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脂质代谢在新生血管性年龄相关性黄斑变性进展及治疗中的作用

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国际眼科杂志 2024年第9期24卷 1432-1437页

作者：宋维晨陈雯池敬毅祝文文山东第二医科大学附属医院眼科中心中国山东省潍坊市261041 山东第二医科大学中国山东省潍坊市261053

新生血管性年龄相关性黄斑变性(nARMD)是一种普遍发生的、与年龄相关的严重影响患者视力的视网膜疾病。大量研究显示,脂质代谢紊乱在nARMD的进展中发挥着促进作用,而这种关系涉及到多个因素,包括脂肪酸、胆固醇、脂质代谢基因变异等。... 详细信息

新生血管性年龄相关性黄斑变性(nARMD)是一种普遍发生的、与年龄相关的严重影响患者视力的视网膜疾病。大量研究显示,脂质代谢紊乱在nARMD的进展中发挥着促进作用,而这种关系涉及到多个因素,包括脂肪酸、胆固醇、脂质代谢基因变异等。脂质代谢紊乱通过刺激氧化应激、抑制自噬,以及二者间的相互作用,引起了视网膜血管的异常和炎症反应,从而加速新生血管的形成,导致黄斑区细胞和组织的损伤。在动物实验中,开发针对脂质代谢紊乱的药物证实了通过调节脂质代谢是治疗nARMD的一种潜在有效策略。基于这一发现,文章对脂质代谢在nARMD进展及治疗中的作用进行综述,旨在为下一步的临床研究提供参考和依据,为nARMD的临床治疗开辟新的思路。

关键词：脂质代谢新生血管性年龄相关性黄斑变性氧化应激自噬脂质代谢相关药物治疗

Localization and secretory pathways of a 58K-like protein in multi-vesicular bodies in callus of Arabidopsis thaliana

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Science China(Life Sciences) 2008年第9期51卷 827-832页

作者： XU Shan QIAN Jie song Xin zhu Jian School of Life Science and Technology Tongji UniversityShanghai 200092China Laboratory of Electron Microscopy Faculty of Basic Medicine ScienceSecond Military Medical UniversityShanghai 200433China

Multi-vesicular bodies in endocytosis and protoplasts are special cellular structures that are consid-ered to be originated from invagination of plasma membranes. However, the genesis and function of multi-vesicular bodies, the relationship with Golgi bodies and cell walls, and their secretory pathways remain controversial and ambiguous. Using a monoclonal antibody against an animal 58K protein, we have detected, by Western blotting and confocal microscopy, that a 58K-like protein is present in the calli of Arabidopsis thaliana and Hypericum perforatum. The results of immuno-electron microscopy showed that the 58K-like protein was located in the cisternae of Golgi bodies, secretory vesicles, multi-vesicular bodies, cell walls and vacuoles in callus of Arabidopsis thaliana, suggesting that the multi-vesicular bodies may be originated from Golgi bodies and function as a transporter carrying substances synthesized in Golgi bodies to cell walls and vacuoles. It seems that multi-vesicular bodies have a close relationship with the development of the cell wall and vacuole. The possible secretory pathways of multi-vesicular bodies might be in exocytosis, in which multi-vesicular bodies carry sub-stances to the cell wall for its construction, and in endocytosis, in which multi-vesicular bodies carry substances to the vacuole for its development, depending on what they carry and where the materials are transported. We hence propose that there is more than one pathway for the secretion of multi-vesicular bodies. In addition, our results provided a paradigm that a plant molecule, such as the 58k-like protein in callus of Arabidopsis thaliana, can be detected using a cross-reactive monoclonal antibody induced by an animal protein, and illustrate the existence of analog molecules in both animal and plant kingdoms.

