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Influence of Cultural Alienation on Happiness of Overseas Students: Mediating Role of Stress Relief and Regulating Role of Cultural Intelligence

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International Journal of Mental Health Promotion 2021年第2期23卷 289-302页

作者： xiaoxia zhu Xu Guo Yishu Teng John Gershenson Institute of advanced Studies in Humanities and Social Sciences Beijing Normal UniversityZhuhai519000China School of Economics and Management YanShan UniversityQinhuangdao066000China School of College of Engineer Pennsylvania State universityBellefonte16802USA

When the global outbreak of new coronary pneumonia broke out in 2020,online public opinion events triggered by cultural differences among overseas students had come into the public *** further explore the relationship between the cultural alienation of overseas students and their own happiness,this study takes visualization and analysis of positive,negative sentiment analysis of Weibo netizens’comment data in the“Xu Kexin Incident”as the starting point,on the basis of introducing cultural alienation,stress relief methods,and cultural intelligence,combining gender and social ability,social relations and other individual attributes,designed a questionnaire to investigate 502 overseas students,through the construction and analysis of the adjusted Cox risk ratio intermedi-ary model,comprehensive single factor interference and multi-factor cross-over comprehensive *** results show that the cultural alienation of overseas students has a significant effect on their own *** study concluded as follows:(1)Netizens hold polarized views on the three dimensions of overseas students’mask,safety,and culture;(2)Stress relief methods play an intermediary role between cultural alienation and the happiness of overseas students,among which Negative stress relief methods play a greater role;(3)The level of cultural intelligence regulates the intermediary process of stress relief *** higher the level of cultural intelligence,the stronger the regulatory effect.

关键词： Cultural alienation happiness emotional analysis stress relief cultural intelligence

A Common Functional Variant at the Enhancer of the Rheumatoid Arthritis Risk Gene ORMDL3 Regulates its Expression Through Allele-Specific JunD Binding

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Phenomics 2023年第5期3卷 485-495页

作者： Wenjing Ye Yiyun Yu xiaoxia zhu Weiguo Wan Yun Liu Hejian Zou Zaihua zhu Division of Rheumatology and Immunology Huashan HospitalFudan UniversityShanghai 200040China Institute of Rheumatology Immunology and AllergyFudan UniversityShanghai 200040China The Ministry of Education Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China

Genome-wide association studies(GWASs)have identified over 100 loci associated with rheumatoid arthritis(RA);how-ever,the functionally affected genes and the underlying molecular mechanisms contributing to these associations are often *** this study,we conducted an integrative genomic analysis incorporating multiple“omics”data and identified a functional regulatory DNA variant,rs56199421,and a plausible mechanism by which it regulates the expression of a puta-tive RA risk gene,ORMDL Sphingolipid Biosynthesis Regulator 3(ORMDL3).The T allele of rs56199421,located in the enhancer region of ORMDL3,exhibited stronger direct binding ability than the other C allele of rs56199421 did in vitro with the transcription factor JunD and demonstrated higher transcriptional ***,the T allele of rs56199421 is associated with elevated RA risk,and ORMDL3 expression is increased in RA ***,these findings suggest that the T allele of rs56199421 enhances JunD transcription factor binding,increases enhancer activity,and elevates the expression of the RA risk gene ORMDL3.

关键词： Rheumatoid arthritis Genome-wide association study Enhancer ORMDL Sphingolipid Biosynthesis Regulator 3

Ginsenoside modified lipid-coated perfluorocarbon nanodroplets: A novel approach to reduce complement protein adsorption and prolong in vivo circulation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1845-1863页

作者： Jie Zhou Binyang Gao Huan Zhang Rui Yang Jianbo Huang Xin Li Yi Zhong Yan Wang xiaoxia zhu Yan Luo Feng Yan Ultrasound Department of West China Hospital Sichuan UniversityChengdu 610041China Laboratory of Ultrasound Imaging of West China Hospital Sichuan UniversityChengdu 610041China West China Washington Mitochondria and Metabolism Research Center West China HospitalSichuan UniversityChengdu 610041China Research Core Facilities of West China Hospital Sichuan UniversityChengdu 610041China

Lipid-coated perfluorocarbon nanodroplets(lp-NDs)hold great promise in bio-medicine as vehicles for drug delivery,molecular imaging and vaccine ***,their clinical utility is restricted by limited targeted accumulation,attributed to the innate immune system(IIS),which acts as the initial defense mechanism in *** study aimed to optimize lp-ND formulations to mini-mize non-specific clearance by the ***(Gs),the principal components of Panax ginseng,possessing complement inhibition ability,structural similarity to cholesterol,and comparable fat solubi-lity to phospholipids,were used as promising candidate IIS *** different types of ginsenoside-based Ip-NDs(Gs Ip-NDs)were created,and their efficacy in reducing IS recognition was *** Gs p-NDs were observed to inhibit the adsorption of C3 in the protein corona(PC)and the generation of *** Gs to Ip-NDs reduced complement adsorption and phagocytosis,resulting in a longer blood circulation time in vivo compared to lp-NDs that did not contain *** results suggest that Gs can act as anti-complement and anti-phagocytosis adjuvants,potentially reducing non-specific clear-ance by the IS and improving lifespan.

