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加味痛泻要方治疗腹泻型肠易激综合征肝郁脾虚证的临床疗效观察

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广州中医药大学学报 2024年第3期41卷 562-568页

作者：沈正寅单静怡朱凌宇上海中医药大学附属龙华医院脾胃病科上海200032

【目的】观察加味痛泻要方治疗腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)肝郁脾虚证患者的临床疗效。【方法】将60例IBS-D肝郁脾虚证患者随机分为治疗组和对照组,每组各30例。治疗组患者给予加味痛泻... 详细信息

【目的】观察加味痛泻要方治疗腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)肝郁脾虚证患者的临床疗效。【方法】将60例IBS-D肝郁脾虚证患者随机分为治疗组和对照组,每组各30例。治疗组患者给予加味痛泻要方治疗,对照组患者给予匹维溴铵片(得舒特)治疗,疗程为4周。观察2组患者治疗前后中医证候积分、肠易激综合征生活质量量表(IBS-QOL)评分、汉密尔顿焦虑量表(HAMA)评分的变化情况,并根据IBS病情严重程度量表(IBS-SSS)积分的分级情况评价2组患者的总体症状改善疗效,比较2组患者的腹痛、腹泻单项症状改善疗效和停药4周后的复发情况。【结果】(1)总体症状改善疗效方面,治疗4周后,治疗组的总有效率为83.33%(25/30),对照组为43.33%(13/30),组间比较(χ2检验),治疗组的总体症状改善疗效明显优于对照组(P<0.01)。(2)单项症状改善疗效方面,治疗4周后,治疗组腹痛、腹泻症状改善疗效的总有效率分别为80.00%(24/30)、90.00%(27/30),对照组分别为43.33%(13/30)、46.67%(14/30),组间比较(χ2检验),治疗组的腹痛、腹泻症状改善疗效均明显优于对照组(P<0.01)。(3)量表评分方面,治疗4周后,2组患者的中医证候积分、IBS-QOL评分、HAMA评分均较治疗前明显降低(P<0.05或P<0.01),且治疗组的降低幅度均明显优于对照组(P<0.01)。(4)复发情况方面,停药4周后,治疗组的复发率为24.00%(6/25),明显低于对照组的61.54%(8/13),组间比较,差异有统计学意义(P<0.05)。【结论】加味痛泻要方治疗IBS-D肝郁脾虚证患者疗效确切,能有效改善患者的腹痛、腹泻症状和中医证候积分,提高患者的生活质量,缓解患者的焦虑状态。

关键词：加味痛泻要方腹泻型肠易激综合征(IBS-D) 肝郁脾虚生活质量焦虑状态

Global Burden of Disease, Injury and Risk Factor Study 2010: Its Policy Implications for China

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Biomedical and Environmental Sciences 2014年第1期27卷 45-48页

作者： yu Shi Cheng TAN Feng ZHOU Mai Geng LIU Shi Wei zhu Xiao Jun zhu yu ling Chinese Center for Disease Control and Prevention (China CDC) National Institute for Occupational Health and Poison Control China CDC National Center for Non-communicable Chronic Disease Control China CDC

Results of the Global Burden of Disease, Injury and Risk Factor Study 2010 （GBD 2010） were released on December 13, 2012 in London, a series of papers concerning the project have been published in the Lancet[1]. Research findings of the project have been reported in the United States, the United Kingdom, Indonesia, China[2] and Australia, and widely applied across the world. In addition, the GBD 2010 will see more countries report their project research findings and implement these findings in the near future. The GBD 2010 provides researchers, administrators and policymakers with new and critical sources for their research, teaching and policymaking.

关键词： 2010 Global Burden of Disease Its Policy Implications for China

高浓度磷酸盐缓冲液中多巴胺电化学氧化过程的在线质谱分析

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质谱学报 2024年第1期45卷 103-110,I0003页

作者：林嘉美王昊天李慧余振东宋丽丽朱玉玲徐加泉东华理工大学江西省质谱科学与仪器重点实验室江西南昌330013

研究高浓度缓冲盐体系中物质的电化学氧化还原过程,对于准确理解电化学反应机理具有重要意义。本研究研制了一款体积小、性能稳定、结构简单、制作方便的流动电解池,将其与大气压化学电离质谱联用,构建了一种可在线分析高浓度缓冲盐溶... 详细信息

