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From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations

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Journal of Bioresources and Bioproducts 2024年第2期9卷 185-196页

作者： Zongpu Xu Fang He Jing Yu Zhangze Yang Yu zhu Rong Liao Ruyin Lyu Mei Yang liangjun zhu Mingying Yang Institute of Applied Bioresources College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Neurosurgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic value.Chitosan as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable bioactivities.However,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering scaf-folds.Thus,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very important.Here,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating technique.This biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(>87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and proliferation.More importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.

关键词： Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility

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Soil hydraulic conductivity as affected by vegetation restoration age on the Loess Plateau,China

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Journal of Arid Land 2016年第4期8卷 546-555页

作者： REN Zongping zhu liangjun WANG Bing CHENG Shengdong State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi'an University of Technology State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau Institute of Soil and Water ConservationChinese Academy of Science State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

The Loess Plateau of China has experienced extensive vegetation restoration in the past several decades, which leads to great changes in soil properties such as soil bulk, porosity, and organic matter with the vegetation restoration age. And these soil properties have great effect on the soil infiltration and soil hydraulic conductivity. However, the potential changes in soil hydraulic conductivity caused by vegetation restoration age have not been well understood. This study was conducted to investigate the changes in soil hydraulic conductivity under five grasslands with different vegetation restoration ages （3, 10, 18, 28 and 37 years） compared to a slope farmland, and further to identify the factors responsible for these changes on the Loess Plateau of China. At each site, accumulative infiltration amount and soil hydraulic conductivity were determined using a disc permeameter with a water supply pressure of -20 mm. Soil properties were measured for analyzing their potential factors influencing soil hydraulic conductivity. The results showed that the soil bulk had no significant changes over the initial 20 years of restoration （P〉0.05）; the total porosity, capillary porosity and field capacity decreased significantly in the grass land with 28 and 37 restoration ages compared to the slope farmland; accumulative infiltration amount and soil hydraulic conductivity were significantly enhanced after 18 years of vegetation restoration. However, accumulative infiltration amount and soil hydraulic conductivity fluctuated over the initial 10 years of restoration. The increase in soil hydraulic conductivity with vegetation restoration was closely related to the changes in soil texture and structure. Soil sand and clay contents were the most influential factors on soil hydraulic conductivity, followed by bulk density, soil porosity, root density and crust thickness. The Pearson correlation coefficients indicated that the soil hydraulic conductivity was affected by multiply factors. These results are helpful to understan

关键词： disc permeameter effect factors soil infiltration vegetation restoration Loess Plateau

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涡流恢复导叶对螺旋桨气动和声学性能影响研究

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推进技术 2024年第5期45卷 63-75页

作者：韦卿张武陈正武仝帆朱文浩王良军上海大学力学与工程科学学院上海市应用数学与力学研究所上海200072 中国空气动力研究与发展中心气动噪声控制重点实验室四川绵阳621000 上海大学信息化办公室上海200444

为了对比安装涡流恢复导叶与单排螺旋桨气动性能和气动噪声的差异,采用数值模拟的方法研究了安装六种不同间距涡流恢复导叶和单排螺旋桨的气动力及气动噪声。研究结果表明:在起飞状态,级间距Δx=0.27的工况下,安装涡流恢复导叶使得推力... 详细信息

为了对比安装涡流恢复导叶与单排螺旋桨气动性能和气动噪声的差异,采用数值模拟的方法研究了安装六种不同间距涡流恢复导叶和单排螺旋桨的气动力及气动噪声。研究结果表明:在起飞状态,级间距Δx=0.27的工况下,安装涡流恢复导叶使得推力系数增加6.4%,效率增加6.7%。随着间距的增大,前级叶片的桨尖涡、尾迹涡等涡系结构在通过后级叶片时破碎并向下游传播,且强度逐渐减小。噪声强度随着级间距的增加而逐渐减小,最大级间距涡流恢复导叶的噪声与最小级间距涡流恢复导叶噪声相比降低5.7 dB,噪声下降幅度随级间距的增加逐渐减缓,存在级间距最优位置使得推力增加最大,噪声强度适中。

