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A low-cost wide bandgap polymer based on carboxylate substituted thiazole enables efficient organic solar cells with remarkable batch-to-batch reproducibility

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Science China Chemistry 2024年

作者： xiaodong zhu Yuchen Lei Jianhong Gao Yanjun He Jinsicheng liu Qian Guo Xiang Gao Liwei Xiong Xunchang Wang Renqiang Yang Zhitian liu Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials Hubei Key Laboratory of Plasma Chemistry and Advanced MaterialsSchool of Materials Science and EngineeringWuhan Institute of Technology Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education) School of Optoelectronic Materials&TechnologyJianghan University

Constructing the low-cost, high-efficiency, and good batch-to-batch reproducibility polymer donor is vitally important for the application of organic solar cells. Herein, we develop a structurally simple carboxylate-substituted thiazole as an electronwithdrawing building block to construct a low-cost polymer, PBTTzE, containing a facilely prepared chlorinated benzo[1,2-b:4,5-b′]dithiophene(BDTCl) donor unit. Benefiting from synergistic electron deficient effects of chlorination and ester group and C=N, as well as the noncovalent interaction of S···O and S···N, PBTTzE exhibits a deep HOMO energy level(-5.59 eV),and a planar skeleton structure. When combined with the IT-4F acceptor, the polymer(54 kDa) demonstrated a champion PCE of15.87%, which is the highest value in the IT-4F-based binary devices to date. Moreover, PBTTzE exhibits excellent batch-tobatch reproducibility due to its very similar PCEs within a range of 43–76 kDa. In addition, an alloyed state and complementary absorption can be formed between PM6 and PBTTzE. Therefore, in a ternary device with PBTTzE added to the PM6:BTP-eC9blend, a top PCE of 18.76% is achieved due to the suppressed energy loss, prolonged exciton diffusion distance, and improved charge transport. Our work demonstrates that the carboxylate-substituted thiazole is a highly promising acceptor unit for constructing low-cost and high-performance polymers.

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Acquired immune thrombotic thrombocytopenic purpura(TTP)associated with inactivated COVID-19 vaccine CoronaVac

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Frontiers of Medicine 2024年第4期18卷 744-751页

作者： Zhangbiao Long Suyu Jiang Honglei Xin Lu Zhang Ruinan Lu Fengqi liu Yong Xu Linv Wang Jun Wang Xuezhong Zhang Hui Liao Jinning Shi Xue Yan Xiang zhu Ruonan Shao Zijian Li Yilin zhu Han Yan Jiao Wu Chao Fang xiaodong Xi Xiaofeng Shi Department of Hematology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Hematology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210003China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Hematology The Affiliated Hospital of Nanjing University of Chinese MedicineThe First Clinical Medical College of Nanjing University of Chinese MedicineNanjing210009China Department of Hematology Zhongda Hospital of Southeast UniversityNanjing210044China Department of Hematology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Hematology The Air Force Hospital of Eastern Theater commandNanjing210016China Department of Hematology Jiangning Hospital Affiliated of Nanjing Medical UniversityNanjing211199China Department of Hematology Nanjing Hospital of Chinese MedicineNanjing210006China Department of Pharmacology School of Basic MedicineTongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesHuazhong University of Science and TechnologyThe Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei ProvinceWuhan430030China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

Corona virus disease 2019(COVID-19)due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the whole *** thrombotic thrombocytopenic purpura(TTP)has been reported after administration of mRNA-or adenoviral vector-based COVID-19 vaccines,including ***2-S,BNT162b2,mRNA-1273,and ChAdOx1 ***,whether inactivated vaccines,such as CoronaVac,could cause TTP and whether the symptoms in TTPs caused by inactivated vaccines are different from previously reported cases are *** this study,two cases were *** cases developed TTP after the second CoronaVac vaccination shot,but not the *** demonstrated symptoms of fever,neurological abnormalities,renal dysfunction,thrombocytopenia,and *** patients achieved complete remission through several sessions of plasma exchanges and immune *** incidence of TTP in Nanjing area was *** number of patients with TTP was 12 in 2019,6 in 2020,16 in 2021,and 19 in *** the authors’knowledge,this report is the first report of TTP associated with inactivated COVID-19 vaccine(CoronaVac).The rarity and delayed onset may be due to the relatively milder immune response caused by the inactivated vaccines than mRNA-based *** plasma exchange is a vital treatment for CoronaVac-related TTP,similar to activated vaccine-related TTP.