研究高浓度缓冲盐体系中物质的电化学氧化还原过程,对于准确理解电化学反应机理具有重要意义。本研究研制了一款体积小、性能稳定、结构简单、制作方便的流动电解池,将其与大气压化学电离质谱联用,构建了一种可在线分析高浓度缓冲盐溶液中电化学过程的电化学-质谱分析装置,用于在线、实时研究缓冲盐溶液中多巴胺的电化学氧化过程。结果表明,通过热沉积方式可高效地在线去除缓冲溶液中的无机盐组分,有机组分可经大气压化学电离方式进行离子化,随后进入质谱检测。多巴胺电化学氧化质谱分析结果表明:在0 V氧化电位下,多巴胺不发生氧化,主要获得多巴胺的质子化信号m/z 154[M+H]^(+);当氧化电位为+0.3 V时,除多巴胺的质子化信号外,还可获得多巴胺失去4个e-的氧化产物多巴色素(dopachrome)质子化峰m/z 150[M+H]^(+),以及多巴色素与多巴胺通过分子间氢键形成的加合物信号m/z 303[M+H]^(+);当氧化电位升高至+0.6 V时,氧化产物m/z 150和303的丰度进一步提高。

关键词：高浓度缓冲盐电化学反应机理多巴胺电化学-质谱

Effectiveness of urban distributed runoff model for discharge and water depth calculation in urban drainage pipe networks

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Journal of Hydrodynamics 2024年第3期36卷 582-591页

作者： Yang Zhou Yi-ling Leng Peng-yu Wang Shang-hong Zhang yu-long zhu yu-jun Yi School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing102206China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing100875China

Effective urban land-use re-planning and the strategic arrangement of drainage pipe networks can significantly enhance urban flood defense *** at reducing the potential risks of urban flooding,this paper presents a straightforward and efficient approach to an urban distributed runoff model(UDRM).The model is developed to quantify the discharge and water depth within urban drainage pipe networks under varying rainfall intensities and land-use *** Nash efficiency coefficient of UDRM exceeds 0.9,which indicates its high computational efficiency and potential benefit in predicting urban *** prediction of drainage conditions under both current and re-planned land-use types is achieved by adopting different flood recurrence *** findings reveal that the re-planned land-use strategies could effectively diminish flood risk upstream of the drainage pipe network across 20-year and 50-year flood recurrence ***,in the case of extreme rainfall events(a 100-year flood recurrence),the re-planned land-use approach fell short of fulfilling the requirements necessary for flood disaster *** these instances,the adoption of larger-diameter drainage pipes becomes an essential requisite to satisfy drainage ***,the proposed UDRM effectively combines land-use information with pipeline data to give practical suggestions for pipeline modification and land-use optimization to combat urban ***,this methodology warrants further promotion in the field of urban re-planning.

关键词： Stormwater runoff water depth urban distributed runoff model urban drainage pipe networks urban land-use re-planning

Poly(3-hexylthio) thiophene Field-effect Transistor Device Performance: Impact of the Content of Hexylthio Side Chain on Backbone

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Chinese Journal of Polymer Science 2024年第1期42卷 14-23,I0005页

作者： Hao-yu Liu Lian-He Han ling-Wei Kong Li-Ping zhu Xiao-Lan Qiao Mei-Fang zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Regioregular poly(3-hexylthio)thiopene(P3HTT) has emerged tremendous potential in organic electronic applications due to the strong noncovalent interactions from the sulfur atom linked to thiophene. However, P3HTT generally exhibits low charge mobility mostly due to poor solution processability attributed to dense arrangement of hexylthio side chain in polymer, which led to strong noncovalent interactions among sulfur atoms. To balance the nonvalent interaction and aggregation for P3HTT, herein, we systematically study the effect of hexylthio side chain content in polymer backbone on the structure and properties. A series of regioregular P3HTT-based homopolymers(P3HTT, P3HTT-50,P3HTT-33 and P3HTT-25) were prepared via Kumada catalyst transfer polycondensation method from a set of mono-, bi-, ter-and quarterthiophenes containing different contents of hexylthio side chain. The DFT calculation shows the planarity of polymers backbone could be improved through reducing the density of hexylthio side chain in polymer mainchain. And significant changes in their crystallinity, aggregation and optical properties were observed with the content of hexylthio side chain reducing. The P3HTT-33 displayed the highest field-effect transistor hole mobility of 2.83×10^(-2) cm^(2)·V^(-1)·s^(-1) resulting from a balance between the crystallinity and planarity. This study demonstrates modulating the content of hexylthio side chain in P3HTT is an effective strategy to optimize the opto-electronic properties of polymer obtaining excellent semiconductor device performance.

