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Distribution of oval cells and c-myc mRNA expression in mouse hepatocarcinogenesis

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 433-439页

作者： Chi-Hua Fang, Gang-qing Zhang, Xin-Yong zhu and jia-qing Gong Department of Hepatobiliary Surgery, zhujiang Hos-pital of the First Military Medical University, Guangzhou 510282, China Department of Hepatobiliary Surgery Zhujiang Hospital of the First Military Medical University Guangzhou 510282 China. fch58520@***

BACKGROUND: This study was designed to assess theroles of oval cells and c-myc mRNA in the process of hepa-tocarcinogenesis and to clarify the function of carcinogenec-myc in the development of hepatocellular carcinoma( HCC) and the mechanism of inhibitory function of uscha-ridin on HCC in mouse ***: A total of 120 clean SD mice were divided intonormal group, cancer induction group, and interventiongroup. The normal group was fed with standard foragewhile the rest two groups were given p-dimethylaminoazo-benzene (DAB) to induce cancer. Thirteen weeks after in-duction of cancer, the two groups were fed with standardforage and water. Once the pattern was set up, the inter-vention group was given uscharidin injection into the ab-dominal cavity from the first week to the 14th week. Onthe 2nd, 4th, 6th, 8th, 10th, 12th, 14th, 16th, 18th, 20th,22nd, and 24th week, all mice were killed and biopsiedfrom the liver lobe for pathological analysis. At the sametime, the number of tumor nodes was counted and the ex-pression of c-myc mRNA was tested by ***: Since the 2nd week after cancer induction, pro-liferated oval cells could be seen in the portal area. Initially,the oval cells appeared in the cortical layer of the portalarea, then proliferated gradually and immigrated into theliver parenchyma. In the period of fibrosis after liver proli-feration, proliferated heaps of oval cells were noted in bothportal and peripheral areas. In the period of carcinomatouschange, oval cells could be seen both outside and inside ofcancer nodes, but most of them were distributed *** c-myc gene was expressed negatively in the liver tissueof mice. The quantity of the expression began to increaseat the time of infection of the liver and tended to increasewith the degree of hepatic injury. In the period of cancera-tion, the expression level of c-myc mRNA increased gra-dually. The intervention of uscharidin could not inhibit butdelay the increase of the exp

关键词： oval cell hepatocellular carcinoma c-myc mRNA uscharidin

Water-requirement Characteristics and Water-saving Irrigation Indices of Dry-raised Rice Seedlings in Paddy Field

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Agricultural Sciences in China 2001年第1期 107-115页

作者： YANG jian-chang WANG Wei WANG Zhi-qin LIU Li-jun DING Zhi-jia zhu qing-sen Agricultural College Yangzhou University Yangzhou 225009 Agricultural College Yangzhou University Yangzhou 225009 Agricultural College Yangzhou University Yangzhou 225009 Agricultural College Yangzhou University Yangzhou 225009 Seed Station of Yiling Township Jiangdu County Agricultural College Yangzhou University Yangzhou 225009

The dry-raised seedlings (D-RS)of rice had obvious superiority in tillering and growth after transplanting. Especially under the condition of water-saving irrigation or low soil moisture, D-RS had more productive tillers, higher dry matter accumulation, larger grain-filling rate, slower senescence of leaves and stronger root activity during ripening, and higher grain yield, compared with the moist-raised seedlings (MRS). D-RS had smaller yield reduction than M-RS when subject to heavy water stress. The results suggested that D-RS had the ability to adapt to lower soil moisture in paddy field. Basedon the response of D-RS to soil moisture at each growth stage, the water-saving and high-yielding irrigation indices through controlling lowlimit soil water potential were proposed, i.e. soil water potential was - 15 - - 20 kPa from the recovery to the criticalleaf-age of productive tillering, - 20 - - 40 kPa from the critical leaf-age of productive tillering to secondary branch-differentiating stage, - 15 - - 25 kPa from secondary branch-differentiating stage to 20 days after heading and - 25 - - 35 kPa from 21 to 45 days after heading.

