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Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

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Infectious Diseases of Poverty 2024年第1期13卷 53-62页

作者： Qing-Nan Shi hui-Jie Qin qiao-Shan Lu hu li Zhong-Fa Tao Meng-guang Fan Mu-Heta Aishan zeng-Qiang Kou Qiu-Lan Chen Wen-Wu Yin Yan-Ping Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionChangbai RoadChangping DistrictBejing 102206China School of Public Health Guangxi Medical UniversityNanningChina Nanning Center for Disease Control and Prevention NanningChina Guizhou Center for Disease Control and Prevention GuiyangChina Inner Mongolia Center for Disease Control and Prevention HohhotChina Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention UrumqiChina Shandong Center for Disease Control and Prevention JinanChina

Background Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of *** A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model *** A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the most prevalent. Complications in other organ systems included the genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Several factors were found to be associated with focal brucellosis. These factors included a long delay in diagnosis [odds ratio (OR) = 3.963, 95% confidence interval(CI): 1.906-8.238 for > 90 days], the presence of underlying disease (OR = 1.675, 95%CI: 1.176-2.384), arthralgia (OR = 3.197, 95%CI: 1.986-5.148), eye bulging pain (OR = 3.482, 95%CI:

关键词： Brucellosis Complications Clinical spectrum Warning signs

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang li Gong li Dong liu Zheng-Yao Jin Xing-zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong liu Han Yi Yang li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-zhu He Yong-Cheng He Yang Hong Yi-Wei hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang ling Kang Bo li Chao li Jia-Wen li Xiao li Jie liu Shu-Bin liu guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Xin Tan li-Jiao Wang Peng-Cheng Wang Zhao-hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu li-Kun Xie Yong-Ji Yu Guo-hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen li Wei Xu Tao li Ze‑Bin lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu Han‑Xiong huang Wei‑hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑da Tang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang li li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu Han‑Xiong huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin ling Kang Bo li Gong li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang Sun Zhi‑Xin Tan Sheng‑da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

OsPPR9 encodes a DYW-type PPR protein that affects editing efficiency of multiple RNA editing sites and is essential for chloroplast development

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Journal of Integrative Agriculture 2023年第4期22卷 972-980页

作者： CHEN Chang-zhao WANG Ya-liang HE Meng-xing li Zhi-wen SHEN Lan li Qing REN Deyong hu Jiang zhu li ZHANG guang-heng GAO Zhen-yu zeng da-li GUO Long-biao QIAN Qian ZHANG Qiang State Key Lab of Rice Biology China National Rice Research InstituteHangzhou 310006P.R.China College of Chemistry and life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China College of life and Environmental Sciences Hangzhou Normal UniversityHangzhou 310006P.R.China

Photosynthesis occurs mainly in chloroplasts,whose development is regulated by proteins encoded by nuclear *** them,pentapeptide repeat(PPR)proteins participate in organelle RNA *** there are more than 450 members of the PPR protein family in rice,only a few affect RNA editing in rice *** editing technology has created new rice germplasm and mutants,which could be used for rice breeding and gene function *** study evaluated the functions of OsPPR9 in chloroplast RNA editing in *** osppr9 mutants were obtained by CRISPR/Cas9,which showed yellowing leaves and a lethal phenotype,with suppressed expression of genes associated with chloroplast development and accumulation of photosynthetic-related *** addition,loss of OsPPR9 protein function reduces the editing efficiency of rps8-C182,rpoC2-C4106,rps14-C80,and ndhB-C611 RNA editing sites,which affects chloroplast growth and development in *** data showed that OsPPR9 is highly expressed in rice leaves and encodes a DYW-PPR protein localized in ***,the OsPPR9 protein was shown to interact with OsMORF2 and ***,our findings provide insights into the role of the PPR protein in regulating chloroplast development in rice.

关键词： rice(Oryza sativa L.) PPR protein chloroplast development RNA editing

Reduction of OsFLW7 expression enhanced leaf area and grain production in rice

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Science Bulletin 2017年第24期62卷 1631-1633页

作者： Jing Xu li Wang Yue-xing Wang da-li zeng Meng-yu Zhou Xue Fu Wei-jun Ye Jiang hu li zhu De-yong Ren Zhen-yu Gao Guo-jun Dong Long-biao Guo guang-heng Zhang Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 Zhejiang China

Increasing rice production is important to ensure food security in China. Exploring yield potential and identifying genes beneficial to yield are important goals in the modern rice breeding. Generally, controlling leaf morphology, increasing photosynthesis efficiency and modulating the ＂sink-source＂ relationship can pro- mote the breeding of high-yield rice as well as other cereal crops . The morphology of the leaf includes length, width and degree of curl after its emergence from the meristem and is determined by the establishment of polariW along the adaxial-abaxial, ventral-dorsal and medial-lateral axes and regulated at genetic, hormonal and environmental levels . Rice leaf morphology varies widely among rice subspecies and cultivars. Quantitative trait loci （QTLs） affecting leaf shape commonly have pleiotropic effects on rice yield , which are more useful than mutant genes for studying the molecular mechanism of leaf shape regulation and their application to rice breeding.

