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Hierarchical Self-assembly of Atomically Precise Au nanoclusters with Molecular Rotor-based ligands

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Chemical Research in chinese Universities 2024年第4期40卷 670-674页

作者： WANG Guanzhong LU Hui li Jiang WANG lihua {2. ying SONG Shiping GE Zhilei li Qian CHEN Jing FAN Chunhai Division of Physical biology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800P.R.China University of chinese academy of sciences Beijing100049P.R.China Zhangjiang laboratory Shanghai201210P.R.China institute of Materiobiology Department of ChemistryCollege of SciencesShanghai UniversityShanghai200444P.R.China School of Chemistry and Chemical Engineering New Cornerstone Science LaboratoryFrontiers Science Center for Transformative MoleculesZhangjiang Institute for Advanced Study and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240P.R.China

The hierarchical assemblies of precise nanoparticles(NPs)have created materials with emergent properties and ***,the complex assemblies remain unclear at a precise ***,we show the hierarchical self-assembly of atomically precise gold nanoclusters(Au NCs)with molecular rotor-based ligands(MRL),featuring a double-layer *** to two other types of monolayer-protected(MLP)Au NCs,the significantly reduced surface density for MRL Au NCs profoundly influences their assembly behavior within the ***,the long length of rotor-based ligands and the rotational freedom of the phenyl-rings of rotor-based ligands also facilitate the assembly of *** works elucidate the hierarchical assembly on a precise scale,suggesting that the rotor-based ligand’s strategy offers promising potential for designing well-defined and more complex structures in supercrystals.

关键词： Gold nanocluster Molecular rotor Hierarchical assembly Double-layer surface

nanographene oxide labeling with (188)~Re

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Nuclear Science and Techniques 2011年第2期22卷 99-104页

作者： ZHANG Xiaoyong li Jing zhu {2. QI Yujin zhu Zhiyong li wenxin HUANG Qing laboratory of Physical biology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate School of chinese academy of sciences Beijing 100049 China

nanographene oxide (NGO) is currently being explored for various biomedical ***,little information is known about its biological behaviors in vitro and in *** further stud{2. its pharmacokinetics and related biological behaviors in living systems,an effective and convenient tracing method is particularly *** this work,NGO was labeled with radionuclide 188Re (188Re-NGO).To obtain high labeling yield and purity,a number of labeling conditions,including concentration of SnCl2.and ascorbic acid,reaction time and temperature,and pH were optimized,and stability of the 188Re-NGO in vitro and in vivo was *** results showed that NGO could be effectively labeled with high *** purified 188Re-NGO showed high stability in vitro and in vivo.A pretest of NGO biodistribution with single photon emission computed tomography showed that the 188Re-NGO was rapidly taken by organs such as lungs,liver,and *** biodistribution of 188Re-NGO differs significantly from the free radionuclide,indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.

关键词：氧化物标签非政府组织铼计算机断层扫描生物学行为放射性核素生物医学应用

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo ying Bryan WBrooks Deyi Hou Damian EHelb{2.ng Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwa{2. Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang A{2. El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao {2. Tong Zhang Natà{2.a Corcoll Min {2.u Daniel SAlessi Hui {2. Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Phi{2.ppe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Wil{2.e Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Tao{2.n Zhang Yongming Luo {2.zhong zhu Xiangdong {2. DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Paw{2.szyn Yong-guan zhu Andreas Schaeffer Matthias C.Ril{2.g Fengchang Wu Gang Yu James M.Tiedje State Key laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese academy of sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs,a case study on white ginseng

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Ultra-high-performance liquid chromatography-quadrupole/time...

Size-dependent cellular uptake and sustained drug release of PLGA particles

中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

作者： Song-lin li~(a,*),Hong Shen~a,ling-ying zhu~a,Jun Xu~a,Xiao-Bin Jia~a,Hong-Mei Zhang~b,Ge lin~c, Hao Cai~d,Bao-Chang Cai~d,Shi-lin Chen~e,Hong-Xi Xu~(b,*) a Department of Metabolomics and Key laboratory of New Drug Delivery System of {2. Materia Medica,Jiangsu Province academy of {2. medicine,Nanjing 210028,PR China b School of {2. medicines,shanghai University of Traditional {2. medicine,shanghai 201203,PR China c School of Biomedical sciences,The {2. University of Hong Kong,Hong Kong SAR,PR China d Nanjing Haichang {2. medicine Co.lit and Nanjing University of {2. medicine, Nanjing 210029,PR China e The institute of Medicinal Plant Development,{2. academy of Medical sciences & Peking Union Medical College,Beijing 100193,PR China

