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Protective eff ect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection

World Journal of Emergency Medicine 2024年第1期15卷 28-34页

作者： Yangyang Guo Yaqi Sun Hongxia Wu Jian Lu Yuan Lin jiaqing zhu Meihong Lai Meiqi Zhang Jun Wang Jungang Zheng Department of Intensive Care Medicine Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China National Children’s Regional Medical Center National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Spleen and Stomach Diseases Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China Department of Ultrasonic Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Zhejiang University School of Medicine Hangzhou 310058China The First People’s Hospital of Yuexi County Yuexi 616650China

BACKGROUND:Streptococcus pneumoniae(***)is a common pathogen that causes bacterial ***,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat *** *** with a 14-carbon saturated fatty acid(ND-C14)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide ***,it is unclear whether ND-C14 is effective against lung infections caused by ***:In vitro,three groups were established,including the control group,and the HD5 and ND-C14 treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C14 against *** morphological changes of *** treated with HD5 or ND-C14 were observed by scanning electron *** vivo,mice were divided into sham,vehicle,and ND-C14 treatment *** in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C14 treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×108 CFU/mL(total bacterial count:5×10^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C14(including 20μg or 50μg),*** rates were evaluated in the vehicle and ND-C14 treatment *** burden in the blood and bronchoalveolar lavage fluid were *** lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C14 against ***:Compared with HD5,ND-C14 had a better bactericidal eff ect against *** because of its stronger ability to destroy the membrane structure of *** in *** vivo,ND-C14 significantly delayed the death time and improved the survival rate of mice infected with ***-C14 reduced bacterial burden and lung tissue ***,ND-C14 had a membrane per

关键词： Streptococcus pneumoniae Antimicrobial peptides Humanα-defensin 5 Infection

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基于精细分区的省级森林资源资产清查价格体系优化研究——以浙江省为例

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上海国土资源 2024年第1期45卷 120-125页

作者：李媛媛朱佳清朱兵浙江省测绘科学技术研究院浙江杭州311100

在全民所有自然资源资产清查背景下,探究森林资源资产清查价格体系的优化路径具有现实意义。本文以浙江省为例,以国家级均质区划分为基础,采用分类别、分树种定价的思路测算林地林木调整系数和价格,形成一套“精细分区—树种筛选—系数... 详细信息

在全民所有自然资源资产清查背景下,探究森林资源资产清查价格体系的优化路径具有现实意义。本文以浙江省为例,以国家级均质区划分为基础,采用分类别、分树种定价的思路测算林地林木调整系数和价格,形成一套“精细分区—树种筛选—系数调整—省级均值区价格确定”的全民所有森林资源资产清查省级价格体系。研究结果表明:浙江省划定19个省级林地和林木(乔木林为例)均质区,分区数目合理,各区域间的森林资源特征空间异质性显著,测算所得的森林资源资产价格成果与实际情况相符。本文以精细化分区方法为核心的全民所有森林资源资产清查价格体系优化框架可以助力自然资源资产清查价值量核算工作。

关键词：自然资源资产清查森林资源价格体系森林均质区精细分区

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人工智能术前规划系统辅助人工全髋关节置换术后翻修手术的疗效研究

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中国修复重建外科杂志 2024年第4期38卷 455-460页

作者：朱家庆孙家豪刘金柱马博闻张驰宇张超夏天卫沈计荣南京中医药大学附属医院骨伤科南京210029 常州市中医医院骨伤科江苏常州213004

目的探究人工智能术前规划系统(AIHIP系统)辅助髋关节翻修手术的早期疗效。方法回顾分析2019年6月—2023年3月收治且符合选择标准的22例(23髋)髋关节翻修患者临床资料。其中男12例,女10例;年龄44~90岁,平均69.7岁。初次翻修19髋,2次翻修... 详细信息

