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Shexiang Tongxin Dropping Pill(麝香通心滴丸)Reduces Coronary Microembolization in Rats via Regulation of Mitochondrial Permeability Transition Pore Opening and AKT-GSK3βPhosphorylation

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Chinese Journal of Integrative Medicine 2021年第7期27卷 527-533页

作者： DING Yu zhu hou-yong ZHANG Li-zong GAO Bei-bei Zhou Liang HUANG Jin-yu Central Laboratory Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Department of Cardiology Hangzhou Chinese Medical HospitalHangzhou310007China Experimental Animal Research Center Zhejiang Chinese Medical UniversityHangzhou310053China Department of Cardiology Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China

Objective To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STDP)following sodium laurate-induced coronary microembolization(CME)in *** Forty rats were divided into 4 groups:the control(sham)group,CME group,low-dose STDP pretreatment group(20 mg·kg^(−1)·d^(−1)),and high-dose STDP pretreatment group(40 mg·kg^(−1)·d^(−1)).The rats were intragastric administrated with STDP 2 weeks before ***,the histopathological alterations were observed using optical microscopy and transmission electron *** biomarkers were analyzed by enzyme-linked immunosorbent *** functions including the mitochondrial permeability transition pore(mPTP)mtDNA copy number were determined and proteins of AKT/GSK3βwere analyzed by Western *** The rats in the CME group showed a significant increase in the fibrinogen-like protein 2 expression level and mitochondrial dysfunction and a decrease in the expression level of antioxidant biomarkers(superoxide dismutase and catalase,P<0.01 for all).In contrast,the rats in the low-and high-dose STDP pretreatment groups showed a significant decrease in coronary microthrombi(P<0.05);moreover,STDP restored the antioxidant-related protein activities and mitochondrial function,inhibited mPTP opening,decreased AKT-Ser473 phosphorylation,and increased GSK3β-Ser9 phosphorylation(P<0.05 or P<0.01).Conclusion STDP may be useful for treatment of CME,possibly via regulation of mPTP opening and AKT/GSK3βphosphorylation.

关键词： Shexiang Tongxin Dropping Pill Chinese medicine coronary microembolization mitochondrial permeability transition pore AKT GSK3β

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Defect Engineering with Rational Dopants Modulation for High-Temperature Energy Harvesting in Lead-Free Piezoceramics

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Xi, Kaibiao Guo, Jianzhe Zheng, Mupeng zhu, Mankang hou, Yudong Beijing Univ Technol Coll Mat Sci & Engn Key Lab Adv Funct Mat Minist Educ Beijing 100124 Peoples R China

High temperature piezoelectric energy harvester (HT-PEH) is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors. However, simultaneously excellent performances, including high figure of merit (FOM), insulation resistivity (rho) and depolarization temperature (T-d) are indispensable but hard to achieve in lead-free piezoceramics, especially operating at 250 degrees C has not been reported before. Herein, well-balanced performances are achieved in BiFeO3-BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese doping. Due to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization, regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole, comprehensive excellent electrical performances (T-d = 340 degrees C, rho(250) (degrees C) > 10(7) Omega cm and FOM2(50 degrees C) = 4905 x 10(-15 )m(2) N-1) are realized at the solid solubility limit of manganese ions. The HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250 degrees C with high energy conversion efficiency (eta = 11.43%). These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements, paving a new way in developing self-powered wireless sensors working in HT environments.

关键词： Lead-free piezoceramic Defect engineering Dopants modulation High-temperature Piezoelectric energy harvester

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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耻骨上经膀胱前列腺切除术治疗前列腺增生症216例临床资料分析

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中国全科医学 2016年第30期19卷 3719-3721页

作者：侯铸姜永光赵佳晖罗勇首都医科大学附属北京安贞医院泌尿外科北京市100029

目的分析近20年来耻骨上经膀胱前列腺切除术在治疗前列腺增生症(BPH)患者的临床应用效果变化。方法回顾性分析1992年1月—2012年1月首都医科大学附属北京安贞医院收治的216例行耻骨上经膀胱前列腺切除术的BPH患者的临床资料,根据治疗时... 详细信息