关键词： 58K-like protein Arabidopsis thaliana localization multi-vesicular bodies secretory pathway

The effect of attention to distractor on inhibitory processes in selective attention

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Chinese Science Bulletin 2005年第16期50卷 1743-1750页

作者： GENG Haiyan song Qianlan LI Yunfeng zhu Ying Department of Psychology Peking University Beijing 100871 China Department of psychology Purdue university West Lafayette IN 47906 USA

Selective attention has been viewed as a dual- process mechanism, that is, exciting targets and inhibiting distractors. Most early studies concentrated mainly on the target-excitation, whereas recent investigations began to pay more attention to the inhibitory selective attention mecha-nism. A measure named negative priming (NP) was exten-sively employed to probe into the inhibitory processes. The Houghton and Tipper Model put forward a notion: the inhi-bition that feeds back to the distractor is reactive. That means, the level of inhibition is determined by the activation state of the distractor. Distractors that are more salient and intrude into the control of action receive greater inhibitory feedbacks than less salient distractors. Because increasing attention to an object would enhance the early processing of this object, we thus hypothesized that augmenting the level of attention to a distractor might lead to a higher level of inhi-bition, revealed as a corresponding augmentation in the magnitude of NP effect. To test this assumption, an object- based identification task was then applied, and participants were asked to make the animate/inanimate categorization. Attention level was manipulated by varying the relative spa-tial locations of target and distractor (overlapped or sepa-rated). A reliable greater NP effect was found in the over-lapped than separated condition, indicating that distractors under the high-level attention condition (overlapped) got greater initial excitation, and then evoked greater subsequent inhibitory feedbacks, therefore resulting in a larger NP effect. These results provide direct evidence for the reactive inhibi-tion suggested by the Houghton and Tipper model. Mean-while a coincident greater positive priming (PP) effect was obtained under the overlapped than separated condition, which could be attributed to the higher level of target activa-tion in the overlapped condition. The covariation of NP and PP effects further confirmed that

关键词：选择性阴性爆炸物抑制过程干涉效果

Selectivity regulation of CO_(2)electroreduction on asymmetric AuAgCu tandem heterostructures

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Nano Research 2022年第9期15卷 7861-7867页

作者： Yating zhu Zengqiang Gao Zhicheng Zhang Ting lin Qinghua Zhang Huiling Liu lin Gu Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for New Energy Materials and Low-Carbon Technologies School of Materials Science and EngineeringTianjin Key Laboratory of Advanced Functional Porous MaterialsTianjin University of TechnologyTianjin 300384China

Rational design and synthesis of multimetallic nanostructures(NSs)are fundamentally important for electrochemical CO_(2)reduction reaction(CO_(2)RR).Herein,a multi-step seed-mediated growth method is applied to synthesize asymmetric AuAgCu heterostructures using Au nanobipyramids as nucleation seeds,in which their composition and structures are well *** find that the selectivity of C_(2)products for CO_(2)RR could be effectively regulated by tandem catalysis and electronic effect over trimetallic AuAgCu ***,the Faraday efficiency toward ethanol could reach up to 37.5%at a potential of−0.8 V versus reversible hydrogen electrode over asymmetric Au1Ag1Cu5 heterostructures with segregated domains of three constituent *** work provides an efficient strategy for the synthesis of multicomponent architectures to boost their promising application in CO_(2)RR.

关键词： CO_(2)reduction electrocatalysis tandem catalysis multimetallic nanostructure asymmetric heterostructure

血清FIB及尿RBP、NAG、TRF与紫癜性肾炎患儿肾脏病理分级的相关性

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分子诊断与治疗杂志 2024年第8期16卷 1555-1558,1563页

作者：吴琳彭寅朱颖邓芳安徽省儿童医院儿童肾脏科安徽合肥230051

目的探讨血清纤维蛋白原(FIB)及尿视黄醇结合蛋白(RBP)、尿N⁃乙酰⁃β⁃D氨基葡萄糖苷酶(NAG)、转铁蛋白(TRF)与紫癜性肾炎(HSPN)患儿肾脏病理分级的关系。方法选取2021年1月至2023年5月安徽省儿童医院收治的114例HSPN患儿作为研究组,按... 详细信息

