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Privacy-preserving integration of multiple institutional data for single-cell type identification with scPrivacy

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Science china(Life Sciences) 2023年第5期66卷 1183-1195页

作者： Shaoqi Chen Bin Duan Chenyu zhu Chen Tang Shuguang Wang Yicheng Gao Shaliu Fu Lixin {1. Qiang Yang Qi Liu Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji university) Ministry of EducationOrthopaedic Department of Tongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of AI WeBankShenzhen 518055China Translational Medical Center for Stem Cell Therapy and Institution for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China

The rapid accumulation of large-scale single-cell RNA-seq datasets from multiple institutions presents remarkable opportunities for automatically cell annotations through integrative ***,the privacy issue has existed but being ignored,since we are limited to access and utilize all the reference datasets distributed in different institutions globally due to the prohibited data transmission across institutions by data regulation *** this end,we present scPrivacy,which is the first and generalized automatically single-cell type identification prototype to facilitate single cell annotations in a data privacy-preserving collaboration *** evaluated scPrivacy on a comprehensive set of publicly available benchmark datasets for single-cell type identification to stimulate the scenario that the reference datasets are rapidly generated and distributed in multiple institutions,while they are prohibited to be integrated directly or exposed to each other due to the data privacy regulations,demonstrating its effectiveness,time efficiency and robustness for privacy-preserving integration of multiple institutional datasets in single cell annotations.

关键词： preserving integration utilize

针对电力CPS数据驱动算法对抗攻击的防御方法

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中国电力 2024年第9期57卷 32-43页

作者：朱卫平汤奕魏兴慎刘增稷国网江苏省电力有限公司江苏南京210024 东南大学电气工程学院江苏南京211189 南瑞集团有限公司(国网电力科学研究院有限公司) 江苏南京211106

大规模电力电子设备的接入为系统引入了数量庞大的强非线性量测/控制节点,使得传统电力系统逐渐转变为电力信息物理系统(cyber-physical system,CPS),许多原本应用模型驱动方法解决的系统问题不得不因维度灾难等局限转而采取数据驱动算... 详细信息

大规模电力电子设备的接入为系统引入了数量庞大的强非线性量测/控制节点,使得传统电力系统逐渐转变为电力信息物理系统(cyber-physical system,CPS),许多原本应用模型驱动方法解决的系统问题不得不因维度灾难等局限转而采取数据驱动算法进行分析。然而,数据驱动算法自身的缺陷为系统的安全稳定运行引入了新的风险,攻击者可以对其加以利用,发起可能引发系统停电甚至失稳的对抗攻击。针对电力CPS中数据驱动算法可能遭受的对抗攻击,从异常数据剔除与恢复、算法漏洞挖掘与优化、算法自身可解释性提升3个方面,提出了对应的防御方法:异常数据过滤器、基于生成式对抗网络(generative adversarial network,GAN)的漏洞挖掘与优化方法、数据-知识融合模型及其训练方法,并经算例分析验证了所提方法的有效性。

关键词：对抗攻击数据驱动算法电力CPS 攻击防御

Using live vegetation volume to analyze the effects of plot Pinus massoniana Lamb on water and soil conservation under natural rainfall events

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International Journal of Sediment Research 2013年第4期28卷 579-587页

作者： zhu-jun GU Xiao-xia WU Xiao-lei WANG Shao-{1. PENG Hao LUO Xue-zheng SHI Dong-sheng YU school of Bio-Chemical and Environmental Engineering Nanjing Xiaozhuang University Fujian Changting Bureau of soil and water conservation Institute of Hydro-geophysical prospecting Chongqing Research Institute of China Coal Technology&Engineering Group Corporation State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences

