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Characterization of human IgM and IgG repertoires in individuals with chronic HIV-1 infection

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Virologica Sinica 2022年第3期37卷 370-379页

作者： Xiaolong Tian Binbin Hong xiaoyi zhu Desheng Kong Yumei Wen Yanling Wu Liying Ma Tianlei Ying MOE/NHC Key Laboratory of Medical Molecular Virology School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai200032China Central Laboratory The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou362000China State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Shanghai Engineering Research Center for Synthetic Immunology Shanghai200032China Shanghai Key Laboratory of Lung Inflammation and Injury Shanghai200032China

Advancements in high-throughput sequencing(HTS)of antibody repertoires(Ig-Seq)have unprecedentedly improved our ability to characterize the antibody repertoires on a large ***,currently,only a few studies explored the influence of chronic HIV-1 infection on human antibody repertoires and many of them reached contradictory conclusions,possibly limited by inadequate sequencing depth and *** better understand how HIV-1 infection would impact humoral immune system,in this study,we systematically analyzed the differences between the IgM(HIV-IgM)and IgG(HIV-IgG)heavy chain repertoires of HIV-1 infected patients,as well as between antibody repertoires of HIV-1 patients and healthy donors(HH).Notably,the public unique clones accounted for only a negligible proportion between the HIV-IgM and HIV-IgG repertoires libraries,and the diversity of unique clones in HIV-IgG remarkably *** aspect of somatic mutation rates of CDR1 and CDR2,the HIV-IgG repertoire was higher than ***,the average length of CDR3 region in HIV-IgM was significant longer than that in the HH repertoire,presumably caused by the great number of novel VDJ rearrangement patterns,especially a massive use of ***,some of the B cell clonotypes had numerous clones,and somatic variants were detected within the clonotype lineage in HIV-IgG,indicating HIV-1 neutralizing *** in-depth characterization of HIV-IgG and HIV-IgM repertoires enriches our knowledge in the profound effect of HIV-1 infection on human antibody repertoires and may have practical value for the discovery of therapeutic antibodies.

关键词： Ig-seq HIV-1 Antibody repertoire VDJ rearrangement Junctional diversity

Natural Variation in the Sequence of SNAC1 and Its Expression Level Polymorphism in Rice Germplasms under Drought Stress

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Journal of Genetics and Genomics 2014年第11期41卷 609-612页

作者： Khamdok Songyikhangsuthor Zilong Guo Nili Wang xiaoyi zhu Weibo Xie Tongmin Mou Lizhong Xiong National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

Water is a major limiting factor for food production and many countries fail to produce sufficient food for their population due to severe water scarcity （Jury and Vaux, 2005）. Rice is the main staple food worldwide. More than 50% of rice in the world is rain-fed and drought causes severe reduction in rice grain yield in rain-fed environments （Venuprasad et al., 2007; Zhang, 2007; Sandhu et al., 2014）. Therefore, enhancing drought resistance （DR） of rice is important for food security. However, DR is a complex trait, which is controlled by a large number of loci with small effect and is also affected by different genetic background, genotype-by-environment interaction and other stresses such as heat （Hu and Xiong, 2014）.

关键词： SNAC Natural Variation in the Sequence of SNAC1 and Its Expression Level Polymorphism in Rice Germplasms under Drought Stress

Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

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Light(Science & Applications) 2022年第6期11卷 1238-1252页

作者： xiaoyi zhu Qiang Huangl Anthony Dispirito Tri Vu Qiangzhou Rong Xiaorui Peng Huaxin Sheng Xiling Shen Qifa Zhou Laiming Jiang Ulrike Hoffmann Junjie Yao Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Pediatric Surgery Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Roski Eye Institute Department of OphthalmologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Anesthesiology Duke UniversityDurhamNC 27708USA

High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular *** imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks,and tracking fast pathophysiological activities at the microvessel level,which will enable advances in current queries in neurovascular and brain metabolism research,including stroke,dementia,and acute brain ***,real-time imaging of oxygen saturation of hemoglobin(sO_(2))can capture fast-paced oxygen delivery dynamics,which is needed to solve pertinent questions in these fields and ***,we present a novel ultrafast functional photoacoustic microscopy(UFF-PAM)to image the whole-brain hemodynamics and ***-PAM takes advantage of several key engineering innovations,including stimulated Raman scattering(SRS)based dual-wavelength laser excitation,water-immersible 12-facet-polygon scanner,high-sensitivity ultrasound transducer,and deep-learning-based image upsampling.A volumetric imaging rate of 2 Hz has been achieved over a field of view(FOV)of 11×7.5×1.5 mm^(3) with a high spatial resolution of~10 μ*** the UFF-PAM system,we have demonstrated proof-of-concept studies on the mouse brains in response to systemic hypoxia,sodium nitroprusside,and *** observed the mouse brain's fast morphological and functional changes over the entire cortex,including vasoconstriction,vasodilation,and *** interestingly,for the first time,with the whole-brain FOV and micro-vessel resolution,we captured the vasoconstriction and hypoxia simultaneously in the spreading depolarization(SD)*** expect the new imaging technology will provide a great potential for fundamental brain research under various pathological and physiological conditions.