目的探讨血清纤维蛋白原(FIB)及尿视黄醇结合蛋白(RBP)、尿N⁃乙酰⁃β⁃D氨基葡萄糖苷酶(NAG)、转铁蛋白(TRF)与紫癜性肾炎(HSPN)患儿肾脏病理分级的关系。方法选取2021年1月至2023年5月安徽省儿童医院收治的114例HSPN患儿作为研究组,按病理等级分为Ⅱ级63例、Ⅲ级51例;另选取同期住院无肾脏损伤的过敏性紫癜患儿57例作为对照组。对比两组和研究组亚组血清FIB及尿RBP、NAG、TRF水平,分析血清FIB及尿RBP、NAG、TRF与肾脏病理分级的关系及对紫癜性肾炎的预测价值。结果研究组血清FIB、RBP、NAG、TRF水平高于对照组,差异有统计学意义(t=3.160、11.001、2.882、4.168,P<0.05)。Ⅲ级组血清FIB、RBP、NAG、TRF水平高于Ⅱ级组,差异有统计学意义(t=3.995、10.123、4.324、2.893,P<0.05)。血清FIB、RBP、NAG与HSPN肾脏病理分级均呈正相关(r=0.360、0.666、0.400、0.239,P<0.05)。ROC曲线分析显示,血清FIB及尿RBP、NAG、TRF联合检测预测紫癜性肾炎的AUC为0.930,高于各指标单独检测。结论血清FIB及尿RBP、NAG、TRF水平与HSPN患儿病理分级密切相关,联合检测能作为判断HSPN的有效指标。

关键词：紫癜性肾炎血清纤维蛋白原尿视黄醇结合蛋白尿N⁃乙酰⁃β⁃D氨基葡萄糖苷酶转铁蛋白

Effect of Microfibrillated Cellulose Loading on Physical Properties of Starch/Polyvinyl Alcohol Composite Films

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Journal of Wuhan University of Technology(Materials Science) 2020年第4期35卷 825-831页

作者： TIAN Yu zhu Puxin ZHOU Mi lin Yi CHENG Fei College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China

The starch/polyvinyl alcohol(PVA)/microfibrillated cellulose(MFC)composite films were prepared using solution casting method after adding MFC into starch/PVA blend *** effects of MFC content on the mechanical properties of starch/PVA composite films were *** MFC content increases,the elongation at break and tensile strength increase firstly and then *** the content of MFC is 2wt%,the tensile strength is 26.6 MPa and reaches the *** Fourier transform infrared(FTIR),scanning electron microscopy(SEM),X-ray diffraction(XRD)and thermogravimetric analysis(TGA),good dispersion of MFC in starch/PVA matrix at the loading of 2wt%,lower crystallinity of the starch/PVA/MFC films in comparison with starch/PVA blend and the effect of glass transition temperature increasing with MFC content from 0.5wt%to 4wt%can be found ***,incorporating MFC does not change the composition and crystal structure of the starch/PVA composite ***,the reinforcing mechanism for the improvement of mechanical properties is attributed to the homogeneous dispersion of MFC with large aspect ratio,good compatibility and interfacial interactions between starch/PVA blend matrix and MFC.

关键词： biopolymers fillers blends composites mechanical properties

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混合储能微电网新能源多时段动态调度方法

电子设计工程 2024年第9期32卷 11-14页

作者：周晓东宋卫东朱柯许继电气股份有限公司河南许昌461000

由于对电量的需求不断增大,混合储能微电网的日常发电成本不断增长,为有效降低发电成本,优化发电的经济效益性,提出混合储能微电网新能源多时段动态调度方法。以柴油发电系统、可再生能源发电系统运行成本与负荷收益为优化目标,设定发... 详细信息

由于对电量的需求不断增大,混合储能微电网的日常发电成本不断增长,为有效降低发电成本,优化发电的经济效益性,提出混合储能微电网新能源多时段动态调度方法。以柴油发电系统、可再生能源发电系统运行成本与负荷收益为优化目标,设定发电容量与系统平衡约束;利用日前优化调度结果,将调度时间区间缩短至15 min,细化预测结果,实现日内循环调度;结合烟花算法和多目标灰熵算法,求解日内循环调度模型,完成新能源多时段动态调度。经实验验证可知,通过该方法调度后的柴发机组在峰时段发电功率得到显著降低,同时风电机组与光伏机组可以在不同时段完成有效配合,使两者调度后的功率降低,能够保障不同时段下的备用容量。

