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Fluctuating magnetic droplets immersed in a sea of quantum spin liquid

The Innovation 2023年第5期4卷 33-40页

作者： Zihao zhu Bing{1.n Pan {1.npeng Nie Jiamin Ni Yanxing Yang Changsheng chen chengyu jiang Yeyu Huang Erjian cheng Yunjie Yu Jianjian Miao Adrian D.Hi{1.er Xianhui chen Tao Wu Yi Zhou Shiyan {1. Lei Shu State Key Laboratory of Surface Phys ics and Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Stronglycoupled Quantum Matter Physics Department of PhysicsUniversity of Science and Technology of ChinaHefeiAnhui 230026China Department of Physics the University of Hong KongHong KongChina ISIS Pulsed Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell CampusDidcotOxfordshire 0X110QXUK Collaborative Innovation Center of Advanced Micr ostructures Nanjing 210093China CAS Center for Excellence in Superconducting Electronics(CENSE) Shanghai 200050China institute of Physics and {1. National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory DongguanGuangdong 523808China Kavli {1. for Theoretical sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Shanghai Research Center for Quantum sciences Shanghai 201315China

The search of quantum spin liquid(QSL),an exotic magnetic state with strongly fluctuating and highly entangled spins down to zero temperature,is a main theme in current condensed matter ***,there is no smoking gun evidence for deconfined spinons in any QSL candidate so *** disorders and competing exchange interactions may prevent the formation of an ideal QSL state on frustrated spin *** we report comprehensive and systematic measurements of the magnetic susceptibility,ultralow-temperature specific heat,muon spin relaxation(μSR),nuclear magnetic resonance(NMR),and thermal conductivity for NaYbSe2 single crystals,in which Yb3+ions with effective spin-1.2 form a perfect triangular *** these complementary techniques find no evidence of long-range magnetic order down to their respective base ***,specific heat,μSR,and NMR measurements suggest the coexistence of quasi-static and dynamic spins in *** scattering from these quasi-static spins may cause the absence of magnetic thermal ***,we propose a scenario of fluctuating ferrimagnetic droplets immersed in a sea of *** may be quite common on the way pursuing an ideal QSL,and provides a brand new platform to study how a QSL state survives impurities and coexists with other magnetically ordered states.

关键词： NMR immersed quantum

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离散小波去噪后冬小麦叶片含水量高光谱估算

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光谱学与光谱分析 2024年第9期44卷 2559-2567页

作者：王延仓朱玉晨齐焱鑫张志通曹会琼王金杲顾晓鹤唐瑞尹何跃君李笑芳罗巍北华航天工业学院遥感信息工程学院河北廊坊065000 廊坊师范学院河北廊坊065000 中国地质科学院水文地质环境地质研究所河北石家庄050061 北京农林科学院信息技术研究中心北京100097 航天遥感信息应用技术国家地方联合工程研究中心河北廊坊065000 河北省航天遥感信息处理与应用协同创新中心河北廊坊065000

光谱噪声去除是遥感区域应用的必要过程,噪声去除效果能直接影响区域地表信息的监测精度。为分析离散小波算法对光谱数据的分解机理,探寻基于离散小波算法光谱噪声信息去除与光谱处理方法,以冬小麦冠层光谱与叶片含水量为数据源,先利用... 详细信息

光谱噪声去除是遥感区域应用的必要过程,噪声去除效果能直接影响区域地表信息的监测精度。为分析离散小波算法对光谱数据的分解机理,探寻基于离散小波算法光谱噪声信息去除与光谱处理方法,以冬小麦冠层光谱与叶片含水量为数据源,先利用离散小波算法对光谱数据进行去噪处理,采用的小波基为Meyer;然后以Meyer、Sym2、Coif2为小波基对去噪后的光谱数据进行信息分离,并结合相关性分析算法、偏最小二乘算法构建冬小麦叶片含水量估测模型,研究结论如下:(1.在离散小波算法下,合并的光谱曲线随合并尺度数的不断增加,原光谱曲线局部的大、中、小特征依次凸显;随H1.—H1.解尺度的依次加入,分解信息对合并曲线的修正幅度也逐步减弱,其中,将H3—H1.次合并后,合并的光谱曲线几乎无变动。(2)提出的去噪方法可在一定程度上改变了部分光谱对冬小麦叶片含水量的敏感性及敏感波段的分布:其中在1.3尺度内,降低了光谱对冬小麦叶片含水量的敏感性,改变了敏感波段的波段位置的分布情况。在4~1.尺度内,能明显提升光谱对冬小麦叶片含水量的敏感性(Coif2);提出的去噪方法可提升局部波段对冬小麦叶片含水量的敏感性(Sym2)。(3)提出的去噪方法能明显提升光谱对模型的稳定性,能提升Sym2、Coif2小波基内最优模型的精度与稳定性,其中验证精度提高了8.6%(Sym2)、34.1.(Coif2),表明该研究提出的去噪处理是有效的。

