculty of MedicineHealth and Human SciencesMacquarie UniversitySydney NSW 2109Australia

SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population,causing over 5.5 million confirmed cases worldwide.As COVID-19 has posed a global threat with significant human casualties and severe economic losses,there is a pressing demand to further understand the current situation and develop rational strategies to contain the drastic spread of the virus.Although there are no specific antiviral therapies that have proven effective in randomized clinical trials,currently,the rapid detection technology along with several promising therapeutics for COVID-19 have mitigated its drastic transmission.Besides,global institutions and corporations have commenced to parse out effective vaccines for the prevention of COVID-19.Herein,the present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for COVID-19 as well as some insightful discussions of the status of COVID-19.

关键词： Coronavirus COVID-19 SARS-CoV-2 Precise prevention and control Drug discovery Vaccine development

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Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4235-4248页

作者： Chunying Liu Shuangrong Ruan Ying He Xuejing Li Yuefei zhu Honglan Wang Hanwei Huang zhiqing Pang School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China The Institute for Biomedical Engineering&Nano Science Tongji University School of MedicineShanghai 200092China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China

Anti virulence strategy has been considered as one of the most promising approaches to combat drug-rcesistant bacterial infections.Porc-forming toxins(PFTs)are the largest class of bacterial toxins,inficting their virulence ffect through creating pores on the cell membrane.However,curent solutions for eliminating PFTs are mostly designed based on their molecular structure,requiring customized design for different interactions.In the present study,we employed erythroliposome(denoted as RM-PL),a biomimetic platform constructed by artificial lipid membranes and natural erythrocyle membranes,to necutralize different hemolytic PFTs regardless of their molecular structure.When tested with model PFTs,including a-hemolysin,listeriolysin O,and streptolysin O,RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent manner.In vivo studies further confirmed that RM-PL.could eficiently neuralize various toxins and save animals'lives without causing damage to 0rgans or tissues.In addition,we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in lysosomes.In summary,the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mech-anism of lysosome-mediaed loxin degradation.

关键词： Eythroliposome Broad-spectrum detoxifcation Hybrid nanovesicle Pore-forming toxins Macrophage uptake Red blood cell membrane Atificial lipid membrane

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Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2054-2074页

作者： Yuefei zhu Xiangrong Yu Soracha D.Thamphiwatana Ying Zheng zhiqing Pang Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Key Laboratory of Smart Drug Delivery School of PharmacyFudan UniversityMinistry of EducationShanghai 201203China Department of Medical Imaging Zhuhai People’s HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China Department of Biomedical Engineering Faculty of EngineeringMahidol UniversityNakhon Pathom 73170Thailand State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

Cancer immunotherapy has veered the paradigm of cancer treatment.Despite recent advances in immunotherapy for improved antitumor efficacy,the complicated tumor microenvironment(TME)is highly immunosuppressive,yielding both astounding and unsatisfactory clinical successes.In this regard,clinical outcomes of currently available immunotherapy are confined to the varied immune systems owing in large part to the lack of understanding of the complexity and diversity of the immune context of the TME.Various advanced designs of nanomedicines could still not fully surmount the delivery barriers of the TME.The immunosuppressive TME may even dampen the efficacy of antitumor immunity.Recently,some nanotechnology-related strategies have been inaugurated to modulate the immunosuppressive cells within the tumor immune microenvironment(TIME)for robust immunotherapeutic responses.In this review,we will highlight the current understanding of the immunosuppressive TIME and identify disparate subclasses of TIME that possess an impact on immunotherapy,especially those unique classes associated with the immunosuppressive effect.The immunoregulatory cell types inside the immunosuppressive TIME will be delineated along with the existing and potential approaches for immunosuppressive cell modulation.After introducing the various strategies,we will ultimately outline both the novel therapeutic targets and the potential issues that affect the efficacy of TIME-based nanomedicines.

