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Intrahepatic portal venous systems in adult patients with cavernous transformation of portal vein: Imaging features and a new classification

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 481-486页

作者： Xin Huang Qian Lu Yue-Wei Zhang Lin Zhang Zhi-zhong Ren Xiao-Wei Yang ying Liu Rui Tang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background: Cavernous transformation of the portal vein(CTPV) due to portal vein obstruction is a rare vascular anomaly defined as the formation of multiple collateral vessels in the hepatic hilum. This study aimed to investigate the imaging features of intrahepatic portal vein in adult patients with CTPV and establish the relationship between the manifestations of intrahepatic portal vein and the progression of CTPV. Methods: We retrospectively analyzed 14 CTPV patients in Beijing Tsinghua Changgung Hospital. All patients underwent both direct portal venography(DPV) and computed tomography angiography(CTA) to reveal the manifestations of the portal venous system. The vessels measured included the left portal vein(LPV), right portal vein(RPV), main portal vein(MPV) and the portal vein bifurcation(PVB). Results: Nine males and 5 females, with a median age of 40.5 years, were included in the study. No significant difference was found in the diameters of the LPV or RPV measured by DPV and CTA. The visualization in terms of LPV, RPV and PVB measured by DPV was higher than that by CTA. There was a significant association between LPV/RPV and PVB/MPV in term of visibility revealed with DPV( P = 0.01), while this association was not observed with CTA. According to the imaging features of the portal vein measured by DPV, CTPV was classified into three categories to facilitate the diagnosis and treatment. Conclusions: DPV was more accurate than CTA for revealing the course of the intrahepatic portal vein in patients with CTPV. The classification of CTPV, that originated from the imaging features of the portal vein revealed by DPV, may provide a new perspective for the diagnosis and treatment of CTPV.

关键词： Cavernous transformation of the portal vein Classification Direct portal venography Intrahepatic portal venous system

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RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

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Genes & Diseases 2024年第1期11卷 87-90页

作者： Hongxia Zhang Yueya zhong Yuanming He Yujia Xu ying Ren Haixia Zhuang Tong Sun Zhigang Zhu Xinliang Mao Institute of Clinical Pharmacology Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouGuangdong 510403China Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 511436China Department of Pharmacology College of Pharmaceutical SciencesSoochow UniversitySuzhouJiangsu 215123China Division of Hematology&Oncology Department of GeriatricsGuangzhou First People's HospitalCollege of MedicineSouth China University of TechnologyGuangzhouGuangdong 510180China

Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene *** addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1 RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1,TLE3,FOXA1,and MAD1.^(2) However,its specific mechanism in CML is not known.

关键词： ubiquitin myelogenous leukemia

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Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-zhong Sun Si-Yu Wei Qiu-Man Xu Wei Shang Qing Li Jing-Sheng Cheng ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

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Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

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Biomedical and Environmental Sciences 2024年第1期37卷 19-30页

作者： MENG Li ying TAO Wen Fu LI Jing ZHU Min zhong De Bin ZHOU Jing QIN Xue WEI Rong Guo Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Jiangsu Key Laboratory of Environmental Engineering Jiangsu Academy of Environmental SciencesNanjing 210000JiangsuChina

Objective The aim of this study was to assess the impact of bisphenol A(BPA)and its substitute,bisphenol F(BPF),on the colonic fecal community structure and function of *** We exposed 6–8-week-old male C57BL/6 mice to 5 mg/(kg∙day)and 50μg/(kg∙day)of BPA or BPF for 14 *** samples from the colon were analyzed using 16S rRNA *** Gut microbiome community richness and diversity,species composition,and function were significantly altered in mice exposed to BPA or *** change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and ***,pathways related to carbohydrate and amino acid metabolism showed substantial *** Mice exposed to different BP analogs exhibited distinct gut bacterial community richness,composition,and related metabolic *** the essential role of gut bacteria in maintaining intestinal homeostasis,our study highlights the intestinal toxicity of BPs in vertebrates.

关键词： Bisphenol A(BPA) Bisphenol F(BPF) 16S rRNA Microbiota

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Sand control mechanism of radial well filled with phase change material in hydrate reservoir

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Petroleum Science 2024年第4期21卷 2571-2582页

作者： Xiao-Qiang Liu zhong-Xi Han Zhi-Lin Luo Hai-Long Lu ying Sun Qing You Tian-Kui Guo Zhan-Qing Qu School of Energy Resources China University of Geosciences (Beijing) Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences (Beijing) China Research Institute of Petroleum Exploration and Development Engineering Technology Research Institute of Southwest Oil & Gas Field Company PetroChina Beijing International Center for Gas Hydrate School of Earth and Space Sciences Peking University School of Advanced Material Peking University Shenzhen Graduate School School of Petroleum Engineering China University of Petroleum (East China)

Radial well filled with phase change material has been proposed as a novel sand control method for hydrate exploitation. In order to reveal the sand control mechanism, CFD-DEM coupling method is applied to simulate the migration, settlement, and blockage processes of sand particles in the radial *** obtained results indicate that three scenarios have been recognized for sand particles passing through sand control medium, based on the diameter ratio of sand control medium to sand particle（Dd）:fully passing（Dd= 8.75-22.5）, partially passing and partially blocked（Dd= 3.18-5.63）, and completely blocked（Dd= 2.18-3.21）. After being captured by the sand control medium, sand particles can block pores, which increases fluid flow resistance and causes a certain pressure difference in the radial *** pressure in the radial well should be lower than the hydrate phase equilibrium pressure during sand control design, for the purpose of promoting hydrate decomposition, and sand capture. The length of the radial well should be optimized based on the reservoir pore pressure, production pressure difference,bottom hole pressure, and the pressure gradient in the radial well. It should be noticed that the sand control medium leads to a decrease in permeability after sand particles captured. Even the permeability is reduced to several hundred millidarcy, it is still sufficient to ensure the effective flow of gas and water after hydrate decomposition. Increasing fluid velocity reduces the blocking capacity of the sand control medium, mainly because of deterioration in bridging between sand particles.

