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New model of linkage evolution for the transtensional fault systems in the Nanpu Sag of Bohai Bay Basin: Insight from seismic interpretation and analogue modelling

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Petroleum Science 2024年第4期21卷 2287-2310页

作者： yu-Heng Wang Fu-Sheng yu Bao-Yin Zhao ling-Jian Meng College of Geosciences China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum (Beijing) Jidong Oilfield Company PetroChina Limited Company

The evolution of faults within the same stress field is frequently influenced by numerous factors,involving the reactivation of pre-existing structures, stress transmission through ductile detachment layers, and the growth, interaction, as well as linkage of new fault segments. This study analyses a complex multi-phase oblique extension fault system in the Nanpu Sag(NPS) of the Bohai Bay Basin(BBB),China. High-resolution three-dimensional(3D) seismic data and analogue modelling indicate that the oblique extensional reactivation of pre-existing structures governs the sequential arrangement of fault segments in the caprock, and they dip synthetically to the reactivated fault at depth. During the NW-SE extension in the Eocene, the predominant movement of the pre-existing fault is strike-slip. Subsequently,during the N-S extension since the Oligocene, inclined at *** the pre-existing fault, forming splay fault segments and ultimately creating large en-echelon arcuate faults linked by relay ramps. Using fault throw-distance(T-D) and laser scanning, we reconstructed the fault evolution model of oblique extension reactivation in the presence of a ductile detachment basement. Our study illustrates that the arcuate faults can be categorized into linear master fault segments controlled by pre-existing structures, bending splay faults in the termination zone, and normal fault segments responding to the regional stress *** interaction between faults occurs among normal faults and strike-slip faults, and the kinematic unification of the two fault systems is accomplished in the intersection zone. As the faults continue to evolve, the new fault segments tend to relinquish the control of pre-existing structures and concentrate more on the development of planar and continuous major faults. The ductile detachment layer significantly contributes to the uniform distribution of strain, resulting in narrow shear zones and discontinuous normal faults in its absence.

关键词： Analogue modelling Transtensional deformation Fault linkage Fault intersection zone Nanpu Sag of Bohai Bay basin

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Constructing S-scheme charge separation in cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4) heterojunction with enhanced photothermal-assisted photocatalytic H_(2) evolution

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Rare Metals 2024年第1期43卷 198-211页

作者： Wei-Long Shi Zheng Xu yu-Xing Shi ling-ling Li Jia-Lin Lu Xin-Hai Sun Xin Du Feng Guo Chang-yu Lu School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Water Resource and Environment Hebei Province Key Laboratory of Sustained Utilization and Development of Water RecourseHebei Center for Ecological and Environmental Geology ResearchHebei Geo UniversityShijiazhuang 050031China

Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific ***,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) *** multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through *** addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme *** optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,*** work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.

关键词： Photothermal Photocatalytic H_(2)evolution Cobalt phthalocyanine Oxygen-doped g-C_(3)N_(4) Sscheme heterojunction

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Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG yu-xia ZHAO Yan-na yu Xiao-ling YIN Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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Evolution of MnO–SiO2–Al_(2)O_(3)–MgO inclusions during heat treatment at 1100℃

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Journal of Iron and Steel Research International 2024年第5期31卷 1221-1231页

作者： Xu-bo Lei Jian-li Li Qiang Zeng Hang-yu zhu yue yu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To investigate the evolutionary behavior of the MnO–SiO_(2)–Al_(2)O_(3)–MgO inclusions during heat treatment,water quenched samples were isothermally held at 1100°C for 120 min in Ar and air atmosphere,and the obtaining samples were analyzed by X-ray diffraction,scanning electron microscopy and energy dispersive *** showed that 3MnO·Al_(2)O_(3)·3SiO_(2)and MnO·SiO_(2)were detected in the 5 wt.%MgO system after isothermal holding in Ar atmosphere,while MgO·Al_(2)O_(3),MnO·SiO_(2)and Mn7O8·SiO4 were detected in air *** evolutionary behavior of the 10,15 and 20 wt.%MgO systems after isothermal holding in different atmosphere were *** affected the solid phase transformation of the low MgO content *** calculation results of FactSage 8.1 showed that MgO·Al_(2)O_(3)was formed in the 5 wt.%MgO system with air *** solid phase transformation was accompanied by grain coarsening during the isothermal holding *** differences in the solid phase transformation in different atmosphere of the 5 wt.%MgO system indicated that it was a gas-phase transport grain coarsening *** enrichment of Al element in the liquid phase region at the grain edges,the homogeneous distribution of Mg element and the disappearance of the liquid phase within the crystal revealed that other MgO content systems were liquid–solid transport grain coarsening mechanism.

关键词： Evolution Glassy phase Inclusion Heat treatment MgO·Al_(2)O_(3)

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Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China

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Petroleum Science 2024年第3期21卷 1552-1568页

作者： Xiao-Lin Wang Xiao-Min zhu Jin Lai Xing-yue Lin Xiang Wang yu-Shan Du Chao Huang yu-Rui zhu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield SINOPECDongying257000ShandongChina

The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas *** sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine *** article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)***,the OM enrichment model was *** results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source *** source of OM is a mixture of lower bacteria,algae,and *** the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low *** the late sedimentary period,the climate became warmer and more *** a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous *** and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of *** warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic *** research results may have implications for the genetic mechanisms of organic matter *** will provide theoret

关键词： Elemental geochemical Paleoenvironment Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin

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Novel milestones for early esophageal carcinoma:From bench to bed

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1104-1118页

作者： Ji-Han Qi Shi-ling Huang Shi-zhu Jin Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina

