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Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China

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Biomedical and Environmental Sciences 2017年第9期30卷 632-640页

作者： zhu zheng bao HUANGFU Xin Feng ZHONG Chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Department of Epidemiology Tongliao Center for Disease Prevention and Control Department of Neurology Affiliated Hospital of Nantong University

Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease（CVD） and high serum C‐reactive protein（CRP） on the stroke incidence in an Inner Mongolian population in China. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio（HR） of 1.78 [95% confidence interval（CI）, 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14（95% CI, 1.09‐4.20; P = 0.027） of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant（all P 〉 0.05）. Conclusion Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD.

关键词： Family history of cardiovascular disease C‐reactive protein Stroke Prospective study

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论光在博物馆室内陈列设计中的作用

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艺术百家 2006年第4期22卷 176-179页

作者：朱翔朱正宝王剑中国矿业大学艺术与设计学院江苏徐州221008 金螳螂南京第八分公司江苏南京210005

博物馆收藏着人类创造的物质文明,当中透过研究发掘物质遗存的文化精神及历史意义,籍着展示让公众走进历史文明的轨迹。博物馆不仅肩负起教育及传播人类文明的使命,还成为了连接历史与人类的文化桥梁。对于博物馆建筑来说,它们的主要活... 详细信息

博物馆收藏着人类创造的物质文明,当中透过研究发掘物质遗存的文化精神及历史意义,籍着展示让公众走进历史文明的轨迹。博物馆不仅肩负起教育及传播人类文明的使命,还成为了连接历史与人类的文化桥梁。对于博物馆建筑来说,它们的主要活动就是展示陈列室中的展品,为了能够吸引人们,愉快的视觉环境尤为重要,因此,必须将照明设计视为一项重要的设计问题,因为光不仅能展示展品,还能将展品的魅力充分展现在观众面前。陈列室光环境的布置好坏直接关系着博物馆的使用效果。因此,创造良好的光环境是博物馆室内设计的重要内容。对博物馆采光来说,最关键的要求是光谱分布。在这方面,自然光被认为是最好的选择,因为其颜色特性极为理想,但天然光具有瞬时性和周期波动性,很难控制光束的强度、形状、尺度以及其方向性,所以我们在使用天然光的同时,还必须辅助以适当的人工照明。本文探讨了博物馆室内展示空间自然采光和人工照明的运用情况,并探讨用其中一种光源照明所牵涉的利弊及设计难点,经过分析,最后得到属于自己的结论。

关键词：博物馆室内展示空间文化桥梁愉悦天然光人工照明利弊

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PLC智能控制四象限变频调速技术试验应用

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煤矿机电 2008年第4期29卷 96-98页

作者：朱振宝颜世忠新汶矿业(集团)公司安全监察局山东新泰271233

采用智能功率模块,选配数字式深度监视器,实现提升机起动、调速、减速和制动无级调速。通过翟镇煤矿的试验应用,具有调速范围大、精度高、操作方便及节电效果好等优点,经济社会效益显著。

关键词：提升机隔爆变频调速智能控制

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血清Klotho蛋白与高血压的关系

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中华高血压杂志 2018年第3期26卷 265-270页

作者：周伊婷薛庆彭浩朱正保许倩张秋李红美苏州大学医学部公共卫生学院流行病与卫生统计学教研室江苏苏州215123 苏州市姑苏区疾病预防控制中心

目的检验血清Klotho蛋白水平与高血压的关系。方法 2010年1-5月在苏州市金阊区进行了高血压及其危险因素的横断面调查,收集研究对象的人口统计学资料、疾病史、高血压家族史等,测量血压、身高、体质量、腰围等指标;并检测血糖、血脂、... 详细信息

目的检验血清Klotho蛋白水平与高血压的关系。方法 2010年1-5月在苏州市金阊区进行了高血压及其危险因素的横断面调查,收集研究对象的人口统计学资料、疾病史、高血压家族史等,测量血压、身高、体质量、腰围等指标;并检测血糖、血脂、血尿酸及尿微量白蛋白、尿肌酐水平。按照性别相同,年龄相差±4岁为条件采用1∶1配对的病例对照方法从该横断面研究中选择高血压患者197例及正常血压者197人,于2016年5月检测这197对研究对象血清中Klotho蛋白的浓度,并进行组间比较。按照Klotho蛋白水平的四分位数(430.27ng/L)进行分组,采用条件Logistic回归分析血清Klotho蛋白水平与高血压的关系。结果 197对研究对象中男性60对,女性137对,年龄(51.7±8.7)岁,血清Klotho蛋白水平中位数(P_(25)~P_(75))为290.48(206.48~430.27)ng/L,其中高血压患者血清Klotho蛋白水平低于正常血压者[269.67(206.22~359.83)比313.95(218.46~483.39)ng/L,P=0.004]。单因素Logistic分析显示,与Klotho蛋白水平最高四分位组相比,第1、2、3分位组患高血压的OR(95%CI)分别为2.46(1.40~4.31),2.24(1.24~4.02)和1.98(1.12~3.51)。在调整年龄、生活方式、高血压家族史、体质量指数、血糖、血脂、尿酸、尿微量白蛋白水平等因素后,与Klotho蛋白水平最高四分位组比较,其余3组患高血压的OR(95%CI)分别为2.01(1.08~3.71),2.29(1.20~4.39)和1.55(0.82~2.92)。结论低水平的血清Klotho蛋白与高血压患病风险呈正相关。