The 3-D spatial distributions of vegetation arc of great significance for water and soil conservation but arc rarely concerned in *** live vegetation volume(LVV) was used to relate to water/soil loss under 1.4 natural erosive rainlall events from 2.07 to 2.1. in a typical water-eroded area of southern *** polynomial regression models were established for five pure tree(Pinus massoniana Lamb) plots between LVV and water(runoff)/soil conservation effects(RE/SE).RE/SE corresponds to the ratios of runoff depth/soil loss of the pure tree plots to that of the control plot under each rainfall *** LVV exhibits descending(DS),descending-ascending(DA),ascending-descending(AD),and ascending(AS) trends in the LVV-RE and LVV-SE *** effects of soil conservation on the plots were generally more noticeable than the effects of water conservation,and most of the RE and SE values reflected the positive effects of water and soil *** effects were mainly positive under heavy rains(e.g.,rainfall erosivity,R = 1.0 MJ mm *** 30min intensity,I30= 1. mm h-1.,whereas the effects were mainly negative under light rains(e.g.,R = 45 MJ mm ha-1.I30= 8 mm h-1..The trees’ water/soil conservation effects notably transformed when rainfall erosivity and intensity were lower than the positive or negative effects to a certain *** 50%rainfall events led to obvious transform effects when LVVs were near 0.5 or *** results are able to aid in the decision making on the forest reconstruction in water-eroded areas.

关键词： Erosion Forest Runoff Transform live vegetation volume Water and soil conservation

A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1.and HBB Loci in Chinese Indigenous Dogs

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Journal of Genetics and Genomics 2015年第4期42卷 173-177页

作者： Ruoxi fan Fei Liu Hong Wu Shifang Wu Chunling {2. Yan Li Guodong Wang Yaping Zhang Laboratory for Conservation and Utilization of Bio-resources Yunnan University State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of Sciences

Hypoxia represents one of the most extreme environmental conditions for both human beings and animals living at high al- titudes （Zhao et al., 2.09）. Over the past few years, great attention has been focused on the genetic bases of adaption to high-altitude environments （Bigham et al., 2.1.; Simonson et al., 2.1.）. The domestic dog （Canisfamiliaris） is the first animal that developed an intimate relationship with human beings. Dogs migrated with human beings and have adapted to variety of ecological niches （Savolainen et al., 2.02.. Our previous research revealed parallel evolution and convergent evolution in the adaptation of dogs and humans to the high-altitude environment of the Tibetan plateau （Wang et al., 2.1., 2.1.）, suggesting that exploring the adaption of domestic dogs to high-altitude hypoxia is an interesting and important question.

关键词： HBB PAS A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1.and HBB Loci in Chinese Indigenous Dogs

岷江上游土地利用变化下的生态系统敏感性研究

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人民长江 2018年第11期49卷 35-42页

作者：朱昌丽张继飞赵宇鸾刘春艳贵州师范大学地理与环境科学学院贵州贵阳550001 中国科学院水利部成都山地灾害与环境研究所四川成都610041

为研究岷江上游土地利用变化对生态系统敏感性的影响,首先利用土地利用动态度分析了青藏高原东缘岷江上游近1. a来的土地利用变化趋势;其次基于生态系统服务价值当量测算了研究区的生态系统服务价值,并借助生态系统传统敏感性系数对测... 详细信息

为研究岷江上游土地利用变化对生态系统敏感性的影响,首先利用土地利用动态度分析了青藏高原东缘岷江上游近1. a来的土地利用变化趋势;其次基于生态系统服务价值当量测算了研究区的生态系统服务价值,并借助生态系统传统敏感性系数对测算结果进行检验;最后利用交叉敏感性系数定量评估了土地利用变化对生态系统服务价值的影响程度及方向。结果表明:(1.2.00~2.05年研究区的土地利用变化主要是耕地转为森林、灌丛和草地,生态系统服务价值增加约0.46亿元;2.05~2.1.年的土地利用变化主要是森林、耕地转为灌从、草地和荒漠,生态系统服务价值减少约0.57亿元。(2.研究期内森林的生态系统服务价值最高,其次是灌丛和草地;各生态系统服务功能类型中气候调节和水文调节的生态系统服务价值最高,食物生产和维持养分循环的生态系统服务价值最低。(3)研究期内岷江上游生态系统传统敏感性系数均小于1.大小依次为:C_(森林)>C_(灌丛)>C_(草地)>C_(水域)>C_(耕地)>C_(荒漠)>C_(裸地)。(4)导致岷江上游生态系统交叉敏感性最高的土地利用变化是森林和水域、草地和水域的相互转换,交叉敏感性系数均大于1.大部分土地利用转换的生态意义并不明显,但水域和其他地类相互转换的生态意义略有上升。研究结论有望为岷江上游土地利用宏观调控及生态系统综合管理提供一定科学依据。