关键词： thrombotic thrombocytopenia purpura(TTP) corona virus disease 2019(COVID-19) CoronaVac acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccine

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饱和地基中劲芯水泥土墙隔振的二维BEM-FEM耦合分析

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世界地震工程 2024年第4期40卷 164-178页

作者：孙立光朱颖时刚王瑜刘攀郜新军朱超杰郑州地铁集团有限公司河南郑州450000 郑州大学土木工程学院郑州450001 中铁隧道集团二处有限公司河北廊坊065000

振动污染在国际上已被列入“七大环境公害”之一,填充沟是振动污染治理的一种常用隔振屏障。传统的填充沟受工程造价和施工工艺等限制工程中应用较困难;为克服上述问题,提出一种新型隔振屏障-内插预制芯墙的劲芯水泥土墙。对于饱和地基... 详细信息

振动污染在国际上已被列入“七大环境公害”之一,填充沟是振动污染治理的一种常用隔振屏障。传统的填充沟受工程造价和施工工艺等限制工程中应用较困难;为克服上述问题,提出一种新型隔振屏障-内插预制芯墙的劲芯水泥土墙。对于饱和地基中劲芯水泥土墙的隔振问题,饱和地基采用饱和土半解析边界元法(boundary element method,BEM)建模,劲芯水泥土墙采用有限元法(finite element method,FEM)建模,根据饱和地基-水泥土墙交界面的平衡和连续性条件,分别建立了劲芯水泥土墙对入射Rayleigh波(瑞利波)的远场被动隔振和对动力机器基础振动近场主动隔振的半解析BEM-FEM耦合分析方法,并对劲芯水泥土墙的隔振效果进行了计算分析。研究结果表明:饱和地基中设置劲芯水泥土墙能够起到较好的隔振作用,其隔振效果与混凝土墙基本相当且远优于纯水泥土墙;预制芯墙在劲芯水泥土墙隔振系统中起关键作用,为避免弹性波从芯墙底绕射而降低隔振效果,预制芯墙深度应与水泥土墙深度保持一致;增大芯墙厚度对隔振效果提升不大。在等深芯墙条件下,增大墙深能显著提高远场隔振效果,但对近场隔振效果提升较小;增大墙厚也可提高隔振效果,但提高幅度不大。实际工程中,建议结合工程造价和施工工艺,选择合适的水泥土墙和预制芯墙墙厚。此外,屏障距振源距离对主动隔振效果影响较小,建议根据被保护建筑与振源之间的实际情况,选择合适位置构建隔振屏障。

关键词：环境振动饱和地基劲芯水泥土搅拌墙隔振效果 BEM-FEM耦合方法

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Heavy Metal Distributions and Source Tracing in the Lacustrine Sediments of Dongdao Island,South China Sea

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Acta Geologica Sinica(English Edition) 2008年第5期82卷 1002-1014页

作者： liu xiaodong sun liguang YIN Xuebin WANG Yuhong Institute of Polar Environment University of Science and Technology of China Hefei Anhui 230026 National Institutes of Health Bethesda MD 20892 USA