目的分析近20年来耻骨上经膀胱前列腺切除术在治疗前列腺增生症(BPH)患者的临床应用效果变化。方法回顾性分析1992年1月—2012年1月首都医科大学附属北京安贞医院收治的216例行耻骨上经膀胱前列腺切除术的BPH患者的临床资料,根据治疗时间分为前10年组(n=100)和后10年组(n=116),对比分析两组患者的平均住院时间、住院费用、手术时间、术中出血量和术中及术后并发症等指标的差异。结果与前10年组比较,后10年组患者住院时间和手术时间缩短,住院费用增加,术中出血量减少,术中及术后并发症减少,差异均有统计学意义(P<0.05)。结论随着医疗水平的不断提高,耻骨上经膀胱前列腺切除术并发症越来越少,手术及住院时间缩短,手术质量不断上升,患者更加受益。

关键词：前列腺增生前列腺切除术手术后并发症

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非线性切换系统基于观测器的容错控制器设计

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控制与决策 2017年第10期32卷 1855-1863页

作者：朱芳来侯永建赵旭东杨俊起同济大学电子与信息工程学院上海201804 大连理工大学信息与控制研究中心辽宁大连116024 渤海大学工学院辽宁锦州121013 河南理工大学电气工程与自动化学院河南焦作454000

针对一类具有执行器故障的非线性切换系统,研究基于系统状态估计和故障重构的容错控制问题.首先,在具有平均驻留时间(ADT)的切换信号下,设计一种切换PI观测器作为状态-故障估计器,以达到对系统状态和故障同时渐近估计的目的;其次,基于... 详细信息

针对一类具有执行器故障的非线性切换系统,研究基于系统状态估计和故障重构的容错控制问题.首先,在具有平均驻留时间(ADT)的切换信号下,设计一种切换PI观测器作为状态-故障估计器,以达到对系统状态和故障同时渐近估计的目的;其次,基于线性矩阵不等式,给出非线性切换系统观测器存在的充分条件;再次,基于PI观测器给出的状态和故障估计,提出一种非线性切换系统的容错控制器设计方法;最后,以一个电子电路为仿真实例进行分析,验证了所提出方法的可行性和适用性.

关键词：切换系统 PI切换观测器故障重构容错控制

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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线粒体tRNA^(Thr) T15941C突变位点与原发性高血压的相关性

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中华高血压杂志 2017年第2期25卷 163-168页

作者：丁禹高贝贝朱侯勇童国新周亮叶显华黄进宇杭州市第一人民医院中心实验室浙江杭州310006 南京医科大学附属杭州医院中心实验室杭州市第一人民医院心内科浙江中医药大学研究生院

目的探讨线粒体DNA突变和原发性高血压的相关性。方法本文报道一个具有母系遗传特征的中国汉族原发性高血压家系的临床和分子遗传学特征。使用聚合酶链反应(PCR)扩增母系成员和正常对照的线粒体基因,经过数据比对筛选突变并进行相关分... 详细信息

目的探讨线粒体DNA突变和原发性高血压的相关性。方法本文报道一个具有母系遗传特征的中国汉族原发性高血压家系的临床和分子遗传学特征。使用聚合酶链反应(PCR)扩增母系成员和正常对照的线粒体基因,经过数据比对筛选突变并进行相关分析。结果该家系的高血压发病率较高,此外,母系成员的线粒体基因全序列分析结果显示,存在同质性的tRNA^(Thr) T15941C的突变以及ND1C3497T突变,T15941C突变位于tRNA^(Thr)基因T_ψC环上高度保守的61号碱基,突变破坏了原有的57A-61T的碱基配对,生物信息学软件分析也发现T15941C突变改变了tRNA^(Thr)的二级结构,可能会引起线粒体tRNA代谢障碍。结论线粒体tRNA^(Thr) T15941C和ND1C3497T突变可能是这个原发性高血压家系发病的重要分子基础。该家系表现出的线粒体DNA同质性突变,发病年龄等表型差异,提示核基因、环境因素和线粒体遗传背景等可能对tRNA^(Thr) T15941C突变的表型表达有一定的影响。

关键词：原发性高血压线粒体突变 tRNA代谢中国家系

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低负荷血流限制和高强度抗阻运动对男性运动青年大腿微循环功能的影响

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中国组织工程研究 2025年第2期29卷 393-401页