关键词：冬小麦叶片含水量离散小波噪声信息高光谱

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Wellbore temperature distribution during drilling of natural gas hydrate formation in South{1. sea

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Petroleum 2021年第4期7卷 451-459页

作者： Xiaolong Zhao Yizhong Zhao Zenglin Wang Gang {1. Peng li Wei liang Xuefeng Gao Hanming Xu lin jiang Na Wei Research institute of Petroleum Engineering Shengli OilfieldSINOPECDongying257000China Shengli Oilfield Company SINOPECDongying257000China State Key Laboratory of Oil and Gas Reservoir geology and Exploitation Southwest Petroleum UniversityChengdu610500China State Key Laboratory of Natural Gas Hydrate Beijing10027China

The natural gas hydrate resources in the South china Sea alone are about 85 tril{1.on cubic *** the dril{1.ng process of marine gas hydrate,the natural gas hydrate will decompose and produce gas,as the rising of temperature and dropping of the pressure in the *** process will have a significant impact on dril{1.ng ***,it is necessary to study the wellbore temperature distribution during the dril{1.ng of marine hydrate *** this paper,the wellbore temperature distribution of safe dril{1.ng in hydrated formation is taken as the research goal,and the research status of relevant domestic and international wellbore temperatures was *** to the characteristics of the marine environment and reservoir-forming characteristics of hydrate reservoirs in the South china Sea,the wellbore temperature distribution model of offshore dril{1.ng wellbore under the condition of hydrate decomposition was *** temperature distribution curve of dril{1.ng straight wellbore in hydrate layer of South china Sea was *** dril{1.ng the hydrate reservoir,the distribution regularity of the wellbore temperature is similar to that of the conventional offshore dril{1.ng ***,the temperature of the wellbore annulus near the hydrate decomposition site is lower than the ambient temperature,mainly due to the hydrate decomposition *** this paper,the sensitivity analysis of several main parameters of the wellbore temperature distribution of dril{1.ng straight wellbore in hydrate layer of South china Sea was carried *** the conduction of experiment and numerical simulation,we have get some new findings:(1.The hydrate saturation has {1.ttle effect on the wellbore temperature;(2)As the dril{1.ng fluid displacement increases,the annulus temperature of the wellbore above the mud{1.ne increases,and the temperature of the wellbore below the mud{1.ne decreases continuously;(3)As the density of the dril{1.ng fluid increases,th

关键词： Wellbore temperature Natural gas hydrate South china Sea Numerical simulation Sensitivity analysis

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Stenting for symptomatic intracranial arterial stenosis in china:1.year outcome of a multicentre registry study

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Stroke & Vascular Neurology 2018年第3期3卷 176-184页

作者： Ning Ma Yong Zhang Jie Shuai Changchun jiang Qiyi {1. Kangning chen li liu Baomin li Xiangqun Shi lianbo Gao Yajie liu Feng Wang Yongli li Tieyan liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityChina National Clinical Research Center for Neurological DiseasesCenter of StrokeBeijing Institute for Brain DisordersBeijingChina Department of Neurology The Affiliated Hospital of Qingdao University Medical CollegeQingdaoChina Department of Neurology Xin Qiao HospitalThird Military Medical UniversityChongqingChina Department of Neurology Baotou Central HospitalBaotouChina Department of Neurology Linyi People's HospitalLinyiChina Department of Neurology Xi Nan HospitalThird Military Medical UniversityChongqingChina Department of Neurology The Hospital of Chifeng CityChifengChina Department of Neurosurgery The PLA General HospitalBeijingChina Department of Neurology The Lanzhou General Hospital of PLALanzhouChina Department of Neurology The Affiliated Fourth Hospital of China Medical UniversityShenyangChina Department of Neurology Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Interventional Therapy The First Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Interventional Radiology Cangzhou Central HospitalCangzhouChina Department of Neurology West China HospitalSichuan UniversityChengduChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityChina National Clinical Research Center for Neurological DiseasesCenter of StrokeBeijing Institute for Brain DisordersBeijingChina Departments of Radiology Kaiser Permanente Los Angeles Medical CenterLos AngelesUSA

background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in china showed that the short-term safety and efficacy of stenting was ***,it remained uncertain whether the low event rate could be of a long *** reported the 1.year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor *** Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were ***-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the *** primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 1.-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after *** From September 201. to January 201.,300 patients(ages 58.3±9.78 years)were *** them,1.9 patients were treated with balloon-mounted stent and 1.1.with balloon plus self-expanding *** the 1.year follow-up,25 patients had a primary end point *** probabi{1.ty of primary outcome at 1.year was 8.1.(95% CI 5.3% to 1..7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21.76)had re-stenosis≥50% and 1..4%(1./76)had re-stenosis≥70%.No base{1.ne characteristic was associated with the primary *** The event rate remains low over 1.year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor *** randomised trial of comparing individually tailored stenting with best medical therapy is needed.