关键词： Hydrate reservoir Sand control Radial well CFD-DEM

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客运专线基础数据管理信息系统研究

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铁道运输与经济 2010年第4期32卷 10-13页

作者：仲莹萤西南交通大学交通运输学院四川成都610031

针对客运专线竣工验收后基础数据整合管理的问题,提出基于地理信息系统技术和数据仓库技术构建客运专线基础数据管理信息系统的思路,对客运专线基础数据的内容体系、数据库设计与存储管理、元数据库设计、系统结构设计、系统功能和数据... 详细信息

针对客运专线竣工验收后基础数据整合管理的问题,提出基于地理信息系统技术和数据仓库技术构建客运专线基础数据管理信息系统的思路,对客运专线基础数据的内容体系、数据库设计与存储管理、元数据库设计、系统结构设计、系统功能和数据整合方法等进行研究设计,以实现客运专线各种基础数据的整合、管理和导航检索,从而为运营管理提供良好的技术支持和服务。

关键词：铁路客运专线基础数据信息系统

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壳聚糖-硅基凝胶微球作为固定化金属螯合亲和色谱基质的研究

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分析化学 2007年第11期35卷 1581-1585页

作者：钟莺莺叶俊超邬建敏浙江大学理学院化学系浙江大学理学院化学系杭州310027

采用溶胶凝胶及微乳液技术制备了以壳聚糖-硅基杂化材料为骨架并带有金属离子螯合官能团的球形基质(CSHB),并对该基质的制备条件及结构形貌进行了研究与表征。实验表明,当微乳液反应体系的组分为:100mL壳聚糖溶液(2%m/V)、100mL Span乳... 详细信息

采用溶胶凝胶及微乳液技术制备了以壳聚糖-硅基杂化材料为骨架并带有金属离子螯合官能团的球形基质(CSHB),并对该基质的制备条件及结构形貌进行了研究与表征。实验表明,当微乳液反应体系的组分为:100mL壳聚糖溶液(2%m/V)、100mL Span乳化剂、250mL环己烷、13.3mL四乙氧基硅烷(TEOS)、1.33mL 3-缩水甘油丙氧基三甲氧基硅烷(GPTMS)和亚氨基二乙酸(IDA)0.802g时,可获得粒径均匀,刚性较好的微球。红外光谱证明了该基质是一种多组分的杂合材料,差热分析数据表明该杂合材料的热稳定性随反应体系中GPTMS的含量增加而增大。CSHB通过动态吸附金属离子Cu2+与Ni2+后,可对金属螯合蛋白产生配位吸附作用。Cu2+-CSHB柱对牛血清蛋白(BSA)具良好的可逆吸附能力,蛋白能被咪唑等金属离子螯合剂洗脱,回收率达76.6%。BSA在CSHB柱上的吸附率只有4.7%,表明CSHB对蛋白的非特异吸附较低。Ni2+-CSHB柱对过氧化氢酶(CAT)也显示出初步的纯化效果,一步纯化倍数为2.43倍。该基质有望用于具有组氨酸纯化标签的基因工程表达蛋白的分离与纯化。

关键词：溶胶凝胶壳聚糖-硅基杂化凝胶金属螯合亲和层析蛋白纯化

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Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-Bin Song zhong-Ze Du ying-Wei Xue Hong-Jiang Song Yuan-Zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

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Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 139-146页

作者： Guan-Wen Yuan Lei Lei Yuan-Zhu Wang Bo Wang Yi-ying Wang Chao Chen Zhao-Qiang Shen Yi-Fu Cai Yi-zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope(JWST),which were unexpected to form at such an early time within the standard Big Bang *** this work,we propose that this puzzle can be explained by the presence of some primordial black holes(PBHs)with a mass of~1000M_(⊙).These PBHs act as seeds for early galaxy formation with masses of~10^(8)-10^(10)M_(⊙)at high redshift,hence accounting for the JWST *** use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models,and find that the Lognormal model with the M_(c)~750M_(⊙)is preferred over other *** rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects,similar to those recently discovered by *** we focused on PBHs in this work,the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

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Geometric based apple suction strategy for robotic packaging

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 12-20页

作者： zhong Wang Qingyu Wang Mingzhao Lou Fan Wu Yaonan Zhu Dong Hu Mingchuan Zhou Yibin ying College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Micro-Nona Mechanical Science and Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Packaging is one of the least automated steps among all the fruit postharvest processes,which is time-consuming and ***,a robust suction strategy for robotic manipulation needs to be *** this research,a geometric-based apple suction strategy for robotic packaging was studied,including suction cup design,optimal suction region selection algorithm,and robot system *** the first place,on the basis of the geometric features of the spheroid fruit,the structure of the suction cups was designed to provide reliable suction ***,suction force measurement experiments on both acrylic balls and apples were *** on the results,the parameters of the suction cup were finally *** results also indicated that the curvature radius of the suction region is supposed to larger than that of the suction ***,a robust suction region selection algorithm was developed,which involves four steps:RGB-D information acquisition,object detection and point cloud generation,spherical fitting,and suction region ***,the above methods were integrated into a robotic packaging *** addition,on the basis of spatial-frequency domain imaging(SFDI)technology,early stage bruise was detected for *** results showed that,the proposed suction strategy and system is potential for robust robotic apple packaging.

关键词： apple suction cup robotic packaging robotic manipulation point cloud

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