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Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment:A Global Meta-Analysis,2000-2022

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China CDC weekly 2024年第25期6卷 589-596,I0001-I0012页

作者： heng Jiang Xing Xing he zhu Tuo Dong School of Public health Harbin Medical UniversityHarbin CityHeilongjiang ProvinceChina School of Public health Peking UniversityBeijingChina

Osteoarthritis(OA)treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid ***,the clinical use of opioids is controversial due to their adverse effects and addiction *** study,drawing on 24 randomized controlled trials(RCTs)with a total of 9,586 patients,thoroughly explored the various side effects associated with opioid use in OA *** results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use,potentially fostering the advancement of safer treatment *** reducing the risks of misuse and addiction,public health and safety can be enhanced.

关键词： potential thoroughly insight

High-entropy design boosts dielectric energy storage

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Rare Metals 2024年第8期43卷 4013-4015页

作者： Qiu-Ying Xia he zhu Si Lan Yang Ren herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Physics City University of Hong KongHong Kong999077China

Dielectric capacitors are vital for advanced electronic and electrical power systems due to their impressive power density and ***,a persistent challenge has been enhancing their energy densities while maintaining high *** in Science,a novel high-entropy design for relaxor ferroelectric materials has been proposed,promising significant improvements in both energy density and efficiency for multilayer dielectric ceramic *** the crucial role of high-entropy design in energy storage materials and devices,this highlight focuses on interpreting the progress and significance of this innovative work.

关键词： ceramic dielectric energy

Prevalence of Cannabis Use around the World:A Systematic Review and Meta-Analysis,2000-2024

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China CDC weekly 2024年第25期6卷 597-604,I0013,I0014页

作者： Qianning Wang Zhen Qin Xing Xing he zhu Zhongwei Jia National Institute of health Data Science Center for Drug Abuse Prevention and ControlPeking UniversityBeijingChina School of Public health Peking UniversityBeijingChina

This study aims to perform a systematic review and meta-analysis on the global prevalence of cannabis use to inform drug prevention strategies,policy-making,and resource *** study initially screened 177,843 studies published between January 1,2000,and January 15,2024,using peer-reviewed databases including Web of Science,PubMed,Scopus,Embase,and Cochrane ***,595 studies were identified for data extraction,and 39 of these were selected as country-representative *** among the selected studies was assessed using the chi-squared test and I2 statistic,while sensitivity analysis was conducted to evaluate the robustness of the *** prevalence of cannabis use varied between 0.42%and 43.90%across 33 European countries,1.40%to 38.12%across 15 North and South American countries,0.30%to 19.10%across 16 Asian countries,and 1.30%to 48.70%across 18 Oceania and African *** pooled prevalence of cannabis use was 12.0%[95%confidence interval(CI):10.0,14.3]in countries where cannabis is legalized,compared to 5.4%(95%CI:4.3,6.9)in non-legalized *** findings indicate that the prevalence of cannabis use has disproportionately increased in most countries with the implementation of medical or recreational cannabis legalization policies and relevant geographic *** efforts are needed to monitor newly cannabis-legalized countries and prevent initial use.

关键词： prevention legal initially

Extraction and evolution of grader’s bionic morphological feature line using shape structure behavior function model

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 74-84页

作者： Bin Qi Yubin Lan Xiaoming Sun he zhu Yanhao Li Ke Lou College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049ShandongChina Shandong Provincial Engineering Technology Research Center for Agricultural Aviation Intelligent Equipment Zibo 255049China

To improve the innovation of agricultural machinery product styling,this paper proposes a shape structure behavior function(SSBF)model suitable for the industrial design *** feature line evolution method combining shape grammar and genetic algorithm was used for modelling the of the grader,which not only maintains the product style characteristics but also reflects the typical identification characteristics of the bionic prototype and produces a new product modelling *** conducting cognitive and recognition experiments on product styling features,the ranking of product styling features and the contribution of each component to product styling were *** method of combining shape grammar and quadratic Bézier curve was used to express and encode feature lines,and genetic algorithm was used to evolve biomimetic forms to form product feature lines with typical biological morphological features;The extracted form bionic elements were integrated into the grader modelling design,and the interaction evaluation was carried out through the genetic algorithm evolution *** basic form elements were extracted and analyzed,and the deduction rules were formulated and *** derived feature line geometric data considered the product’s image features and the bio-inspired prototype,which can be used for the follow-up guidance of industrial design schemes.