关键词： stenosis balloon intracranial

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Tectonic paleogeography of Late Sinian and its significances for petroleum exploration in the middle-upper Yangtze region, South china

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Petroleum Exploration and Development 2020年第5期47卷 946-961页

作者： WANG Zecheng {1. Hua chen Zhiyong liU Jing{1. MA Kui li Wenzheng XIE Wuren {1. Qingchun ZHAI Xiufen SHI Shuyuan li Qi Petrochina Research {1. of Petroleum Exploration&Development Beijing 100083China Petrochina Southwest Oil&Gas Field Company Chengdu 610051China Petrochina Hangzhou Research {1. of geology(HIPG) Xihu DistrictHangzhou 310023China

The paleotectonic pattern,lithofacies paleogeographic features,sedimentary evolution and its controlling effects on hydrocarbon accumulation assemblages during the depositional period of the Sinian Dengying Formation in middle-upper Yangtze region were investigated based on outcrops,drilling,log and seismic *** study shows that,(1.Affected by the breakup of the Rodinia supercontinent,the middle and upper Yangtze areas were in extensional tectonic environment during the depositional period of Dengying *** carbonate platform was structurally ***-platform depressions controlled by syndepositional faults developed,forming a tectonic-paleogeographic pattern of"three platforms with two depressions".(2)During the depositional period of the first and second members of the Dengying Formation,rimmed platforms and intra-platform fault depressions developed in upper Yangtze area and isolated platform developed in middle Yangtze area,and there was the Xuanhan-Kaijiang ancient land block in eastern *** depositional period of the third member of the Dengying Formation is the transformation period of tectonic-paleogeographic pattern,when a set of shallow water shelf sediment rich in mud was deposited due to transgression on the background of the eroded terrain formed in EpisodeⅠof Tongwan *** sediment of the fourth member of the Dengying Formation inherited the paleogeographic pattern of the first and second members of the Dengying Formation in general,but the Deyang-Anyue intra-platform fault depression further expanded,and the middle Yangtze platform evolved into two separated platforms.(3)Tectonic-sedimentary differentiation and evolution of carbonate platform in the Sinian gave rise to two types of accumulation assemblages with wide distribution and great exploration potential,which are platform margin and intra-platform.

关键词： tectonic paleogeography structural differentiation intra-platform fault depression rimmed platform microbial mounds and shoals Sinian Dengying Formation Sichuan Basin the middle-upper Yangtze region

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.chen C.H.chen Chao chen G.chen H.S.chen M.L.chen S.J.chen S.L.chen S.M.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.jiang H.B.jiang P.C.jiang S.S.jiang T.J.jiang X.S.jiang Y.jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.li C.li C.H.li cheng li D.M.li F.li G.li H.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li K.li L.J.li L.K.li Lei li M.H.li P.R.li Q.M.li Q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.H.li X.L.li X.Y.li Y institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central china Normal University Wuhan 430079China Central South University Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China china University of Geo{1. Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China institute of Modern Physics Lanzhou 730000China institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1.taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1.(1.60)π,D^(0)→π(1.00)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1.(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.01._(stat.)±0.01._(syst.))%and(0.951.0.025_(stat.)±0.021.(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

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Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： lin zhu Jian‑Rong Zhou Yuan‑Guang Xia liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng li‑Xin Zeng Jia‑Jie li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑Xun Shen Jun Xu li‑jiang liao Xiao‑zhuang Wang Gui‑An Yang Huai‑Chan chen Ju‑Ping Xu Zhi‑Duo li Song‑lin Wang Jian zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo chen institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of chinese academy of sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the china Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large so{1.d angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3He-filled {1.near position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1.inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 1.0°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to faci{1.tate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1.A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

