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Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease

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Journal of Pharmaceutical Analysis 2024年第4期14卷 552-561页

作者： Panpan Chen Zihan zhu Haoyuan Geng xiaoqing Cui Yuhao Han Lei {2. Yaqi Zhang Heng Lu Xiao {2. Yun Zhang Chenglong Sun key laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province School of Pharmaceutical SciencesQilu University of Technology(Shandong Academy of Sciences)Jinan250014China key laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China School of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Biology institute Qilu University of Technology(Shandong Academy of Sciences)Jinan250103China

Eclipta prostrata *** been used in traditional medicine and known for its liver-protective properties for ***(WEL)and demethylwedelolactone(DWEL)are the major coumarins found in *** ***,the comprehensive characterization of these two compounds on non-alcoholic fatty liver disease(NAFLD)still remains to be *** a well-established zebrafish model of thioacetamide(TAA)-induced liver injury,the present study sought to investigate the impacts and mechanisms of WEL and DWEL on NAFLD through integrative spatial metabolomics with liver-specific transcriptomics *** results showed that WEL and DWEL significantly improved liver function and reduced the accumulation of fat in the *** biodistributions and metabolism of these two compounds in whole-body zebrafish were successfully mapped,and the discriminatory endogenous metabolites reversely regulated by WEL and DWEL treatments were also *** on spatial metabolomics and transcriptomics,we identified that steroid biosynthesis and fatty acid metabolism are mainly involved in the hepatoprotective effects of WEL instead of *** study unveils the distinct mechanism of WEL and DWEL in ameliorating NAFLD,and presents a“multi-omics”platform of spatial metabolomics and liver-specific transcriptomics to develop highly effective compounds for further improved therapy.

关键词： Spatial metabolomics Transcriptomics Non-alcoholic fatty liver disease Wedelolactone Demethylwedelolactone

Epidemiological Characteristics of Human Parainfluenza Viruses Infections-china,2.19-2.2.

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china CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao wang xiaoqing Liu Bing {2. Hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing wang Jie Jiang Zhen {2. Yan Zhang Aili Cui Baicheng Xia Naiying Mao National key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Precision Medicine Research Center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina laboratory of Viral Diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Jiangxi Provincial Center for Disease Control and Prevention Nanchang CityGansu ProvinceChina Virus laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina institute for Immunization and Prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture Center for Disease Control and Prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in china to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2.19 to June 2.2.,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12.866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2.2. to 9.70%in *** median age of HPIVs-infected patients was 3 ***2.was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.2.%).HPIV3(54.16%)and HPIV1(2..18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2.19(COVID-19)*** peak of HPIV3 shifted three months later in 2.2. compared to 2.19 and returned to a summer peak *** peaks of HPIV1 were observed in 2.2. following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:2..12.),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in china was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

Shanghai Gynecologic Oncology Group’s consensus on the academic and industry’s clinical trial types

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中华医学杂志(英文版) 2024年第14期137卷 2024 Apr 24页

作者： Shi Tingyan Liu Jihong zhu Jianqing wang Xipeng Jiang Wei Lu Xin Feng Weiwei Zhou Shengtao Shen Yang Chen Gang Wu Zhenyu Zou Dongling Wu Peng Yang Huijuan Wu Sufang zhu Tao wang Huaying Zhang Yingli Qiu Lihua Guo xiaoqing Xiang Libing Zhang Wei Ren Yulan Feng Yanling Liu Yanfei Chen Xiaojun Zang Rongyu Department of Gynecologic Oncology Fudan University Zhongshan Hospital institute for Ovarian Cancer Fudan University Shanghai China Department of Gynecologic Oncology Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Zhejiang China Department of Obstetrics and Gynecology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Gynecology Obstetrics and Gynecology Hospital Fudan University Shanghai China Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy West China Second Hospital Sichuan University and Collaborative Innovation Center Chengdu Sichuan China Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu China National Clinical Research Center for Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China School of Public Health Key Laboratory of Public Health Safety and Collaborative Innovation Center of Social Risks Governance in Health Fudan University Shanghai China Gynecologic Oncology Center Chongqing University Cancer Hospital Chongqing China Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Gynecologic Oncology Fudan University Shanghai Cancer Center Shanghai China Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Renji Hospital School of Medicine

GRANITOIDS AND TETONIC EVOLUTION OF THE WEST KUNLUN OROGENIC BELT

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地学前缘 2000年第S1期7卷 228-229页

作者： wang Yuanlong 1,Bi Hua 2. wang {2. 2. zhu xiaoqing 2.(1.institute of Geology And Geophysics, chinese academy of Science, Beijing 10002.,china 2.9}, chinese academy of Science,{12.,china)

