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Anisotropic microtopography surface of chitosan scaffold regulating skin precursor-derived Schwann cells towards repair phenotype promotes neural regeneration

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Regenerative Biomaterials 2024年第3期3卷 68-81页

作者： Meng Cong Xia Wu Lingjie zhu Guohao Gu Fei ding Guicai Li {2. Shi Key Laboratory of Neuroregenration of jiangsu and Ministry of Education and Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China department of Pathophysiology School of MedicineNantong UniversityNantong 226001China

For repairing peripheral nerve and spinal cord defects,biomaterial scaffoid-based cell-therapy was emerged as an effective strategy,requiring the positive response of seed cells to biomaterial substrate and environment *** work highlighted that the imposed surface properties of scaffold could provide important guidance cues to adhered cells for ***,the insufficiency of native Schwann cells and unclear cellular response mechanisms remained to be *** that,this study aimed to illuminate the micropatterned chitosan-film action on the rat skin precursor-derived Schwann cells(SKP-SCs).Chitosanfilm with different ridge/groove size was fabricated and applied for the SKP-SCs *** indicated that SKP-SCs cultured on 30μm size microgroove surface showed better oriented alignment *** SKP-sCs presented similar genic phenotype as repair Schwann cells,increasing expression of c-Jun,neural cell adhesion molecule,and neurotrophic receptor ***,SKP-SC-secretome was subjected to cytokine array GS67 assay,data indicated the regulation of paracrine phenotype,a panel of cytokines was verifed up-regulated at secreted level and gene expression level in induced *** up-regulated cytokines exhibit a series of promotive neural regeneration functions,including cell survival,cell migration,cell proliferation,angiogenesis,axon growth,and cellular organization *** bioinformatics ***,the effectively polarized SKP-SCs-sourced secretome,promoted the proliferation and migration capacity of the primarily cultured native rat Schwann cells,and augmented neurites growth of the cultured motoneurons,as well as boosted axonal regrowth of the axotomy-injured *** together,SKP-SCs obtained pro-neuroregeneration phenotype in adaptive response to the anisotropic topography surface of chitosan-film,displayed the oriented parallel growth,the transition towards repair Schwann cell genic phenot

关键词： anisotropic microtopography skin precursor-derived Schwann cells chitosan-flm neural regeneration phenotype regulation

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苍山18种地衣体外抗菌活性及联合药敏研究

食品工业科技 2024年第19期45卷 149-157页

作者：田红巧朱家娜刘梦龙丁海燕大理大学公共卫生学院云南大理671000 西南林业大学西南地区林业生物质资源高效利用国家林业和草原局重点实验室云南昆明650000

本研究旨在探究18种苍山地衣体外抗菌活性及其天然活性产物与抗生素联用对耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus,MRSA)的协同效应。采用打孔法测定18种地衣对6种食源性致病菌的体外抗菌活性,并以MRSA... 详细信息

本研究旨在探究18种苍山地衣体外抗菌活性及其天然活性产物与抗生素联用对耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus,MRSA)的协同效应。采用打孔法测定18种地衣对6种食源性致病菌的体外抗菌活性,并以MRSA为示踪,采用棋盘法测定活性地衣与7种常用抗生素的联合作用,并进行体外杀菌曲线、防突变浓度及抗生素后效应的测定。结果显示18种地衣中有10种地衣具备体外抗MRSA活性,以白边岛衣的抗菌活性最强,达到了极度敏感(抑菌圈直径为2..0 mm)。其中,光肺衣、寸石蕊与哌拉西林具有协同抗菌作用,二者与哌拉西林联用可以显著降低MRSA的菌体浓度(P<0.05),增强细菌防突变的能力,延长了哌拉西林的后效应。本试验结果表明多种苍山地衣提取物对MRSA具有较好的抗菌活性,且寸石蕊、光肺衣与哌拉西林具有协同抗MRSA的作用,具有进一步开发为抗生素及抗生素佐剂的潜力。

关键词：云南地衣抗菌活性联合药敏协同作用

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(n+2.-Angulated Quotient Categories

