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中晚期原发性肝细胞癌的联合治疗研究进展及其展望

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肝胆胰外科杂志 2024年第5期36卷 262-268页

作者：朱生威杨彦李章睿梁昌富海南医学院第一附属医院肝胆外科海南海口570100

近年来肝癌领域取得了一系列令人鼓舞的突破,免疫检查点抑制剂(ICIs)在中晚期肝细胞癌(HCC)治疗中大放异彩,ICIs联合靶向治疗及局部治疗为患者提供了新的治疗选择和更大的希望,并不断在临床实践中展现出良好的效果,展示了医学界不断努... 详细信息

近年来肝癌领域取得了一系列令人鼓舞的突破,免疫检查点抑制剂(ICIs)在中晚期肝细胞癌(HCC)治疗中大放异彩,ICIs联合靶向治疗及局部治疗为患者提供了新的治疗选择和更大的希望,并不断在临床实践中展现出良好的效果,展示了医学界不断努力改善肝癌治疗的成果。这些突破不仅为肝癌患者提供了更多的治疗机会,还为未来的研究铺平了道路,但是多种治疗方法的组合如何让肝癌患者得到最好的获益,仍然是非常重要的问题。本文综述了中晚期原发性HCC目前的联合治疗进展及未来展望。

关键词：肝细胞癌原发性肝癌 T+A方案双艾方案 tira+T+A方案 STRIDE方案进展及展望

Preparation of mesoporous activated carbons from coal liquefaction residue for methane decomposition

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Journal of Natural Gas Chemistry 2012年第6期21卷 759-766页

作者： Jianbo Zhang Lijun Jin shengwei zhu Haoquan Hu State Key Laboratory of Fine Chemicals Institute of Coal Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Mesoporous activated carbons were prepared from direct coal liquefaction residue （CLR） by KOH activation method, and the experiments were carried out to investigate the effects of KOH/CLR ratio, solvent for mixing the CLR and KOH, and carbonization procedure on the resultant carbon texture and catalytic activity for catalytic methane decomposition （CMD）. The results showed that optimal KOH/CLR ratio of 2 ： 1; solvent with higher solubility to KOH or the CLR, and an appropriate carbonization procedure are conductive to improving the carbon pore structure and catalytic activity for CMD. The resultant mesoporous carbons show higher and more stable activity than microporous carbons. Additionally, the relationship between the carbon textural properties and the catalytic activity for CMD was also discussed.

关键词： mesoporous activated carbon KOH methane decomposition coal liquefaction residue hydrogen

Rapid plant regeneration from cotton (Gossypium hirsutum L.)

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Chinese Science Bulletin 2000年第19期45卷 1771-1774页

作者： shengwei zhu Jingsan Sun Chinese Acad Sci Inst Bot Beijing 100093 Peoples R China

A simple and rapid regeneration method of cotton (Gossypium hirsutum L. cv. Xinluzao4) is described. The proper use of phytohormone KT and IBA validly promoted the survival rate of test-tube plants and shortened the p... 详细信息

关键词： Gossypium hirsutum L. tissue culture in vitro regeneration graft.

Shear resistance characteristics and influencing factors of root-soil composite on an alpine metal mine dump slope with different recovery periods

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Journal of Mountain Science 2024年第3期21卷 835-849页

作者： PANG Jinghao LIANG Shen LIU Yabin LI shengwei WANG Shu zhu Haili LI Guorong HU Xiasong Department of Geological Engineering Qinghai UniversityXining 810016China Key Laboratory of Genozoic Resource&Environment in North Margin of the Tibetan Plateau Xining 810016China

Artificial vegetation restoration is the main measure for vegetation restoration and soil and water conservation in alpine mine dumps on the Qinghai-Tibet Plateau,***,there are few reports on the dynamic changes and the influencing factors of the soil reinforcement effect of plant species after artificial vegetation restoration under different recovery *** selected dump areas of the Delni Copper Mine in Qinghai Province,China to study the relationship between the shear strength and the peak displacement of the root-soil composite on the slope during the recovery period,and the influence of the root traits and soil physical properties on the shear resistance characteristics of the root-soil composite via in situ direct shear *** results indicate that the shear strength and peak displacement of the rooted soil initially decreased and then increased with the increase of the recovery *** shear strength of the rooted soil and the recovery period exhibited a quadratic function *** is no significant function relationship between the peak displacement and the recovery *** positive correlations(P0.05)between the shear strength of the root-soil composite and the root length density,and the root volume ratio of the coarse roots to the fine roots.A significant negative linear correlation(P0.05)with the root traits,other soil physical property indices(the moisture content and dry density of the soil),and slope *** coarse-grain content is the main factor controlling the peak displacement of the rooted soil.