关键词： Reduction OsFLW7 expression enhanced leaf area grain production in rice

Characterization and Fine Mapping of Non-panicle Mutant (nop) in Rice

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Rice science 2009年第3期16卷 165-172页

作者： Wu Kun RAO Yu-chun hu Jiang zhu Guan-lin ZHANG guang-hen hu Xin-ming Guo Long-biao WANG Yong-hong QIAN Qian zeng da-li State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Agricultural College Yangzhou University Yangzhou 225009 China

A mutant of panicle differentiation in rice called non-panicle （nop） was discovered in the progeny of a cross between 93-11 and Nipponbare. The mutant exhibits normal plant morphology but has apparently few tillers. The most striking change in nop is that its panicle differentiation is blocked, with masses of fluffy bract nodes generate from the positions where rachis branches normally develop in wild-type plants. Genetic analysis suggests that nop is controlled by a single recessive gene, which is temporarily named Nop（t）. Based on its mutant phenotype, Nop（t） represents a key gene controlling the initiation of inflorescence differentiation, By using simple sequence repeat markers and sequence tagged site markers, Nop（t） gene was fine mapped in a 102-kb interval on the long arm of chromosome 6. These results will facilitate the positional cloning and functional studies of the gene.

关键词： non-panicle gene panicle differentiation fine mapping rice (Oryza sativa)

LSCHL4 from Japonica Cultivar, Which Is Allelic to NAL 1, Increases Yield of Indica Super Rice 93-11

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Molecular Plant 2014年第8期7卷 1350-1364页

作者： guang-Heng Zhang Shu-Yu li li Wang Wei-Jun Ye da-li zeng Yu-Chun Rao You-lin Peng Jiang hu Yao-Long Yang Jie Xu De-Yong Ren Zhen-Yu Gao li zhu Guo-Jun Dong Xing-Ming hu Mei-Xian Yan Long-Biao Guo Chuan-You li Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute 359 Tiyuchang Road Hangzhou 310006 Zhejiang China State Key Laboratory of Plant Genomics National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of Sciences Beijing 100101 China

The basic premise of high yield in rice is to improve leaf photosynthetic efficiency and coordinate the sourcesink relationship in rice plants. Quantitative trait loci （QTLs） related to morphological traits and chlorophyll content of rice leaves were detected at the stages of heading to maturity, and a major QTL （qLSCHL4） related to flag leaf shape and chlorophyll content was detected at both stages in recombinant inbred lines constructed using the indica rice cultivar 93-11 and the japonica rice cultivar Nipponbare. Map-based cloning and expression analysis showed that LSCHL4 is allelic to NAL1, a gene previously reported in narrow leaf mutant of rice. Overexpression lines transformed with vector carrying LSCHL4 from Nipponbare and a near-isogenic line of 93-11 （NIL-9311） had significantly increased leaf chlorophyll content, enlarged flag leaf size, and improved panicle type. The average yield of NIL-9311 was 18.70% higher than that of 93-11. These results indicate that LSCHL4 had a pleiotropic function. Exploring and pyramiding more high-yield alleles resem- bling LSCHL4 for super rice breeding provides an effective way to achieve new breakthroughs in raising rice yield and generate new ideas for solving the problem of global food safety.

关键词： rice breeding QTL qLSCHL4 panicle type pleiotropism yield potential.

Functional Analysis of Three Rice Chloroplast Transit Peptides

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Rice science 2019年第1期26卷 11-20页

作者： HE Lei CHEN guang ZHANG Sen QIU Zhennan hu Jiang zeng dali ZHANG guangheng DONG Guojun GAO Zhenyu REN Deyong SHEN Lan GUO Longbiao QIAN Qian zhu li State Key Laboratory of Rice Biology China National Rice Research Institute

Chloroplast transit peptides(CTPs) can be used to transport non-chloroplastic proteins into the chloroplasts. Here, we studied the CTPs of three rice(Oryza sativa L.) chloroplast-localized proteins and found that their CTPs could be used to transport non-chloroplast-localized proteins into the chloroplasts. Fusion proteins lacking the CTP remained located in the cytoplasm. Furthermore, we constructed green fluorescent protein fusion vectors with the three CTPs and three non-chloroplast-localized proteins, Ghd10, MULTI-FLORET SPIKELET1(MFS1), and SHORTENED UPPERMOST INTERNODE 1(SUI1). After transforming these constructs into rice protoplasts, the fusion proteins all localized in the chloroplasts. Collectively, our results showed that these CTPs can transport non-chloroplast-localized proteins into the chloroplasts, and more importantly, these CTPs can be applied to engineer chloroplast metabolism.

关键词： rice chloroplast transit peptide translocated function subcellular location