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Algebra Colloquium 2019年第4期26卷 689-720页

作者： Qilian Zheng Jiaqun Wei nanqing ding Institute of mathematics School of Mathematical Sciences Nanjing Normal UniversityNanjing 210023China 不详

The notion of D-mutation pairs of subcategories in an n-exangulated category is defined in this ***(Z,Z)is a P-mutation pair in an n-exangulated category(C,E,s),the quotient category Z/Dcarries naturally an(n+2.-angul... 详细信息

关键词： Q・mutation pair exangulated category (n+2.-angulated category quotient category

Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao Yidan zhu Zheng Zhang Guizhou Tao haiyan Xu Guanchang Cheng Wen Gao Liping Ma Liping Qi Xiaoyan Yan Haibo Wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian {2. Qiang Guo Wanjun Dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu Shubin Qiao department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking university Clinical Research Institute Peking University First HospitalBeijing 100191China department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China department of Cardiology Puyang People’s HospitalPuyangHenan 457099China department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)*** study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-PA)in Chinese patients with ***:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42.mg in 90 *** primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2.or *** secondary endpoint was clinically justified *** endpoints included 30-day major adverse cardiovascular and cerebrovascular events(MACCEs)and safety ***:From July 2.16 to September 2.19,767 eligible patients were randomly assigned to receive rhTNK-tPA(n=384)or rt-PA(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified *** used a–15%difference as the non-inferiority efficacy *** comparison to rt-PA,both the proportion of patients with TIMI grade 2.or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tPA group were *** occurrence of 30-day MACCEs(10.2.[39/384]vs.11.0%[42.383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between *** safety outcomes significantly differed between ***:rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute ***

关键词： Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction

Identification of potential electrotrophic microbial community in paddy soils by enrichment of microbial electrolysis cell biocathodes

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Journal of Environmental Sciences 2020年第1期32卷 411-420页

作者： Xiaomin Li Longjun ding haiyan Yuan Xiaoming Li Yongguan {2. State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesShuangqing RoadNo.18Haidian DistrictBeijing 100085China university of Chinese Academy of Sciences Beijing 100049China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesJimei RoadNo.1799Jimei DistrictXiamen 361021China

Electrotrophs are microbes that can receive electrons directly from cathode in a microbial electrolysis cell(MEC).They not only participate in organic biosynthesis,but also be crucial in cathode-based ***,little is known about the electrotrophic community in paddy ***,the putative electrotrophs were enriched by cathodes of MECs constructed from five paddy soils with various properties using bicarbonate as an electron acceptor,and identified by 16S rRNA-gene based Illumina *** electrons were gradually consumed on the cathodes,and 2.%–45% of which were recovered to reduce bicarbonate to acetic acid during MEC *** was the dominant bacterial phylum on the cathodes,and Bacillus genus within this phylum was greatly enriched and was the most abundant population among the detected putative electrotrophs for almost all ***,several other members of Firmicutes and Proteobacteria may also participate in electrotrophic process in different *** pH,amorphous iron and electrical conductivity significantly influenced the putative electrotrophic bacterial community,which explained about 33.5% of the community structural *** study provides a basis for understanding the microbial diversity of putative electrotrophs in paddy soils,and highlights the importance of soil properties in shaping the community of putative electrotrophs.

关键词： Electrotroph Paddy soil Microbial electrolysis cell Microbial community Soil property

考虑薄煤层影响的致密砂岩气藏地质工程双甜点评价方法——以鄂尔多斯盆地神府区块为例

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天然气工业 2024年第10期44卷 170-181页

作者：张兵周展米洪刚朱海燕张兆鹏魏超徐伟龚丁王泽宇贺甲元中联煤层气有限责任公司北京市033000 成都理工大学能源学院(页岩气现代产业学院) 四川省成都市610059 中海艾普油气测试(天津)有限公司西南石油大学石油与天然气工程学院中国石化石油勘探开发研究院