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心绞痛牵涉痛与穴位敏化的关系

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针刺研究 2018年第5期43卷 277-284页

作者：施静王健王渊刘坤付勇孙建华赵吉平邵晓梅冯斯峰杨有为李杰曹乾安何勋刘梅芳陈璐崔翔吴江昀吴媛媛高昕妍朱兵云南省中医医院针灸科昆明650000 山东中医药大学针灸推拿学院济南250355 陕西中医药大学针药结合创新研究中心陕西咸阳712046 中国中医科学院针灸研究所北京100700 江西中医药大学附属医院针灸一科南昌330006 江苏省中医院针灸康复科南京210029 北京中医药大学东直门医院针灸科北京100700 浙江中医药大学第三医院杭州310053

目的:观察冠心病稳定型心绞痛牵涉痛分布区域与穴位的关系,并结合动物实验探讨局部敏化出现的规律。方法:临床研究部分,观察1.046例冠心病稳定型心绞痛患者外周压痛敏感部位、局部皮肤形态异常改变,并测量了77位患者疼痛阈值的变化。动... 详细信息

目的:观察冠心病稳定型心绞痛牵涉痛分布区域与穴位的关系,并结合动物实验探讨局部敏化出现的规律。方法:临床研究部分,观察1.046例冠心病稳定型心绞痛患者外周压痛敏感部位、局部皮肤形态异常改变,并测量了77位患者疼痛阈值的变化。动物实验部分,以SD大鼠冠状动脉左前降支结扎4h为心肌缺血模型组(n=1.),以假手术为对照组(n=4),分别用在自然光下拍摄观察和活体荧光成像的方法,记录大鼠尾静脉注射Evans Blue后体表出现蓝染的部位,并检测痛阈变化。结果:心绞痛患者压痛部位以及皮肤局部组织结构的改变多分布在左侧胸前区、背部、肩部、上肢尺侧部;右侧也有一定数量的分布。压痛点出现在穴位上、穴位附近和穴位以外。心肌缺血的大鼠模型出现类似的变化。结论:心脏发生缺血性病变时,其相应节段(T 1.T 5)神经支配皮节区域发生规律性的牵涉性的"敏化"反应,这些敏感度改变的部位与"穴位"形成有关。

关键词：心绞痛牵涉痛穴位敏化机械痛阈

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Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： jiang-Ming {1. Wei-Jian zhu Jie liu Gui-Zhen Wang Xiao-Qin {1. Yun Tan Wei-Wei Xu li-Wei Qu Jin-Yan li Huan-Ju Yang Lan Huang Ning Cai Wei-Da Wang Ken Huang Jian-Quan Xu Guo-Hui li Sheng He Tian-Ying Luo Yi Huang Song-Hua liu Wen-Qiang Wu Qi-Yang Lu Mei-Guang Zhou Shu-Ying {1. Rong-Lan li Mei-ling Hu Ying Huang Jin-Hua Wei Jun-Min li Sai-Juan {1. Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 1. years or older were randomly assigned to receive placebo or thalidomide for 1. weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 1..0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 1. weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 1..3±6.4 U,respectively(P1..Adverse events of drowsiness,dizziness,fatigue,pyrexia,sore throat,and rash were more common with thalidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 1.4.9±1..0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1.-MYB(rs93991.7 C/T,C/C;rs4895441.A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

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Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla

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Natural Products and Bioprospecting 2017年第5期7卷 413-419页

作者： Xin Wei li-Ping {1. Ying Guo Afsar Khan Ya-Ping liu Hao-Fei Yu Bei Wang Cai-Feng Ding Pei-Feng zhu Ying-Ying chen Yun-li Zhao Yong-Bing chen Yi-Fen Wang Xiao-Dong Luo State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of chinese academy of sciences Beijing 100049People’s Republic of China Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223People’s Republic of China Department of Chemistry COMSATS Institute of Information TechnologyAbbottabad 22060Pakistan Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming 650201People’s Republic of China

Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness,cerebrovascular diseases,and nervous disorders in ***,the neuro-protective activities of the alkaloids from *** were intensively *** current work,three new indole alkaloids(1.3),identified as geissoschizic acid(1.,geissoschizic acid N4-oxide(2),and 3b-sitsirikine N4-oxide(3),as well as 26 known analogues were isolated from ***,in the neural stem cells(NSCs)proliferation assay for all isolated compounds,geissoschizic acid(1.,geissoschizic acid N4-oxide(2),isocorynoxeine(6),isorhynchophylline(7),(4S)-akuammigine N-oxide(8),and(4S)-rhynchophylline N-oxide(1.)showed unexpected inhibitory activities at 1. μ*** previous neuro-protective reports,as a warning or caution,our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of ***,while the structure–activity relationships of the isolated compounds were discussed also.

关键词： Uncaria rhynchophylla Indole alkaloids NSCs proliferation

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