关键词： Lipid-coated perfluorocarbon nanodroplets Protein corona Complement C3 Phagocytosis Ginsenosidelipid-coated perfluorocarbon nanodroplets Innate immune system Complement system Mononuclear phagocytic system

Evaluation of the metabolism of PEP06,an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

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Journal of Pharmaceutical Analysis 2022年第5期12卷 766-773页

作者： Liyun Niu Huiyu Zhou Yueru Lian Ya Gao Yulu Liu Ruolan Gu zhuona Wu xiaoxia zhu Hui Gan Zhiyun Meng Guifang Dou State Key Laboratory of Drug Metabolism and Pharmacokinetics Department of Pharmaceutical SciencesBeijing Institute of Radiation MedicineBeijing100850China Henan University KaifengHenan475004China

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp(RGDRGD)30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N *** active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral ***,little is known about the kinetics and degradation products of PEP06 in vitro or in *** this study,we investigated the in vitro metabolic stability of PEP06 after it was incubated with living cells obtained from animals of different species;we further identified the degradation characteristics of its cleavage ***06 underwent rapid enzymatic degradation in multiple types of living cells,and the liver,kidney,and blood play important roles in the metabolism and clearance of the peptides resulting from the molecular degradation of *** identified metabolites of PEP06 using full-scan mass spectrometry(MS)and tandem MS(MS2),wherein 43 metabolites were characterized and identified as the degradation metabolites from the parent peptide,formed by successive losses of amino *** metabolites were C and N terminal truncated products of *** structures of 11 metabolites(M6,M7,M16,M17,M21,M25,M33,M34,M39,M40,and M42)were further confirmed by comparing the retention times of similar full MS spectrum and MS2 spectrum information with reference standards for the synthesized *** have demonstrated the metabolic stability of PEP06 in vitro and identified a series of potentially bioactive downstream metabolites of PEP06,which can support further drug research.

关键词： PEP06 HRMS Metabolic stability Metabolites identification

IgE Reactivity of Potential Allergens from the Swimming Crab Portunus trituberculatus and the Research of ELISA Reagent for Detecting Crab Food Anaphylaxis

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Journal of Ocean University of China 2022年第2期21卷 421-429页

作者： QIU Xueni ZHOU Qiongyan zhu xiaoxia LIN Wei MU Changkao LI Ronghua YE Yangfang SONG Weiwei SHI Ce LIU Lei WANG Huan WANG Chunlin XU Suling Key Laboratory of Aquatic Biotechnology Ministry of EducationNingbo UniversityNingbo 315211China Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture Ningbo UniversityNingbo 315211China The Affiliated Hospital of Medical School of Ningbo University Ningbo 315020China

Crustacean is one of the major allergic *** is of great significance to identify more crab allergens and research the detection methods for crab food *** this study,IgE reactivity to three recombinant proteins from Portunus trituberculatus,including tropomyosin(rPtTM),myosin light chain(rPtMLC),and pancreatic lipase(rPtPL),were detected by enzyme-linked im-munosorbent assay(ELISA).The expressions of tropomyosin(TM)in various tissues of *** were detected by Western blot(WB).Furthermore,microplates were coated with rPtTM and the ELISA conditions were *** cut-off value was deter-mined by the receiver operating characteristic(ROC)*** 51 crab-allergic sera,21(41.2%)showed positive IgE to *** 70 crab-allergic sera more frequently recognized rPtPL(9/70;12.9%),followed by rPtMLC(1/70;1.4%).WB results showed that TM was mainly expressed in the muscle,followed by the heart and a small amount in gills and the *** optimal results showed that the coating condition of rPtTM was 50 ng per well with coating for 3 h at 37℃.The optimal blocking condition was 1.2%BSA with blocking for 3 h at 37℃,and the optimal dilution of the second antibody was 1:*** ROC curve showed that the ELISA reagent had high sensitivity(83.52%)and specificity(98.00%)when the cut-off value was *** results indicated that tropomyosin is the major allergen of ***,and myosin light chain and pancreatic lipase are the potential ***-tionally,the ELISA reagent developed with the rPtTM was feasible for laboratory detection of crab anaphylaxis.

关键词： Portunus trituberculatus potential allergens food anaphylaxis ELISA reagent

APPLICATION OF THE SULFONATE ESTER GROUP AS A LINKER FOR SOLID PHASE ORGANIC SYNTHESIS

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Chinese Journal of Reactive Polymers 2001年第1期10卷 21-26页

作者： SUN Weimin LUO Juntao HUANG Wenqiang zhu xiaoxia The State Key Laboratory of Functional Polymer Material for Adsorption and Separation Institute of Polymer ChemistryNankai UniversityTianjin 300071China Department of Chemistry University of MontrealMontrealQuebecCANADA H3C 3J7

A use of Sulfonate ester as a linker in synthesis of (-aminoalkanols was reported. Diols were tethered onto polystyryl sulfonyl chloride resin, yielding sulfonate resins (2). After cleaved by diethyl amine, diisopropy... 详细信息

关键词： Polystyryl sulfonate ester Immobilization of diol (-Aminoalkanol Solid phase organic synthesis.

美国加利福尼亚大学班克罗夫特图书馆口述历史工作研究

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国家图书馆学刊 2018年第3期27卷 56-62页

作者：朱晓霞铁道警察学院图书馆

美国加利福尼亚大学班克罗夫特图书馆是口述资料采集与收藏的先行者,通过网络调查、Email咨询、文本分析等方法,对其口述历史资源采集、组织及利用,用户服务,教育职能,团队构成及经费来源等方面进行分析,总结出主题范围广泛、创造商业... 详细信息

美国加利福尼亚大学班克罗夫特图书馆是口述资料采集与收藏的先行者,通过网络调查、Email咨询、文本分析等方法,对其口述历史资源采集、组织及利用,用户服务,教育职能,团队构成及经费来源等方面进行分析,总结出主题范围广泛、创造商业收入、服务方式灵活、积极参与教育等四个方面的特点,继而提出落实著作权保护、开发社会资本,提供多样服务、灵活利用方式,加强专业培训、打造专业团队,注重宣传推广、鼓励公众参与等建议。

关键词：口述历史加利福尼亚大学班克罗夫特图书馆口述历史中心

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区域创新系统中的“区域边界”问题研究

科技进步与对策 2008年第9期25卷 24-27页

作者：朱晓霞哈尔滨工程大学经济管理学院黑龙江哈尔滨150001

在探讨区域创新系统(RIS)时,不得不首先面对一个现实而又极其重要的问题——RIS中的区域边界问题。正确认识和理解其边界以及与行政边界这二者之间的关系,对于我们针对具体行政区域及其中心城市建立可行的RIS十分重要。因此,从分析RIS... 详细信息

在探讨区域创新系统(RIS)时,不得不首先面对一个现实而又极其重要的问题——RIS中的区域边界问题。正确认识和理解其边界以及与行政边界这二者之间的关系,对于我们针对具体行政区域及其中心城市建立可行的RIS十分重要。因此,从分析RIS的由来及内涵出发,从RIS的系统运行机制、运行目的以及运行过程来看,发现RIS的区域边界应该与行政边界等同。通过进一步的分析,得出了RIS是一个开放系统,区域边界不应成为限制各要素流动的障碍。最后提出构建RIS时要强调地方政府的职责,但同时也要强调区域间的分工与合作。

关键词：区域创新系统区域边界行政边界

A new method for preparing a rat intracerebral hemorrhage model by combining focused ultrasound and microbubbles

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Animal Models and Experimental Medicine 2023年第2期6卷 103-110页

作者： Yao He Jie Yang Fengying Hu Min Liao Yuru Nie xiaoxia zhu Tao Zhang Keer Song Qinxi Li Xiaojie Li Chenghan Mei Zhe Wu Qiang Lu Zhihui Zhong Laboratory of Nonhuman Primate Disease Modeling Research State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Medical Ultrasound West China HospitalSichuan UniversityChengduChina School of Life Science and Technology University of Electronic Science and Technology of ChinaChengduChina School of Bioscience and Technology Chengdu Medical CollegeChengduChina Franklin College of Arts and Science University of GeorgiaAthensGeorgiaUSA

Background:We aimed to prepare a non-invasive,reproducible,and controllable rat model of intracerebral hemorrhage with focused ultrasound(FUS).Methods:A rat intracerebral hemorrhage(ICH)model was established by combining FUS and microbubbles(μBs),and edaravone was used to verify whether the free radical scavenger had a protective effect on the *** brain tissue of each group was sectioned to observe the gross histology,blood-brain barrier(BBB)permeability,cerebral infarction volume,and histopathological ***:Compared with the FUS group,the BBB permeability was significantly increased in the FUS+μBs(F&B)group(p=0.0021).The second coronal slice in the F&B group had an obvious hemorrhage lesion,and the FUS+μBs+edaravone(F&B&E)group had smaller hemorrhage areas;however,ICH did not occur in the FUS *** cerebral infarction volume in the F&B group was significantly larger than that in the FUS group(p=0.0030)and F&B&E group(p=0.0208).HE staining results showed that nerve fibrinolysis,neuronal necrosis,microglia production,and erythrocytes were found in both the F&B group and the F&B&E group,but the areas of the nerve fibrinolysis and neuronal necrosis in the F&B group were larger than the F&B&E ***:A rat ICH model was successfully prepared using theμBs assisted FUS treatment,and edaravone had a therapeutic effect on this *** model can be used to study the pathophysiological mechanism of ICH-related diseases and in preclinical research on related new drugs.

关键词： focused ultrasound(FUS) ICH model microbubbles(μBs) rat