关键词：生态系统生态学土地利用生态系统服务交叉敏感性岷江上游青藏高原东缘

基于干涉仪阵列的无人机非合作辐射点定位方法

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航空学报 2024年第17期45卷 310-318页

作者：杨顺张帆张伟师君张晓玲电子科技大学信息与通信工程学院成都611731 成都飞机设计研究所成都610041

非合作辐射点定位是电磁测量中的难点和关键问题,对于异常辐射点发现与电磁兼容诊断具有重要意义。本文利用干涉仪阵列技术实现宽带随机非合作辐射点精确定位。该方法通过时域能量积累提升系统对弱小信号的检测能力,通过阵列信号角度估... 详细信息

非合作辐射点定位是电磁测量中的难点和关键问题,对于异常辐射点发现与电磁兼容诊断具有重要意义。本文利用干涉仪阵列技术实现宽带随机非合作辐射点精确定位。该方法通过时域能量积累提升系统对弱小信号的检测能力,通过阵列信号角度估计技术,并优化最小冗余天线阵列设计,实现非合作辐射点定位,最后通过稀疏重建方法对干涉仪角分辨率进行增强,以提升对多非合作辐射点的精确定位。仿真试验表明:干涉仪阵列可实现对多个宽带随机非合作辐射点空间分离与定位,通过最小冗余阵列优化设计并结合稀疏重建方法,其对特高频频段(UHF)多辐射点定位精度优于1.m,可满足电磁兼容诊断问题对辐射点定位精度的要求。进一步分析表明:干涉仪阵列性能受到外部辐射点数目的影响。一般而言,辐射点数目越少,算法稳定性越高,对于8通道最小冗余阵列,应保证外部辐射点数目<7个,以降低辐射点漏检和虚警问题。

关键词：辐射点定位干涉仪最小冗余天线阵列稀疏重建电磁兼容测试

Fluid Evolution and Scheelite Precipitation Mechanism of the Large-Scale Shangfang Quartz-Vein-Type Tungsten Deposit, South{1.: Constraints from Rare Earth Element(REE) Behaviour during Fluid/Rock Interaction

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Journal of Earth Science 2020年第4期31卷 635-652页

作者： Runsheng Chen Luyun {1. Shao-Yong Jiang Ying Ma Qinghai Hu State Key Laboratory of Geological Processes and Mineral Resources School of Earth ResourcesChina University of GeosciencesWuhan 430074China Fujian Institute of Geological Survey and Research Fuzhou 350013China Key Laboratory of Geochemical Exploration Institute of Geophysical and Geochemical ExplorationCA GSLangfang 065000China