关键词： metabolism ultrafast resolution

Research on High Precision Borehole Temperature Measurement Technology

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Acta Geologica Sinica(English Edition) 2024年第S1期98卷 81-83页

作者： ZHANG Bing zhu xiaoyi WANG Xiaolei XING Lili XUE Bing LI Jiang GAO Shanghua SU Peng WANG Yuru WANG Chuhan Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Institute of Disaster Prevention SanheHebei 065201China

From 2019 to 2021,China Seismic Experimental Site has built twelve 300 m deep well multi-measurement comprehensive observation stations in the cross-fault area of the Aninghe-Zemuhe fault zone,integrating BBVS120 very broadband borehole seismometer,RZB four-gauge borehole strainmeter and geothermometer with resolution up to 0.0001℃.The borehole diameter is 150 mm and the inner diameter of the sleeve is 130 *** multi-item integrated observation system is divided into two parts:underground and *** downhole part is mainly composed of sensor and power supply signal isolation.

关键词： high-precision borehole thermometer downhole integrated observation seismic science experiment field

Measurement and Analysis of Vibration Effect of Free-falling Corner Cube Driving Mechanism in Free Fall Absolute Gravimeter

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Acta Geologica Sinica(English Edition) 2024年第S1期98卷 84-86页

作者： ZHANG Bing zhu xiaoyi WU Qiong XUE Bing XING Lili WU Yanxiong SU Peng WANG Xiaolei WANG Yuru WANG Chuhan Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Institute of Geophysics China Earthquake AdministrationBeijing 100081China Institute of Disaster Prevention SanheHebei 065201China

The vibration interference of the reference corner cube runs through the free flight process of the free-falling corner cube,which is superimposed on the whole laser interference ***,it is necessary to solve the inter... 详细信息

关键词： laser interference absolute gravimeter gravity measurement vibration influence

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中国先锋艺术之回顾及90年代中国先锋电影

电影艺术 2001年第1期 79-82页

作者：朱晓艺北京电影学院

中国先锋艺术的历史回顾什么是真正的先锋①?先锋一词源于法语'Avant Guarde'原义是'军中前卫',即战场上的先头部队,这至少表明了几点含义:一Avant Guarde的工作有极大的冒险性,他们随时可能在探险中丧命,使所有努力前功尽弃;二前瞻性,... 详细信息

中国先锋艺术的历史回顾什么是真正的先锋①?先锋一词源于法语'Avant Guarde'原义是'军中前卫',即战场上的先头部队,这至少表明了几点含义:一Avant Guarde的工作有极大的冒险性,他们随时可能在探险中丧命,使所有努力前功尽弃;二前瞻性,如果他们能历尽千辛万苦完成任务,后面的大部队便会沿着他们的指引展开进攻;三艰难性,他们的工作不遵循旧有规律,必须在恶劣的工作条件下孤独地寻找解决方案;四Avant Guarde关注的永远是这个世界的未知部分,因而他们永远保持对世界的好奇心和思维的活力.引申到艺术创作,先锋艺术具有三个特点:思想上的革命性,形成上的实验性和社会身份的边缘化.

关键词：先锋艺术先锋电影前卫前瞻性探险孤独寻找展开年代部队

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基于WinCE的便携式导弹检测仪软件设计

弹箭与制导学报 2010年第5期30卷 235-237页

作者：朱笑仪母勇民中国兵器工业第203研究所西安710065

WinCE操作系统下设计的导弹检测仪软件,集成了对CAN总线通讯技术、RS422通讯技术、AD、IO和定时计数器技术的控制和使用,满足对导弹检测的各项功能。通过硬件测试,该软件的设计是合理有效的。

关键词： WinCE 导弹检测仪 CAN总线

铝铁复合淀粉絮凝-微波/H_2O_2氧化协同处理垃圾渗滤液

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环境工程学报 2015年第10期9卷 4735-4740页

作者：林亲铁黎宏飞朱笑仪广东工业大学环境科学与工程学院广州510006

针对垃圾渗滤液成分复杂、污染物浓度高、可生化性差等特点,采用铝铁复合淀粉(CAFS)絮凝-微波/H2O2联用技术对垃圾渗滤液进行处理,考察了初始p H、絮凝剂投加量、微波辐射反应时间和H2O2投加量等因素对处理水质的影响。结果表明,絮凝最... 详细信息

针对垃圾渗滤液成分复杂、污染物浓度高、可生化性差等特点,采用铝铁复合淀粉(CAFS)絮凝-微波/H2O2联用技术对垃圾渗滤液进行处理,考察了初始p H、絮凝剂投加量、微波辐射反应时间和H2O2投加量等因素对处理水质的影响。结果表明,絮凝最佳反应条件为p H 6.0,投加量13 m L/L;微波/H2O2氧化的最佳反应条件为p H 3.0,30%H2O225m L/L,温度70℃,反应时间5 min。在上述最佳条件下,单独CAFS絮凝、单独微波/H2O2和CAFS絮凝-微波/H2O2联用对垃圾渗滤液COD的去除率分别为32.3%、42.4%和85.7%,CAFS絮凝与微波/H2O2联用,可利用CAFS残余的Fe2+与H2O2构成Fenton氧化体系,实现絮凝与微波催化氧化工艺的耦合,两者起到很好的协同作用。

关键词：垃圾渗滤液铝铁复合淀粉微波 H2O2

Exploration of endogenous genes for drought resistance improvement in rice

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Exploration of endogenous genes for drought resistance impro...