关键词： bionic design shape-structure-behavior-function SSBF biologically inspired design BID shape grammars Quadratic Bézier curves

Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu zhu helen he zhu Hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research International 2024年第2期31卷 389-400页

作者： Li-ping Pan Ya-wei Li Fang-guan Tan Yi-chen Chen Yang-fan Xu zhu he Bao-kuan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

The Spatial Differences and Influencing Factors of Tourism Resources in Ningxia,China

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Journal of Resources and Ecology 2024年第4期15卷 1068-1082页

作者： ZHANG Shengrui CHI Lei zhu he ZHANG Tongyan JU Hongrun Management College Ocean University of ChinaQingdaoShandong 266100China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China School of Tourism and Geography Science Qingdao UniversityQingdaoShandong 266071China

The analysis of the spatial distribution of tourism resources and the identification of its influencing factors are crucial for supporting the sustainable development of regional *** study established a comprehensive database of tourism resources in Ningxia Hui Autonomous Region(Ningxia)through a combination of literature review and field *** examined the quantitative,qualitative,and categorical characteristics of tourism resources in Ningxia,and determined the spatial patterns based on kernel density and spatial association *** study also comprehensively evaluated the societal,economic,and environmental factors influencing the spatial distribution of tourism resources in the entire region by employing the geographical detector model to quantify the influence of each *** following results were obtained.(1)There were 29218 individual tourism resources in Ningxia,comprising eight main types,23 subtypes,and 105 fundamental types,and they exhibit a hierarchical pyramidal structure.(2)The tourism resources in Ningxia displayed characteristics of“widespread regional dispersion and limited regional agglomeration”.The spatial distribution of tourism resources was highly imbalanced,and most types of tourism resources exhibit strong positive spatial correlation.(3)The altitude,annual precipitation,population density,distance from urban centers,urbanization rate,and per capita GDP were identified as significant factors influencing the spatial distribution of tourism resources in *** on the results,we recommend that the government should formulate tourism development policies in Ningxia based on local conditions to effectively address the spatial imbalances,enhance the sustainability of tourism development,and continue to promote high-quality tourism development in Ningxia.

关键词： tourism resource spatial pattern influencing factors Geo-detector Ningxia

融合信息对抗及混合特征表示的社交网络谣言检测方法

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情报杂志 2024年第2期43卷 118-127页

作者：朱贺河南师范大学图书与档案信息中心新乡453007

[研究目的]针对现实社交网络中广泛存在的不实评论对谣言检测的负面影响问题,提出对抗学习框架下的谣言检测方法,从而在提升谣言检测准确率的同时,增强模型对噪声信息的容抗性。[研究方法]以信息对抗机制为基础,搭建具有融合结构及时序... 详细信息

[研究目的]针对现实社交网络中广泛存在的不实评论对谣言检测的负面影响问题,提出对抗学习框架下的谣言检测方法,从而在提升谣言检测准确率的同时,增强模型对噪声信息的容抗性。[研究方法]以信息对抗机制为基础,搭建具有融合结构及时序特征表示的生成网络,利用部分网络结构的共享及加强具有自注意力机制的二次鉴别网络,实现将非监督的对抗生成网络向有监督学习任务上的成功拓展。[研究结论]在PheMEv5和新浪微博两个数据集上,该研究提出的模型在谣言检测的准确率上,相较于9种较为先进的基准模型至少提升了3.1%和4.1%;同时,实验显示,该研究提出的模型对于噪声信息并不敏感。充分证明了该模型在跨平台不同语言环境数据集上较高的谣言检测效果及较强的噪声容抗性。

关键词：网络谣言谣言检测信息对抗对抗生成网络特征融合自注意力机制

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温度影响下碳纤维导线分层力学特性有限元分析

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西南交通大学学报 2024年第3期59卷 700-711页

作者：祝贺袁鸣郭鑫东北电力大学建筑工程学院吉林吉林132000

为探明温度对碳纤维导线分层力学特性的影响,考虑拐点温度,利用电热模块施加不同电压得到多种温度,并计算分析不同温度和拉断力条件下碳纤维导线的各层、各股和各截面应力应变分布.研究结果表明:拐点温度后,碳芯受到正向应力但铝绞线承... 详细信息

为探明温度对碳纤维导线分层力学特性的影响,考虑拐点温度,利用电热模块施加不同电压得到多种温度,并计算分析不同温度和拉断力条件下碳纤维导线的各层、各股和各截面应力应变分布.研究结果表明:拐点温度后,碳芯受到正向应力但铝绞线承受负向应力,使碳纤维导线失去了承担拉断力的作用;各股线的最大应力和应变均出现在线的两端,倒角位置的应力和应变结果略大于对应股线主体上的应力;碳纤维导线各个截面的最大应力均为正值,均出现在碳芯上,其靠近外力施加端截面的最大应力出现突然下降的现象;碳纤维导线更适用于各种温度条件,但应注意导线两端夹持位置和梯形截面中小截面的力学特性变化.

关键词：碳纤维导线温度效应分层力学温度-力学模型有限元仿真