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A STUDY OF DRAG COEFFICIENT RELATED WITH VEGETATION BASED ON THE FLUME EXPERIMENT

Journal of Hydrodynamics 2010年第3期22卷 329-337页

作者： HUI Er-qing HU Xing-e JIANG Chun-bo MA Fang-kai zhu zhen-duo China Three Gorges Corporation Yichang 443002 China State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China

This study is focused on the effects of ecological factors （diameter and flexibility） and vegetation community composition on the drag coefficient related with vegetation. The single leafy shrub and three mixed communities （including shrub-grass, shrub-reed and reed-grass community） were studied. The flow velocity and water level were measured and used to calculate the drag coefficient based on the Bernoulli＇s equation, Darcy drag formula and the expression for the drag coefficient related with Darcy drag factor. The trend of the drag coefficient in the vertical direction was analyzed against flow depth, diameter, diameter P（eynolds number, flow depth Reynolds number and relative roughness height in different discharges. The results show that beside the dense leafy shrubs community, the vertical trend of the drag coefficient among other cases against flow depth, diameter, diameter Reynolds number, flow depth Reynolds number and relative roughness height can be approximately expressed by power law functions under different flow discharges. Moreover, in a mixed community with two plants with distinctly different ecological factors, the one with the most distinct variations of ecological factors determines the vertical trend of the drag coefficient; the other one only affects the magnitude of the drag coefficient. Furthermore, if the ecological factors of the vegetation in the vertical direction are kept almost not changed, the drag coefficient can be approximately regarded as a constant.

关键词： vegetated channel drag coefficient flume experiment

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pH响应型纳米药物载体的释药机制及性能研究进展

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无机化学学报 2018年第8期34卷 1399-1412页

作者：李祥子胡平静朱振铎朱国兴沈小平汪茗孙玉冯德香江苏大学化学与化工学院镇江212013 皖南医学院药学院安徽省多糖药物工程技术研究中心芜湖241002

pH响应型纳米载体因具有智能的酸敏或碱敏释药性能,已成为当前一类重要的多功能纳米载体,并得到了研究人员的广泛关注。特别是酸敏性纳米载体,可用于肿瘤弱酸微环境的药物控释,因而对药物的定点释放和癌症的靶向治疗等生物医学应用发挥... 详细信息

pH响应型纳米载体因具有智能的酸敏或碱敏释药性能,已成为当前一类重要的多功能纳米载体,并得到了研究人员的广泛关注。特别是酸敏性纳米载体,可用于肿瘤弱酸微环境的药物控释,因而对药物的定点释放和癌症的靶向治疗等生物医学应用发挥了积极作用。本文综述了近年来各类pH响应型纳米载体的典型合成方法,系统地介绍了共价键、分子间作用力以及物理结构变化3种方式引发的pH响应释药机制。深入阐述了pH响应型纳米载体的载药性能、体外释药性能、体外细胞毒性、体内抗癌性能及体内分布性能,并详细列举了近年来pH响应型纳米载体的各类实验参数,进而为pH响应型纳米载体的深入研究提供了方法学的借鉴和性能参考。

关键词： pH响应纳米载体释药机制负载释放

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei zhu Lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen Wang Yuchen Wang Mengjie zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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老年性痴呆的中医理论探讨

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山东中医杂志 2006年第10期25卷 655-657页

作者：崔德芝张恭新朱振铎山东中医药大学附属医院山东济南250011

通过复习古今文献,结合现代流行病学研究,论述了老年痴呆的发病机制,提出了肾虚是老年性痴呆发病的病理基础,与心、肝、脾功能失调关系密切,痰浊瘀血既是其病理产物,又是其致病因素,为老年性痴呆的中医治疗提供了理论依据。

关键词：老年性痴呆脏腑理论肾虚发病机制

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减阻实验研究在水力学实验教学中的应用

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实验技术与管理 2008年第10期25卷 32-34页

作者：李玲晏智锋王薇宇朱振铎清华大学水沙科学与水利水电工程国家重点实验室

详细介绍了减阻实验研究的概况、主要内容和研究成果以及将减阻实验研究与水力学教学实验相结合的方法,丰富了水力学实验教学中沿程水头损失量测实验的内容,在已有圆管恒定流动水头损失规律的基础上,分析减阻材料的糙率系数随雷诺数和... 详细信息

详细介绍了减阻实验研究的概况、主要内容和研究成果以及将减阻实验研究与水力学教学实验相结合的方法,丰富了水力学实验教学中沿程水头损失量测实验的内容,在已有圆管恒定流动水头损失规律的基础上,分析减阻材料的糙率系数随雷诺数和相对粗糙度的变化规律,揭示管道内壁涂层减阻技术对管道糙率系数的影响。该实验综合了水力学学科内有关领域的知识与技术,大大激发了学生做实验的兴趣,加深学生对理论知识的理解,也使学生得到综合训练。

