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HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

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Biomedical and Environmental Sciences 2023年第9期36卷 800-813页

作者： YU De E XU Yu Jun LI Mu YANG Yuan LIANG Hua Yue ZHONG Shan Mei QIN Cai LAN Ya Nan LI Da Wei YU Ji Peng PANG Yuan QIN Xue Qiu LIANG Hao zhu kao kao YE Li LIANG Bing Yu Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina International School of Public Health and One Health Hainan Medical UniversityHaikou 571199HainanChina Prevention and Treatment Department the Fifth People's Hospital of Hainan Province&Affiliated Dermatology Hospital of Hainan Medical UniversityHaikou 570102HainanChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Life Sciences InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Oncology Medical College Guangxi Medical UniversityNanning 530021GuangxiChina The First Clinical Medical College Guangxi Medical UniversityNanning 530021GuangxiChinaGuangxi Key Laboratory of AIDS Prevention and TreatmentSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,*** A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in *** used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol *** resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance *** A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were *** 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,*** patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of ***,HIVDR was less likely to affect female *** common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against *** The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.

关键词： HIV-1 subtypes Antiretroviral therapy Virological failure Drug resistance

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海南省抗病毒治疗失败HIV/AIDS患者HIV-1亚型及基因型耐药分析

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中国热带医学 2021年第6期21卷 594-599页

作者：冯玉婷许玉军马岳绒朱考考符惠冰海南省第五人民医院海南省皮肤性病防治中心海南海口570206

目的了解海南省经艾滋病抗病毒治疗(antiretroviral therapy,ART)失败HIV/AIDS患者的HIV-1基因型耐药特点,为海南省HIV/AIDS患者有效抗病毒治疗提供基础依据。方法采集2014-2019年ART治疗失败的患者血样进行基因型耐药检测,分析HIV-1毒... 详细信息

目的了解海南省经艾滋病抗病毒治疗(antiretroviral therapy,ART)失败HIV/AIDS患者的HIV-1基因型耐药特点,为海南省HIV/AIDS患者有效抗病毒治疗提供基础依据。方法采集2014-2019年ART治疗失败的患者血样进行基因型耐药检测,分析HIV-1毒株亚型与耐药突变特点。结果 172例治疗失败患者通过Pol基因区扩增及测序成功,其中男性150例(占87.21%),年龄中位数为35.81(27.38,41.32)岁,未婚者102例(占59.30%),性传播128例(占74.42%),治疗前CD4+T淋巴细胞中位数为225.93(73.00,328.25)个/μL;HIV-1毒株亚型为CRF01AE 122例(占70.93%),其次CRF07BC亚型31例(占18.02%)。109例(63.37%)患者发生HIV-1低度以上耐药位点突变,非核苷逆转录酶抑制剂(NNRTI)耐药109例(占63.37%);核苷逆转录酶抑制剂(NRTI)的耐药86例(占50.00%),NRTI/NNRTI同时发生耐药86例(占50.00%例);未发生蛋白酶抑制剂低度以上耐药位点突变。共检测出31种耐药位点,主要突变位点为M184V/I(38.95%),Y181C/I/V/L(23.26%),K65R(22.09%),V179D/E(20.93%)和K103N(19.77%)。对奈韦拉平(NVP)、依非韦伦(EFV)、拉米夫定(3TC)、替诺福韦(TDF)、齐多夫定(AZT)的高度耐药构成比依次是61.05%、50.00%、40.12%、12.79%、3.49%。扩增阳性者耐药构成比在性别、婚姻状况、传播途径、病毒亚型、基线CD4+T淋巴细胞间差异均有统计学意义(P<0.05)。结论海南省ART治疗失败患者中,以NNRTIs耐药为主,应加强监测治疗效果及耐药情况,以及时调整治疗方案和减少耐药的发生与传播。

关键词：艾滋病抗病毒治疗耐药突变位点

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海南省2005—2019年首次接受艾滋病抗病毒治疗病人的流行病学特征

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中国热带医学 2021年第7期21卷 681-685页

作者：冯玉婷许玉军马岳绒朱考考陈善逸海南省第五人民医院海南省皮肤性病防治中心海南海口570206

目的了解海南省2005—2019年艾滋病病毒感染者/艾滋病病人(human immunodeficiency virus/acquired immunodeficiency syndrome,HIV/AIDS)开始抗病毒治疗(antiretroviral therapy,ART)时的流行病学特征。方法收集海南省2005—2019年首次接受艾滋病抗病毒治疗的HIV/AIDS病人基线相关资料进行回顾性分析。结果3301例研究对象中,男性占85.8%,男女性别比为6.05∶1;平均年龄为(35.95±13.37)岁;未婚者占53.6%;感染途径以性传播为主,占82.4%;WHO临床分期Ⅰ期者占82.9%;治疗病人治疗前基线CD4^(+)T淋巴细胞计数M(P_(25),P_(75))为271(139,391)个/mm^(3);从确诊到开始治疗的时间间隔中位数为1.35个月。2005—2019年首次接受抗病毒治疗的HIV/AIDS病人中,男性、未婚者、≥50岁年龄组、同性性传播感染者、治疗时临床分期为Ⅰ期、确诊到治疗的时间间隔小于1个月者的构成比呈增加趋势,CD4^(+)T淋巴细胞计数<200个/mm^(3)者的构成比呈逐年下降趋势(P<0.001)。结论海南省艾滋病抗病毒治疗以青壮年男性为主,其覆盖面逐渐扩大,治疗时机有所提前,应进一步采取有效措施,早发现,早治疗。

