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Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

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Neural Regeneration Research 2024年第7期19卷 1568-1574页

作者： Qi Gu Weiping Sha Qun Huang Jin Wang Yi zhu Tianli Xu Zhenhua Xu Qiancheng zhu Jianfei Ge Shoujin Tian xiaolong Lin Department of Orthopaedic Surgery Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina Orthopedics Laboratory The First People’s Hospital of Zhangjiagang CitySuzhouJiangsu ProvinceChina Department of Anesthesiology Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord *** growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species *** relationship between heme oxygenase-1and ferroptosis remains controve *** this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord *** addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord *** r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme ***,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd *** findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关键词： ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation neuron reactive oxygen species spinal cord injury

Characteristics of strontium isotopes and their implications in the Qixing Cave of Guizhou, China

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Chinese Science Bulletin 2011年第7期56卷 670-675页

作者： zhu xiaolong WANG ShiJie LUO WeiJun State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550002China Graduate University of Chinese Academy of Sciences Beijing 100049China

The strontium isotopic compositions (87Sr/86Sr) of samples including soils, bedrock, soil waters, drip waters and their corresponding speleothems in the Qixing Cave (QXC), Guizhou Province, China, were systemically measured and analyzed. The results indicate that there are significant Sr isotopic differences among samples. The mean 87Sr/86Sr ratios in drip water for the samples 1#, 4# and 9# were 0.709568, 0.709139 and 0.708761, respectively, which possibly result from different flow paths, residence times, and other hydrogeological processes in the unsaturated zone overlying QXC. Meanwhile, levels of 40.8%, 57.6% and 72.4% of Sr in drip waters for 1#, 4# and 9#, respectively, were derived from bedrock dissolution, which was calculated by the mixture model of the two end-members (soil and bedrock). There is, however, no positive correlation between the relative proportion from bedrock dissolution (δ13C value is 1.8‰) and drip water δ13CDIC values. The mean drip water δ13CDIC value in 1# is the heaviest (–4.5‰) with the lowest contribution rate of bedrock dissolution, whereas the value in 9# is the lightest (–9.3‰) with the highest contribution rate of bedrock dissolution. The proportion from host rock dissolution in 4# is higher than that in 1# and lower than that in 9#, while its mean drip water δ13CDIC value (–8.6‰) is higher than that of 9# and lower than that for 1#. This suggests that the prior calcite precipitation (PCP) processes in the unsaturated zone overlying the cave are responsible for the δ13CDIC value differences between different drip waters, and not bedrock dissolution. Furthermore, this study also demonstrates that the 87Sr/86Sr ratios of speleothems in the 1# and 4# mainly reflect the variation in the relative proportions from the soil system (soil water) and bedrock dissolution overlying the cave. It is, therefore, feasible to use the strontium isotopic signals of speleothems as an indicator for soil chemical weathering intensity, and consequentl

关键词：锶同位素同位素特征贵州省中国洞穴堆积物同位素组成流动路径停留时间

Blind source separation with unknown and dynamically changing number of source signals

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Science in China(Series F) 2006年第5期49卷 627-638页

作者： YE Jimin ZHANG Xianda zhu xiaolong Key Laboratory for Radar Signal Processing Xidian University Xi'an 710071 China Department of Automation State Key Laboratory of Intelligent Technology and Systems Tsinghua University Beijing 100084 China

The contrast function remains to be an open problem in blind source separation （BSS） when the number of source signals is unknown and/or dynamically changed. The paper studies this problem and proves that the mutual information is still the contrast function for BSS if the mixing matrix is of full column rank. The mutual information reaches its minimum at the separation points, where the random outputs of the BSS system are the scaled and permuted source signals, while the others are zero outputs. Using the property that the transpose of the mixing matrix and a matrix composed by m observed signals have the indentical null space with probability one, a practical method, which can detect the unknown number of source signals n, ulteriorly traces the dynamical change of the sources number with a few of data, is proposed. The effectiveness of the proposed theorey and the developed novel algorithm is verified by adaptive BSS simulations with unknown and dynamically changing number of source signals.

关键词： blind source separation independent component analysis natural gradient mutual information contrast function neural networks.