作者：彭永胡江平朱欢湖北民族大学体育学院湖北省恩施市445000 广西民族师范学院体育学院广西壮族自治区崇左市532200

背景:微循环作为人体物质能量代谢交换的唯一场所,与人体运动能力密切相关。抗阻运动是提高微循环功能的有效方式,但也有研究指出血流限制训练也能提高微循环功能,且具有负荷小和安全性高等优点。目的:比较6周低负荷血流限制运动、高强... 详细信息

背景:微循环作为人体物质能量代谢交换的唯一场所,与人体运动能力密切相关。抗阻运动是提高微循环功能的有效方式,但也有研究指出血流限制训练也能提高微循环功能,且具有负荷小和安全性高等优点。目的:比较6周低负荷血流限制运动、高强度抗阻运动对运动型男性青年大腿微循环功能的影响,并从血管内皮功能角度探讨运动改善微循环功能的可能机制。方法:将湖北民族大学60名体育专业男性大学生按照随机数表法分为对照组、高强度抗阻运动组和低负荷血流限制运动组,每组20人。低负荷血流限制运动组进行6周(每周3次、每次90 min、运动强度为30%1RM)的低负荷血流限制运动;高强度抗阻运动组进行6周(每周3次、每次90 min、运动强度为70%1RM强度)的抗阻训练;对照组该时间段不进行任何形式的运动训练。分别在干预开始的前1 d以及6周干预结束后次日的晨起空腹状态下对3组受试者微血管血流灌注量、经皮氧分压、肌氧饱和度、一氧化氮、内皮型一氧化氮合酶、内皮素1、血管内皮细胞生长因子及大腿围、肌力等指标进行测试。结果与结论:①运动干预后,低负荷血流限制运动组和高强度抗阻运动组的微血管血流灌注量加热值、血细胞移动速度加热值与对照组及运动干预前相比有显著差异(P<0.05);低负荷血流限制运动组微血管血流灌注量加热值、血细胞移动速度加热值与高强度抗阻运动组相比有显著差异(P<0.05);经皮氧分压和肌氧饱和度与干预前相比有显著性差异(P<0.05)。②运动干预后,低负荷血流限制运动组和高强度抗阻运动组一氧化氮、内皮型一氧化氮合酶、内皮素1、血管内皮细胞生长因子与对照组及运动干预前相比有显著差异(P<0.05)。③运动干预后,低负荷血流限制运动组和高强度抗阻运动组大腿围和大腿肌肉力量与运动干预前相比有显著差异(P<0.05)。④上述结果证实,6周低负荷血流限制运动和高强度抗阻运动可能通过调节内皮型一氧化氮合酶、内皮素1、血管内皮细胞生长因子等血管因子的分泌,提高体育专业大学生大腿微循环功能,并增加大腿肌肉的收缩力量,且低负荷血流限制运动对微血管血流灌注量、血细胞移动速度的干预效果更佳,因此低负荷血流限制运动较高强度抗阻运动在提高微循环功能方面更具优势。

关键词：低负荷血流限制高强度抗阻微循环功能肌肉力量微血管血流灌注量经皮氧分压肌氧饱和度一氧化氮内皮素1 血管内皮生长因子

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong yong Chen Chang-Jiang Yao Yuan-Yuan zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Linear Dynamic Viscoelastic Response of Melts for Crosslinkable Polyethylene Insulation Cable Granules During Cross-linking

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Chemical Research in Chinese Universities 2010年第1期26卷 142-147页

作者： YANG Hong-mei YANG yong-zhu HE Xiao ZHENG Qiang Zhou hou-qiang Department of Polymer Science and Engineering Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Zhejiang University Hangzhou 310027 P. R. China Ningbo Dongfang Cable Ltd. Ningbo 315040 R R. China

Two commercial crosslinkable polyethylene insulation cable granules, designed for 110 and 35 kV voltage insulation, with similar crosslinking temperature but different melting temperature, were chosen as experimental samples for examining their linear dynamic responses during cross-linking. It has been found that the gel contents of cable compounds for 110 and 35 kV insulation are almost the same after they have been cross-linked at the same temperature, pressure and time. And the sample melts show the similar dependence of the dynamic storage modulus, G; on strain. On the other hand, the dynamic temperature ramp test and the dynamic time sweep test indicate that the samples exhibit different dynamic viscoelastic responses during their crosslinking. An expression for describing their erosslinking process was proposed via probing rheokinetics of crosslinking for the two samples.

关键词： XLPE Insulation cable Crosslinking Rheological behavior

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