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Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway

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Chinese Journal of Integrative Medicine 2025年第2期31卷 118-130页

作者： li zhu-qing ZHANG Feng li Qi WANG li SUN Xiao-qiang li Chao YIN Xue-mei liU Chun-lei WANG Yan-xin DU Xiao-yu LU Cheng-zhi Department of Cardiology Tianjin First Central HospitalTianjin300192China The First Central Clinical School Tianjin Medical UniversityTianjin300070China Department of Cardiology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People’s HospitalYichangHubei Province443003China School of Medicine Nankai UniversityTianjin300071China

Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,aiming to reduce ***:Eight-week-old male ApoE-deficient mice were randomly divided into 2 groups(n=10 per group):the vehicle group and the GPS treatment *** groups were fed a high-fat diet for 16 ***(40 mg/kg per day)was administered by oral gavage to the GPS group,while the vehicle group received an equivalent volume of the vehicle *** the end of the treatment,blood and aortic tissues were collected for assessments of atherosclerosis,lipid profiles,oxidative stress,and molecular expressions related to NLRP3 inflammasome activation,ROS production,and ***,in vitro experiments on human aortic endothelial cells treated with oxidized low-density lipoprotein(ox-LDL)were conducted to evaluate the effects of GPS on NLRP3 inflammasome activation,pyroptosis,apoptosis,and ROS production,specifically examining the role of the sirtuin 1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)***1 and Nrf2 inhibitors were used to confirm the pathway's ***:GPS treatment significantly reduced atherosclerotic lesions in the en face aorta(Plike protein containing a CARD,cleaved-caspase-1,and cleavedgasdermin D expressions(all P<0.01).GPS also decreased ROS production,apoptosis,and pyroptosis,with the beneficial effects being significantly reversed by SIRT1 or Nrf2 ***:GPS exe

关键词： endothelial dysfunction gentiopicroside NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine

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Leucine-Rich Repeat Protein Family Regulates Stress Tolerance and Development in Plants

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Rice science 2025年第1期32卷 32-43页

作者： HAO Zhiqi WANG Tingyi CHEN Dongdong SHEN Lan ZHANG Guangheng QIAN Qian zhu li State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Yazhouwan National Laboratory Sanya 572024China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China

The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense *** proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR ***,various LRR proteins are primarily involved in plant development and responses to environmental ***,the LRR protein family plays a central role in signal transduction pathways related to stress *** this review,we classify and analyze the functions of LRR proteins in *** extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress *** review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic *** upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.

关键词： leucine-rich repeat classification function stress tolerance plant development

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Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

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Nano Research 2025年第1期18卷 270-277页

作者： HuangJingWei li Xin Zi Jun Wu Xinli Wang li zhu Qiyou Wang Jianfu Han Junwei Fu Hongmei li Kai Huang Yu Chen Min liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

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High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries:a propensity score matched analysis

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 409-414页

作者： li-li zhu Bing-Xue zhu Yue Han Yong-Yan Tang Ying-Ying Wen Xu-Hong Zhang li-Yue Zhang Ri-Lei zhu Dong-Yu Guo Department of Ophthalmology First Affiliated Hospital of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology People’s Hospital of Haixi Autonomous Prefecture of Qinghai ProvinceDelingha 817000Qinghai ProvinceChina

AIM:To compare analysis of the impact of high altitude on corneal endothelial cells,and the prognosis in patients with cataract ***:Totally 265 plateau patients with cataract surgeries performed between January 2019 and July 2022(average altitude=3000 m),and 524 plain patients with cataract surgeries performed between January 2020 and July 2022 were *** propensity score matching(PSM)method was applied to match the basic information of patients in both regions on a 1:1 *** endothelial cell density(ECD),coefficient of variation(CV),hexagonal cell ratio(HEX),duration of surgery,and pre-and postoperative visual acuity(VA)were compared retrospectively,and correlation tests were ***:Totally 223 pairs have been matched *** HEX in the plateau group was higher than that in the plain group(61.95%±6.191%vs 44.91%±6.829%,P0.1).The pre-and postoperative VA of patients with cataract surgeries in the plateau group were lower(1.40±0.610 vs 0.71±0.514,Plial parameters(P>0.05),while the post-operative VA was significantly related to the pre-operative VA and the duration of surgery(Plial cells,but may lead to the compensatory increase of their *** plateau patients,no significant associations are found between the poor VA and the corneal endothelial functions early after cataract surgeries.

关键词： cataract surgery corneal endothelial cells hypoxia plateau propensity score matching

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Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年第01期 48-57页

作者： li zhu JIA Zhenyang DONG Jing liU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge losses in lives and property security. Based on multi-source remote sensing data, this study established decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

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Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年第1期28卷 48-57页

作者： li zhu JIA Zhenyang DONG Jing liU Zhenghong College of Earth Sciences Jilin UniversityChangchun 130061China Dandong No.2 High School Dandong 118009China

Flood disasters can have a serious impact on people's production and lives, and can cause hugelosses in lives and property security. Based on multi-source remote sensing data, this study establisheddecision tree classification rules through multi-source and multi-temporal feature fusion, classified groundobjects before the disaster and extracted flood information in the disaster area based on optical imagesduring the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision treeclassification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectralinformation to overcome the shortcomings of single-temporal image classification and achieveground-truth object classification.