关键词： Alpine mine dump Artificial vegetation restoration period Rooted soil Shear resistance characteristics Root traits Soil physical properties

PIF3 Is Involved in the Primary Root Growth Inhibition of Arabidopsis Induced by Nitric Oxide in the Light

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Molecular Plant 2014年第4期7卷 616-625页

作者： Sulan Bai Tao Yao Miaomiao Li Xiaomin Guo Yaochuan Zhang shengwei zhu Yikun He College of Life Sciences Capital Normal University Beijing 100048 PR China Beijing Vocational College of Agriculture Beijing 102442 PR China Institute of Botany Chinese Academy of Sciences Beijing 100731 PR China

PHYTOCHROME INTERACTING FACTOR3 （PIF3） is an important component in the phytochrome signaling pathway and mediates plant responses to various environmental conditions. We found that PIF3 is involved in the inhibition of root growth of Arabidopsis thaliana seedlings induced by nitric oxide （NO） in light. Overexpression of PIF3 partially alleviated the inhibitory effect of NO on root growth, whereas the pif3-1 mutant displayed enhanced sensitivity to NO in terms of root growth. During phytochrome signaling, the photoreceptor PHYB mediates the degradation of PIF3. We found that the phyB-9 mutant had a similar phenotype to that of PIF3ox in terms of responsiveness to NO. Furthermore, NO treatment promoted the accumulation of PHYB, and thus reduced PIF3 content. Our results further show that the activity of PIF3 is regulated by the DELLA protein RGL3[RGA （repressor of gal-3） LIKE 3]. Therefore, we speculate that PIF3 lies downstream of PHYB and RGL3, and plays an important role in the inhibitory effect of NO on root growth of Arabidopsis seedlings in light.

关键词： nitric oxide PIF3 PHYB RGL3 root growth inhibition.

Expressing PHB synthetic genes through chloroplast genetic engineering

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Chinese Science Bulletin 2002年第16期47卷 1373-1376页

作者： ZHANG Jingyu SU Ning ZHANG Zhonglin ZHAO Huayan zhu shengwei SONG Yanru Key Laboratory of Photosynthesis and Enviromental Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China

Chloroplast integration and expression vector containing expression cassettes for phbB, phbA, phbC and aadA genes was constructed and bombarded into the tobacco chloroplast genome. Transplastomic plants were analyzed with PCR and Southern blot. Their homoplastomy was also judged. Northern dot and RT-PCR analysis were employed to investigate transgene expression at transcriptional level. The results indicate that the chloroplast transformation system is compatible for poly-3-hydroxybutyrate (PHB) production.

关键词： chloroplast genetic engineering poly-3-hydroxybutyrate transplastomic tobacco transcriptional level gene silencing.

可持续发展观视域下的住宅户型设计趋势——以温州·九山金茂府项目为例

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房地产世界 2022年第7期 70-72页

作者：朱胜伟上海齐越建筑设计有限公司

现阶段,为缓解住宅的供需矛盾、保护生态环境和满足人们对居住品质日益提高的需求,寻求多样化和可持续的住宅空间设计策略是十分必要的,这也是推动我国建筑行业健康发展、切实满足社会发展需求的必由之路。基于此,本文以住宅户型设计趋... 详细信息

现阶段,为缓解住宅的供需矛盾、保护生态环境和满足人们对居住品质日益提高的需求,寻求多样化和可持续的住宅空间设计策略是十分必要的,这也是推动我国建筑行业健康发展、切实满足社会发展需求的必由之路。基于此,本文以住宅户型设计趋势为切入点,结合温州·九山金茂府项目实例,阐述了可持续发展观视域下的住宅户型设计要求及常见问题,探讨住宅户型设计的主要趋势,以供相关人员参考。

关键词：可持续发展观住宅户型设计趋势

基于改进压缩与激活块的遥感影像语义分割方法

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激光与光电子学进展 2024年第12期61卷 277-286页

作者：吴盛葳方娇莉朱大明昆明理工大学国土资源工程学院云南昆明650000 昆明理工大学计算中心云南昆明650000

针对传统方法在提取背景复杂的遥感影像时出现的语义识别错误等问题,基于压缩与激活块(SE-block)构建了一种简单而有效的卷积注意模块——区域压缩与激活块(RSE-block)。该模块能汲取特征的局部上下文信息,从而指导网络筛选重要的特征,... 详细信息

针对传统方法在提取背景复杂的遥感影像时出现的语义识别错误等问题,基于压缩与激活块(SE-block)构建了一种简单而有效的卷积注意模块——区域压缩与激活块(RSE-block)。该模块能汲取特征的局部上下文信息,从而指导网络筛选重要的特征,并在空间和通道两个方向上重新激活特征表达。此外,该模块能无缝集成到任何卷积神经网络构架中与网络一起进行端到端的训练。同时,提出了一种与该模块对应的解决不同尺寸地物目标识别问题的多尺度集成方法,并在此基础上构建了一个新的语义分割网络——RSENet。实验结果表明:RSENet在Potsdam数据集上的平均F1分数和平均交并比分别比基线网络高出0.028和0.021;与当下一些先进方法相比,RSENet具有竞争力。

关键词：遥感影像语义分割注意力机制卷积神经网络

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基于聚类算法的建筑用能行为减碳

浙江建筑 2023年第1期40卷 79-82页

作者：吴剑平朱晟炜浙江大学建筑设计研究院有限公司浙江杭州310028

对浙江省某办公建筑5月份末端能耗进行案例分析,将人的用能行为与碳排放量挂钩,基于k⁃means聚类算法对末端用户进行横向比较,以实现对不同用能行为的评价。对各类用能行为(空调、照明、插座设备用电、生活热水)的碳排放量分别进行聚类评... 详细信息

对浙江省某办公建筑5月份末端能耗进行案例分析,将人的用能行为与碳排放量挂钩,基于k⁃means聚类算法对末端用户进行横向比较,以实现对不同用能行为的评价。对各类用能行为(空调、照明、插座设备用电、生活热水)的碳排放量分别进行聚类评价,并计算节能减碳潜力,从而可为末端用户实现行为减碳提供具体方向及减碳目标。

关键词：建筑能耗用能行为碳排放量聚类算法行为减碳