关键词： Rice Dry-raised seedlings Soil water potential Irrigation indices

基于财政视角的公共福利分配地区间公平性研究

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中国软科学 2009年第3期 46-52,99页

作者：苏素朱家庆重庆大学经济与工商管理学院重庆400030

社会分配差距测定是评价和建设和谐社会的重要指示数,公共福利分配是社会分配的重要方面,但当前对公共福利分配差距研究却相当不足。公共福利分配主要通过公共财政实现,本文在对公共福利及公共福利分配界定基础上,探讨了基于财政视角公... 详细信息

社会分配差距测定是评价和建设和谐社会的重要指示数,公共福利分配是社会分配的重要方面,但当前对公共福利分配差距研究却相当不足。公共福利分配主要通过公共财政实现,本文在对公共福利及公共福利分配界定基础上,探讨了基于财政视角公共福利分配的构成。将测定个人收入分配差距的基尼系数方法引用到公共福利分配差距测定中,采用我国近十年的财政支出数据,测定了我国总体范围内的地区公共福利分配差距,以及公共福利各分项指标对地区公共福利分配差距的贡献;测定了东、中、西部组间和组内的公共福利分配差距。分析了我国公共福利分配差距的形成原因并提出了缩小差距的政策建议。

关键词：公共福利分配差距基尼系数财政支出

Proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood under the culture conditions of hypoxia and serum deprivation

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Chinese Medical Journal 2011年第23期124卷 3959-3967页

作者： FU Wei-li jia zhu-qing WANG Wei-ping ZHANG Ji-ying FU Xin DUAN Xiao-ning LEUNG Kevin Kar Ming ZHOU Chun-yan YU jia-kuo Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background The proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood （PB-MSCs） were investigated under hypoxia and serum deprivation conditions in vitro so as to evaluate the feasibility for autologous PB-MSCs applications in cartilage repair. Methods MSCs were mobilized into peripheral blood by granulocyte colony stimulating factor （G-CSF） and AMD3100. The blood samples were collected from central ear artery of rabbits. Adhered cells were obtained by erythrocyte lysis buffer and identified as MSCs by adherence to plastic, spindle shaped morphology, specific surface markers, differentiation abilities into osteoblasts, adipocytes and chondroblasts in vitro under appropriate conditions. MSCs were cultured in four groups at different oxygen tension （20% 02 and 2% O2）, with or without 10% fetal bovine serum （FBS） conditions： 20% 02 and 10% FBS complete medium （normal medium, N）, 20% 02 and serum deprivation medium （D）, 2% 02 and 10% FBS complete medium （hypoxia, H）, 2% 02 and serum deprivation （HD）. Cell proliferation was determined by CCK-8 assay. Apoptosis was detected by Annexin V/PI and terminal deoxynucleotide transferase dUTP nick end labeling （TUNEL） staining. Results Spindle-shaped adherent cells were effectively mobilized from peripheral blood by a combined administration of G-CSF plus AMD3100. These cells showed typical fibroblast-like phenotype similar to MSCs from bone marrow （BM-MSCs）, and expressed a high level of typical MSCs markers CD29 and CD44, but lacked in the expression of hematopoietic markers CD45 and major histocompatibility complex Class II （MHC II）. They could also differentiate into osteoblasts, adipocytes and chondroblasts in vitro under appropriate conditions. No significant morphological differences were found among the four groups. It was found that hypoxia could enhance proliferation of PB-MSCs regardless of serum concentration, but serum deprivation inhibited proliferation at the later stage of cul

关键词： mesenchymal stem cells derived from peripheral blood hypoxia serum deprivation proliferation apoptosis

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《傅青主女科》调经方剂组方用药挖掘分析

中国中药杂志 2015年第8期40卷 1610-1613页

作者：朱佳卿车玉霞中国中医科学院信息管理中心北京100700 中国中医科学院中医药信息研究所北京100700

该文筛选《傅青主女科》中的调经门类方剂,通过SPSS,Clementine及中医传承辅助系统,结合运用GRI算法、相关分析法、层次聚类方法对筛选方剂进行用药挖掘分析,共筛选15首治疗月经病方剂,涉及中药45味。分析发现方中补血药、补气药出现频... 详细信息

该文筛选《傅青主女科》中的调经门类方剂,通过SPSS,Clementine及中医传承辅助系统,结合运用GRI算法、相关分析法、层次聚类方法对筛选方剂进行用药挖掘分析,共筛选15首治疗月经病方剂,涉及中药45味。分析发现方中补血药、补气药出现频次较高;频次最高的单味药为白芍,占总处方数的9.6%;频率最高的药对为白芍-熟地,白芍-当归。关联分析结果显示,傅山在治疗月经病的方剂中关联系数达到0.05以上的药物组合有61对,从中演化得到核心组合16对。通过分析得知《傅青主女科》上卷治疗月经病方剂组方以补益中药为主,涉及肝脾肾3脏,根据气、血、寒、热、湿之变化而辨证用药,可为深入研究傅山学术思想和中医药临床治疗月经病提供一定参考。