关键词：对转螺旋桨涡流恢复导叶桨尖涡尾迹涡干涉噪声

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基于流域系统模拟一情景优化的精细治理决策支持方法

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地理学报 2024年第1期79卷 58-75页

作者：秦承志朱良君申申吴彤肖桂荣吴升陈芸芝汪小钦冯险峰朱阿兴陆锋中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院大学资源与环境学院北京100049 数字中国研究院(福建) 福州350108 福州大学空间数据挖掘与信息共享教育部重点实验室福州350108 南京师范大学地理科学学院南京210023 威斯康星大学麦迪逊分校地理系美国麦迪逊WI 53706

面向美丽中国生态文明建设所需,亟待有效实现流域精细治理的科学决策,以根据流域综合治理愿景目标,优化流域管理措施(BMP)的空间布局方案(即BMP情景)、制定符合实际需求的实施路线图。对此,“流域系统模拟—情景优化”方法框架近年展现... 详细信息

面向美丽中国生态文明建设所需,亟待有效实现流域精细治理的科学决策,以根据流域综合治理愿景目标,优化流域管理措施(BMP)的空间布局方案(即BMP情景)、制定符合实际需求的实施路线图。对此,“流域系统模拟—情景优化”方法框架近年展现出广阔应用前景。本文介绍了该框架在应对实际应用需求中尚存的一系列问题,开展了体系性的方法研究:①提出新的流域过程建模框架,以兼顾建模灵活性和高性能计算、高效实现流域系统模拟;②提出以坡位单元作为BMP空间配置单元、并在情景优化过程中可进行单元边界动态调整的BMP情景优化方法,可有效考虑流域综合治理的经验知识,保障优化结果合理性;③提出考虑分阶段投资约束的BMP情景实施次序优化方法,可推荐出符合实际落地需求的实施路线图;④设计研发用户友好的参与式流域规划系统,供各方利益相关者协商决策。通过典型小流域应用案例验证了上述新方法、工具和原型系统的有效性和实用价值。

关键词：流域系统模拟流域管理措施情景分析智能优化决策支持

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结合机器学习的SA湍流模型闭合系数修正

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上海大学学报（自然科学版） 2024年第2期30卷 341-351页

作者：徐向阳胡冠男王良军朱文浩张武上海大学力学与工程科学学院上海200444 上海大学计算机工程与科学学院上海200444 上海大学信息化工作办公室上海200444

将修正Morris分类筛选法与极端梯度提升(extreme gradient boosting,XGBoost)相结合,在计算流体动力学(computational fluid dynamics,CFD)数据驱动下,用于SA(Spalart-Allmaras)湍流模型闭合系数的修正.利用分类筛选法有效缩小闭合系数研究范围,同时依据XGBoost方法在小规模数据集下取得精度较高的拟合模型,有效提升系数修正效率.在三维DLR-F6-WB构型下进行了数值实验,实验结果显示利用本方法能够在三维复杂模型上基于小样本数据进行系数修正,修正后的升阻力系数计算精度得到了显著提升.

关键词： SA(Spalart-Allmaras)湍流模型敏感度极端梯度提升(extreme gradient boosting,XGBoost) 线性回归系数修正

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情境创意下的西兰卡普文创设计研究

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纺织报告 2024年第1期43卷 55-57页

作者：陈镇朱依梦李梁军湖北美术学院湖北武汉430205

情境创意在西兰卡普文化产品设计中的应用能显著提升生活体验,并推动非物质文化遗产的发展。文章结合西兰卡普的设计理念与“四位一体”的框架(定位、品质、市场和形象)为设计师提供了全面的指导,帮助他们在创新中保持文化的真实性和市... 详细信息

情境创意在西兰卡普文化产品设计中的应用能显著提升生活体验,并推动非物质文化遗产的发展。文章结合西兰卡普的设计理念与“四位一体”的框架(定位、品质、市场和形象)为设计师提供了全面的指导,帮助他们在创新中保持文化的真实性和市场相关性,这样不仅保留了文化的核心精神,也满足了现代市场需求,为西兰卡普文化的传播和发展开辟了新途径。

关键词：情境创意西兰卡普文化文化产品设计设计融合

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In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease:Mechanism and pharmacological interventions

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Liver Research 2023年第4期7卷 285-295页