目的探究人工智能术前规划系统(AIHIP系统)辅助髋关节翻修手术的早期疗效。方法回顾分析2019年6月—2023年3月收治且符合选择标准的22例(23髋)髋关节翻修患者临床资料。其中男12例,女10例;年龄44~90岁,平均69.7岁。初次翻修19髋,2次翻修3髋,3次翻修1髋。翻修原因:假体松动12髋,髋臼杯松动4髋,骨溶解3髋,髋臼脱位2髋,术后感染1髋,假体磨损1髋。Paprosky髋臼骨缺损分期:ⅡA期6髋,ⅡB期9髋,ⅡC期4髋,ⅢA期3髋,ⅢB期1髋。记录患者更换假体型号、手术时间、住院时间、下地情况等,以及术后感染、骨折、假体松动等不良事件发生情况。术前、术后1周及6个月采用Harris评分评价患肢功能,比较术前及术后6个月髋关节活动度。结果患者手术时间85~510 min,平均241.8 min;住院时间7~35 d,平均15.2 d;脱离助行器时间2~108 d,平均42.2 d。22例患者均获随访,随访时间8~53个月,平均21.7个月。除1例患者术后出现大腿血肿、1髋发生髋关节脱位外,余患者均无假体松动、感染等不良事件发生。术后髋臼杯型号匹配程度为完全匹配22髋,不匹配1髋(+2号),匹配率95.65%;股骨柄型号匹配程度为完全匹配22例髋、一般匹配1髋(–1号),匹配率100%。术后1周及6个月Harris评分分别为(55.3±9.8)分和(89.6±7.2)分,较术前(33.0±8.6)分显著改善(P<0.05),术后6个月较1周时进一步改善(P<0.05);术后6个月根据Harris评分评价患者髋关节功能,获良21髋、中2髋,可满足日常生活需求。术后6个月髋关节活动度为(111.09±10.11)°,与术前(79.13±18.50)°比较差异有统计学意义(t=−7.269,P<0.001)。结论AIHIP系统辅助治疗THA术后翻修患者,可提升翻修手术的精准性,降低手术难度,患者术后恢复效果好,早期疗效满意。

关键词：人工智能术前规划人工全髋关节置换术翻修手术

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Hybridized triboelectric-electromagnetic nanogenerators and solar cell for energy harvesting and wireless power transmission

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Nano Research 2022年第3期15卷 2069-2076页

作者： Yandong Chen Yang Jie jiaqing zhu Qixin Lu Yu Cheng Xia Cao Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Bioengineering and Sensing Technology Beijing Key Laboratory for Bioengineering and Sensing TechnologySchool of Chemistry and Biological EngineeringBeijing Municipal Key Laboratory of New Energy Materials and Technologiesand Center for Green InnovationSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China Center on Nanoenergy Research School of Physical Science and Technology Guangxi UniversityNanning 530004China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA30332-0245USA

Energy harvesting and power transmission is a signiﬁcant challenge for the self-powered technologies towards mobile electronic ***,we propose a hybridized energy harvester to complement each other's strengths for simultaneously scavenging multiple types of energy and then wirelessly transmit the *** harvester consists of electromagnetic-triboelectric nanogenerator units for collecting rotational energy and a commercial water-proof flexible solar *** a rotation rate of 500 rpm,the output current of electromagnetic-triboelectric nanogenerator units can reach about 630 mA through energy ***,the power harvested by hybridized energy harvester can be wirelessly transmitted up to a distance of about 100 cm in real time to charge mobile phone,anemometer,and hygrometer based on self-resonant *** hybridized energy harvester with wireless power transmission has potential applications in large-scale energy collection,long-distance wireless power transmission and sustainably driving mobile electronic devices.

关键词： triboelectric nanogenerator electromagnetic generator solar cell hybridized energy harvester

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Paper triboelectric nanogenerator designed for continuous reuse and quick construction

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Nano Research 2022年第2期15卷 1109-1114页

作者： Zhenhuan Zhang Yang Jie jiaqing zhu Zongye zhu Hong Chen Qixin Lu Yuanming Zeng Xia Cao Ning Wang Zhonglin Wang Research Center for Bioengineering and Sending Technology Beijing Key Laboratory for Bioengineering and Sensing technologySchool of Chemistry and Biological engineeringand Beijing Municipal Key Laboratory of New Energy Materials and TechnologiesUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China College of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA

Along with the unceasing growth of worldwide economic and the associated issues on resources,energy and environment,clean energy generating technologies that are based on recyclable materials,if possible,may become the future trend of ***,we report the design of a cheap,lightweight,and recyclable single-electrode triboelectric nanogenerator(TENG)that utilizes waste paper as the triboelectric *** the current strategy,we successfully developed green energy machines without vastly increasing the mining of various critical minerals around the *** as-designed TENG could not only collect and convert mechanical energy into electricity with sound efficiency,but also has the merit for continuous reuse and quick *** maximum output power density is as high as 171 mW·m^(-2) at a resistance of 130 MQ and could be integrated into a book for monitoring reading actions,thus providing a new approach to the low-cost,green and sustainable self-powered electronic systems.