关键词： multi-temporal decision tree classification flood disaster monitoring

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Effects of mode of reproduction on genetic polymorphism and divergence in wild yams(Dioscoreaceae:Dioscorea)

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Plant Diversity 2025年第1期47卷 136-147页

作者： Xin Wang Qing-Hong Feng Zhi-Hua Zeng Zhi-Qiang Zhang Jie Cai Gao Chen De-zhu li Hong Wang Wei Zhou Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology Institute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunmingYunnan 650504China Research Institute of Tropical Forestry Yunnan Academy of Forestry and GrasslandXishuangbannaYunnan 666102China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Key Laboratory of Phytochemistry and Natural Medicines Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiangYunnan 674100China

Evolutionary transitions from sexual to asexual reproduction should have significant influences on genetic divergence and polymorphism at the genome *** lineages with diverse reproductive systems provide opportunities to investigate this question using comparative approaches and studies of molecular *** investigated evidence for differences among the transcriptomes of 19 Dioscorea species(wild yams)with diverse reproductive *** included sexual species,those that propagate primarily by bulbils,and those with mixed sexual and asexual reproductive *** examined how transitions between these reproductive systems affected between-species divergence and within-species *** asexual species exhibited a reduced efficacy of natural selection and accumulation of deleterious mutations for both divergence and *** contrast,species with mixed reproductive strategies involving both seed and clonal reproduction showed no evidence of an increased fixation of harmful mutations at the divergence level,while an accumulation of genetic load present in polymorphism was *** study indicates that the genetic consequences of evolutionary transitions from sexual to predominantly clonal reproduction is likely to depend on both the duration and extent of asexuality occurring in populations.

关键词： Asexual Deleterious mutations Dioscorea Molecular evolution Selection

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Strategies for discovering novel hepatocellular carcinoma biomarkers

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World Journal of Hepatology 2025年第2期17卷 14-30页

作者： Shi-Tao Wu li zhu Xiao-ling Feng Hao-Yu Wang Fang li Department of Hepatopancreatobiliary Surgery Chongqing General HospitalChongqing 401147China Department of General Surgery Chongqing General HospitalChongqing 401147China

liver cancer,particularly hepatocellular carcinoma(HCC),remains a significant global health challenge due to its high mortality rate and late-stage *** discovery of reliable biomarkers is crucial for improving early detection and patient *** review provides a comprehensive overview of current and emerging biomarkers for HCC,including alpha-fetoprotein,des-gamma-carboxy prothrombin,glypican-3,Golgi protein 73,osteopontin,and *** advancements,the diagnostic limitations of existing biomarkers underscore the urgent need for novel markers that can detect HCC in its early *** review emphasizes the importance of integrating multi-omics approaches,combining genomics,proteomics,and metabolomics,to develop more robust biomarker *** integrative methods have the potential to capture the complex molecular landscape of HCC,offering insights into disease mechanisms and identifying targets for personalized *** significance of large-scale validation studies,collaboration between research institutions and clinical settings,and consideration of regulatory pathways for clinical implementation is also *** conclusion,while substantial progress has been made in biomarker discovery,continued research and innovation are essential to address the remaining *** successful translation of these discoveries into clinical practice will require rigorous validation,standardization of protocols,and crossdisciplinary *** advancing the development and application of novel biomarkers,we can improve the early detection and management of HCC,ultimately enhancing patient survival and quality of life.

关键词： Hepatocellular carcinoma Biomarkers Multi-omics Early detection liver cancer

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Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin WANG Shulin XU Man zhu li BAI Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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QuEChERS样品制备系统联合高效液相色谱质谱法测定土壤中7种烟碱类杀虫剂残留

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化学研究与应用 2025年第1期37卷 10-16页

作者：朱丽丽潍坊市寿光生态环境监控中心山东潍坊262700

实验建立了QuEChERS样品制备系统联合高效液相色谱质谱法测定土壤中氯虫苯甲酰胺、噻虫嗪、吡虫啉、啶虫脒、烯啶虫胺、噻虫啉、噻虫胺7种烟碱类杀虫剂的分析方法。7种烟碱类杀虫剂在0.005~0.80μg·mL^(-1)范围内线性关系良好,相关系... 详细信息

实验建立了QuEChERS样品制备系统联合高效液相色谱质谱法测定土壤中氯虫苯甲酰胺、噻虫嗪、吡虫啉、啶虫脒、烯啶虫胺、噻虫啉、噻虫胺7种烟碱类杀虫剂的分析方法。7种烟碱类杀虫剂在0.005~0.80μg·mL^(-1)范围内线性关系良好,相关系数均大于0.995,方法检出限分别为0.011、0.009、0.007、0.005、0.009、0.006、0.012μg·kg^(-1),三水平平均加标回收率在87.4%~103.2%之间。此方法具有专属性好、检测准确度和灵敏度高等优点,适用于物种植土壤中微量烟碱类杀虫剂残留的监测。

关键词： QuEChERS样品制备系统 UPLC-MS/MS 土壤杀虫剂

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