关键词： Cancer immunotherapy Nanomedicine Tumor immunosuppressive microenvironment Drug delivery

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Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3427-3447页

作者： Longlong Zhang Yuefei zhu Xunbin Wei Xing Chen Yang Li Ying zhu Jiaxuan Xia Yiheng Huang Yongzhuo Huang Jianxin Wang zhiqing Pang Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationShanghai 201203China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteMed-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Institute of Materia Medica Academy of Chinese and Western Integrative MedicineFudan UniversityShanghai 201203China

Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes by fusing platelet membranes with lipid membranes(P-Lipo) to restrain metastatic tumor formation more efficiently. It was shown nanoplateletsomes bound with circulating tumor cells(CTC)efficiently, interfered with CTC arrest by vessel endothelial cells, CTC extravasation through endothelial layers, and epithelial-mesenchymal transition of tumor cells as nanodecoys. More importantly, in the mouse breast tumor metastasis model, nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape. Therefore, nanoplatelesomes might usher in a new avenue to suppress lung metastasis.

关键词： Nanoplateletsome Breast cancer Tumor metastasis Circulating tumor cells Nanodecoy Immunosuppressive micrometastatic environment Lung pre-metastasis

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Strong interface contact between NaYF_(4):Yb,Er and CdS promoting photocatalytic hydrogen evolution of NaYF_(4):Yb,Er/CdS composites

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Journal of Materials Science & Technology 2022年第7期102卷 1-1,2-7页

作者： Huaze zhu Yongqiang Yang Yuyang Kang Ping Niu Xiangdong Kang zhiqing Yang Hengqiang Ye Gang Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110819China Jihua Laboratory Foshan 528000China

To acquire efficient photocatalysts,it is necessary to make effective use of visible light/Near Infrared(NIR)light,which takes up a large percentage of sunlight.Integrating upconversion materials with visible light active photocatalysts has attracted much attention in this regard.The interface contact between upcon-version material and photocatalyst has potential influence on the properties and thus the performance of the system.In this work,NaYF_(4):Yb,Er/CdS composites of the upconversion material NaYF_(4):Yb,Er nanorods and CdS nanoparticles were synthesized by ion adsorption/precipitation process and were then annealed in an argon atmosphere at different temperatures to modulate the microstructures.The annealing pro-cess endows the crystal transformation of cubic CdS with low crystallinity to hexagonal CdS with high crystallinity and,importantly,good interface contact between NaYF_(4):Yb,Er and CdS.Consequently,the hy-drogen evolution activity greatly increases from 171 to 2539μmol h^(−1) g^(−1) under the light irradiation ofλ>400 nm,and from 0 to 19μmol h^(−1) g^(−1) under the light irradiation ofλ>600 nm.This work might provide a useful reference for the rational design of promising photocatalyst involving upconversion ma-terials.

关键词： NaYF_(4):Yb Er CdS Upconversion Photocatalytic Composite

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P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis

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Neural Regeneration Research 2024年第5期19卷 1078-1083页

作者： zhiqing Yang Zhenchao Wang Xiaoqi Deng Lingxin zhu Zhaomeng Song Changyu Cao Xinran Li School of Life Science and Engineering Foshan UniversityFoshanGuangdong ProvinceChina Foshan University Veterinary Teaching Hospital FoshanGuangdong ProvinceChina

Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain.3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine(P7C3-A20)can be neuroprotective in various diseases,including ischemic stroke and neurodegenerative diseases.However,whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are unclear.Therefore,in the present study,we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular mechanisms.We established a traumatic brain injury rat model using a modified weight drop method.P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain injury.Severe neurological deficits were found in rats after traumatic brain injury,with deterioration in balance,walking function,and learning memory.Furthermore,hematoxylin and eosin staining showed significant neuronal cell damage,while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of apoptosis.The presence of autolysosomes was observed using transmission electron microscope.P7C3-A20 treatment reversed these pathological features.Western blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ)autophagy protein,apoptosis-related proteins(namely,Bcl-2/adenovirus E1B 19-kDa-interacting protein 3[BNIP3],and Bcl-2 associated x protein[Bax]),and elevated ubiquitin-binding protein p62(p62)autophagy protein expression.Thus,P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis.