Sulfur-fumigation may induce chemical transformation of medicinal *** of rapid method to reveal potential sulfur-fumigation induced chemical transformation of herbs is a very important issue for efficacy and safety of herb *** present study,a new strategy was proposed to rapidly reveal chemical transformation of sulfur-fumigated herbs by ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry (UHPLC-QTOF-MS/MS)based chemical profiling *** non-fumigated herb was water-wetted and further treated with burning sulfur to get sulfur-fumigated *** the chemical fingerprints of both non-fumigated and sulfur-fumigated samples were compared by UHPLC-QTOF-MS/MS *** identities of all detected peaks,in particular those newly-generated in sulfur-fumigated samples were confirmed by comparing the mass spectra and retention times of peaks with that of reference compounds,and/or tentatively assigned by matching empirical molecular formula with that of published compounds,and/or elucidating quasi-molecular ions and fragment ions referring to available literature *** identification could be rationalized through deducing possible reactions involved in the generation of these newly detected *** proposed strategy was extensively investigated in the case of white *** 82.components were detected in non-fumigated and sulfur-fumigated white ginseng samples,among them 35 sulfur-containing compounds detected only in sulfur-fumigated white ginseng and its decoction were assigned to be sulfate or sulfite derivatives of original ginsenosides,and were deduced to be generated via reactions of esterification,addition,hydrolysis and dehydration during sulfur-fumigation and decocting of white *** established approach was applied to discriminate sulfur-fumigated white ginseng among commercial samples from America,Canada,and Hong Kong SAR,Macau SAR and Mainland of China,which indicated

关键词： UHPLC-QTOF-MS/MS Ginseng Ginsenoside Chemical transformation Sulfur-fumigation

来源： cnki会议评论

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Particuology 2023年第2期73卷 1-7页

作者： Rui Sun Xia liu Yu Zhang Qian li {2. zhu Chunhai Fan Division of Physical biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China The Interdisciplinary Research Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China University of chinese academy of sciences Beijing 100049China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China

Poly(lactic-co-glycolic)acid(PLGA)particles have become a commonly used drug delivery strategy in the pharmaceutical *** this work,we aim to investigate the size-dependent cellular internalization of PLGA particles and its effects on sustained drug *** prepared three different-sized particles using PLGA(2.0,500 and 2.00 nm)ranging from submicrometer to ***(DEX)with excellent anti-inflammatory properties was used as a model drug to prepare DEX-loaded PLGA particles(DPs).We comprehensively investigated the encapsulation efficiency,cellular uptake and in vitro drug release *** assessment revealed that,in the lipopolysaccharide(LPS)-induced RAW 2.4.7 cells model,500 nm DPs showed sustained anti-inflammatory *** work provides important information for designing PLGA-based drug delivery systems for biomedical applications.

关键词： DEX-loaded PLGA particles(DPs) Sustained release Anti-inflammatory efficacy

Genetically encoded X-ray cellular imaging for nanoscale protein localization

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National Science Review 2020年第7期7卷 1218-1227页

作者： Huating Kong Jichao Zhang Jiang li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu lihua Wang {2. zhu Chunhai Fan Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang Laboratory Shanghai Advanced Research Institute Chinese Academy of Sciences Division of Physical biology CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Canadian light Source Inc. University of Saskatchewan Pohang Accelerator laboratory POSTECH School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and Shanghai Key Laboratory for Nucleic Acids Chemistry and NanomedicineInstitute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University

Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells. Whereas synchrotron-based X-ray microscopy(XRM) represents a unique approach for imaging a whole cell with {2.scale resolution due to its intrinsic {2.scale resolution and great penetration ability, existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone. Here, we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET) for site-specific labeling of protein-of-interest in mammalian cells. We find that 3,3-diaminobenzidine(DAB) polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM. Using this new tag, we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 {2.meters. Importantly, the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags. The development of GXET enlightens the way to {2.scopic imaging for biological studies.

关键词： synchrotron-based X-ray microscopy cellular imaging nanoscale protein localization genetically encoded X-ray tags 3,3-diaminobenzidine polymers

Development and Validation of a Nomogram Based on Perioperative Factors to Predict Post-hepatectomy liver Failure

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 291-300页

作者： Bin Xu Xiao-Long li Feng Ye Xiao-Dong zhu {2.-Hao Shen Cheng Huang Jian Zhou Jia Fan Yong-Jun Chen Hui-Chuan Sun Department of liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Key laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education ShanghaiChina Department of Hepatobiliary Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

(PHLF)is a severe complication and main cause of death in patients undergoing *** aim of this study was to build a predictive model of PHLF in patients undergoing ***:We retrospectively analyzed patients undergoing hepatectomy at Zhongshan Hospital,Fudan University from July 2.15 to June 2.18,and randomly divided them into development and internal validation *** validation was performed in an independent *** absolute shrinkage and selection operator(commonly referred to as LASSO)logistic regression was applied to identify predictors of PHLF,and multivariate binary logistic regression analysis was performed to establish the predictive model,which was visualized with a ***:A total of 492.eligible patients were *** and multivariate analysis identified three preoperative variables,total bilirubin(p=0.001),international normalized ratio(p2.and blood loss(p=0.004),as independent predictors of *** area under receiver operating characteristic curve(referred to as AUROC)of the predictive model was 0.838 and outperformed the model for end-stage liver disease score,albumin-bilirubin score and platelet-albumin-bilirubin score(AUROCs:0.72.,0.695 and 0.663,respectively;plidation showed the model could predict PHLF accurately and distinguish high-risk ***:PHLF can be accurately predicted by this model in patients undergoing hepatectomy,which may significantly contribute to the postoperative care of these patients.