关键词： single-electrode triboelectric nanogenerator paper clean energy green

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宏基因组二代测序指导抗生素治疗人工全膝关节置换术后感染的疗效研究

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中国修复重建外科杂志 2024年第8期38卷 995-1000页

作者：朱家庆孙家豪马博闻张驰宇曹逊郑善斌陈志远张超沈计荣夏天卫南京中医药大学附属医院骨伤科南京210029

目的探讨宏基因组二代测序(metagenomic next-generation sequencing,mNGS)在人工全膝关节置换术(total knee arthroplasty,TKA)后假体周围感染(periprosthetic joint infection,PJI)诊治中的临床价值。方法2020年4月—2023年3月,收治10例TKA术后PJI患者。男3例,女7例;年龄44~83岁,平均69.9岁。置换术后8~35个月发生感染,平均19.5个月;感染病程16~128 d,平均37 d。术前红细胞沉降率(erythrocyte sedimentation rate,ESR)15~85 mm/1 h,平均50.2 mm/1 h;C反应蛋白(C reactive protein,CRP)4.4~410.0 mg/L,平均192.8 mg/L;白细胞计数(3.4~23.8)×10^(9)/L,平均12.3×10^(9)/L;中性粒细胞绝对值(1.1~22.5)×10^(9)/L,平均9.2×10^(9)/L。入院后抽取关节液行细菌培养及mNGS检测,根据检测结果调整敏感抗生素,并结合手术控制感染。结果细菌培养检测阳性7例(70%),共检出7种病原菌,最常见病原菌为停乳链球菌。mNGS检测阳性10例(100%),共检出11种病原菌,最常见病原菌为痤疮丙酸杆菌。两种方法检测阳性率差异有统计学意义(P=0.211)。7例细菌培养法和mNGS检测均为阳性患者中,3例病原菌类型结果完全一致,符合率42.86%(3/7)。细菌培养检测时间(送样本至出结果)为(4.95±2.14)d,mNGS检测为(1.60±0.52)d,差异有统计学意义(t=4.810,P<0.001)。根据细菌培养及mNGS检测培养结果采取敏感抗生素治疗。一期术后3 d CRP为6.8~48.2 mg/L,平均23.6 mg/L;ESR 17~53 mm/1 h,平均35.5 mm/1 h;白细胞计数(4.5~8.1)×10^(9)/L,平均6.1×10^(9)/L;中性粒细胞绝对值(2.3~5.7)×10^(9)/L,平均4.1×10~9/L。患者均获随访,随访时间12~39个月,平均23.5个月。1例术后6个月感染复发,其余9例均未出现感染征象,感染控制率为90%。结论与细菌培养相比,mNGS能更快速准确地检测TKA术后PJI病原菌,对指导抗生素联合手术治疗PJI具有重要意义。

关键词：宏基因组二代测序细菌培养假体周围感染人工全膝关节置换术诊断

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基于HPLC-Q-TOF-MS/MS和网络药理学探讨温肾宣痹汤治疗膝骨关节炎的作用机制

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中医药导报 2024年第1期30卷 117-124页

作者：孙家豪夏天卫朱家庆李志鹏王海平沈计荣南京中医药大学附属医院江苏南京210029

目的:基于高效液相-四极杆串联飞行时间质谱(HPLC-Q-TOF-MS/MS)分析温肾宣痹汤有效成分,并运用网络药理学探究温肾宣痹汤治疗膝骨关节炎(KOA)的作用靶点及通路,探讨其治疗膝骨关节炎的作用机制。方法:采用HPLC-Q-TOF-MS/MS分析温肾宣痹... 详细信息

目的:基于高效液相-四极杆串联飞行时间质谱(HPLC-Q-TOF-MS/MS)分析温肾宣痹汤有效成分,并运用网络药理学探究温肾宣痹汤治疗膝骨关节炎(KOA)的作用靶点及通路,探讨其治疗膝骨关节炎的作用机制。方法:采用HPLC-Q-TOF-MS/MS分析温肾宣痹汤中化学成分。检索TCMSP V2.0获得温肾宣痹汤的活性成分;运用TCMSP数据库筛选活性成分靶点,利用Uniprot数据库对靶点进行标准化命名;通过“GeneCards”等数据库,查询膝骨关节炎相关靶点;利用VennDiagram得到“中药化合物疾病”共同靶点。应用STRING数据库和Cytoscape软件构建蛋白-蛋白相互作用网络图。筛选核心作用靶点,进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析。结果:在温肾宣痹汤的正、负离子模式下采用液质联用综合分析,共鉴定出24种化合物,分别归属于狗脊、附子、天麻、山萸肉、细辛、白术、木香、甘草。筛选出温肾宣痹汤181个活性成分和134个相应蛋白靶点,与膝骨关节炎的2171个疾病相关靶点相交集的核心靶点为72个。GO富集分析共筛选得到76条生物过程(BP)富集结果、12条细胞组成(CC)富集结果及29条分子功能(MF)富集结果。KEGG富集分析共筛选得到相关通路共27条。结论:温肾宣痹汤可以通过抗炎、免疫调节、抗血管生成、抗氧化等作用,发挥治疗膝骨关节炎的功效。