关键词：减阻水力学实验教学水头损失

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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu zhu Wen-Wei Lin Sui Chen zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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Flower-like CuS/graphene oxide with photothermal and enhanced photocatalytic effect for rapid bacteria-killing using visible light

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Rare Metals 2022年第2期41卷 639-649页

作者： Rui Lv Yan-Qin Liang Zhao-Yang Li Sheng-Li zhu zhen-duo Cui Shui-LinWu School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin UniversityTianjin 300072China

Pathogenic bacteria have been threatening the daily life of human *** effective methods without causing drug-resistance of bacteria need to be developed to fight against these ***,flower-like CuS/-graphene oxide(GO)hybrids have been successfully synthesized via simple one-pot hydrothermal *** worked as an excellent electron acceptor to transport the photogenerated electrons from CuS,which can suppress the recombination of hole–electron pairs efficiently,thus enhancing the photocatalytic *** addition,the morphology of CuS and GO with high specific surface area and the increased defect in GO also improved photocatalytic performance of the *** to the synergy of photothermal,enhanced photocatalytic effect and released Cu ions,CuS/GO exhibited outstanding antibacterial efficacy under visible light irradiation for 15 ***,the hybrid showed great biocompatibility to L929 ***,the synthesized CuS/GO would be a promising antibacterial material for daily life including rapid water disinfection and wounds sterilization.

关键词： Antibacterial Photocatalytic CuS Graphene oxide Photoresponsive

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Influence of He ion irradiation on the microstructure and hardness of Ni-TiC_(NP)composites

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Nuclear Science and Techniques 2021年第11期32卷 32-41页

作者： Min Liu Yong-Feng Yan zhen-Bo zhu Lin-Feng Ye Ren-duo Liu He-Fei Huang Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

In the present study,samples of a titanium carbide nanoparticle-reinforced nickel alloy(Ni-TiC_(NP)composite)were irradiated with 1 MeV He ions at 700°*** evolution of He bubbles and nanohardness was characterized using transmission electron microscopy(TEM)and nanoindentation,*** images showed that the size and number density of He bubbles in the grains were affected by the He ion *** number density first increased significantly and then decreased with increasing ion dose,while the size exhibited an inverse ***,the swelling induced by He bubbles continuously increased with increasing ion *** bubbles also formed in the grain boundaries,interior of the TiC nanoparticles,and interfaces between the TiC nanoparticles and Ni *** measurements indicated a decrease in nanohardness after irradiation,which is attributed to the disappearance of intrinsic dislocation lines caused by He ion irradiation.

关键词： Ni–TiC_(NP)composites He bubbles Swelling Irradiation-induced softening

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Microstructure and mechanical properties of TC4 joints brazed with Ti-Zr-Cu-Sn amorphous filler alloy

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Rare Metals 2021年第7期40卷 1881-1889页

作者： Hui-Hui Zhang zhen-duo Cui Sheng-Li zhu Shi-Wei Guo Xian-Jin Yang Akihisa Inoue School of Materials Science and Engineering Tianjin UniversityTianjin 30007China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin 300072China Tianjin Key Laboratory of Composite and Functional Materials Tianjin 300072China Department of Physics King Abdulaziz UniversityJeddah 22254Saudi Arabia

The Ti_(51.44)Zr_(16.26)Cu_(30)Sn_(2.3)(at%)amorphous filler alloy in a ribbon form was prepared by melt *** Ti-6 Al-4 V alloy was brazed in vacuum furnace by using the Ti_(51.44)Zr_(16.26)Cu_(30)Sn_(2.3)amorphous filler *** effects of brazing temperature and holding time on the interfacial microstructure and mechanical properties of the Ti-6 Al-4 V brazed joints were *** brazed joints are composed ofα-Ti,β-Ti,and(Ti,Zr)_(2)Cu *** shear strength of the joints increases with brazing temperature increasing from 1153 to 1193 K and holding time from 10 to 15 min,while decreases with brazing temperature and time further *** temperature brazing results in the formation of microcracks and voids in the seams,which are harmful for the shear strength of the *** the joint brazed at 1193 K for 15 min,a fineα+βWidmansta¨tten structure beneficial to the mechanical property is formed,and the joint exhibits relatively high joint strength of 180 MPa.

关键词： Amorphous alloy Brazing Titanium alloy Microstructure Mechanical property

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