关键词： Klotho蛋白高血压 1∶1配对病例对照

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体外染氡对V79细胞凋亡影响及其机制研究

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扬州大学学报（农业与生命科学版） 2012年第3期33卷 13-16页

作者：韦晔刘玉萍吴周伟吕雪朱正保童建李建祥苏州大学医学部公共卫生学院江苏苏州215123 苏州工业园区疾病防治中心江苏苏州215123

建立中国仓鼠肺细胞(V79细胞)体外染氡早期损伤模型,对V79细胞凋亡的分子机制进行探析。筛选确定合适的染氡浓度及时间后将V79细胞分为对照组和染氡组,以每孔1.5×105个细胞接种于Transwell培养皿,细胞贴壁后将Transwell培养皿置于细胞... 详细信息

建立中国仓鼠肺细胞(V79细胞)体外染氡早期损伤模型,对V79细胞凋亡的分子机制进行探析。筛选确定合适的染氡浓度及时间后将V79细胞分为对照组和染氡组,以每孔1.5×105个细胞接种于Transwell培养皿,细胞贴壁后将Transwell培养皿置于细胞动式气体染氡装置中染毒,染氡后收集各代细胞,常规培养后检测细胞周期、细胞凋亡及Caspase-3蛋白表达情况。结果表明:确定染氡浓度为40 000Bq·m-3,时间为10min,染毒后细胞G1期缩短,S期延长,细胞凋亡率逐渐升高,Caspase-3蛋白的表达有明显上升趋势,成功构建了V79细胞体外染氡早期损伤模型。在染毒早期阶段,V79细胞凋亡率上升与Caspase-3蛋白表达增加间无良好相关性。

关键词：肺癌氡中国仓鼠肺细胞凋亡 Caspase-3蛋白

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BIM-based framework of automatic tunnel segment assembly and deviation control

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Underground Space 2024年第3期16卷 59-78页

作者： Jian Gong Tengfei bao zheng zhu Hong Yu Yangtao Li The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China Zhejiang Design Institute of Water Conservancy and Hydro-Electric Power Hangzhou 310002China

The design of universal segments and deviation control of segment assembly are essential for robust and low-risk tunnel construction.A building information modeling(BIM)-based framework was proposed for parametric modeling,automatic assembly,and deviation control of universal ***,segment models of different levels of detail(LoDs)were built based on BIM visual programming language(VPL)for different project life ***,the geometric constraints,requirements,and procedures for parametric segment assembly were distilled to develop a program that combines a novel typesetting algorithm with a 3D path replanning *** is implemented by introducing a point indication matrix,characterizing segments by sides,and manipulating geometries in a ***,3D path replanning,with non-uniform rational B-splines(NURBS)and arcs as basic shapes,was used to resolve unacceptable deviation situations after ***,the proposed framework was validated on a water diversion line and was found to be more effective and accurate than the previous method.

关键词： Parametric generative design BIM Deviation control Typesetting 3D path replanning

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Deformation early-warning index for heightened gravity dam during impoundment period

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Water Science and Engineering 2021年第1期14卷 54-64页

作者： Bo Chen Zi-shen Huang Teng-fei bao zheng zhu State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

The mechanical parameters of materials in a dam body and dam foundation tend to change when dams are reinforced in aging *** is important to use an early-warning index to reflect the safety status of dams,particularly of heightened projects in the impoundment ***,a new method for monitoring the safety status of heightened dams is proposed based on the deformation monitoring data of a dam structure,a statistical model,and finite-element numerical ***,a fast optimization inversion method for estimation of dam mechanical parameters was developed,which used the water pressure component extracted from a statistical model,an improved inversion objective function,and a genetic optimization iterative ***,a finite element model of a heightened concrete gravity dam was established,and the deformation behavior of the dam with rising water levels in the impoundment period was ***,mechanical parameters of aged dam parts were calculated using the fast optimization inversion method with simulated deformation and the water pressure deformation component obtained by the statistical model under the same conditions of water pressure ***,a new earlywarning index of dam deformation was constructed by means of the forward-simulated deformation and other components of the statistical *** early-warning index is useful for forecasting dam deformation under different water levels,especially high water levels.