A new design of foam spray nozzle used for precise dust control in underground coal mines

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International Journal of Mining Science and Technology 2016年第2期26卷 241-246页

作者： Han Fangwei Wang Deming Jiang Jiaxing zhu xiaolong College of Safety Science and Engineering Liaoning Technical UniversityHuludao 125105China Faculty of Safety Engineering China University of Mining&TechnologyXuzhou 221116China

In order to improve the utilization rate of foam,an arc jet nozzle was designed for precise dust *** theoretical analysis,the different demands of foam were compared amongst arc jets,flat jets and full cone jets when the dust source was covered identically by *** is proved that foam consumption was least when an arc jet was *** production capability of an arc jet nozzle under different conditions was investigated through *** results show that with the gas liquid ratio(GLR)increasing,the spray state of an arc jet nozzle presents successively water jet,foam jet and *** a reasonable working condition range of foam production and a fixed GLR,foam production quantity increases at first,and then decreases with the increase of liquid supply *** the inner diameter of the nozzle is 14 mm,the best GLR is 30 and the optimum liquid supply quantity is0.375 m^3/*** results of field experiments show that the total dust and respirable dust suppression efficiency of arc jet nozzles is 85.8%and 82.6%respectively,which are 1.39 and 1.37 times higher than the full cone nozzles and 1.20 and 1.19 times higher than the fiat nozzles.

关键词：精确控制泡沫煤矿井下设计射流喷嘴呼吸性粉尘喷咀生产能力

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民机雷达罩的抗鸟撞非线性力学行为仿真研究

南京理工大学学报 2024年第1期48卷 62-73页

作者：庞小强朱小龙荆雲杰龙舒畅唐维王焰刘卫中航成飞民用飞机有限责任公司四川成都610092 华南理工大学土木与交通学院广东广州510641

为了研究某民机雷达罩结构的抗鸟撞性能,基于ABAQUS建立了采用纤维增强非线性动力本构的雷达罩模型,综合考虑了复合材料与泡沫芯材的非线性行为与应变率效应。该文通过仿真模拟,分析了面板材料(包括复合材料和泡沫芯材)是否考虑非线性... 详细信息

为了研究某民机雷达罩结构的抗鸟撞性能,基于ABAQUS建立了采用纤维增强非线性动力本构的雷达罩模型,综合考虑了复合材料与泡沫芯材的非线性行为与应变率效应。该文通过仿真模拟,分析了面板材料(包括复合材料和泡沫芯材)是否考虑非线性与应变率效应、夹芯结构铺层顺序与角度,以及前后面板厚度比对结构鸟撞响应失效行为的影响。结果表明:纤维增强复合材料的非线性动力本构能够很好地描述雷达罩复合材料结构在动态加载下的应变率强化效应。不同铺层角度下的雷达罩面板的破坏形式基本相同,其最主要的失效形式是基体拉伸破坏,而前后面板铺层顺序为[0/-45/45]/[45/-45/0],且前后面板层厚比接近1的模型具有较好的吸能效果。

关键词：复合材料雷达罩鸟撞数值模拟非线性分析本构模型

Transformer Partial Discharge Monitoring Based on Optical Fiber Sensing

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Photonic Sensors 2014年第2期4卷 137-141页

作者： Kun WANG Xinglin TONG xiaolong zhu National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology Wuhan430070 China

然而，力量变压器是高电压力量格子的最重要的设备联机部分分泌物监视的一些传统的方法有一些限制。基于察觉到技术的光纤维的许多优点，我们在察觉到能为联机部分分泌物监视上的变压器是有用的纤维光学 Fabry-Perot (FP ) 上做了一些... 详细信息

然而，力量变压器是高电压力量格子的最重要的设备联机部分分泌物监视的一些传统的方法有一些限制。基于察觉到技术的光纤维的许多优点，我们在察觉到能为联机部分分泌物监视上的变压器是有用的纤维光学 Fabry-Perot (FP ) 上做了一些研究。这研究瞄准了改进监视的力量系统安全的可靠性。我们如下做了一些工作：为纤维光学 FP 传感器准备设计一个集合，根据严格地认出传感器的制造过程，造为察觉到的纤维光学 FP 的一个合理信号解调系统，做关于联机部分分泌物信号监视的初步的分析，与一样的分泌物紧张与一样的测量距离和不同测量距离在不同分泌物紧张上包括研究，然后做试验性的结果的详细分析。

关键词：光纤传感技术电源变压器在线监测局部放电热传感器信号监控放电强度测量距离

Effect of Microstructure and Sulfide on Corrosion of Cu-Ni Alloys in Seawater

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Journal of Materials Science & Technology 2000年第4期16卷 411-415页