关键词：《傅青主女科》调经配伍规律用药分析

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汇率跳跃风险对跨国并购的影响研究

中山大学学报（社会科学版） 2019年第3期59卷 175-185页

作者：朱佳青李广众广东外语外贸大学金融学院广州华南财富管理中心研究基地中山大学管理学院

本文旨在从宏观层面考察汇率跳跃风险对企业跨国并购的影响。首先利用自回归跳跃模型估计香港对全球38个国家1990—2009年间双边汇率的跳跃风险。在解决了跨国并购与汇率波动的逆向因果关系以及引力模型OLS估计中存在的异方差和样本选... 详细信息

本文旨在从宏观层面考察汇率跳跃风险对企业跨国并购的影响。首先利用自回归跳跃模型估计香港对全球38个国家1990—2009年间双边汇率的跳跃风险。在解决了跨国并购与汇率波动的逆向因果关系以及引力模型OLS估计中存在的异方差和样本选择偏差问题后,实证结果表明,双边汇率跳跃风险的增加显著抑制了并购国企业对目标国企业的跨国并购。进一步的机制分析发现,汇率跳跃对跨国并购的抑制作用是通过信贷约束的渠道实现的。

关键词：汇率跳跃跨国并购信贷约束

陶对陶全髋置换后炎性假瘤并脱位:1例报告和综述

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中国矫形外科杂志 2024年第1期32卷 50-55页

作者：孙家豪朱家庆夏天卫沈计荣南京中医药大学附属医院骨伤科江苏南京210004

本文报道了1例陶对陶(ceramic on ceramic,CoC)全髋置换术(total hip arthroplasty,THA)后炎性假瘤(inflammatory pseudotumor,IP)并发髋关节后脱位的患者,该患者CoC THA术后8年,因深蹲致左髋关节假体脱位,闭合复位7次失败后采用切开复... 详细信息

本文报道了1例陶对陶(ceramic on ceramic,CoC)全髋置换术(total hip arthroplasty,THA)后炎性假瘤(inflammatory pseudotumor,IP)并发髋关节后脱位的患者,该患者CoC THA术后8年,因深蹲致左髋关节假体脱位,闭合复位7次失败后采用切开复位术治疗,切开后见陶瓷球头存在线性磨损,将髋臼杯及四周数十枚IP取出后将股骨假体成功复位。通过对该病例的分析,作者认为尽管CoC假体磨损率低且所产生的陶瓷颗粒生物活性极差,较少引起细胞反应及炎症的发生,但其并不完全是惰性的,可能会导致不良局部组织反应(adverse local tissue reaction,ALTR)及IP的发生。此外,本文通过文献回顾,着重介绍CoC THA术后IP出现的原因、早期诊断及治疗方法,旨在为临床提供参考。

关键词：陶对陶假体全髋关节置换术后炎性假瘤个案报道

2011年-2015年国内中医药治疗原发性痛经研究现状的文献计量学分析

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中华中医药杂志 2017年第6期32卷 2776-2778页

作者：张艺然朱佳卿中国中医科学院中医药信息研究所北京100700 国家中医药管理局北京100027

目的:采用文献计量学方法对近五年国内中医药治疗原发性痛经文献特征分析,了解该领域文献发研究现状以及发展水平,为临床和科研提供参考。方法:选用CNKI 2011年至2015年所收录的中医药治疗原发性痛经相关文章,从文献发表地域和期刊分布... 详细信息

目的:采用文献计量学方法对近五年国内中医药治疗原发性痛经文献特征分析,了解该领域文献发研究现状以及发展水平,为临床和科研提供参考。方法:选用CNKI 2011年至2015年所收录的中医药治疗原发性痛经相关文章,从文献发表地域和期刊分布等5个维度进行分析。结果:上海针灸杂志、内蒙古中医药等杂志上发表文献较多;华东地区在发表文献总量和核心期刊上发表数量较多;发表文献的性质主要是临床实验和综述;第一作者单位主要为医院和高校。医院作者发表论文多以临床实验类型为主,高校作者发表论文多以综述类为主;从论文质量分析,研究院所和高校质量较好。结论:不同地区、单位论文数量及质量存在一定差距;且发表论文类型各有侧重;总体上看论文质量有待提高。

关键词：中医药治疗原发性痛经文献计量学

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang qing Shi Guofan Zhang Yuxuan zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation