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Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei wang Qingfeng Zou Xiaodong zhu Qin Lin Yi Jiang Yan Sun Liangfang Shen Lin wang Guorong Zou xiaoyan Lin Shaojun Lin Minying Li Ying wang Ruilian Xu Rui Ao Rensheng wang Haifeng Lin Shuang Huang Tingting Xu Wenting Li Mengying Xia Yu Xia Zhongmin wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in china enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

HF-VHF NEMS resonators enabled by 2D semiconductor ReSe

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Science china(Information Sciences) 2024年

作者： Jie TANG Ziluo SU Shuang CAI Yalan wang Luming wang Jiaqi WU Jiaze QIN Jiankai zhu Bo XU Juan XIA Zenghui wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China State key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences State key laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China

Two-dimensional （2D） semiconductors offer a plethora of new opportunities for constructing novel *** them, rhenium diselenide (ReSe2, crystal structure in Figure 1（a）) stands out due to its unique interlayer coupling, which can improve homogeneity in device performances when combined with wafer scale growth. It has since been employed to realize 2D laser, transistor, and photodetector. However, unlike the optical and electrical degrees of freedom, its mechanical degree of freedom has remained unexplored to date, undermining its potential in sensing,signal processing, and computing by building novel nanoelectromechanical systems （NEMS）[1, 2].

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从固定到可变:情感对认知影响的再认识

心理科学 2018年第2期41卷 285-291页

作者：方平马焱王雷朱文龙首都师范大学心理学院北京100048 北京师范大学心理学部北京100875

情感-认知领域的最新研究发现,已有研究通常认为的积极和消极情感对认知加工的固定影响,会在某些条件下发生反转。这致使情感-认知联系的固定观受到挑战,而情感-认知反馈假说(AACF)的出现则从联系可变的视角上为上述冲突提供了有效的解... 详细信息

情感-认知领域的最新研究发现,已有研究通常认为的积极和消极情感对认知加工的固定影响,会在某些条件下发生反转。这致使情感-认知联系的固定观受到挑战,而情感-认知反馈假说(AACF)的出现则从联系可变的视角上为上述冲突提供了有效的解释。该假说认为,情感对认知之所以存在可变影响,其关键在于个体具备认知加工的预先准备状态,即可通达策略的存在。后续研究围绕众多认知现象,验证并支持了AACF的观点。针对这一理论构想,未来研究还应结合对概念本质的哲学反思以及不同视角的实证研究,对情感与认知的内在关系进行更为深入的探索。

关键词：情感心境情绪情感-认知反馈假说认知加工方式可通达性

HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science china(Physics,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing Jie wang Chen Xu Ziming Liu Qingze Chen Tiantian Liang Jinlong Xu Yixian Cao Jing wang Huijie Hu Chuan-Peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS key laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth Sciences Guilin University of TechnologyGuilin 541004China Department of Physics Anhui Normal UniversityWuhu 241002China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China key laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 19 beams were only slightly(~5%)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1 and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1)is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

帧同步混合小波包变换快速算法及其在语音处理中的应用

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数据采集与处理 2002年第3期17卷 256-259页

作者：王炜朱学文杨道淳牟峰徐柏龄南京大学近代声学国家重点实验室南京210093

帧同步的小波包快速算法是一种类似 FFT的小波变换算法。本文提出帧同步混合小波包的分析方法 ,其特点是在发挥小波变换的时频分析特点的同时 ,分析时窗能够满足语音处理中帧长的要求 ,从而可以实现实时处理。这种混合小波包具有完全重... 详细信息

帧同步的小波包快速算法是一种类似 FFT的小波变换算法。本文提出帧同步混合小波包的分析方法 ,其特点是在发挥小波变换的时频分析特点的同时 ,分析时窗能够满足语音处理中帧长的要求 ,从而可以实现实时处理。这种混合小波包具有完全重构特性。文中用实验对比表明了帧同步混合小波包分析的优越特性。

关键词：帧同步混合小波变换快速算法语音处理语音分析语音信号处理

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局部判别损失无监督域适应方法

计算机工程与科学 2024年第1期46卷 132-141页

作者：王姗姗汪梦竹骆志刚安徽大学计算智能与信号处理教育部重点实验室安徽合肥230039 国防科技大学计算机学院并行与分布计算重点实验室湖南长沙410073

在无监督域适应任务中,源域和目标域的分布不同,源域数据标签已知,但是目标域的数据标签未知。最大平均差异MMD是一种具有代表性的分布度量方法,广泛应用于源域与目标域之间的分布差异度量。然而,MMD度量及其变种方法通常忽略了样本的... 详细信息