关键词：艾滋病抗病毒治疗流行病学特征分析

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灰色模型GM(1,1)在海南省梅毒发病率预测中的应用

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海南医学 2015年第12期26卷 1850-1852页

作者：鲁建瑜刘巧许玉军朱考考方为民华中科技大学同济医学院湖北武汉430032 海南省皮肤性病防治中心海南海口570206

目的探讨灰色模型预测海南省梅毒发病率的适用性,并对未来5年梅毒发病趋势进行预测,为科学制定梅毒防控措施、合理配置防控资源提供依据。方法运用GM(1,1)建模方法对2009-2013年海南省梅毒的发病率进行模型拟合,对拟合精度进行评判,并... 详细信息

目的探讨灰色模型预测海南省梅毒发病率的适用性,并对未来5年梅毒发病趋势进行预测,为科学制定梅毒防控措施、合理配置防控资源提供依据。方法运用GM(1,1)建模方法对2009-2013年海南省梅毒的发病率进行模型拟合,对拟合精度进行评判,并运用模型进行梅毒发病率预测。结果海南省梅毒发病率的GM(1,1)模型,拟合精度和预测效果好(C=0.290 7<0.35,P=1),模型预计今后5年海南省梅毒发病率结果分别为45.98/10万,52.60/10万,60.19/10万,68.85/10万,78.78/10万。结论预测结果表明,GM(1,1)模型能够很好地预测梅毒发病率的趋势。未来5年海南省梅毒发病率呈逐年上升的趋势。

关键词：梅毒发病率灰色模型预测

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Numerical Simulation of Co-Combustion of Pulverized Coal and Different Proportions of Refused Derived Fuel in TTF Precalciner

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Journal of Renewable Materials 2021年第7期9卷 1329-1343页

作者： Jiekun zhu Hongtao kao College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China

Based on the theory of computational fluid dynamics(CFD),pulverized coal combustion alone,and the co-combustion of pulverized coal and refuse-derived fuel(RDF)in a Trinal-sprayed calciner(TTF)precalciner were *** results revealed that when coal was used as a single fuel,the velocity field in the precalciner had good symmetry,and formed three spray effects and multiple recirculation *** main combustion zone was distributed in the lower tertiary air and pulverized coal area,and the highest temperature reached up to 1,500 *** to the simulation results,the predicted decomposing rate of raw meal was 90.12%,which is in good agreement with the actual measured *** addition,with the increase in RDF content,the average temperature of the furnace,the decomposition rate of the raw meal,and the NO_(x) concentration all exhibited a downward *** the condition of ensuring the normal operation of the precalciner,blending with 20%RDF is the most reasonable strategy,and the NO_(x) emissions decreased by approximately 16%.

关键词： Numerical simulation TTF precalciner RDF co-combustion NO_(x)emission

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Nitrogen fertilization has minimal influence on rhizosphere effects of smooth crabgrass (Digitaria ischaemum) and bermudagrass (Cynodon dactylon)

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Journal of Plant Ecology 2015年第4期8卷 390-400页

作者： Biao zhu Kevin Panke-Buisse Jenny kao-Kniffin Earth Sciences Division Lawrence Berkeley National LaboratoryCyclotron RoadBerkeleyCA 94720USA School of Integrative Plant Science Cornell University134 Plant Sciences BuildingIthacaNY 14853USA

Aims Plants generally respond to nitrogen(N)fertilization with increased growth,but N addition can also suppress rhizosphere effects,which consequently alters soil *** quantified the influence of N addition on rhizosphere effects of two C4 grasses:smooth crabgrass(Digitaria ischaemum)and bermudagrass(Cynodon dactylon).Methods Plants were grown in nutrient-poor soil for 80 days with either 20 or 120μg NH4No3-N g dry soil−1.N mineralization rates,microbial biomass,extracellular enzyme activities and bacterial community structure were measured on both rhizosphere and bulk(unplanted)soils after plant *** Findings Fertilization showed nominal differences in net N mineralization,extracellular enzyme activity and microbial biomass between the rhizosphere and bulk soils,indicating minimal influence of N on rhizosphere ***,the presence of plant roots showed the strongest impact(up to 80%)on rates of net N mineralization and activities of three soil enzymes indicative of N release from organic *** component analysis of terminal restriction fragment length polymorphism(t-rFlP)also reflected these trends by highlighting the importance of plant roots in structuring the soil bacterial community,followed by plant species and N fertilization(to a minor extent).overall,the results indicate minor contributions of short-term N fertilization to changes in the magnitude of rhizos-phere effects for both grass species.