关键词：膝骨关节炎温肾宣痹汤 HPLC-Q-TOF-MS/MS 网络药理学作用机制

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The Metabolic Profiling of Chinese Yam Fermented by Saccharomyces boulardii and the Biological Activities of its Ethanol Extract in Vitro

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Food Science and Human Wellness 2023年

作者： Xue Li Yiwen Shao Limin Hao Qiaozhen Kang Xiaolong Wang jiaqing zhu Changcheng Zhao Yanling Shi Jike Lu Juanjuan Yi Food Laboratory of Zhongyuan Zhengzhou University 3. Systems Engineering Institute Academy of Military Sciences (AMS) 4. Henan Yinfeng Biological Engineering Technology Co. Ltd. School of Life Sciences Zhengzhou University

Chinese yam (Dioscorea opposita Thunb.)， as one of the medicinal and edible homologous plants， is rich in various nutrients and functional factors. In this study， Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic profile. And then， the main bioactive components and biological activities of fermented Chinese yam ethanol extract (FCYE) were evaluated. Results showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese yam. Besides， corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcohol-soluble small molecular substances. Ulteriorly， the total polyphenol content and the total flavonoid content in FCYE were significantly increased， and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly enhanced. Our study provided a new reference for the comprehensive utilization of Chinese yam and it also laid a theoretical foundation for the development and application of natural probiotic-fermented products.

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Co-vacancy-rich CO1-xS nanosheets anchored on rGO for high-efficiency oxygen evolution

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Nano Research 2017年第5期10卷 1819-1831页

作者： jiaqing zhu Zhiyu Ren Shichao Du Ying Xie Jun Wu Huiyuan Meng Yuzhu Xue Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China School of Chemistry College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China

Developing cost-efficient electrocatalysts for oxygen evolution is vital for the viability of H2 energy generated via electrolytic water. Engineering favorable defects on the electrocatalysts to provide accessible active sites can boost the sluggish reaction thermodynamics or kinetics. Herein, Col_xS nanosheets were designed and grown on reduced graphene oxide （rGO） by controlling the successive two-step hydrothermal reaction. A belt-like cobalt-based precursor was first formed with the assistance of ammonia and rGO, which were then sulfurized into Col_xS by L-cysteine at a higher hydrothermal temperature. Because of the non-stoichiometric defects and ultrathin sheet-like structure, additional cobalt vacancies （V^o） were formed/exposed on the catalyst surface, which expedited the charge diffusion and increased the electroactive surface in contact with the electrolyte. The resulting Col_xS/rGO hybrids exhibited an overpotential as low as 310 mV at 10 ***-2 in an alkaline electrolyte for the oxygen evolution reaction （OER）. Density functional theory calculations indicated that the Vco on the Col_xS/rGO hybrid functioned as catalytic sites for enhanced OER. They also reduced the energy barrier for the transformation of intermediate oxygenated species, promoting the OER thermodynamics.

关键词： cobalt vacancies (Vco) Co1-xS oxygen evolution reaction electrocatalysis nanosheets

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A highly active oxygen evolution electrocatalyst： Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly

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Nano Research 2016年第3期9卷 713-725页

作者： Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi jiaqing zhu Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China School of Chemistryand Materials Science Heilongjiang University Harbin 150080 China

A cost-efficient and stable oxygen evolution electrocatalyst is essential for improving energy storage and conversion efficiencies. Herein, 2D nanosheets with randomly cross-linked CoNi layered double hydroxide （LDH） and small CoO nanocrystals were designed and synthesized via in situ reduction and interface- directed assembly in air. The formation of CoNi LDH/CoO nanosheets was attributed to the strong extrusion of hydrated metal-oxide clusters driven by the interfacial tension. The obtained loose and porous nanosheets exhibited low crystallinity due to the presence of numerous defects. Owing to the orbital hybridization between metal 3d and O 2p orbitals, and electron transfer between metal atoms through Ni-O-Co, a number of Co and Ni atoms in the CoNi LDH present a high ＋3 valency. These unique characteristics result in a high density of oxygen evolution reaction （OER） active sites, improving the affinity between OH- and catalyst, and resulting in a large accessible surface area and permeable channels for ion adsorption and transport. Therefore, the resulting nanosheets exhibited high catalytic activity towards the OER. The CoNi LDH/CoO featured a low onset potential of 1.48 V in alkaline medium, and required an overpotential of only 300 mV at a current density of 10 ***-2, while displaying good stability in accelerated durability tests.

关键词： CoNi double hydroxide interface-directedassembly oxygen evolution reaction electrocatalysis nanosheet

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