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First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang chan zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

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Surface-clean low-doped PdB/C as superior electrocatalysts toward ethanol oxidation in alkaline media

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Journal of Energy Chemistry 2018年第2期27卷 389-394页

作者： Yuan-Fang Wang chan zhu Yao-Yue Yang Zhi-Gang Zhao College of Chemistry and Environmental Protection Engineering Southwest Minzu University

Developing highly active, low-cost and organic surfactants-free Pd-based catalysts for ethanol oxidation reaction（EOR） is now critically important for direct ethanol fuel cells. Herein, surface-clean low-doped PdB/C catalysts（typically ca. 1.5 at% of B） are successfully prepared in an aqueous condition without adding any organic surfactants. TEM characterization shows that as-prepared low-doped Pd B nanoparticles are evenly distributed on carbon support. Cyclic voltommagrams of as-prepared low-doped PdB/C in 0.5 M NaOH ＋ 1 M C2H5OH indicate that its onset oxidation potential of ethanol is ca. 80-120 mV more negative than that on commercial Pd/C. Meanwhile, the EOR mass activity of our home-made catalysts is up to 4018 m A·mg-1 Pd. Moreover, the durability on low-doped PdB/C catalysts is at most 2 times higher than that on commercial Pd/C. Geometric and electronic effects are adopted to understand the above mentioned enhancement of activity and durability. This work may provide a facile, low-cost and green strategy on preparing electrocatalysts toward EOR in alkaline media.

关键词： EOR Surface-clean low-doped PdB/C Alkaline media Geometric and electronic effects

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Research on the logic coverage method of white-box testing

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通讯和计算机（中英文版） 2008年第6期5卷 16-20页

作者： zhu You-chan YE Wei Department of Compute Science North China Electric Power University Baoding 071000 China

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Extended Rough Set Model Based on Prior Probability and Valued Tolerance Relation

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Journal of Electronic Science and Technology 2011年第1期9卷 46-50页

作者： Hao-Dong zhu Hong-chan Li the School of Computer and Communication Engineering Zhengzhou University of Light Industry Zhengzhou 450002 China

Based on equivalence relation,the classical rough set theory is unable to deal with incomplete information *** this case,an extended rough set model based on valued tolerance relation and prior probability obtained from incomplete information systems is firstly *** a part of the model,the corresponding discernibility matrix and an attribute reduction of incomplete information system are then ***,the extended rough set model and the proposed attribute reduction algorithm are verified under an incomplete information system.

关键词： Attribute reduction discernibility matrix incomplete information system prior probability,rough set.

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Rough Set Processing Model for Fuzzy Decision Tables with Weights

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Journal of Electronic Science and Technology 2011年第2期9卷 133-135页

作者： Hao-Dong zhu Hong-chan Li School of Computer and Communication Engineering Zhengzhou University of Light IndustryZhengzhou 450002China

The classical rough set can not show the fuzziness and the importance of objects in decision procedure because it uses definite form to express each object. In order to solve this problem,this paper firstly introduces a special decision table in which each object has a membership degree to show its fuzziness and has been assigned a weight to show its importance in decision procedure. Then,the special decision table is studied and the relevant rough set model is provided. In the meantime,relevant definitions and theorems are proposed. On the above basis,an attribute reduction algorithm is presented. Finally,feasibility of the relevant rough set model and the presented attribute reduction algorithm are verified by an example.

关键词： Attribute reduction decision table membership degree rough set

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New Attribute Reduction Algorithm on Fuzzy Decision Table

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Journal of Electronic Science and Technology 2011年第2期9卷 103-107页

作者： Hao-Dong zhu Hong-chan Li School of Computer and Communication Engineering Zhengzhou University of Light IndustryZhengzhou 450002China

Classical rough set has a limited processing capacity in fuzzy decision table. Combining fuzzy set with classical rough set,attribute reduction algorithm on fuzzy decision table is studied. First,new similarity degree and new similarity category are defined. In the meantime,similarity category clusters which are divided by condition attribute are provided. And then,two theorems are presented. Subsequently,a new attribute reduction algorithm is proposed. Finally,the new attribute reduction algorithm is verified through a performance evaluation decision table of the self-repairing flight-control system. The result shows the proposed attribute reduction algorithm is able to deal with fuzzy decision table to a certain extent.

关键词： Attribute reduction fuzzy set rough set similarity category

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近5年骨质疏松英文文献的计量学及可视化分析：Web of Science来源数据

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中国组织工程研究 2020年第17期24卷 2752-2758页

作者：张强朱婵四川省骨科医院四川省成都市610041 成都中医药大学四川省成都市610000

背景:骨质疏松一直是医学研究的热点,对骨质疏松研究领域的英文文献进行可视化分析,能更直观地了解该领域的研究现状、热点及前沿,有助于科研人员把握科研选题及方向。目的:对有关骨质疏松的英文文献进行计量、共现、共被引及可视化分析... 详细信息

背景:骨质疏松一直是医学研究的热点,对骨质疏松研究领域的英文文献进行可视化分析,能更直观地了解该领域的研究现状、热点及前沿,有助于科研人员把握科研选题及方向。目的:对有关骨质疏松的英文文献进行计量、共现、共被引及可视化分析,探索该领域近5年的研究现状、热点及前沿。方法:以Web of Science(WOS)中Science Citation Index Expanded(SCI-E)收录的2015至2019年骨质疏松相关文献为对象,应用CiteSpace软件进行作者、机构、国家、关键词共现分析,被引作者、文献、期刊共被引分析,并绘制可视化图谱。结果与结论:①共得到2980篇文献,高产国家包括中国、美国、日本、韩国、英国等,主要研究机构有匹兹堡大学、哈佛大学、麦克马斯特大学、牛津大学等世界知名大学,上海交通大学占有一席之地。②高产作者HONG-WEN DENG关注基因与骨质疏松机制;HIROYUKI KATO、YUKIO NAKAMURA、TAKAKO SUZUKI共同关注地诺单抗、伊班膦酸等抗骨质疏松药物开发;JONATHAN D ADACHI关注维生素D与骨质疏松、骨代谢的研究;WILLIAM D LESLIE关注双能骨密度仪评估骨质疏松;JA KANIS关注抗骨质疏松的适宜人群及时机。《国际骨质疏松症杂志》《骨与矿物研究杂志》收录文献最多;《新英格兰医学杂志》《柳叶刀》《美国医学会杂志》等顶级刊物同样关注骨质疏松研究成果。③研究学科涉及临床及基础学科,以基础学科为主。抗骨质疏松药物开发获得进展是目前基础医学研究重要切入点。缺乏引起的骨质疏松、唑来膦酸、糖皮质激素诱发的骨质疏松、脂肪量、卵巢切除术、骨质疏松、矿物质密度、卵巢癌组、抗骨质疏松药、骨代谢是骨质疏松研究前沿领域。④2015至2016年,动物研究、老年骨质疏松是热点;2016至2017年,随机试验的设计、成人骨代谢、体力活动的干预是此阶段新兴领域;2017至2019年,糖皮质激素诱导的骨质疏松、间充质干细胞,细胞通路激活等关键词取得了爆发增长,是目前骨质疏松研究新兴领域。⑤结果表明,应用CiteSpace进行骨质疏松英文文献计量能相对直观地展示近5年整体发展,在选题参考内容和发展方向能够骨质疏松学者提供参考,结果具有一定意义。

关键词：骨质疏松文献计量学可视化分析 CiteSpace 地诺单抗伊班膦酸间充质干细胞细胞通路激活

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New insight into the origin and evolution of the flora and fauna of Hainan Island, China

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Science China Earth Sciences 2025年第1期68卷 52-61页

作者： Hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

关键词： Molecular phylogeny Biogeography Paleobotany Origin of flora and fauna Hainan Island of China

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基于禁忌遗传算法的RNA二级结构预测

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电子科技大学学报 2011年第5期40卷 765-771页

作者：刘勇国朱婵晏华电子科技大学计算机科学与工程学院成都611731 苏州大学江苏省计算机信息处理技术重点实验室江苏苏州215006 四川建筑职业技术学院图书馆四川德阳618000

生物RNA二级结构预测是生物信息学领域的一个重要研究问题。近来,研究人员提出应用元启发式算法来预测RNA二级结构。该文提出基于禁忌遗传算法的RNA二级结构预测方法(TGARNA),给出茎区相容性检测改进方法,保留最长茎区构造茎区相容个体... 详细信息

生物RNA二级结构预测是生物信息学领域的一个重要研究问题。近来,研究人员提出应用元启发式算法来预测RNA二级结构。该文提出基于禁忌遗传算法的RNA二级结构预测方法(TGARNA),给出茎区相容性检测改进方法,保留最长茎区构造茎区相容个体,以改善种群性能;同时将禁忌搜索融入遗传操作以防止近亲繁殖,保持种群多样性。仿真实验表明TGARNA算法能够有效预测RNA二级结构。

关键词：遗传算法最小自由能 RNA二级结构预测禁忌搜索

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体育课堂教学的多层次模糊综合评判

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浙江体育科学 1999年第5期21卷 50-53,57页

作者：朱金婵郑州轻工业学院河南郑州450002

体育课堂教学评价指标体系中指标较多，为了更好地分配权重，充分利用所得到的信息，有效易行的办法是采用多层次模糊综合评判方法进行评判。

关键词：体育课堂教学多层次模糊综合评判评价指标体系

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