The West Kunlun orogenic belt, one of the least studied areas in china, is located at the junction between the Qinghai—Tibetan Plateau and Tarim Basin and has undergone intense tectonic action and frequent *** West Kunlun orogenic belt can be divided into five tectonic\|magmatic evolution stages according to the character of the igneous rocks, metamorphic rocks, sedimentation mode, tectonic phases and isotopic ages(Fig 1).Active stages have dominated with only short intervening stable stages. This kind of evolution is not simply repeated but that a later stage is elevation and development of its former ***\|time distribution of granitoids varies with each different tectonic\| magmatic stage as well as within different periods of the same tectonic\| magmatism stage. Take time into condition , It is an important turning movement of tectonics\|magmatism evolution during the Indo\|Sinian movement, as space the middle fault (Jiang Chunfa 1982. of the West Kunlun orogenic belt is a significant border o f tectonics\|magmatism evolution. Granitoids formed before Indo\|Sinian movement are mainly distributed to the north of the middle fault of West Kunlun. These granitoids are mostly granites of early and middle Proterozoic, Caledonian and Hercynian ages. A unique control on the granitoid evolution is that they become younger from NE to SW, crossing the regional structure line. Granitoids formed after Indo\|Sinian movement are mainly distributed to the south of the middle fault. But distribution of granitoids of early Yanshan cycle cut across the middle fault of West Kunlun Mountain. Their age distribution shows a bidirectional control with the granitoids becoming younger across the regional structural lines from NE and SW boundary fault to the interior of the fracture belts.

关键词： the West Kunlun orogenic belt tectonic\|magmatic evolution gr anitoids

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Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian Li Deng-xing Lun Ningning Gong Gang Meng Xin-ying Du He wang Xiangxiang Bao Xin-yang Li Ji-wu Song Kewei Hu Lala Li Si-ying Li Wenbo Liu Wanping zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou {2. Han Furong Hao Yongcheng Hu Lin Liu Hongguang zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China School of Life sciences Nankai UniversityTianjin300071China Weifang Traditional chinese Medicine Hospital WeifangShandong261000China Shaanxi key laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda institute of Biological sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

中国东部海区重点盆地演化与中深层油气资源潜力

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海洋地质前沿 2024年第9期40卷 1-13页

作者：王明健陈晓辉朱晓青黄龙李汞潘军中国地质调查局青岛海洋地质研究所青岛266237 青岛海洋科技中心矿产资源评价与探测技术功能实验室青岛266237 福州东鑫矿业技术有限公司福州350108

石油和天然气资源的短缺已经严重制约了中国国民经济的发展，开拓油气勘探新领域和寻找后备油气基地已经上升为国家战略。以近些年海洋区域调查实测资料为基础，结合前人研究成果，对中国东部海域重点盆地构造特征和演化过程进行研究，... 详细信息

石油和天然气资源的短缺已经严重制约了中国国民经济的发展，开拓油气勘探新领域和寻找后备油气基地已经上升为国家战略。以近些年海洋区域调查实测资料为基础，结合前人研究成果，对中国东部海域重点盆地构造特征和演化过程进行研究，分析各盆地油气成藏要素和成藏条件，并指出有利勘探区域。研究表明：按照盆地发育位置和成因，中国东部海域沉积盆地可划分为2.类型;受块体之间相互作用的控制，各盆地经历了不同的构造演化历史，发育明显不同的构造和地层特征，进而导致油气成藏要素和成藏模式截然不同;渤海湾盆地油气资源主要赋存于古近系中上部、新近系下部和前新生界潜山，北黄海盆地勘探重点是东部坳陷中生界，南黄海盆地应以中—古生界海相油气勘探为重点，东海陆架盆地则应兼顾中生界和新生界油气勘探。研究结果可以为中国东部海域沉积盆地油气勘探提供一定的参考。

关键词：中国东部海区沉积盆地油气成藏有利勘探区域

Understanding the boundary and mechanism of gas-induced explosion for lithium-ion cells:Experimental and theoretical analysis

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Journal of Energy Chemistry 2023年第11期86卷 546-558,I0012页

作者： Tongxin Shan xiaoqing zhu Zhenpo {2. National Engineering Research Center of Electric Vehicles Beijing Institute of TechnologyBeijing 100081China key laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