在薄煤层发育的致密砂岩气藏,由于薄煤层割理发育且塑性较强,容易限制水力压裂裂缝的缝高扩展,进而导致遴选的地质、工程双甜点区域的实际产能无法达到预期效果。为获得更加准确的双甜点评价结果,以鄂尔多斯盆地神府南区致密砂岩气藏为... 详细信息

在薄煤层发育的致密砂岩气藏,由于薄煤层割理发育且塑性较强,容易限制水力压裂裂缝的缝高扩展,进而导致遴选的地质、工程双甜点区域的实际产能无法达到预期效果。为获得更加准确的双甜点评价结果,以鄂尔多斯盆地神府南区致密砂岩气藏为研究对象,首先构建了多属性融合的地质、工程双甜点评价模型,然后开展了双甜点三维分布的初次预测,进而采用Abaqus软件分析了煤层厚度、起裂点距煤层垂直距离对水力压裂裂缝穿煤层扩展的影响规律,最后形成了穿煤层双甜点二次优选评价技术。研究结果表明:①当煤层厚度大于等于4 m或起裂点距煤层垂直距离大于等于4 m时,水力压裂裂缝难以纵向穿过煤层扩展,可压性降低;②研究区双甜点指数划分标准为,Ⅰ类双甜点≥0.46,0.37≤Ⅱ类双甜点30≤Ⅲ类双甜点37。结论认为:①考虑薄煤层影响的致密砂岩气二次甜点评价技术能够准确筛选出优质的地质、工程双甜点,且优选结果与实际高产区域的匹配度较高;②建立的评价方法对于砂泥岩互层非常规储层的开发和多气合采中甜点的同步动用具有较好的理论与实际意义。

关键词：神府区块致密砂岩气薄煤层地质工程双甜点裂缝扩展

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基于“气化理论”探讨细胞自噬在骨髓增生异常综合征中的作用

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中医药学报 2024年第8期52卷 1-6页

作者：朱义文谌海燕王文儒丁晓庆北京中医药大学北京100029 北京中医药大学东方医院北京100078

气化理论是中医基础理论之一,气机是气化的基础,气化是气机的根本,二者的协调作用是维持脏腑功能正常的关键,气机、气化失常是导致疾病发生的重要因素。细胞自噬通过机体降解大分子物质、蛋白质及细胞器以防御外邪入侵,作为一种机体防... 详细信息

气化理论是中医基础理论之一,气机是气化的基础,气化是气机的根本,二者的协调作用是维持脏腑功能正常的关键,气机、气化失常是导致疾病发生的重要因素。细胞自噬通过机体降解大分子物质、蛋白质及细胞器以防御外邪入侵,作为一种机体防御机制在代谢、免疫方面与中医“气”的功能类似。骨髓增生异常综合征(MDS)在中医中属于“髓毒劳”“虚劳”,以本虚标实为特点,肾虚为本,阳虚无以温煦推动,气化失常,水液代谢障碍,痰浊、瘀血、邪毒形成,久居骨髓而发病。本文通过气化理论分析MDS的自噬机制,将中医“气化理论”与MDS中细胞自噬相结合,寻找其中的关系及内在联系,认为气化失常是MDS发病的主要病机,提出以补虚扶正、化痰解毒、填精益髓、温阳化气为治则,调畅气机,协调阴阳,延缓MDS进程,改善MDS患者临床症状,为MDS的临床诊疗提供新思路。

关键词：气化理论细胞自噬骨髓增生异常综合征

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桉树-红锥混交林林分生长和土壤肥力分析

林业与环境科学 2024年第3期40卷 100-108页

作者：马安琪邓海燕朱琪申琳琳丁晓纲莫晓勇华南农业大学林学与风景园林学院广东广州510642 广东省林业科学研究院广东广州510520 广东省林业调查规划院广东广州510520

为探究不同比例桉树Eucalyptus—红锥Castanopsis hystrix混交林林分生长和林地质量间伐后的变化,以不同混交比例桉树—红锥混交林和桉树纯林为研究对象,采用对比分析和方差分析方法探讨间伐前和间伐后不同比例桉树—红锥混交林林分生... 详细信息