The levels and depth distributions of As, Cd, Cu, Zn, Pb, Hg, Fe and Mn in two sediment cores DY2 and DY4 collected from the ＂Cattle Pond＂ of Dongdao Island, South China Sea, were determined and analyzed with the main objective to identify the sources of these elements and evaluate the corresponding sedimentological and geochemical processes. Lithological characters and sedimentary parameters such as LOI950℃, CaO, LOI550℃ and TOC indicate that the depth of 96 cm and 87 cm are the critical points for DY2 and DY4 cores, respectively. As, Cd, Cu, Zn, Hg and P are remarkably enriched in the ornithogenic sediments above the critical depth points; their concentration-versus-depth profiles are similar to those of TOC and LOI550℃; the ratios of As, Cd, Cu, Zn, Hg over Ca are significantly correlated with P/Ca. Statistical and comparative analyses of these elements＇ levels in the ornithogenic sediments of DY2 and DY4 strongly suggest that seabird droppings are the main source of these elements. Additionally, for the upper sediment layers of DY2 and DY4 cores, Fe oxide sorption mechanism, like organic matter, may also play an important role in the abundances of heavy metals. Heavy metal Pb has geochemical characteristics distinctly different from those of As, Cd, Cu, Zn, Hg and P, and its isotope composition indicates an origin of anthropogenic emissions from the surrounding countries. These geochemical characteristics in the orinithogenic sediments of Xisha Islands are compared with the studies in the remote Antarctic and Arctic regions.

关键词： heavy metals elemental geochemistry ornithogenic sediments Dongdao Island South China Sea

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软质聚氨酯泡沫燃烧特性及参数敏感性

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工程热物理学报 2024年第2期45卷 588-596页

作者：黄梦真朱虹刘乃安谢小冬马超张首蕤中国科学技术大学火灾科学国家重点实验室合肥230026

本研究基于火焰蔓延量热仪(FPA),在不同辐射热流及样品厚度条件下,开展软质聚氨酯泡沫(FPUF)燃烧特性实验研究。结果表明,FPUF燃烧可分为三个阶段:阶段一主要为FPUF热解与甲苯二异氰酸酯(TDI)燃烧,阶段二主要为多元醇燃烧,阶段三主要为... 详细信息

本研究基于火焰蔓延量热仪(FPA),在不同辐射热流及样品厚度条件下,开展软质聚氨酯泡沫(FPUF)燃烧特性实验研究。结果表明,FPUF燃烧可分为三个阶段:阶段一主要为FPUF热解与甲苯二异氰酸酯(TDI)燃烧,阶段二主要为多元醇燃烧,阶段三主要为焦炭氧化。基于Box-Behnken设计方法建立质量响应模型,方差分析结果表明,模型对单个参数敏感性为:样品底面温度>辐射热流>样品厚度;多个参数敏感性为:样品底面温度×样品厚度>样品底面温度的平方>样品厚度的平方。

关键词：软质聚氨酯泡沫热解燃烧敏感性分析火焰蔓延量热仪

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高端装备创新方法知识系统构建与优选推送

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机械工程学报 2024年第11期60卷 169-180页

作者：刘江南黄琬清杜文轩刘小冬沈龙江朱颖谋湖南大学汽车车身先进设计制造国家重点实验室长沙410082 北京工业大学机械与能源工程学院北京100124 中车株洲电力机车有限公司株洲412001

高端装备创新链中不同环节对创新方法知识的需求不尽相同,日趋复杂的创新活动已无法满足于局部、单一方法的运用。集成的创新方法知识及其优选推送,对于计算机辅助高效实现高端装备的创新设计具有重要意义。以先进轨道交通装备为例,追... 详细信息

高端装备创新链中不同环节对创新方法知识的需求不尽相同,日趋复杂的创新活动已无法满足于局部、单一方法的运用。集成的创新方法知识及其优选推送,对于计算机辅助高效实现高端装备的创新设计具有重要意义。以先进轨道交通装备为例,追溯其重大科技成果的形成过程、提炼发明专利的高频普适方法,分析其中的创新特征及控制其涌现效应的关键因素,挖掘一系列创新方法作为基础信息;为使其成为可传播、学习和应用的知识,对创新方法进行规范化知识描述和单元化数据建模;构建装备领域创新方法应用情境空间,借助结构化本体语言,建立应用情境空间下创新方法知识表征数据模型,以利于知识的获取、存储、处理和调用;设计开发创新方法多维度集成的知识系统,系统化管理离散的创新方法知识;确定创新方法适用度评价指标及权重,建立其优选决策模型,提出基于统计学原理突破个人经验法的多方法序列推送方法,为程序化自动推送提供理论基础;构建创新方法知识优选与推送实施流程,并通过辅助某研发设计的应用示例,验证知识系统及实施流程的可操作性和有效性。