Thermal runaway(TR)of lithium-ion(Li-ion)batteries(LIBs)involves multiple forms of hazards,such as gas venting/jetting,fire,or even ***,as the most extreme case,is caused by the generated flammable gases,and a deflagration to detonation transition(DDT)may occur in this ***,overheat-to-TR tests and the corresponding outgas-induced explosion tests were conducted on 42.Ah Li-ion cells with Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]*** sum of CO_(2.,H_(2.,C_(2.H_(4),CO,and CH4accounted for more than 90%of the ***/upper explosion limits(LEL/UEL),laminar flame speed,and ideal stable detonation pressure were calculated to interpret the explosion characteristics and *** turned out that shockwave was easily to be compressed and accelerated under higher state of charge(SOC)***,Li-ion cells explosion may evolve into unstable detonation in encapsulated battery pack and its evolution mechanism was explained,which provides a new idea for explosion-proof design of LIBs ***,a comprehensive assessment method was developed to intuitively characterize TR *** of explosion presented an upward trend with the increase of SOC while the sensitivity was not the *** study provides a further anatomy of TR,which is instructive to the safety of power battery systems.

关键词： Lithium-ion battery Thermal runaway Gas explosion Evolution mechanism Safety

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Madouzi-type (nodular) sedimentary copper deposit associated with the Emeishan basalt

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Science china Earth sciences 2011年第12期54卷 1880-1891页

作者： wang FuDong zhu {2. wang zhonggang State key laboratory of Ore {2. geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Graduate University of chinese academy of sciences Beijing 100049 China

Ore minerals in the sedimentary-type Cu deposits in the Xuanwei Formation overlying the Emeishan basalt are dominated by copper sulfides and native copper. As the ores mostly exhibit concretionary structure, previous researchers named them the "Madouzi-type Copper deposit". Here the authors carried out mineralogical and isotopic studies on copper nodules in this ore deposit. The mineralogical study shows that copper nodules are composed of copper sulfides that have been cemented by ferruginous amorphous minerals, clay, and carbonaceous fragments in the modes of metasomatism and sedimentation. The nodules are preliminarily present as aggregates of gelatinous material. The isotopic analysis shows that the δ 13CPDB values of an- thraxolite are within the range of-2..8‰--2..9‰, indicating that the anthraxolite is the product of sedimentary metamorphism of in-situ plants. The δ 34SV-CDT values of chalcocite are within the range of 7.6‰-13.1‰, close to those (about 11‰) of Permian seawater. The δ 34SV-CDT values of bornite and chalcopyrite are 2..6‰-2..2., similar to the sulfur isotopic composition (2.‰) of marine sulfate, indicative of different sources of sulfur. The above characteristics indicate that the copper nodules were formed in such a process that Cu-bearing basalt underwent weathering-leaching and copper-bearing material was transported into waters (e.g., rivers, lakes, and swamps) and then adsorbed on clay and ferruginous amorphous mineral fragments. Then, the copper-bearing material was suspended and transported in the form of gelinite. In lake or swamp environment, it was co-deposited with sediments to form copper nodules. At later stages there occurred metasomatism and hydrothermal su- perimposition, followed by the replacement of chalcocite by bornite and the superimposition of chalcopyrite over bornite, finally resulting in the formation of the "Madouzi-type" nodular copper deposit.

关键词：峨眉山玄武岩铜矿床沉积型结节硫同位素组成同位素分析沼泽环境热液叠加

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Dinitrogen cleavage and hydrogenation to ammonia with a uranium complex

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National Science Review 2023年第2期10卷 165-173页

作者： xiaoqing Xin Iskander Douair Yue Zhao Shuao wang Laurent Maron Congqing {2. State key laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing University School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine LPCNO CNRS and INSA Université Paul Sabatier State key laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow University

The Haber-Bosch process produces ammonia(NH3) from dinitrogen(N2. and dihydrogen(H2.,but re quires high temperature and *** iron-based catalysts were exploited in the current industrial Haber-Bosch process,uranium-based materials served as effective catalysts for production of NH3from *** some molecular uranium complexes are known to be capable of combining with N2.further hydrogenation with H2.orming NH3has not been reported to ***,we describe the first example of N2.leavage and hydrogenation with H2.o NH3with a molecular uranium *** N2.leavage product contains three uranium centers that are bridged by three imido μ2.NH ligands and one nitridoμ3-N *** experiments with15N demonstrate that the nitrido ligand in the product originates from *** of the N2.cleaved complex with H2.r H+forms NH3under mild conditions.A synthetic cycle has been established by the reaction of the N2.cleaved complex with trimethylsilyl *** isolation of this trinuclear imido-nitrido product implies that a multi-metallic uranium assembly plays an important role in the activation of N2.

关键词： N