Unlike classic skarn-type scheelite deposits directly acquiring sufficient Ca2. from surrounding limestones, all of the scheelite orebodies of the Shang{1.g tungsten(W) deposit occur mainly in amphibolite, and this provides a new perspective on the mineralization mechanism of W deposits. The ability of hydrothermal scheelite(CaWO4) to bind REE3+ in their Ca2. crystal lattices makes it a useful mineral for tracing fluid-rock interactions in hydrothermal mineralization systems. In this study, the REE compositions of scheelite and some silicate minerals were measured systematically in-situ by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) to assess the extent of fluid-rock interactions for the Late Mesozoic quartz-vein-type Shang{1.g W deposits. According to the variations in CaO and REE among scheelite and silicate minerals, the amphibole and actinolite in amphibolite may be able to release large amounts of Ca2. and REE3+ into the ore-forming fluids during chlorite alteration, which is critical for scheelite precipitation. Furthermore, an improved batch crystallization model was adopted for simulating the process of scheelite precipitation and fluid evolution. The results of both the in-situ measurements and model calculations demonstrate that the precipitation of early-stage scheelite with medium rare-earth elements(MREE)-rich and [Eu/Eu*]N1. The early-stage scheelite would consume more MREE than LREE and HREE of fluid, which will gradually produce residual fluids with strong MREE-depletion and [Eu/Eu*]N>1. Even though the partition coefficient of REE is constant, the later-stage scheelite will also inherit a certain degree of MREE-depletion and [Eu/Eu*]N future from the residual fluids. As a common mineral, sheelite forms in various types of hydrothermal ore deposits(e.g., tungsten and gold deposits). Hence, the improved batch crystallization model is also possible for obtaining detailed information regarding fluid evolution for other types

关键词： scheelite quartz vein type REE pattern Eu anomaly fluid evolution

细微特征增强的多级联合聚类跨模态行人重识别算法

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电子测量与仪器学报 2024年第3期38卷 94-103页

作者：范馨月张阔张干李嘉辉重庆邮电大学通信与信息工程学院重庆400065

目前跨模态行人重识别研究注重于通过身份标签在全局特征或局部特征上提取模态共享特征来减少模态差异,但却忽视了具有辨别力的细微特征。为此提出了一种基于特征增强的聚类学习网络,该网络通过全局和局部特征来挖掘并增强不同模态的细... 详细信息

目前跨模态行人重识别研究注重于通过身份标签在全局特征或局部特征上提取模态共享特征来减少模态差异,但却忽视了具有辨别力的细微特征。为此提出了一种基于特征增强的聚类学习网络,该网络通过全局和局部特征来挖掘并增强不同模态的细微特征,并结合多级联合聚类学习策略,最小化模态差异和类内变化。针对训练数据设计了随机颜色转换模块,在图像输入端增加模态之间的交互,以克服颜色偏差的影响。通过在公共数据集上进行实验,验证了所提方法的有效性,其中在SYSU-MM01.据集的全搜索模式下Rank-1.mAP分别达到了70.52.和64.02.;在RegDB数据集的V2.检索模式下Rank-1.mAP分别达到了88.88%和80.93%。

关键词：行人重识别跨模态随机颜色转换细微特征增强多级联合聚类学习

适应新型电力系统的电网基建功能化投资结构演化研究

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中国电力 2024年第9期57卷 194-204页

作者：朱瑞娄奇鹤靳晓凌刘畅国网能源研究院有限公司北京102209 国家电网有限公司北京100031 华北电力大学经济与管理学院北京102206

构建新型电力系统不仅是物理形态的变革,更是生产组织关系的变革,伴随着大量的投资,如何保证投资效率将是构建新型电力系统的关键问题之一。当前,电网侧、电源侧、负荷侧形态发生了巨大变化,从功能化视角厘清投资结构变化是当前发现投... 详细信息

构建新型电力系统不仅是物理形态的变革,更是生产组织关系的变革,伴随着大量的投资,如何保证投资效率将是构建新型电力系统的关键问题之一。当前,电网侧、电源侧、负荷侧形态发生了巨大变化,从功能化视角厘清投资结构变化是当前发现投资变化规律、引导资金高效投资、发现和改善电网基础建设投资效率的关键,尤其要发现功能化投资结构演变的规律。首先,通过系统动力学模型识别影响电网基建投资的关键因素,进一步研究各因素间的相互联系、相互影响和动态变化关系;在此基础上,系统仿真在关键情景下电网基建投资结构中各投资功能的演化趋势,为企业中长期电网投资决策提供建议和数据支撑,并推动电网基础设施优化升级,高质量构建新型电力系统。

关键词：电网基建投资投资结构演变新型电力系统系统动力学