关键词：高端装备创新方法本体论知识集成优选与决策全创新链

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A 2200-year Record of Seabird Population on Ganquan Island,South China Sea

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Acta Geologica Sinica(English Edition) 2011年第4期85卷 957-967页

作者： XU Liqiang liu xiaodong sun liguang YAN Hong liuYi LUO Yuhan HUANG Jing Institute of Polar Environment School of Earth and Space Sciences University of Science and Technology of China Hefei Anhui 230026 China University of Science and Technology of China-City University ofHong Kong Joint Advanced Research Center Suzhou Jiangsu 215123 China

Geochemical characteristics of a 107 cm long sediment profile,collected from Ganquan Island,South China Sea,were *** on concentrations of bio-elements（Cu,Zn,Cd,Ba,As, Se,P）,^（210）Pb and AMS^（14）C dating,we reconstructed seabird population of Ganquan Island over the past 2200 *** inhabited this island more than 2200 years ago,and their population displayed remarkable fluctuations with two peaks around 2100-1850 yr BP and 900-300 yr BP,*** seabird population change profile on Ganquan Island is similar to that on Dongdao Island over the past 1800 *** examined the relationship between the seabird population and climate,and found it quite *** seabird population did not reach the maximum during the Medical Warm Period（MWP）with relatively high average temperature;however,it remained near the peak value for about 600 years during the climatic transition period and the Little Ice Age（LIA）,indicating that a relatively cool climate is favorable for seabirds on Ganquan Island.

关键词： seabird population South China Sea Ganquan Island climate change ecological response

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髓母细胞瘤分子亚型中CD8+T淋巴细胞浸润的临床病理特点

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北京大学学报（医学版） 2024年第3期56卷 512-518页

作者：柴晓东孙子文李海爽朱靓怡刘小旦刘延涛裴斐常青北京大学第三医院病理科北京100191 北京大学基础医学院病理学系北京100191 北京市神经外科研究所神经病理中心北京100070

目的:研究CD8+T细胞在髓母细胞瘤(medulloblastoma,MB)各个分子亚型中的浸润特点,分析CD8+T细胞浸润与患者预后的关系,以及C-X-C基序趋化因子11(C-X-C motif chemokine ligand 11)的表达及其受体CXCR3在CD8+T细胞中的表达情况,为进一步... 详细信息

目的:研究CD8+T细胞在髓母细胞瘤(medulloblastoma,MB)各个分子亚型中的浸润特点,分析CD8+T细胞浸润与患者预后的关系,以及C-X-C基序趋化因子11(C-X-C motif chemokine ligand 11)的表达及其受体CXCR3在CD8+T细胞中的表达情况,为进一步探索MB中CD8+T细胞浸润可能的调节机制提供临床病理依据。方法:筛选2012—2019年间来自多所医学中心、具有完整临床资料的MB患者共48例(4个分子亚型各12例),利用NanoString PanCancer IO360 TM基因表达检测平台对48例MB患者的肿瘤标本进行转录组学分析,对患者肿瘤组织的石蜡切片进行CD8免疫组织化学染色分析,验证各亚型MB中CD8+T细胞数量的差异。通过数据库生物信息学分析,探讨CD8+T细胞浸润与患者预后的关系及各种趋化因子在各亚型MB中的表达差异,并采用双重免疫荧光染色验证MB中CD8+T细胞表面CXCR3受体的表达情况,探讨CD8+T细胞浸润至肿瘤内的可能分子机制。结果:MB的WNT亚型中的CD8+T细胞特征指数相对较高,提示WNT亚型中的CD8+T细胞数量显著高于其他三个亚型,这一现象通过CD8免疫组织化学染色方法以及R2在线数据分析平台对美国基因表达数据库Gene Expression Omnibus(GEO)进行数据挖掘得到了证实,且CD8+T细胞增多与患者的生存期呈正相关。数据库分析显示,CXCL11在WNT亚型MB中的表达量明显高于其他三个亚型。免疫荧光染色结果显示,CD8+T细胞表面存在CXCL11的受体CXCR3,提示CD8+T细胞可能通过表面受体CXCR3受CXCL11趋化至MB的微环境中。结论:CD8+T细胞在WNT亚型MB中的浸润相对多于其他亚型,其机制可能与CXCL11-CXCR3趋化因子系统的激活相关,且肿瘤内CD8+T细胞浸润较多的患者预后较好,此结果可能为MB中CD8+T细胞浸润调节机制提供有益的临床病理依据,为未来MB的免疫治疗提供新的潜在治疗靶点。