Esophageal cancer(EC)is the seventh most common cancer worldwide,and esophageal squamous cell carcinoma(ESCC)accounts for the majority of cases of *** effectively diagnose and treat ESCC and improve patient prognosis,timely diagnosis in the initial phase of the illness is *** article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of *** biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quanti-tative polymerase chain reaction(qPCR),high-throughput sequencing technology(next-generation sequencing),and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decision-making basis for the diagnosis,treatment,and prognosis of *** invest-igation of the microbiome is a swiftly progressing area in human cancer research,and microorganisms with complex functions are potential components of the tumor *** intratumoral microbiota was also found to be connected to tumor *** application of endoscopy as a crucial technique for the early identification of ESCC has been essential,and with ongoing advancements in technology,endoscopy has continuously *** the advancement of artificial intelligence(AI)technology,the utilization of AI in the detection of gastrointestinal tumors has become increasingly *** implementation of AI can effectively resolve the discrepancies among observers,improve the detection rate,assist in predicting the depth of invasion and differentiation status,guide the pericancerous margins,and aid in a more accurate diagnosis of ESCC.

关键词： Early esophageal squamous cell carcinoma Epidemiology and risk factors Molecular biology Epigenetic Microbiology Endoscopy and artificial intelligence

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Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel

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Energy & Environmental Materials 2024年第2期7卷 191-203页

作者： ling yu yubin Liang Lei Gao Peipei Chen Zhiqiang yu Minzhou Zhang Aleksander Hinek Shuai Mao Second Clinical College Guangzhou University of Chinese Medicine Department of Critical Care Medicine Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Branch of National Clinical Research Centre for Chinese Medicine Cardiology Department of Radiation Medicine and Applied Sciences University of California San Diego Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Research Affiliated Dongguan Hospital Southern Medical University Translational Medicine Hospital for Sick Children

Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death, highlighting the urgent clinical need for effective therapies. Recently, tanshinone IIA has been identified as a promising therapeutic agent for myocardial infarction. However, efficient delivery remains a major issue that limits clinical translation. To address this problem, an injectable thermosensitive poly(lactic acid-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid-co-glycolic acid) gel(PLGA-PEG-PLGA) system encapsulating tanshinone IIA-loaded reactive oxygen species-sensitive microspheres(Gel-MS/tanshinone IIA) has been designed and synthesized in this study. The thermosensitive hydrogel exhibits good mechanical properties after reaching body temperature. Microspheres initially immobilized by the gel exhibit excellent reactive oxygen speciestriggered release properties in a high-reactive oxygen species environment after myocardial infarction onset. As a result, encapsulated tanshinone IIA is effectively released into the infarcted myocardium, where it exerts local antipyroptotic and anti-inflammatory effects. Importantly, the combined advantages of this technique contribute to the mitigation of left ventricular remodeling and the restoration of cardiac function following tanshinone ***, this novel, precision-guided intra-tissue therapeutic system allows for customized local release of tanshinone IIA, presenting a promising alternative treatment strategy aimed at inducing beneficial ventricular remodeling in the post-infarct heart.

关键词： myocardial infarction ROS-sensitive polymer tanshinone IIA thermoreversible hydrogel ventricular remodeling

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Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiayi Wu Feifei Li Peng yu Changhao yu Chuyi Han Yitian Wang Fanyuan yu ling Ye State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PLA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PLA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

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In^(3+)-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6−δ)cathode with improved performance for an intermediate-temperature solid oxide fuel cell

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Nano Research 2024年第1期17卷 407-415页

作者： yumei Ma Lijie Zhang Kang zhu Binze Zhang Ranran Peng Changrong Xia ling Huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Promoting the oxygen reduction reaction(ORR)is critical for commercialization of intermediate-temperature solid oxide fuel cells(IT-SOFCs),where Sr_(2)Fe_(1.5)Mo_(0.5)O_(6)−δ(SFM)is a promising cathode by working as a mixed ionic and electronic *** this work,doping of In^(3+)greatly increases the oxygen vacancy concentration and the content of adsorbed oxygen species in Sr_(2)Fe_(1.5)Mo_(0.5−x)InxO_(6−δ)(SFMInx),and thus effectively promotes the ORR *** a typical example,SFMIn_(0.1)reduces the polarization resistance(R_(p))from 0.089 to 0.046Ω∙cm^(2)at 800°C,which is superior to those doped with other metal *** addition,SFMIn0.1 increases the peak power density from 0.92 to 1.47 W∙cm^(−2)at 800°C with humidified H_(2)as the fuel,indicating that In3+doping at the Mo site can effectively improve the performance of SOFC cathode material.

关键词： solid oxide fuel cell cathode In3+doping oxygen reduction reaction(ORR) Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)

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Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2006-2025页

作者： Bingwen Ding zhu zhu Cong Guo Jiaxin Li Yong Gan Miaorong yu State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmacy Henan UniversityKaifeng 475004China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Diabetes,characterized by hyperglycemia,is a major cause of death and disability ***,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ability to mimic or enhance insulin's actions in the *** to subcutaneous injection,oral administration of anti-diabetic peptides is a preferred ***,biological barriers significantly reduce the efficacy of oral peptide *** advancements in drug delivery systems and formulation techniques have greatly improved the oral delivery of peptide therapeutics and their efficacy in treating *** review will highlight(1)the benefits of oral anti-diabetic peptide therapeutics;(2)the biological barriers for oral peptide delivery,including pH and enzyme degradation,intestinal mucosa barrier,and biodistribution barrier;(3)the delivery platforms to overcome these biological ***,the review will discuss the prospects in this *** information provided in this review will serve as a valuable guide for future developments in oral anti-diabetic peptide therapeutics.

关键词： Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 Biodistribution Biological barriers Targeted delivery

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