为探究不同比例桉树Eucalyptus—红锥Castanopsis hystrix混交林林分生长和林地质量间伐后的变化,以不同混交比例桉树—红锥混交林和桉树纯林为研究对象,采用对比分析和方差分析方法探讨间伐前和间伐后不同比例桉树—红锥混交林林分生长和林地肥力变化。结果表明:(1)桉树—红锥1∶1混交林间伐50%强度桉树后能显著促进桉树—红锥混交林林分中桉树胸径和单株材积生长(2.桉树-红锥1∶1、3∶1混交林间伐50%强度桉树后能增加桉树和红锥蓄积,桉树—红锥5∶1、3∶3混交林间伐50%强度桉树后能增加红锥蓄积;(3)桉树—红锥1∶1混交林间伐50%强度桉树后土壤毛管孔隙度和pH明显降低,桉树—红锥3∶1混交林间伐50%强度桉树后碱解氮含量降低最明显,有效磷含量增幅最大,桉树—红锥5∶1混交林间伐50%强度桉树后有机碳和速效钾含量增幅最高,桉树—红锥3∶3混交林间伐50%强度桉树后土壤容重增幅最大,有机碳含量略有增加,有效磷含量明显降低。混交比例和间伐是影响林木生长的主要经营模式,根据造林目的和营林需求综合确定经营模式是精准提升桉树—红锥混交林经济和生态效益的关键。

关键词：经营模式抚育间伐林分生长土壤肥力

不同混交比例桉树—红锥混交林对林下植被和土壤肥力的影响研究

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林业与环境科学 2024年第4期40卷 70-79页

作者：朱琪邓海燕马安琪申琳琳丁晓纲莫晓勇华南农业大学林学与风景园林学院广东广州510642 广东省林业科学研究院广东广州510520 广东省林业调查规划院广东广州510520

为探究不同混交比例的桉树Eucalyptus robusta、红锥Castanopsis hystrx混交林对土壤肥力和林下植被多样性的影响,以广东省廉江市石岭林场4种混交比例的桉树—红锥混交林(桉树为华桉一号,红锥为当年生盆栽实生苗)为研究对象,通过野外调... 详细信息

为探究不同混交比例的桉树Eucalyptus robusta、红锥Castanopsis hystrx混交林对土壤肥力和林下植被多样性的影响,以广东省廉江市石岭林场4种混交比例的桉树—红锥混交林(桉树为华桉一号,红锥为当年生盆栽实生苗)为研究对象,通过野外调查、取样、分析以及综合比较,对不同混交比例下的桉树—红锥混交林的土壤理化性质、林下植被组成和植物多样性进行分析。结果表明,桉树—红锥5∶1混交林林下灌木和草本植物最多,1∶1混交林林下灌木物种组成最少,3∶3混交林林下草本物种组成最少。4种桉树—红锥混交林林下植被Patrick丰富度指数存在显著差异(P1混交林显著高于3∶3混交林。3∶1混交林林地的土壤最大持水量最大,其次为5∶1混交林;3∶1混交林的土壤最大持水量在0~2. cm,2.~40 cm,40~60 cm,3个土层均显著高于1∶1混交林,在2.~60 cm土层均显著高于3∶3混交林;5∶1混交林林地的最大持水量仅在0~2. cm土层显著高于1∶1混交林,在2.~40 cm土层显著高于3∶3混交林。桉树—红锥混交林林下植被的Simpson多样性指数在5∶1混交林和1∶1混交林与全磷含量显著负相关;Shannon-Wiener变化度指数在3∶3混交林与全磷含量显著负相关,在1∶1混交林与全磷含量显著负相关;Patrick丰富度指数在3∶3混交林与土壤非毛管孔隙度显著正相关,在3∶3混交林与全氮含量显著负相关;Pielou均匀度指数在3∶1混交林与土壤非毛管孔隙度和土壤通气度均显著负相关,在5∶1混交林与与全磷含量显著正相关。综上所述,5∶1混交比例更适合林下植物的生长,但1∶1的混交比例更适合土壤肥力的保存。

关键词：林下植被土壤肥力混交桉树