在无监督域适应任务中,源域和目标域的分布不同,源域数据标签已知,但是目标域的数据标签未知。最大平均差异MMD是一种具有代表性的分布度量方法,广泛应用于源域与目标域之间的分布差异度量。然而,MMD度量及其变种方法通常忽略了样本的类内紧凑性和类间可分离性,降低了特征表达的可判别性。因此,提出局部判别损失无监督域适应方法,从2个方面提升域适应方法的判别能力:(1)重新设计MMD度量方法的权重,解决类别不均衡问题,使难对齐类别在域间分布上保持一致;(2)探索局部对比损失,平衡正样本对和负样本对之间的关系,从而学习到更好的判别性特征。结合域间损失和类间损失,可使同一类样本靠近,不同类样本之间远离。该方法简单有效,即插即用,可扩展至注意力机制的网络结构上。在多个域适应数据集上,该方法的有效性均得到了验证。

关键词：无监督域适应基于类的最大平均差异局部对比损失注意力机制

基于BERT与细粒度特征提取的数据法学问答系统

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上海师范大学学报（自然科学版中英文） 2024年第2期53卷 211-216页

作者：宋文豪汪洋朱苏磊张倩吴晓燕上海师范大学信息与机电工程学院上海201418 上海交通大学电子信息与电气工程学院上海200240

首先利用bidirectional encoder representations from transformers(BERT)模型的强大的语境理解能力来提取数据法律文本的深层语义特征,然后引入细粒度特征提取层,依照注意力机制,重点关注文本中与数据法律问答相关的关键部分,最后对... 详细信息

首先利用bidirectional encoder representations from transformers(BERT)模型的强大的语境理解能力来提取数据法律文本的深层语义特征,然后引入细粒度特征提取层,依照注意力机制,重点关注文本中与数据法律问答相关的关键部分,最后对所采集的法律问答数据集进行训练和评估.结果显示:与传统的多个单一模型相比,所提出的模型在准确度、精确度、召回率、F1分数等关键性能指标上均有提升,表明该系统能够更有效地理解和回应复杂的数据法学问题,为研究数据法学的专业人士和公众用户提供更高质量的问答服务.

关键词： bidirectional encoder representations from transformers(BERT)模型细粒度特征提取注意力机制自然语言处理(NLP)

A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex

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signal Transduction and Targeted Therapy 2022年第3期7卷 635-637页

作者： Fugang Duan Yifan wang Taoyu Chen zhu zhu Meng Yu Hui Dai Shangen Zheng Yinying Lu Tingting Li xiaoyan Qiu Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China NHC key laboratory of Medical Immunology Peking University Health Science CenterBeijing 100191China key laboratory of Molecular Immunology Chinese Academy of Medical SciencesBeijing 100191China Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing W0191China Department of Transfusion General Hospital of Central Theater Command of the People's Liberation ArmyWuhanHubei 430070China Comprehensive Liver Cancer Center The 5th Medicine Center of PLA General HospitalBeijing 100039China

Dear Editor,COVID-19(Coronavirus Disease 2019)is a disease caused by the single-stranded sense RNA virus SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),which has caused a global public health crisis.1 However,so far no effective serum marker has been found as a biomarker for COVID-19 diagnosis,except that viral nucleic acid detection is an effective evidence of SARS-CoV-2 infection.

关键词： diagnosis acute respiratory

基于L型轮辐结构膜片的窄频光纤F-P声波传感器研究

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仪器仪表学报 2024年第5期45卷 110-117页

作者：王巧云闻妲王纪龙严重越朱子恒东北大学秦皇岛分校秦皇岛066004 河北省微纳精密光学传感与检测技术重点实验室秦皇岛066004

光纤声传感器被广泛应用在工业、医疗等领域。为了提高光纤F-P声传感器的性能,本文提出了一种L型轮辐结构的F-P传感膜片。膜片的厚度为15μm、梁宽度为0.5 mm、中心膜片的半径为1 mm。膜片由激光加工技术在304不锈钢上刻蚀而成。实验对1... 详细信息

光纤声传感器被广泛应用在工业、医疗等领域。为了提高光纤F-P声传感器的性能,本文提出了一种L型轮辐结构的F-P传感膜片。膜片的厚度为15μm、梁宽度为0.5 mm、中心膜片的半径为1 mm。膜片由激光加工技术在304不锈钢上刻蚀而成。实验对1000 Hz下的传感器灵敏度进行研究,将传感器应用于光声池共振频率为1600 Hz的光声光谱气体检测系统中,并实现对50~100×10^(-6)的乙炔(C_(2)H_(2))气体浓度测量。实验结果表明,该传感器在1000 Hz下的声压灵敏度为25.4 nm/Pa,传感器可实现的最小可探测声压(MDP)为38.2μPa/Hz^(1/2)@1 kHz,声压信噪比为76.8 dB。实验所得到的光声光谱二次谐波信号的峰值与乙炔浓度呈现良好的线性关系,乙炔浓度的响应度为1.8 pm/10^(-6)。该传感器在光声光谱等单频声信号检测领域具有广泛的应用前景。

关键词：光纤声传感器 F-P干涉 L型轮辐结构光声光谱