关键词： apoptosis autophagy cortex hippocampus motor function P7C3-A20 traumatic brain injury

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Nanoplateletsomes for rapid hemostasis performance

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Chinese Chemical Letters 2022年第6期33卷 2937-2941页

作者： Honglan Wang Yuefei zhu Longlong Zhang Huiwen Liu Chunying Liu Bo Zhang Yanan Song Yu Hu zhiqing Pang Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027United States

Uncontrollable hemorrhage remains staple trouble in surgical procedures and a leading cause after major trauma.The bleeding issue may trigger various pathologic scenarios that can lead to tissue morbidities and mortalities,and currently available on-site hemostatic agents are confined to a narrow therapeutic index and may carry the risk of immunogenicity.Inspired by the crucial role of platelets in the process of thrombus,a platelet-mimetic plateletsome with wound targeting and blood coagulation properties is developed for hemorrhage control.Plateletsome is formulated by integrating platelet membranes with functionalized synthetic liposomes and exhibits superior wound targeting and effective hemostasis properties.It presents less blood loss and shorter hemostasis time than the platelet membrane vehicles or the conventional liposomes in the mouse tail transection model.The strong homing of the biomimetic plateletsome to the thrombus was also confirmed,demonstrating the potential of this engineered cell membrane vesicle as a biomimetic hemostat for bleeding treatment.

关键词： Hemostasis Plateletsome Biomimetic Hemorrhage Thrombus targeting

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Perfluorooctyl bromide nanoemulsions holding MnO_(2) nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death

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Acta Pharmaceutica Sinica B 2022年第2期12卷 967-981页

作者： Xinping Kuai Yuefei zhu Zheng Yuan Shengyu Wang Lin Lin Xiaodan Ye Yiping Lu Yu Luo zhiqing Pang Daoying Geng Bo Yin Department of Radiology Huashan HospitalFudan UniversityShanghai 200040China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Department of Radiology Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 201800China Department of Radiology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of High Performance Ceramics and Superfine Microstructure School of Chemical Science and EngineeringShanghai 200092China

Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However,existing platforms suffer from low efficacy,inability to induce strong immunogenic cell death(ICD),and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones.Here,an innovative platform,perfluorooctyl bromide(PFOB)nanoemulsions holding MnO_(2) nanoparticles(MBP),was developed to orchestrate cancer immunotherapy,serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD.By simultaneously depleting the GSH and eliciting the ICD effect via highintensity focused ultrasound(HIFU)therapy,the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells(DCs)and facilitating the activation of CD8^(+)and CD4^(+)T cells.The synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung metastasis.Together,these findings inaugurate a new strategy of tumor-targeted immunotherapy,realizing a novel therapeutics paradigm with great clinical significance.

关键词： Immunogenic cell death Nanoemulsions Manganese dioxide nanoparticles Glutathione depletion Dual-modality imaging High-intensity focused ultrasound Tumor microenvironment

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Large-area surface-enhanced Raman scattering-active substrates fabricated by femtosecond laser ablation

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Science China(Physics,Mechanics & Astronomy) 2013年第9期56卷 1806-1809页

作者： ZHU ZhiQing YAN ZhenDong ZHAN Peng WANG ZhenLin School of Physics and National Laboratory of Solid State Microstructures Nanjing University

A rapid and simple approach to fabricate large-area surface-enhanced Raman scattering-active(SERS-active) substrates is reported.The substrates are fabricated by using femtosecond laser(fs-laser) direct writing on Silicon wafers,followed by thin-film coating of metal such as gold.The substrates are demonstrated to exhibit signal homogeneity and good enhancement ability for SERS.The maximum enhancement factor(EF) up to 3×10 7 of such SERS substrates for rhodamine 6G(R6G) at 785 nm excitation wavelength was measured.This technique could demonstrate a functional microchip with SERS capability of signal homogeneity,high sensitivity and chemical stability.

关键词：表面增强拉曼散射 SERS活性飞秒激光激光烧蚀面积基底制备罗丹明6G

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