关键词： Hepatectomy Post-hepatectomy liver failure LASSO Nomogram

Structural and functional imaging of brains

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Science China Chemistry 2023年第2期66卷 324-366页

作者： Zhichao liu ying {2. liming Zhang Weiping Jiang Yawei liu Qiaowei Tang Xiaoqing Cai Jiang li lihua Wang Changlu Tao Xianzhen Yin Xiaowei li Shangguo Hou Dawei Jiang Kai liu Xin Zhou Hongjie Zhang Maili liu Chunhai Fan Yang Tian shanghai Key laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200241China Interdisciplinary Research Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai201210China State Key laboratory of Magnetic Resonance and Atomic and Molecular physics Chinese Academy of SciencesWuhan National Laboratory for OptoelectronicsWuhan430071China State Key laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Department of Chemistry Tsinghua UniversityBeijing100084China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai200240China Interdisciplinary Center for Brain Information Brain Cognition and Brain Disease InstituteShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China lingang laboratory Shanghai201602China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200240China institute of Systems and Physical biology Shenzhen Bay LaboratoryShenzhen518055China Department of Nuclear medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Analyzing the complex structures and functions of brain is the key issue to understanding the physiological and pathological *** neuronal morphology and local distribution of neurons/blood vessels in the brain have been known,the subcellular structures of cells remain challenging,especially in the live *** addition,the complicated brain functions involve numerous functional molecules,but the concentrations,distributions and interactions of these molecules in the brain are still poorly *** this review,frontier techniques available for multiscale structure imaging from organelles to the whole brain are first overviewed,including magnetic resonance imaging(MRI),computed tomography(CT),positron emission tomography(PET),serial-section electron microscopy(ss EM),light microscopy(LM)and synchrotron-based X-ray microscopy(XRM).Specially,XRM for three-dimensional(3D)imaging of large-scale brain tissue with high resolution and fast imaging speed is ***,the development of elegant methods for acquisition of brain functions from electrical/chemical signals in the brain is *** particular,the new electrophysiology technologies for neural recordings at the single-neuron level and in the brain are also *** also focus on the construction of electrochemical probes based on dual-recognition strategy and surface/interface chemistry for determination of chemical species in the brain with high selectivity and long-term stability,as well as electrochemophysiological microarray for simultaneously recording of electrochemical and electrophysiological signals in the ***,the recent development of brain MRI probes with high contrast-to-noise ratio(CNR)and sensitivity based on hyperpolarized techniques and multi-nuclear chemistry is ***,multiple optical probes and instruments,especially the optophysiological Raman probes and fiber Raman photometry,for imaging and biosensing in live brain are emphas

关键词： brain structure brain function brain chemistry chemical signal biosensing and bioimaging

Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2.Knockout Rat Model of Rett Syndrome

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Engineering 2022年第5期8卷 83-89页

作者： Yanhong Sun Zhifang Chen Yi Xu Yuefang Zhang Zhilei Ge Chenglie lin Yi Zhou Fangfei Zhao Meiling Yan Xinyi liu ying zhu Jimin Gao Hongyi li lihua Wang Jun Hu Zilong Qiu Chunhai Fan Bioimaging Center Shanghai Synchrotron Radiation FacilityZhang Jiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Division of Physical biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China institute of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of laboratory medicine and {2.fe {2. Wenzhou Medical UniversityWenzhou 325035China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Basic medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China Cardiology Department Beijing HospitalBeijing 100730China

Rett syndrome is a progressive neurodevelopmental disorder that lacks effective *** deep-brain stimulation can alleviate some symptoms in Rett model mice,this interventional manipula-tion requires deliberate surgical ***,we report that electro-acupuncture stimulation(EAS)can ameliorate symptoms of an Mecp2.knockout rat model of Rett syndrome from the remote acupoints Baihui(GV 2.),Yongquan(KI 1),and Shenmen(HT 7).We find that EAS not only prolongs the survival time of Rett rats,but also improves their behavior ability,including locomotion,motor coordination,and social *** activation was observed in the substantia nigra of the midbrain,corpus striatum,and cerebral cortex of wild-type and Rett model rats,as reflected by the increased expression of the c-Fos ***,EAS provides a potential promising therapeutic tool for treating neurodevel-opmental diseases.

关键词： Neurodevelopmental disorder Electro-acupuncture stimulation Rett syndrome Motor function Social interaction