作者： xiaolong zhu (General Research Institute for Nonferrous Metals, Beijing 100088, China) General Research Institute for Nonferrous Metals Beijing 100088 China

The microstructure and the corrosion product films have been investigated on Cu-Ni alloys by TEM, SEM, AES and electrochemical technique as well as natural seawater exposure tests. Experimental results showed that the alloys had two kinds of microstructure, i.e. recrystallizatjon and incomplete recrystallization. In synthetic seawater containing 2x10^-6 S^2-, the stability of the alloy increased with the increase of deformation and annealing temperature, i.e., the degree of recrystallization. After exposure to natural seawater for different periods of time, the corrosion product films of the recrystallized alloy were rich in Ni and compact, and there were cracks in the outer layer which contained a small amount of S; the films of the alloy of incomplete recrystallization became thick, loose and porous, and obviously of layered structure, and the intergranular corrosion took place in the underlying substrate Besides, a great amount of seawater substance existed in the outer layer and some sulfur was found within the grain boundaries that prefer to corrode. The accelerating effect of sulfides in corrosion of Cu-Ni alloys in seawater is attributed to the coexistence and absorption of sulfides and carbides promoting the preference of corrosion where they absorb, and the formation of dissolvable Cu2S results in keeping the surface of the alloys in the active state.

关键词： Effect of Microstructure and Sulfide on Corrosion of Cu-Ni Alloys in Seawater Cu Ni

High Performance Work Systems and Employee Creativity： The Mediating Effect of Knowledge Sharing

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Frontiers of Business Research in China 2014年第3期8卷 367-387页

作者： Chunling zhu xiaolong Chen School of Business Renmin University of China Beijing 100872 China

Employee creativity is both the core element of a firm＇s innovation capabilities and the sources for its growth. To improve an organization＇s ability to innovate, it is necessary to improve the creativity of its employees. Based on theories from strategic human resource management, creativity and organizational learning, this paper investigates the relationship between high performance work systems and employee creativity and explores the role knowledge sharing plays in their relationship. A questionnaire is designed and administered to a group of part-time executive students in the winter of 2012. Two hundred students are invited to answer the survey questions with 117 valid responses. Data are collected and processed by using statistical regressions. The empirical findings reveal that high performance work systems positively affect knowledge sharing and employee creativity. Knowledge sharing plays a mediating role in the relationship between high performance work systems and employee creativity. Implications for practice and future research are discussed.

关键词： high performance work systems (HPWS) knowledge sharing,employee creativity

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华北平原水源地水文地球化学演变特征及机制

人民长江 2024年第3期55卷 59-67页

作者：汪洋朱小龙白雪山单强张旭虎田西昭河北省地质资源环境监测与保护重点实验室河北石家庄050081 河北省地质环境监测院河北石家庄050081

随着地下水的减采、南水北调补水以及河道生态补水等一系列措施,华北平原水源地地下水环境发生了较大变化。以华北平原廊坊城区水源地为例,借助统计分析、piper三线图、离子组合比等手段,分析地下水水文地球化学特征及演变机制。结果表... 详细信息

随着地下水的减采、南水北调补水以及河道生态补水等一系列措施,华北平原水源地地下水环境发生了较大变化。以华北平原廊坊城区水源地为例,借助统计分析、piper三线图、离子组合比等手段,分析地下水水文地球化学特征及演变机制。结果表明:①自水源地开采初期至强开采期,区域地下水具有较强的动力条件,地下水中水化学作用以矿物溶解作用为主,水化学类型以HCO_(3)-Na、HCO_(3)·Cl-Na型为主;南水北调后地下水动力条件相对减弱,地下水中水化学作用以阳离子交替吸附作用为主,水化学类型以HCO_(3)-Na、HCO_(3)·SO_(4)-Na型为主。②水文地球化学模拟结果显示,1974,1995,2019年地下水中矿物溶解量分别为0.17,1.43,0.21 mmol/L,水-岩相互作用呈弱-强-弱的趋势变化,研究区深层地下水的水质变化主要受萤石矿物及碳酸盐、硅酸盐矿物的溶解作用和阳离子交替吸附作用的影响,表明区域地质、水文地质条件以及人类活动等影响地下水流场,改变水岩相互作用的反应程度。研究成果可为华北平原地下水资源开发利用提供科学依据。

关键词：水源地水文地球化学特征水-岩相互作用矿物溶解作用华北平原