关键词： rhizosphere effect N fertilization belowground carbon allocation microbial biomass extracellular enzyme net N mineralization microbial community composition

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FGFR2-TSC22D1,a novel FGFR2 fusion gene identified in a patient with colorectal cancer:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6867-6871页

作者： Xiao-Ming kao Xi zhu Jun-Ling Zhang Shi-Qing Chen Chao-Gang Fan Research Institure of General Surgery Jinling HospitalNanjing 210002Jiangsu ProvinceChina Department of Medical 3D Medicines Inc.Shanghai 201114China Department of General Surgery The Affiliated BenQ Hospital of Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND The FGFR signaling pathway is activated in multiple tumor types through gene amplifications,single base substitutions,or gene *** FGFR gene fusions may represent candidate targets for the development of tyrosine kinase *** SUMMARY Herein,we report a patient with colorectal cancer(CRC)harboring a novel FGFR2 fusion gene.A 59-year-old man felt discomfort in his right upper abdomen with loss of appetite for 6 *** abdominal computed tomography scan revealed the existence of a space-occupying lesion in the ascending *** pathological diagnosis was a poorly differentiated *** biopsy specimen was subjected to next-generation sequencing analysis,and a novel FGFR2-TSC22D1 fusion with complete kinase structure of FGFR2 protein was *** We report the first case of CRC harboring FGFR2-TSC22D1,which enriches the FGFR2 fusion ***2 inhibitors might be effective in the later treatment for this patient.

关键词： FGFR2-TSC22D1 Colorectal cancer Next-generation sequencing Case report

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Treatment Effects of Acupuncture and Calligraphy Training on Cognitive Abilities in Senile Demented Patients

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Chinese Medicine and Culture 2019年第2期2卷 95-98页

作者： Henry S.R.kao Miqu Wang Shuguang Yu Shihong Yuan Miranda MY Fung Lin zhu Stewart P.W.Lam Tin Tin kao Xiaoyang kao Departments of Psychology 9Psychology and GeographyUniversity of Hong KongHKSAR Calligraphy Therapy Research Laboratory Shenzhen Institute of NeuroscienceShenzhen Institute of Psychology and Genetics of Chinese Medicine School of Acup uncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu Department of Medicine Shanxi Medical College for Continuing Education Beijing Tong Ren Tang Chinese Medicine Clinic Beijing Tong Ren Tang Taiyuan Chinese Medicine Hospital Department of Chinese Medicine China Academy of Chinese Medical Sciences Division of Research Advocacy 21^st Century Education Research InstituteBeijingChina 不详 Department of Electrical Engineering University of Illinois at Urbana-ChampaignChampaignIllinoisUSA

Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile *** and Methods:A randomized controlled trial(RCT)with 17 mild-to-moderate dementia patients with an average age of 77.29 years were randomly assigned with 9 to the calligraphy handwriting group and 8 to the acupuncture treatment group for a month of consecutive *** participants'cognitive abilities,as well as symptoms of senile dementia,were measured by the Chinese version of the Mini-mental State Examination(CMMSE)and the Chinese Medicine Quantitative Diagnostic Survey for Senile Dementia Symptoms,respectively,before and after the ***:The calligraphy group showed a significant increase in calculation and memory as well as a decline in the symptoms of senile *** in the acupuncture group experienced a significant growth in total CMMSE scores and the subscales in orientation to time and place,behavioral operations,as well as reduced clinical ***,no significant changes were found in their memory and calculation ***:Both CCH and acupuncture treatments were found significantly effective for,respectively,enhancing the patients'cognitive abilities and reducing their clinical ***,calligraphy handwriting also improved the level of their attention and concentration,physical relaxation,and emotional stability.

关键词： Acupuncture calligraphy handwriting cognitive abilities senile dementia

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Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： SHENG Jia-Yun WANG Si-Qi LIU kao-Hua zhu Bo ZHANG Qiao-Yan QIN Lu-Ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review

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Improvement on Mixograph test through water addition and parameter conversions

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Journal of Integrative Agriculture 2015年第9期14卷 1715-1722页

作者： SUN Jia-zhu YANG Wen-long LIU Dong-cheng ZHAO Jun-tao LUO Guang-bin LI Xin LIU Yan-jun GU O Jin-kao ZHANG Ai-min State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences Zhaoxian Institute of Agricultural Sciences Shijiazhuang Academy of Agriculture and Forestry Sciences

To improve Mixograph testing effect, Farinograph measurements were adopted as a quality standard and changes in water absorption and parameter conversion in Mixograph test were explored. Comparative study showed that increasing water absorption to about 73% and converting original parameters to compound parameters in Mixograph tests signiifcantly increased their predictive power for lfour quality. These efforts also enabled the adoption of ifxed water addition level in Mixograph test and simpliifed the test procedure signiifcantly. With the success in parameter conversions, Mixograph test results were successful y described by Farinograph parameters, which al ow breeders to compare and exchange test results easily. Al these changes optimized the ofifcial method of Mixograph test with simpliifed procedure and enhanced reliability and made the Mixograph being the superior tool for quality assessment in wheat-breeding programs.

关键词： Mixograph water absorption compound parameter constant water addition parameter conversion

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