作者： Zhixian zhu Xiaoxun Zhang Qiong Pan liangjun Zhang Jin Chai Department of Gastroenterology The First Affiliated Hospital(Southwest Hospital)Third Military Medical University(Army Medical University)ChongqingChina Institute of Digestive Diseases of PLA Third Military Medical University(Army Medical University)ChongqingChina Center for Metabolic Associated Fatty Liver Disease and Cholestatic Liver Diseases Center The First Affiliated Hospital(Southwest Hospital)Third Military Medical University(Army Medical University)ChongqingChina

Non-alcoholic fatty liver disease(NAFLD)is characterized by the abnormal buildup of lipids in the liver tissue.Non-alcoholic fatty liver(NAFL)may progress to non-alcoholic steatohepatitis.Triglycerides in the liver can originate from various sources,including de novo lipogenesis(DNL).Research indicates that DNL significantly escalates in NAFLD,worsening steatosis.However,the precise regulatory mechanism of DNL in the development of this disease is not fully understood.Therefore,the targeted reduction of DNL could be a crucial therapeutic strategy.Currently,numerous pharmaceutical agents targeting DNL have been developed,attracting significant attention.This review examines the mechanism of DNL upregulation in NAFLD,assessing its potential as a therapeutic target for hepatic steatosis.Furthermore,we thoroughly examine hepatocellular lipotoxicity and provide an extensive review of the application and limitations of relevant therapeutic drugs,with a focus on key enzymes involved in DNL.The implementation of these pharmacological strategies is expected to significantly improve the management and overall outcomes for patients with NAFLD.

关键词： Non-alcoholic fatty liver disease(NAFLD) De novo lipogenesis(DNL) Therapeutics Molecular mechanism

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选煤厂煤仓瓦斯控制系统的研究

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煤矿现代化 2024年第1期33卷 109-112页

作者：王金磊朱良军赵峰雷兖煤蓝天清洁能源有限公司山东邹城273500 兖矿能源集团股份有限公司东滩煤矿山东邹城273500 兖矿能源集团股份有限公司济三煤矿山东济宁272069

针对选煤厂煤仓局部瓦斯超限问题,对煤仓内的气体的分布与排放路径进行了研究,对仓内通风结构进行了优化,确定了重点区域自然通风与强制通风相结合的方式,并构建了基于PLC的瓦斯控制系统。系统改造后瓦斯浓度基本控制在0.2%以内,同时降... 详细信息

针对选煤厂煤仓局部瓦斯超限问题,对煤仓内的气体的分布与排放路径进行了研究,对仓内通风结构进行了优化,确定了重点区域自然通风与强制通风相结合的方式,并构建了基于PLC的瓦斯控制系统。系统改造后瓦斯浓度基本控制在0.2%以内,同时降低了设备能耗和维护成本,确保了选煤厂安全稳定的运行。

关键词：煤仓瓦斯自然通风控制系统

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Regio-and stereo-selective olefinic C–H functionalization of aryl alkenes in ethanol

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Organic Chemistry Frontiers 2022年第4期9卷 989-994页

作者： Cong Shen Yuhang zhu Shuqi Jin Kejie Xu Shuxin Luo Lixia Xu Guofu Zhong liangjun Zhong Jian Zhang College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhou311121 ZhejiangPeople’s Republic of China Department of Stomatology The Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou310015China

We report on N,N-bidentate-chelation-assistedα-and β-olefinic C–H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio-and stereo-selectivities.The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclo-metallation and seven-membered endo-cyclometallation.The aerobic protocols feature wide functional-ity tolerance,high selectivities and yields,mild conditions and scalable preparation,and the directing group can be easily removed to afford Boc-protected amine by simple reduction.

关键词： reduction membered stereo

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Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice

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Journal of Genetics and Genomics 2022年第1期49卷 63-73页

作者： Shicheng zhu Hanjing Song liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing zhu Institute of Life Sciences College of Life and Environmental SciencesKey Laboratory of Mammalian Organogenesis and RegenerationHangzhou Normal UniversityHangzhouZhejiang 311121China The Affiliated Hospital Hangzhou Normal UniversityHangzhouZhejiang 310015China

Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate.

关键词： Cleft palate Conditional knock-in Mouse model Msx1 Organ development

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