关键词：髓母细胞瘤肿瘤微环境 CD8阳性T淋巴细胞趋化因子CXCL11

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Genetic parameters estimation for growth traits in cultured tiger pufferfish(fugu),Takifugu rubripes

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Acta Oceanologica Sinica 2022年第12期41卷 73-79页

作者： Xin’an Wang Aijun Ma Zhifeng liu Zhibin sun liguang zhu Haowen Chang Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture and Rural AffairsQingdao 266071China Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology Qingdao 266071China Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

The aim of this study was to evaluate the genetic parameters of the growth performance of Takifugu *** and genetic correlations were estimated for body weight(BW),body length(BL),total length(TL),chest measurement(CM)and trunk length(TKL)of *** from measurements of progeny at 6 months and 12 *** results showed that the heritability was 0.37 for BW6,0.19 for BL6,0.35 for TL6,0.29 for CM6,0.26 for TKL6,0.36 for BW12,0.26 for BL12,0.25 for TL12,0.31 for CM12 and 0.15 for *** range of genetic correlations estimated at 6 months was 0.025–0.725 and−0.002–0.706 at 12 *** results indicated that genetic improvement for faster growth rate or increased body weight in cultured *** was *** on selection theory,the selection strategy for traits with medium heritability is *** that these growth traits do not reach the high level of heritability,family selection should be *** positive genetic correlations among BW,BL,TL,CM,and TKL at 6 months,the five traits could be improved simultaneously through selective *** there was high genetic correlation only between BW12,BL12 and TL12,and negative correlations between TKL12 and BL12 as well as between CM12 and TL12,and only BW,BL and TL at 12 months could be improved simultaneously.

关键词： family genetic evaluation heritability genetic correlation

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口蹄疫病毒等小RNA病毒可通过一种共性机制操纵细胞加速病毒复制

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中国兽医科学 2024年第7期54卷 993-993页

作者： Ruoqing Mao Zixiang zhu Fan Yang Dehui sun Xiaoli Zhou Weijun Cao xiaodong Qin Wen Dang Huanan liu Hong Tian Keshan Zhang Qingfeng Wu Xiangtao liu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China. Analysis and Test Group Center for Technical Development and Analysis Service Institute of Modern Physics Chinese Academy of Sciences Lanzhou China.

小RNA病毒是RNA病毒中最小的类群。这种病毒的颗粒为直径22~30 nm的正二十面体,无包膜,并且含有29%~32%的连续线型单链RNA。小RNA病毒科的主要成员包括口蹄疫病毒(FMDV)、脊髓灰质炎病毒(PV)、塞内卡病毒(SVA)、埃可病毒、柯萨奇病毒等... 详细信息

小RNA病毒是RNA病毒中最小的类群。这种病毒的颗粒为直径22~30 nm的正二十面体,无包膜,并且含有29%~32%的连续线型单链RNA。小RNA病毒科的主要成员包括口蹄疫病毒(FMDV)、脊髓灰质炎病毒(PV)、塞内卡病毒(SVA)、埃可病毒、柯萨奇病毒等,能引起多种人或动物传染性疾病,对人和动物的健康构成威胁。小RNA病毒的VP3蛋白是病毒结构中的关键组成部分,尤其在口蹄疫病毒、脊髓灰质炎病毒和塞内卡病毒等病毒中,VP3蛋白被视为病毒复制和致病过程中的关键毒力因子。

关键词：口蹄疫病毒 VP3蛋白病毒结构脊髓灰质炎病毒小RNA病毒致病过程病毒复制毒力因子

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