关键词： Conjugated polymer Polythiophene Noncovalent interaction Molecular aggregation Organic field-effect transistor

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多釜逆流硝化反应网络变负荷动态特性仿真

化工自动化及仪表 2024年第5期51卷 907-915页

作者：洪敏唐凯刘玉枫陶建国李红阳汤德忠王思进祝铃钰浙江鸿盛化工有限公司浙江工业大学化学工程学院

建立甲苯硝化多釜逆流反应网络的动态仿真模型,研究反应过程变负荷时冷却水阶跃调整的方式对反应温度动态稳定的影响。针对冷却水阶跃形式s、冷却水阶跃幅度α、阶跃持续时间tF 3个因素设计仿真实验,利用脚本完成实验变量输入,提出了基... 详细信息

建立甲苯硝化多釜逆流反应网络的动态仿真模型,研究反应过程变负荷时冷却水阶跃调整的方式对反应温度动态稳定的影响。针对冷却水阶跃形式s、冷却水阶跃幅度α、阶跃持续时间tF 3个因素设计仿真实验,利用脚本完成实验变量输入,提出了基于温度偏差、积分和响应时间的评分指标用于评价操作。结果表明:三步阶跃与先滞后1 min再阶跃的实验方案具有最好的减缓温度波动效果,可为实际化工生产提供有效参考。

关键词：温度动态稳定甲苯硝化动态模拟变负荷评分指标

A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun ling-ling zhu Hao Yan Wei Zhao Jing-xuan Liu Lin Ren Xian-tang Zhao Xiao-song Tong Shu-wen yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

Topological Stability and Entropy for Certain Set-valued Maps

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Acta Mathematica Sinica,English Series 2024年第4期40卷 962-984页

作者： yu ZHANG yu Jun zhu School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

In this paper,the dynamics(including shadowing property,expansiveness,topological stability and entropy)of several types of upper semi-continuous set-valued maps are mainly considered from differentiable dynamical systems points of *** is shown that(1)if f is a hyperbolic endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has theε-shadowing property,and moreover,if f is an expanding endomorphism then there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has the Lipschitz shadowing property;(2)when a set-valued map F is generated by finite expanding endomorphisms,it has the shadowing property,and moreover,if the collection of the generators has no coincidence point then F is expansive and hence is topologically stable;(3)if f is an expanding endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that h(F_(f,U,ε))=h(f);(4)when F is generated by finite expanding endomorphisms with no coincidence point,the entropy formula of F is ***,the dynamics of the set-valued maps based on discontinuous maps on the interval are also considered.

关键词： Set-valued map orbit space hyperbolic endomorphism perturbation shadowing expansiveness topological stability entropy

Large-inductance superconducting microstrip photon detector enabling 10 photon-number resolution

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Advanced Photonics 2024年第1期6卷 96-105页

作者： ling-Dong Kong Tian-zhu Zhang Xiao-yu Liu Hao Li Zhen Wang Xiao-Ming Xie Li-Xing You Chinese Academy of Sciences(CAS) Shanghai Institute of Microsystem and Information TechnologyNational Key Laboratory of Materials for Integrated CircuitsShanghaiChina CAS Center for Excellence in Superconducting Electronics ShanghaiChina University of Chinese Academy of Sciences Center of Materials Science and Optoelectronics EngineeringBeijingChina

Efficient and precise photon-number-resolving detectors are essential for optical quantum information *** this,very few detectors have been able to distinguish photon numbers with both high fidelity and a large dynamic range,all while maintaining high speed and high timing *** nanostrip-based detectors excel at counting single photons efficiently and rapidly,but face challenges in balancing dynamic range and ***,we have pioneered the demonstration of 10 true photon-number resolution using a superconducting microstrip detector,with readout fidelity reaching an impressive 98%and 90%for 4-photon and 6-photon events,***,our proposed dual-channel timing setup drastically reduces the amount of data acquisition by 3 orders of magnitude,allowing for real-time photon-number *** then demonstrate the utility of our scheme by implementing a quantum random-number generator based on sampling the parity of a coherent state,which guarantees inherent unbiasedness,robustness against experimental imperfections and environmental noise,as well as invulnerability to *** solution boasts high fidelity,a large dynamic range,and real-time characterization for photon-number resolution and simplicity with respect to device structure,fabrication,and readout,which may provide a promising avenue towards optical quantum information science.

关键词： superconducting microstrips single-photon detector photon-number resolution quantum random number