关键词：混合储能微电网新能源多时段动态调度发电功率

慢性阻塞性肺疾病急性加重期患者血清CCR5、PAI-1水平与肺功能及病情严重程度的关系

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国际检验医学杂志 2024年第10期45卷 1257-1261页

作者：宋文党朱承坡张鹏刘春西藏军区总医院门诊部西藏拉萨610000 西藏军区总医院体检中心西藏拉萨610000 西藏军区总医院内分泌科西藏拉萨610000 西藏军区总医院中医科西藏拉萨610000

目的探究慢性阻塞性肺疾病急性加重期(AECOPD)患者血清细胞趋化因子受体5(CCR5)、纤溶酶原激活物抑制剂-1(PAI-1)水平变化与肺功能及病情严重程度之间的关系。方法选取该院2020年1月至2022年1月急诊收治的114例AECOPD患者为AECOPD组,... 详细信息

目的探究慢性阻塞性肺疾病急性加重期(AECOPD)患者血清细胞趋化因子受体5(CCR5)、纤溶酶原激活物抑制剂-1(PAI-1)水平变化与肺功能及病情严重程度之间的关系。方法选取该院2020年1月至2022年1月急诊收治的114例AECOPD患者为AECOPD组,并选取同期稳定期慢性阻塞性肺疾病(COPD)患者114例为对照组。采用酶联免疫吸附试验(ELISA)测定CCR5、PAI-1水平;比较AECOPD组与对照组及不同病情程度AECOPD患者血清CCR5、PAI-1水平及肺功能指标;Pearson相关性分析AECOPD患者血清CCR5、PAI-1水平与肺功能指标之间的关系;Spearman相关性分析AECOPD患者血清CCR5、PAI-1水平与病情严重程度之间的关系。结果与对照组相比,AECOPD组患者血清CCR5、PAI-1水平均显著升高,差异均有统计学意义(P<0.05),肺功能指标:第1秒用力呼气量(FEV_(1))、FEV_(1)与用力肺活量比值(FEV_(1)/FVC)、FEV_(1)占预计值百分比(FEV_(1)%pred)、最大呼气中期流量(MMEF)占预计值百分比(MMEF%pred)均显著降低,差异有统计学意义(P<0.05),且随着病情程度的增加,血清CCR5、PAI-1水平逐渐增加(P<0.05),FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred、MMEF%pred水平逐渐降低(P<0.05);Pearson相关性分析结果显示,血清CCR5、PAI-1水平与FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred、MMEF%pred均呈显著负相关(P<0.05);Spearman相关性分析结果显示,AECOPD患者血清CCR5、PAI-1水平与病情程度呈显著正相关(r_(1)=0.432,r_(2)=0.451,P<0.05)。结论 AECOPD患者血清CCR5、PAI-1水平显著升高,且血清CCR5、PAI-1水平与AECOPD患者肺功能及病情程度密切相关。

关键词：慢阻肺急性加重期细胞趋化因子受体5 纤溶酶原激活物抑制剂-1 肺功能病情程度

实践与创新融合赋能专业硕士人才培养探究——以塔里木大学土木水利专业硕士为例

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科教文汇 2024年第1期 95-99页

作者：姚宝林张旭贤朱珠李朝阳李林塔里木大学水利与建筑工程学院新疆阿拉尔843300

专业硕士在我国得到了快速发展,该文在分析塔里木大学土木水利专业硕士人才培养过程中存在问题的基础上,提出实践能力和创新能力融合赋能是专业硕士人才质量的重要基础保障,构建了基于“一核两翼四驱动”土木水利专业硕士研究生实践和... 详细信息

专业硕士在我国得到了快速发展,该文在分析塔里木大学土木水利专业硕士人才培养过程中存在问题的基础上,提出实践能力和创新能力融合赋能是专业硕士人才质量的重要基础保障,构建了基于“一核两翼四驱动”土木水利专业硕士研究生实践和创新能力培养模式,实现专业硕士研究生实践能力和创新能力融合发展,提高土木水利专业学位研究生人才培养质量。

关键词：土木水利实践能力创新能力融合赋能