关键词： Concrete gravity dam Parameter inverse analysis Structural health monitoring Early-warning index Finite element simulation

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Minimization of Classification Samples for Supercritical and Subcritical Patterns of Supersonic Inlet

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Journal of Thermal Science 2014年第4期23卷 375-380页

作者： CHANG Juntao zheng Risheng YU Daren bao Wen CHEN Fu JIANG Weiyu zhu Shoumei zheng Riheng Harbin Institute of Technology No.92.Xidazhi Street Science and Technology on Scramjet Laboratory

In order to investigate sample minimization for classification of supercritical and subcritical patterns in supersonic inlet, three optimization methods, namely, opposite one towards nearest method, closest one towards the byper-plane method and random selection method, are proposed for investigation on minimization of classification samples for supercritical and subcritical patterns of supersonic inlet. The study has been carried out to analyze wind tunnel test data and to compare the classification accuracy based on those three methods with or without priori knowledge. Those three methods are different from each other by different selecting methods for samples. The results show that one of the optimization methods needs the minimization samples to get the highest classification accuracy without priori knowledge. Meanwhile, the number of minimization samples needed to get highest classification accuracy can be further reduced by introducing priori knowledge. Furthermore, it demonstrates that the best optimization method has been found by comparing all cases studied with or without introducing priori knowledge. This method can be applied to reduce the number of wind tunnel tests to obtain the inlet performance and to identify the supercritical/subcritical modes for supersonic inlet.

关键词： Supersonic inlet Inlet supercritical/subcritical Sample minimization

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Unimodality of Independence Polynomials of the Cycle Cover Product of Graphs

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Acta Mathematica Sinica,English Series 2022年第5期38卷 858-868页

作者： bao Xuan zhu School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116P.R.China

An independent set in a graph G is a set of pairwise non-adjacent *** ik(G)denote the number of independent sets of cardinality k in *** its generating function I(G;x)=∑^(α(G))^(k=0)ik(G)x^(k),is called the independence polynomial of G(Gutman and Harary,1983).In this paper,we introduce a new graph operation called the cycle cover product and formulate its independence *** also give a criterion for formulating the independence polynomial of a *** on the exact formulas,we prove some results on symmetry,unimodality,reality of zeros of independence polynomials of some *** applications,we give some new constructions for graphs having symmetric and unimodal independence polynomials.

关键词： Independence polynomials unimodality log-concavity real zeros symmetry cycle cover product of graphs

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Tailoring mechanical heterogeneity,nanoscale creep deformation and optical properties of nanostructured Zr-based metallic glass

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Rare Metals 2023年第10期42卷 3430-3442页

作者： Jing-Xian Cui Qiang Luo zheng-Guo Zhang Jing-Tao zhu bao-Long Shen School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjing211189China School of Physics Science and Engineering Tongji UniversityShanghai200092China

Metallic glasses are spatially heterogeneous at the nanometer ***,the effects of external excitation on their structural and mechanical heterogeneity and the correlation to their properties are still ***,atomic force microscopy(AFM) and high-resolution transmis sion elec tron micro scopy(HRTEM) were carried out to explore the effects of cryogenic thermal cycling(CTC) on mechanical/structural heterogeneity,nano sc ale creep deformation and optical properties of nano structured metallic glass thin films(MGTFs).The results indicate that CTC treatment alters the distribution fluctuations of hardness/modulus and energy dissipation and results in an increase-then-decrease variation in mechanical *** applying Maxwell-Voigt model,it can be shown that CTC treatment results in a remarkable activation of more defects with longer relaxation time in soft regions but has only a slight effect on defects in hard *** addition,CTC treatment increases the transition time from primary-state stage to steady-state stage during creep *** enhanced optical reflectivity of the MGTFs after 15 thermal cycles can be attributed to increased aggregation of Cu and Ni *** results of this study shed new light on understanding mechanical/structural heterogeneity and its influence on nanoscale creep deformation and optical characteristics of nanostructured MGTFs,and facilitate the design of high-performance nanostructured MGTFs.

关键词： Metallic glass thin films(MGTFs) Cryogenic thermal cycling(CTC) Structural heterogeneity Mechanical and creep properties Optical characteristics

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